iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSG00000181481.13	ENST00000328381.9	ENSP00000328340.5
ENSG00000181481.13	ENST00000443677.6	ENSP00000411965.2
ENSG00000181481.13	ENST00000324689.8	ENSP00000323693.4
ENSG00000181481.13	ENST00000535306.6	ENSP00000440470.2
ENSG00000181481.13	ENST00000580444.2	ENSP00000464549.1
ENSG00000181481.13	ENST00000434242.2	ENSP00000467799.1

Annotation

Cancer Mutation
TCGA	ICGC	COSMIC	CGAP
IntOGen
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEO	ArrayExpress	TCGA	ICGC
COSMIC	THPA	HPM
DNA & RNA Element
UTRdb	circBase	circRNADb	CircNet
miRTarBase	microRNA	TRANSFAC	TargetScan
RepTar	miRcode	RAID2
Protein-protein Interaction
IID	iRefIndex	PINA	HINT
Mentha	InWeb_IM
Disease-associated Information
ClinVar	OMIM
Post-translational Modifications (PTMs)
dbPAF	PhosphositePlus	BioGRID
DNA Methylation
MethyCancer	TCGA	ICGC	COSMIC
Protein Expression/Proteomics
THPA	HPM	GPMDB

Status

Reviewed

Details

Family	Domain	References (PMIDs)
E3 activity/RING/RING	RING	19017631

Classification

Family	E-value	Score	Start	End
E3 activity/RING/RING	4.80e-08	35.1	21	63

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

E3 activity/RING/RING

   S: 1    CaiCledfkdgplvlpCgHvfhadCl.qkwpglknssskefrCPlCr 46
           C+iC+  ++  p +lpCgH f+++Cl   w g      +++ CP+Cr
   Q: 21   CIICQGLLDW-PATLPCGHSFCRHCLeALW-GAR--DARRWACPTCR 63
           ********99.***************6666.666..99********8 PP

Organism

Homo sapiens

Functional Description
(View)

Acts as an E2-dependent E3 ubiquitin-protein ligase, involved in innate immune defense against viruses. Ubiquitinates DDX58 and is required for full activation of the DDX58 signaling resulting in interferon beta production.

Protein Sequence
(Fasta)

MAGLGLGSAV PVWLAEDDLG CIICQGLLDW PATLPCGHSF CRHCLEALWG ARDARRWACP 60
TCRQGAAQQP HLRKNTLLQD LADKYRRAAR EIQAGSDPAH CPCPGSSSLS SAAARPRRRP 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

TTTCCAGAAA CTTGGCTGTG AAATGGAGAA GAGGAGAGCT GGTTCCAGGG AGGCTCAGGT 60
CAAAGGTGAT TTTATTTTAT TTTTTAATTT TTAATTTTTT TGAGACTAGG TCTAGCTCCT 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0025--Alternative splicing
KW-0175--Coiled coil
KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0225--Disease mutation
KW-0391--Immunity
KW-0399--Innate immunity
KW-0479--Metal-binding
KW-0621--Polymorphism
KW-1185--Reference proteome
KW-0808--Transferase
KW-0833--Ubl conjugation pathway
KW-0862--Zinc
KW-0863--Zinc-finger

Interpro

IPR001870--B30.2/SPRY
IPR003879--Butyrophylin
IPR013320--ConA-like_dom
IPR006574--PRY
IPR003877--SPRY_dom
IPR001841--Znf_RING
IPR013083--Znf_RING/FYVE/PHD
IPR017907--Znf_RING_CS

PROSITE

PS50188--B302_SPRY
PS00518--ZF_RING_1
PS50089--ZF_RING_2

Pfam

PF00622--SPRY

PRINTS

PR01407--BUTYPHLNCDUF

SMART

SM00589--PRY
SM00184--RING
SM00449--SPRY

Gene Ontology

GO:0005737--C:cytoplasm
GO:0005829--C:cytosol
GO:0042802--F:identical protein binding
GO:0043021--F:ribonucleoprotein complex binding
GO:0004842--F:ubiquitin-protein transferase activity
GO:0008270--F:zinc ion binding
GO:0045087--P:innate immune response
GO:0032480--P:negative regulation of type I interferon production
GO:0032728--P:positive regulation of interferon-beta production
GO:0016579--P:protein deubiquitination
GO:0016567--P:protein ubiquitination
GO:0045088--P:regulation of innate immune response

KEGG

hsa:84282

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-002251	Ailuropoda melanoleuca	71.88	2.00e-125	441.00
IUUC-Apl-003301	Anas platyrhynchos	45.60	3.00e-40	157.00
IUUC-Aca-004520	Anolis carolinensis	38.76	5.00e-38	150.00
IUUC-Bta-012846	Bos taurus	64.58	9.00e-143	499.00
IUUC-Cja-019096	Callithrix jacchus	84.32	0.00e+00	668.00
IUUC-Cfa-020135	Canis familiaris	62.84	2.00e-133	469.00
IUUC-Cpo-022042	Cavia porcellus	56.81	3.00e-119	422.00
IUUC-Csa-024154	Chlorocebus sabaeus	88.74	0.00e+00	726.00
IUUC-Cho-024619	Choloepus hoffmanni	64.38	6.00e-104	370.00
IUUC-Dre-027925	Danio rerio	41.94	1.00e-20	94.40
IUUC-Dno-028856	Dasypus novemcinctus	69.69	6.00e-149	520.00
IUUC-Eca-033795	Equus caballus	69.02	8.00e-151	526.00
IUUC-Eeu-035078	Erinaceus europaeus	60.36	2.00e-142	498.00
IUUC-Fca-035503	Felis catus	75.12	3.00e-86	311.00
IUUC-Fal-036914	Ficedula albicollis	50.00	5.00e-34	136.00
IUUC-Ggo-045197	Gorilla gorilla	95.83	0.00e+00	685.00
IUUC-Itr-049007	Ictidomys tridecemlineatus	63.62	3.00e-152	531.00
IUUC-Laf-053812	Loxodonta africana	71.99	6.00e-167	580.00
IUUC-Mcc-055777	Macaca mulatta	89.43	0.00e+00	722.00
IUUC-Meu-056473	Macropus eugenii	49.72	2.00e-43	169.00
IUUC-Mmr-061016	Microcebus murinus	75.00	4.00e-175	607.00
IUUC-Mmu-063129	Mus musculus	56.52	2.00e-127	449.00
IUUC-Mpu-065938	Mustela putorius furo	63.91	8.00e-140	490.00
IUUC-Mlu-067911	Myotis lucifugus	61.57	2.00e-138	485.00
IUUC-Opr-071118	Ochotona princeps	59.86	2.00e-90	325.00
IUUC-Oan-073277	Ornithorhynchus anatinus	37.05	1.00e-65	243.00
IUUC-Ocu-074512	Oryctolagus cuniculus	66.77	1.00e-112	399.00
IUUC-Oga-089086	Otolemur garnettii	72.45	2.00e-171	595.00
IUUC-Oar-089493	Ovis aries	70.71	4.00e-91	327.00
IUUC-Ptr-090466	Pan troglodytes	98.12	0.00e+00	800.00
IUUC-Pan-091817	Papio anubis	89.43	0.00e+00	724.00
IUUC-Psi-093151	Pelodiscus sinensis	29.78	7.00e-49	188.00
IUUC-Pab-098342	Pongo abelii	96.06	0.00e+00	819.00
IUUC-Pca-101052	Procavia capensis	56.90	4.00e-71	261.00
IUUC-Pva-103178	Pteropus vampyrus	72.37	7.00e-123	434.00
IUUC-Rno-105519	Rattus norvegicus	59.68	7.00e-131	461.00
IUUC-Ssc-115925	Sus scrofa	64.81	3.00e-150	524.00
IUUC-Tgu-116757	Taeniopygia guttata	50.00	3.00e-33	134.00
IUUC-Ttr-128972	Tursiops truncatus	54.12	2.00e-61	228.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence