iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

UUCD2 ID

IUUC-Ptr-090901

UUCD1 version

UUC-PaT-00103

Ensembl Protein ID

ENSPTRP00000001947.2

UniProt Accession

H2PZQ4; H2PZQ4_PANTR

Genbank Protein ID

JAA06734.1; JAA13138.1; JAA27311.1

Protein Name

Tripartite motif containing 33

Genbank Nucleotide ID

AACZ03004447; GABF01009007; GABD01005789

Gene Name

TRIM33

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSPTRG00000001133.4	ENSPTRT00000002121.2	ENSPTRP00000001947.2

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 activity/RING/RING	3.30e-06	27.5	125	185
E3 activity/RING/PHD	3.10e-09	36.9	888	933

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

E3 activity/RING/RING

   S: 1    CaiCledf....kdgplvlpCgHvfhadCl...qkw........pglknssskefrCPlCr 46
           Ca+C++++    + +p++lpC H f++ Cl   ++          +   ++ + +rCP+Cr
   Q: 125  CAVCQQSLqsrrEAEPKLLPCLHSFCLRCLpepERQlsvpipggSNGDIQQVGVIRCPVCR 185
           ******999888556***************88844468888666555556667779****8 PP

E3 activity/RING/PHD

   S: 2    kvClvCgeggedekslveCekCrewfHpaClklsveeelpnsekwiCpkCrs 53
           ++C+vC++gg+    l++CekC ++fH +C+ ++   ++p+ + wiC+ Cr+
   Q: 888  DWCAVCQNGGD----LLCCEKCPKVFHLTCHVPT-LLSFPSGD-WICTFCRD 933
           79*********....*******************.*******7.******85 PP

Organism

Pan troglodytes

Protein Sequence
(Fasta)

MAENKGGGEA ESGGGGSGSA PVTAGAAGPA AQEAEPPLTA VLVEEEEEEG GRAGAESGAA 60
GPDDGGVAAA SSGSAQAASS PAASVGTGVA GGAVSTPAPA PASAPAPGPS AGPPPGPPAS 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

CTGCGGCTGG GGCTGGGGGC GGCGGCGGCG GCGACGCGGG CGGCGGGCGG CGCGGGGCGG 60
TCCGGCGGGT TCAAAGAGGA AAACATGGCG GAAAACAAAG GCGGCGGCGA GGCTGAGAGC 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-0479--Metal-binding
KW-1185--Reference proteome
KW-0862--Zinc
KW-0863--Zinc-finger

Interpro

IPR003649--Bbox_C
IPR001487--Bromodomain
IPR019786--Zinc_finger_PHD-type_CS
IPR027370--Znf-RING_LisH
IPR000315--Znf_B-box
IPR011011--Znf_FYVE_PHD
IPR001965--Znf_PHD
IPR019787--Znf_PHD-finger
IPR001841--Znf_RING
IPR013083--Znf_RING/FYVE/PHD
IPR017907--Znf_RING_CS

PROSITE

PS50014--BROMODOMAIN_2
PS50119--ZF_BBOX
PS01359--ZF_PHD_1
PS50016--ZF_PHD_2
PS00518--ZF_RING_1
PS50089--ZF_RING_2

Pfam

PF00439--Bromodomain
PF00628--PHD
PF00643--zf-B_box
PF13445--zf-RING_UBOX

PRINTS

PR00503--BROMODOMAIN

SMART

SM00502--BBC
SM00336--BBOX
SM00297--BROMO
SM00249--PHD
SM00184--RING

Gene Ontology

GO:0005634--C:nucleus
GO:0008270--F:zinc ion binding
GO:0030514--P:negative regulation of BMP signaling pathway
GO:0016567--P:protein ubiquitination
GO:0017015--P:regulation of transforming growth factor beta receptor signaling pathway

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-002364	Ailuropoda melanoleuca	98.32	0.00e+00	1748.00
IUUC-Apl-003894	Anas platyrhynchos	91.56	0.00e+00	1603.00
IUUC-Aca-004658	Anolis carolinensis	90.36	0.00e+00	1567.00
IUUC-Ame-011619	Astyanax mexicanus	60.34	0.00e+00	1059.00
IUUC-Bta-013341	Bos taurus	96.33	0.00e+00	1702.00
IUUC-Cja-018733	Callithrix jacchus	99.40	0.00e+00	1777.00
IUUC-Cfa-020725	Canis familiaris	99.20	0.00e+00	1724.00
IUUC-Cpo-021833	Cavia porcellus	98.41	0.00e+00	1743.00
IUUC-Csa-023040	Chlorocebus sabaeus	99.90	0.00e+00	1722.00
IUUC-Cho-024934	Choloepus hoffmanni	95.90	0.00e+00	1628.00
IUUC-Cin-025200	Ciona intestinalis	31.97	1.00e-45	179.00
IUUC-Csv-026278	Ciona savignyi	47.25	4.00e-20	91.30
IUUC-Dre-027797	Danio rerio	73.18	1.00e-172	600.00
IUUC-Dno-028955	Dasypus novemcinctus	98.21	0.00e+00	1806.00
IUUC-Dme-032143	Drosophila melanogaster	31.98	3.00e-45	177.00
IUUC-Ete-032728	Echinops telfairi	96.06	0.00e+00	929.00
IUUC-Eca-033573	Equus caballus	98.12	0.00e+00	1724.00
IUUC-Eeu-035138	Erinaceus europaeus	86.42	0.00e+00	829.00
IUUC-Fca-035776	Felis catus	99.05	0.00e+00	1634.00
IUUC-Fal-037583	Ficedula albicollis	91.63	0.00e+00	1635.00
IUUC-Gmo-039353	Gadus morhua	61.97	0.00e+00	663.00
IUUC-Gga-040874	Gallus gallus	92.16	0.00e+00	1710.00
IUUC-Gac-041689	Gasterosteus aculeatus	56.02	0.00e+00	1106.00
IUUC-Ggo-045151	Gorilla gorilla	99.28	0.00e+00	1338.00
IUUC-Hsa-046169	Homo sapiens	99.90	0.00e+00	1724.00
IUUC-Itr-048377	Ictidomys tridecemlineatus	98.18	0.00e+00	753.00
IUUC-Lch-050411	Latimeria chalumnae	81.80	0.00e+00	1382.00
IUUC-Loc-051992	Lepisosteus oculatus	71.98	0.00e+00	1293.00
IUUC-Laf-054552	Loxodonta africana	98.43	0.00e+00	1655.00
IUUC-Mcc-055744	Macaca mulatta	99.80	0.00e+00	1721.00
IUUC-Meu-056647	Macropus eugenii	99.15	0.00e+00	707.00
IUUC-Mga-059589	Meleagris gallopavo	92.49	0.00e+00	961.00
IUUC-Mmr-060727	Microcebus murinus	99.70	0.00e+00	1753.00
IUUC-Mdo-063029	Monodelphis domestica	96.52	0.00e+00	1754.00
IUUC-Mmu-064033	Mus musculus	97.02	0.00e+00	1766.00
IUUC-Mpu-066679	Mustela putorius furo	98.71	0.00e+00	1739.00
IUUC-Mlu-067286	Myotis lucifugus	97.90	0.00e+00	1635.00
IUUC-Nle-069156	Nomascus leucogenys	99.60	0.00e+00	1716.00
IUUC-Opr-070309	Ochotona princeps	87.96	0.00e+00	1280.00
IUUC-Ont-071586	Oreochromis niloticus	54.36	0.00e+00	1050.00
IUUC-Oan-073205	Ornithorhynchus anatinus	94.96	0.00e+00	1461.00
IUUC-Ocu-074667	Oryctolagus cuniculus	96.13	0.00e+00	1624.00
IUUC-Ola-086481	Oryzias latipes	67.23	3.00e-165	575.00
IUUC-Oga-089101	Otolemur garnettii	98.51	0.00e+00	1735.00
IUUC-Oar-090167	Ovis aries	98.31	0.00e+00	1749.00
IUUC-Pan-092448	Papio anubis	97.72	0.00e+00	1720.00
IUUC-Psi-093657	Pelodiscus sinensis	91.76	0.00e+00	1484.00
IUUC-Pma-094506	Petromyzon marinus	65.91	1.00e-50	191.00
IUUC-Pfo-097104	Poecilia formosa	69.15	6.00e-160	558.00
IUUC-Pab-097704	Pongo abelii	99.90	0.00e+00	1759.00
IUUC-Pca-101001	Procavia capensis	88.35	0.00e+00	654.00
IUUC-Pva-102733	Pteropus vampyrus	94.28	0.00e+00	1571.00
IUUC-Rno-105512	Rattus norvegicus	98.01	0.00e+00	1758.00
IUUC-Sha-107423	Sarcophilus harrisii	95.51	0.00e+00	1630.00
IUUC-Sar-113181	Sorex araneus	89.25	7.00e-146	511.00
IUUC-Ssc-116330	Sus scrofa	93.39	0.00e+00	1527.00
IUUC-Tgu-117388	Taeniopygia guttata	75.97	0.00e+00	1268.00
IUUC-Tru-118728	Takifugu rubripes	57.58	0.00e+00	981.00
IUUC-Tsy-119053	Tarsius syrichta	98.73	0.00e+00	1052.00
IUUC-Tni-120279	Tetraodon nigroviridis	47.94	5.00e-163	567.00
IUUC-Tbe-127573	Tupaia belangeri	90.21	0.00e+00	842.00
IUUC-Ttr-128594	Tursiops truncatus	98.41	0.00e+00	1745.00
IUUC-Vpa-130619	Vicugna pacos	92.45	0.00e+00	1099.00
IUUC-Xtr-132837	Xenopus tropicalis	85.12	0.00e+00	1502.00
IUUC-Xma-133624	Xiphophorus maculatus	56.70	0.00e+00	1019.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence