iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

iUUCD ID

IUUC-Csv-025967

Ensembl Protein ID

ENSCSAVP00000013170.1

UniProt Accession

H2Z6F8; H2Z6F8_CIOSA

Protein Name

Presenilin

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSCSAVG00000007727.1	ENSCSAVT00000013318.1	ENSCSAVP00000013169.1
ENSCSAVG00000007727.1	ENSCSAVT00000013319.1	ENSCSAVP00000013170.1
ENSCSAVG00000007727.1	ENSCSAVT00000013320.1	ENSCSAVP00000013171.1

Status

Unreviewed

Classification

Family	Identity	E-Value	Score	Source Orthology
UBD/Alpha-Helix/CUE	50.25	3.00e-93	338.00	IUUC-Cel-018553

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Organism

Ciona savignyi

Functional Description
(View)

Probable subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors.

Protein Sequence
(Fasta)

DTEEELRYGA NTVISLFIPV TLCMLVVVAT ITSVSYYTDQ SQGQYLVYTP FHTQNAGTAQ 60
VVWESIANSL IMISVIVVMT IFLVLLYKYR CYKVIHGWLI LSSLLLLFLF AYLYLAEVLR 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

GATACAGAGG AAGAGCTTCG GTACGGTGCA AACACCGTCA TATCGTTGTT CATTCCTGTC 60
ACGCTATGCA TGCTGGTAGT AGTAGCTACC ATCACGTAAG TTCGTACTTC CTATACCATT 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-0256--Endoplasmic reticulum
KW-0333--Golgi apparatus
KW-0378--Hydrolase
KW-0472--Membrane
KW-0914--Notch signaling pathway
KW-0645--Protease
KW-1185--Reference proteome
KW-0812--Transmembrane
KW-1133--Transmembrane helix

Interpro

IPR002031--Pept_A22A_PS1
IPR001108--Peptidase_A22A
IPR006639--Preselin/SPP

Pfam

PF01080--Presenilin

PRINTS

PR01072--PRESENILIN

SMART

SM00730--PSN

Gene Ontology

GO:0005789--C:endoplasmic reticulum membrane
GO:0000139--C:Golgi membrane
GO:0016021--C:integral component of membrane
GO:0004190--F:aspartic-type endopeptidase activity
GO:0035556--P:intracellular signal transduction
GO:0007219--P:Notch signaling pathway
GO:0016485--P:protein processing

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Ata-000686	Aegilops tauschii	35.41	2.00e-30	126.00
IUUC-Aml-001648	Ailuropoda melanoleuca	62.13	3.00e-97	346.00
IUUC-Atr-003039	Amborella trichopoda	32.29	3.00e-42	164.00
IUUC-Apl-003727	Anas platyrhynchos	61.98	1.00e-109	388.00
IUUC-Aca-004582	Anolis carolinensis	63.39	1.00e-113	401.00
IUUC-Aly-005455	Arabidopsis lyrata	51.43	2.00e-23	102.00
IUUC-Ath-006730	Arabidopsis thaliana	40.13	7.00e-24	103.00
IUUC-Ame-010686	Astyanax mexicanus	62.50	2.00e-110	390.00
IUUC-Bta-013026	Bos taurus	61.93	2.00e-111	394.00
IUUC-Bdi-014196	Brachypodium distachyon	36.03	3.00e-39	154.00
IUUC-Bol-015841	Brassica oleracea	36.57	4.00e-38	150.00
IUUC-Bra-017580	Brassica rapa	54.37	9.00e-24	102.00
IUUC-Cel-018553	Caenorhabditis elegans	50.25	1.00e-99	355.00
IUUC-Cja-019994	Callithrix jacchus	63.46	1.00e-109	388.00
IUUC-Cfa-020074	Canis familiaris	63.70	5.00e-112	396.00
IUUC-Cpo-022237	Cavia porcellus	62.96	2.00e-110	390.00
IUUC-Cre-022747	Chlamydomonas reinhardtii	34.62	5.00e-28	117.00
IUUC-Csa-023537	Chlorocebus sabaeus	63.21	1.00e-110	391.00
IUUC-Cho-024735	Choloepus hoffmanni	55.97	3.00e-103	367.00
IUUC-Cin-025780	Ciona intestinalis	82.47	2.00e-171	593.00
IUUC-Dre-028526	Danio rerio	63.33	1.00e-118	418.00
IUUC-Dno-029758	Dasypus novemcinctus	63.70	6.00e-112	395.00
IUUC-Dor-031127	Dipodomys ordii	71.05	2.00e-80	291.00
IUUC-Dme-031929	Drosophila melanogaster	55.29	4.00e-111	393.00
IUUC-Ete-032487	Echinops telfairi	53.88	4.00e-44	170.00
IUUC-Eca-034387	Equus caballus	55.74	6.00e-90	322.00
IUUC-Eeu-035134	Erinaceus europaeus	62.46	5.00e-91	325.00
IUUC-Fca-036243	Felis catus	63.21	3.00e-111	393.00
IUUC-Fal-036600	Ficedula albicollis	63.70	5.00e-113	399.00
IUUC-Gmo-039665	Gadus morhua	60.82	3.00e-94	337.00
IUUC-Gga-040993	Gallus gallus	62.62	8.00e-113	399.00
IUUC-Gac-042511	Gasterosteus aculeatus	62.84	2.00e-109	387.00
IUUC-Gma-043822	Glycine max	61.84	4.00e-20	90.90
IUUC-Ggo-045338	Gorilla gorilla	56.34	9.00e-92	328.00
IUUC-Hsa-046822	Homo sapiens	63.21	1.00e-110	391.00
IUUC-Hvu-047141	Hordeum vulgare	34.98	2.00e-27	115.00
IUUC-Itr-048731	Ictidomys tridecemlineatus	56.34	9.00e-92	328.00
IUUC-Lch-049638	Latimeria chalumnae	58.37	3.00e-104	370.00
IUUC-Lpe-051132	Leersia perrieri	32.53	3.00e-36	144.00
IUUC-Loc-052427	Lepisosteus oculatus	62.20	7.00e-120	422.00
IUUC-Laf-053758	Loxodonta africana	61.92	5.00e-116	409.00
IUUC-Mcc-055682	Macaca mulatta	63.21	1.00e-110	391.00
IUUC-Meu-056004	Macropus eugenii	57.61	3.00e-78	284.00
IUUC-Mtr-058392	Medicago truncatula	32.69	3.00e-36	144.00
IUUC-Mga-059466	Meleagris gallopavo	62.38	3.00e-112	397.00
IUUC-Mmr-060890	Microcebus murinus	59.67	3.00e-102	363.00
IUUC-Mdo-062122	Monodelphis domestica	62.69	1.00e-111	395.00
IUUC-Mmu-063176	Mus musculus	63.12	5.00e-108	382.00
IUUC-Mac-064858	Musa acuminata	36.06	1.00e-23	102.00
IUUC-Mpu-065927	Mustela putorius furo	63.46	1.00e-111	394.00
IUUC-Mlu-067079	Myotis lucifugus	62.72	3.00e-119	420.00
IUUC-Nle-070180	Nomascus leucogenys	63.21	1.00e-110	391.00
IUUC-Opr-070344	Ochotona princeps	60.24	1.00e-103	368.00
IUUC-Ont-071846	Oreochromis niloticus	62.20	1.00e-109	388.00
IUUC-Oan-072783	Ornithorhynchus anatinus	58.17	4.00e-89	319.00
IUUC-Ocu-074527	Oryctolagus cuniculus	63.05	3.00e-110	390.00
IUUC-Oba-075256	Oryza barthii	45.90	7.00e-22	96.70
IUUC-Obr-076302	Oryza brachyantha	41.84	7.00e-22	97.10
IUUC-Ogl-077097	Oryza glaberrima	44.80	1.00e-21	96.30
IUUC-Ogu-078570	Oryza glumaepatula	45.53	1.00e-21	95.90
IUUC-Oin-079244	Oryza indica	45.90	1.00e-21	95.90
IUUC-Olo-080484	Oryza longistaminata	32.14	5.00e-25	106.00
IUUC-Ome-081814	Oryza meridionalis	44.96	3.00e-21	94.40
IUUC-Oni-082057	Oryza nivara	45.53	1.00e-21	95.90
IUUC-Opu-084176	Oryza punctata	33.71	5.00e-36	143.00
IUUC-Oru-084618	Oryza rufipogon	45.53	1.00e-21	95.90
IUUC-Osa-085602	Oryza sativa	45.53	7.00e-22	96.70
IUUC-Ola-086707	Oryzias latipes	70.22	1.00e-76	278.00
IUUC-Olu-087811	Ostreococcus lucimarinus	34.53	2.00e-43	167.00
IUUC-Oga-088560	Otolemur garnettii	56.34	3.00e-92	330.00
IUUC-Oar-090348	Ovis aries	62.96	9.00e-114	402.00
IUUC-Ptr-091060	Pan troglodytes	63.21	1.00e-110	391.00
IUUC-Pan-091742	Papio anubis	56.34	1.00e-91	328.00
IUUC-Psi-093505	Pelodiscus sinensis	61.63	2.00e-111	394.00
IUUC-Pma-094612	Petromyzon marinus	61.67	1.00e-98	351.00
IUUC-Ppa-095431	Physcomitrella patens	28.36	2.00e-40	158.00
IUUC-Pfo-097396	Poecilia formosa	63.08	3.00e-116	410.00
IUUC-Pab-098591	Pongo abelii	63.21	2.00e-110	390.00
IUUC-Pop-099661	Populus trichocarpa	32.90	5.00e-38	150.00
IUUC-Pca-101029	Procavia capensis	62.22	2.00e-103	367.00
IUUC-Ppe-101495	Prunus persica	31.54	4.00e-42	164.00
IUUC-Pva-102244	Pteropus vampyrus	60.99	9.00e-109	385.00
IUUC-Rno-105861	Rattus norvegicus	62.72	1.00e-107	381.00
IUUC-Sha-107045	Sarcophilus harrisii	62.94	3.00e-111	393.00
IUUC-Smo-109325	Selaginella moellendorffii	34.55	7.00e-36	142.00
IUUC-Sit-110624	Setaria italica	34.38	3.00e-31	127.00
IUUC-Sly-110865	Solanum lycopersicum	55.17	1.00e-12	62.80
IUUC-Stu-112433	Solanum tuberosum	32.03	6.00e-36	143.00
IUUC-Sar-113169	Sorex araneus	60.55	6.00e-88	316.00
IUUC-Sbi-114305	Sorghum bicolor	39.86	2.00e-21	95.50
IUUC-Ssc-115766	Sus scrofa	63.12	7.00e-111	392.00
IUUC-Tgu-117280	Taeniopygia guttata	61.92	4.00e-106	376.00
IUUC-Tru-117732	Takifugu rubripes	61.22	2.00e-112	397.00
IUUC-Tsy-119624	Tarsius syrichta	59.20	1.00e-102	364.00
IUUC-Tni-119852	Tetraodon nigroviridis	57.04	6.00e-104	369.00
IUUC-Tca-121865	Theobroma cacao	32.19	8.00e-41	159.00
IUUC-Tae-125925	Triticum aestivum	34.53	1.00e-32	132.00
IUUC-Tur-126237	Triticum urartu	34.95	1.00e-31	129.00
IUUC-Tbe-127632	Tupaia belangeri	72.96	5.00e-89	319.00
IUUC-Ttr-128793	Tursiops truncatus	62.72	8.00e-108	382.00
IUUC-Vpa-130625	Vicugna pacos	53.09	5.00e-89	319.00
IUUC-Vvi-131312	Vitis vinifera	44.53	3.00e-22	97.80
IUUC-Xtr-132756	Xenopus tropicalis	62.47	9.00e-118	415.00
IUUC-Xma-133377	Xiphophorus maculatus	62.47	9.00e-115	405.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence