iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

iUUCD ID

IUUC-Eca-033528

Ensembl Protein ID

ENSECAP00000006135.1

UniProt Accession

F6UWH6; F6UWH6_HORSE

Protein Name

Uncharacterized protein

Gene Name

OPTN

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSECAG00000007747.1	ENSECAT00000008224.1	ENSECAP00000006135.1
ENSECAG00000007747.1	ENSECAT00000008228.1	ENSECAP00000006139.1

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
UBD/Alpha-Helix/UBAN	8.40e-25	86.7	459	515

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

UBD/Alpha-Helix/UBAN

   S: 1    keelletvevLkqQveiYkeDFqaERadRErlneekeeLqeqveklqkqvsklndsl 57
           +ee+let++vL++Q+e+Y++DF+aERa+RE+++eeke+L+ q++ l+k++++++d++
   Q: 459  QEEDLETMTVLRAQMEVYCSDFHAERAAREKIHEEKEQLALQLAILLKENNAFEDGG 515
           79****************************************************986 PP

Organism

Equus caballus

Protein Sequence
(Fasta)

MSHQPLSCLT EKGDSPIETT GNGPPHLAHP SLDTFTPEEL LQQMKELLTE NHQLKEAMKL 60
NNQAMKGRFE ELSAWTEKQK EERLFFEIQS KEAKERLMAL SHENEKLKEE LGKLKGKTER 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

GCAAGCACCC TGGCCGATCC CCTAGTCTGC ATCCGGGTCG GGAGCCCTCC CCCAGTGGGC 60
GCGATGCCGA GGAAGCAGTG ACCCCCGGAG AGGCCGGAGC GCGGGCGCTG GGTGAGCGGG 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0175--Coiled coil
KW-0181--Complete proteome
KW-1185--Reference proteome

Interpro

IPR032419--CC2-LZ_dom
IPR021063--NEMO_N
IPR032939--Optineurin
IPR034735--ZF_CCHC_NOA

PROSITE

PS51801--ZF_CCHC_NOA

Pfam

PF16516--CC2-LZ
PF11577--NEMO

Gene Ontology

GO:0031410--C:cytoplasmic vesicle
GO:0005829--C:cytosol
GO:0005794--C:Golgi apparatus
GO:0005634--C:nucleus
GO:0048471--C:perinuclear region of cytoplasm
GO:0005802--C:trans-Golgi network
GO:0070530--F:K63-linked polyubiquitin binding
GO:0050829--P:defense response to Gram-negative bacterium
GO:0090161--P:Golgi ribbon formation
GO:0043001--P:Golgi to plasma membrane protein transport
GO:0016236--P:macroautophagy
GO:0043124--P:negative regulation of I-kappaB kinase/NF-kappaB signaling
GO:0001920--P:negative regulation of receptor recycling
GO:0061734--P:parkin-mediated stimulation of mitophagy in response to mitochondrial depolarization
GO:1904417--P:positive regulation of xenophagy
GO:0000042--P:protein targeting to Golgi
GO:0043122--P:regulation of I-kappaB kinase/NF-kappaB signaling

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-002037	Ailuropoda melanoleuca	83.33	0.00e+00	830.00
IUUC-Apl-003812	Anas platyrhynchos	55.86	4.00e-144	504.00
IUUC-Aca-004625	Anolis carolinensis	53.65	4.00e-139	488.00
IUUC-Aly-005781	Arabidopsis lyrata	55.00	2.50e-02	33.10
IUUC-Ame-011116	Astyanax mexicanus	36.51	8.00e-65	241.00
IUUC-Bta-013240	Bos taurus	85.81	0.00e+00	931.00
IUUC-Cja-019911	Callithrix jacchus	83.76	0.00e+00	850.00
IUUC-Cfa-020330	Canis familiaris	86.84	0.00e+00	881.00
IUUC-Cpo-021753	Cavia porcellus	80.58	0.00e+00	822.00
IUUC-Csa-023662	Chlorocebus sabaeus	84.77	0.00e+00	861.00
IUUC-Cho-024574	Choloepus hoffmanni	67.17	2.00e-122	432.00
IUUC-Dre-027720	Danio rerio	39.44	6.00e-89	321.00
IUUC-Dno-029079	Dasypus novemcinctus	80.34	0.00e+00	777.00
IUUC-Dor-030890	Dipodomys ordii	80.68	0.00e+00	828.00
IUUC-Ete-032568	Echinops telfairi	78.40	0.00e+00	686.00
IUUC-Eeu-035219	Erinaceus europaeus	75.00	0.00e+00	802.00
IUUC-Fca-035852	Felis catus	88.74	0.00e+00	902.00
IUUC-Fal-036862	Ficedula albicollis	56.57	5.00e-142	497.00
IUUC-Gmo-038735	Gadus morhua	37.36	8.00e-70	257.00
IUUC-Gga-040939	Gallus gallus	55.63	9.00e-141	493.00
IUUC-Gac-041580	Gasterosteus aculeatus	42.24	2.00e-92	332.00
IUUC-Ggo-045034	Gorilla gorilla	75.56	0.00e+00	764.00
IUUC-Hsa-046624	Homo sapiens	83.59	0.00e+00	853.00
IUUC-Itr-048288	Ictidomys tridecemlineatus	76.52	0.00e+00	803.00
IUUC-Lch-049720	Latimeria chalumnae	49.29	4.00e-81	294.00
IUUC-Loc-052185	Lepisosteus oculatus	44.28	2.00e-100	359.00
IUUC-Laf-054079	Loxodonta africana	85.11	0.00e+00	842.00
IUUC-Mcc-055674	Macaca mulatta	85.81	0.00e+00	860.00
IUUC-Meu-056769	Macropus eugenii	84.62	2.00e-71	263.00
IUUC-Mga-060203	Meleagris gallopavo	56.03	5.00e-132	464.00
IUUC-Mmr-061492	Microcebus murinus	83.76	0.00e+00	834.00
IUUC-Mdo-063051	Monodelphis domestica	73.49	0.00e+00	765.00
IUUC-Mmu-063409	Mus musculus	77.01	0.00e+00	852.00
IUUC-Mpu-065907	Mustela putorius furo	83.84	0.00e+00	874.00
IUUC-Mlu-066957	Myotis lucifugus	84.27	0.00e+00	813.00
IUUC-Nle-069973	Nomascus leucogenys	83.76	0.00e+00	851.00
IUUC-Opr-071049	Ochotona princeps	77.12	0.00e+00	719.00
IUUC-Ont-071915	Oreochromis niloticus	42.55	2.00e-88	319.00
IUUC-Oan-072965	Ornithorhynchus anatinus	69.90	0.00e+00	743.00
IUUC-Ocu-074029	Oryctolagus cuniculus	75.37	0.00e+00	654.00
IUUC-Ola-087019	Oryzias latipes	41.70	7.00e-83	301.00
IUUC-Oga-088613	Otolemur garnettii	83.95	0.00e+00	852.00
IUUC-Oar-090386	Ovis aries	85.64	0.00e+00	930.00
IUUC-Ptr-091619	Pan troglodytes	83.42	0.00e+00	849.00
IUUC-Pan-092178	Papio anubis	84.01	0.00e+00	840.00
IUUC-Psi-093214	Pelodiscus sinensis	61.73	6.00e-158	550.00
IUUC-Pfo-096901	Poecilia formosa	38.99	2.00e-80	292.00
IUUC-Pab-097560	Pongo abelii	76.31	0.00e+00	733.00
IUUC-Pca-100853	Procavia capensis	72.59	3.00e-121	428.00
IUUC-Pva-102255	Pteropus vampyrus	85.01	0.00e+00	811.00
IUUC-Rno-105812	Rattus norvegicus	81.06	0.00e+00	855.00
IUUC-Sha-107225	Sarcophilus harrisii	79.09	4.00e-149	520.00
IUUC-Sar-113736	Sorex araneus	70.74	1.00e-129	456.00
IUUC-Ssc-115422	Sus scrofa	87.69	0.00e+00	917.00
IUUC-Tgu-116924	Taeniopygia guttata	57.04	3.00e-142	498.00
IUUC-Tru-117695	Takifugu rubripes	39.07	5.00e-85	308.00
IUUC-Tsy-119090	Tarsius syrichta	80.43	9.00e-150	523.00
IUUC-Tni-120645	Tetraodon nigroviridis	42.24	4.00e-85	308.00
IUUC-Tbe-127970	Tupaia belangeri	71.14	1.00e-135	476.00
IUUC-Ttr-129244	Tursiops truncatus	85.35	0.00e+00	849.00
IUUC-Vpa-130313	Vicugna pacos	85.01	0.00e+00	817.00
IUUC-Xtr-132115	Xenopus tropicalis	43.73	5.00e-94	338.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence