iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSMMUG00000019015.3	ENSMMUT00000026729.3	ENSMMUP00000025010.3
ENSMMUG00000019015.3	ENSMMUT00000068203.1	ENSMMUP00000044831.1
ENSMMUG00000019015.3	ENSMMUT00000058028.1	ENSMMUP00000048757.1

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 activity/HECT	4.50e-122	408.7	1274	1606

Active Site

Position(s)	Description	Evidence
1574	Glycyl thioester intermediate	{ECO:0000256\|PROSITE-ProRule:PRU00104}

Domain Profile

E3 activity/HECT

   S: 3    sdlkkrlevefvgEegldlgGvtreflallskelqnpdlglflysendketlqpnpdsglknpehlklFeflGrllgkalqdgrlld 89
           + ++++l+v+fvgEegld++G++ref++lls+el+np++glf+ys+nd++t+q++p s +  ++hl++F+f Gr+lg+al ++ lld
   Q: 1274 ELQRNKLYVTFVGEEGLDYSGPSREFFFLLSQELFNPYYGLFEYSANDTYTVQISPMSAFV-ENHLEWFRFSGRILGLALIHQYLLD 1359
           567899****************************************************985.6************************ PP
   S: 90   lplsksfyklllgkklsledleevdpelykslkeikenaesdieelgldltfsvseeilgetkeeeLkpgGenipVtneNkeeYvkl 176
           ++++++fyk ll+ +++l+dle +d+e+++sl+++k+n   +i+++ ldltf+v+ee++g+++e+eLk+gG+n++Vt++Nk+eY+++
   Q: 1360 AFFTRPFYKALLRLPCDLSDLEYLDEEFHQSLQWMKDN---NITDI-LDLTFTVNEEVFGQVTERELKSGGANTQVTEKNKKEYIER 1442
           ************************************99...9***9.**************************************** PP
   S: 177  vveyrlkegikeqveafreGfneviplellslFteeelellicGeeeidvedlkketkykggytedspaiqwFwevleefsseerka 263
           +v++r+++g+ +q+ea+ +Gf+ev++ +l+s+F+++elel+i G++eid++d++++t+y+ggy++ + +i+wFw ++e+f++e+r +
   Q: 1443 MVKWRVERGVVQQTEALVRGFYEVVDSRLVSVFDARELELVIAGTAEIDLNDWRNNTEYRGGYHDGHLVIRWFWAAVERFNNEQRLR 1529
           *************************************************************************************** PP
   S: 264  fLqFvTgssrlPlgGfaelk....prlfvirkdasddrlPssnTCfnyLkLPeYsskeilkekLlyAieetkgFels 336
           +LqFvTg+s++P +Gfa+l+     r+f+i+k+++ ++lP+++TCfn+L+LP+Y+s++ l+ekLl+A+eet+ F+l+
   Q: 1530 LLQFVTGTSSVPYEGFAALRgsngLRRFCIEKWGKITSLPRAHTCFNRLDLPPYPSYSMLYEKLLTAVEETSTFGLE 1606
           ************************999***********************************************985 PP

Organism

Macaca mulatta

Protein Sequence
(Fasta)

MLLHLCSVKN LYQNRFLGLA AMASPSRNSQ SRRRCKEPLR YSYNPDQFHN MDLRGGPHDG 60
VTIPRSTSDT DLVTSDSRST LMVSSSYYSI GHSQDLVIHW DIKEEVDAGD WIGMYLIDEV 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

TGCAAGCGGG AGGATAAAGC GATGAAGTGT GCTGCGTTAC CGCGCATCAG GCGCTGTTGT 60
TGGAGCCGGA ACACCGTGCG ACTCTGACCG AATCGGCCCC CTCCACGCGC ACACACTCGT 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0175--Coiled coil
KW-0181--Complete proteome
KW-0436--Ligase
KW-1185--Reference proteome
KW-0808--Transferase
KW-0833--Ubl conjugation pathway

Interpro

IPR000008--C2_dom
IPR000569--HECT_dom
IPR032348--HECW_N
IPR001202--WW_dom

PROSITE

PS50004--C2
PS50237--HECT
PS01159--WW_DOMAIN_1
PS50020--WW_DOMAIN_2

Pfam

PF00168--C2
PF00632--HECT
PF16562--HECW_N
PF00397--WW

SMART

SM00239--C2
SM00119--HECTc
SM00456--WW

Gene Ontology

GO:0005829--C:cytosol
GO:0016874--F:ligase activity
GO:0004842--F:ubiquitin-protein transferase activity

KEGG

mcc:701331

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001636	Ailuropoda melanoleuca	86.83	0.00e+00	2185.00
IUUC-Apl-003299	Anas platyrhynchos	80.41	0.00e+00	2444.00
IUUC-Aca-005024	Anolis carolinensis	79.45	0.00e+00	2414.00
IUUC-Bta-012604	Bos taurus	88.88	0.00e+00	2648.00
IUUC-Cja-019880	Callithrix jacchus	91.78	0.00e+00	2402.00
IUUC-Cfa-021216	Canis familiaris	91.61	0.00e+00	1815.00
IUUC-Cpo-021466	Cavia porcellus	96.99	0.00e+00	1722.00
IUUC-Csa-023080	Chlorocebus sabaeus	99.69	0.00e+00	2943.00
IUUC-Cho-024740	Choloepus hoffmanni	83.69	0.00e+00	1193.00
IUUC-Dre-028750	Danio rerio	73.37	0.00e+00	1552.00
IUUC-Dno-030019	Dasypus novemcinctus	90.85	0.00e+00	2679.00
IUUC-Dor-031030	Dipodomys ordii	73.57	0.00e+00	1139.00
IUUC-Ete-032352	Echinops telfairi	94.29	0.00e+00	1263.00
IUUC-Eca-033948	Equus caballus	89.00	0.00e+00	2568.00
IUUC-Eeu-034474	Erinaceus europaeus	70.55	0.00e+00	837.00
IUUC-Fca-036148	Felis catus	91.97	0.00e+00	2651.00
IUUC-Fal-036957	Ficedula albicollis	81.72	0.00e+00	2443.00
IUUC-Gmo-038714	Gadus morhua	69.00	0.00e+00	1019.00
IUUC-Gga-041194	Gallus gallus	80.48	0.00e+00	2425.00
IUUC-Gac-041366	Gasterosteus aculeatus	77.95	0.00e+00	1376.00
IUUC-Ggo-045442	Gorilla gorilla	81.51	0.00e+00	2159.00
IUUC-Hsa-045730	Homo sapiens	99.19	0.00e+00	2937.00
IUUC-Itr-048439	Ictidomys tridecemlineatus	92.86	0.00e+00	2769.00
IUUC-Loc-052744	Lepisosteus oculatus	75.03	0.00e+00	2229.00
IUUC-Laf-054368	Loxodonta africana	98.71	0.00e+00	1507.00
IUUC-Meu-056751	Macropus eugenii	91.60	0.00e+00	731.00
IUUC-Mga-059545	Meleagris gallopavo	81.36	0.00e+00	2429.00
IUUC-Mmr-061078	Microcebus murinus	91.43	0.00e+00	2596.00
IUUC-Mdo-062176	Monodelphis domestica	84.95	0.00e+00	1717.00
IUUC-Mmu-063513	Mus musculus	87.49	0.00e+00	2571.00
IUUC-Mpu-065786	Mustela putorius furo	90.30	0.00e+00	2647.00
IUUC-Mlu-067780	Myotis lucifugus	83.04	0.00e+00	2356.00
IUUC-Nle-069213	Nomascus leucogenys	98.63	0.00e+00	2853.00
IUUC-Opr-070208	Ochotona princeps	97.44	0.00e+00	1498.00
IUUC-Ont-072132	Oreochromis niloticus	81.41	0.00e+00	1368.00
IUUC-Oan-072807	Ornithorhynchus anatinus	88.11	0.00e+00	1800.00
IUUC-Ocu-074745	Oryctolagus cuniculus	89.46	0.00e+00	2583.00
IUUC-Ola-086981	Oryzias latipes	74.14	0.00e+00	1494.00
IUUC-Oga-087965	Otolemur garnettii	95.89	0.00e+00	1878.00
IUUC-Oar-089749	Ovis aries	91.33	0.00e+00	1878.00
IUUC-Ptr-091243	Pan troglodytes	99.07	0.00e+00	2932.00
IUUC-Pan-092201	Papio anubis	98.25	0.00e+00	2920.00
IUUC-Psi-093511	Pelodiscus sinensis	79.81	0.00e+00	2373.00
IUUC-Pfo-097001	Poecilia formosa	71.80	0.00e+00	1453.00
IUUC-Pab-098728	Pongo abelii	96.95	0.00e+00	2810.00
IUUC-Pca-100129	Procavia capensis	82.93	0.00e+00	1264.00
IUUC-Pva-102250	Pteropus vampyrus	79.65	0.00e+00	2172.00
IUUC-Rno-105031	Rattus norvegicus	87.75	0.00e+00	2590.00
IUUC-Tgu-117515	Taeniopygia guttata	81.81	0.00e+00	2422.00
IUUC-Tru-117914	Takifugu rubripes	75.86	0.00e+00	1382.00
IUUC-Tsy-119379	Tarsius syrichta	85.27	0.00e+00	1488.00
IUUC-Tni-120178	Tetraodon nigroviridis	70.60	0.00e+00	1439.00
IUUC-Tbe-127762	Tupaia belangeri	84.87	0.00e+00	2003.00
IUUC-Ttr-128806	Tursiops truncatus	93.51	0.00e+00	1743.00
IUUC-Xtr-132903	Xenopus tropicalis	74.95	0.00e+00	1877.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence