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Tag Content
iUUCD ID IUUC-Ggo-044643
Ensembl Protein ID ENSGGOP00000025500.1
UniProt Accession G3SBM4; G3SBM4_GORGO
Protein Name Histone-lysine N-methyltransferase
Gene Name WHSC1
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
ENSGGOG00000014144.2 ENSGGOT00000031028.1 ENSGGOP00000025500.1
ENSGGOG00000014144.2 ENSGGOT00000014204.2 ENSGGOP00000013809.2
Status Unreviewed
Classification
Family E-Value Score Start End
E3 activity/RING/PHD 1.10e-15 58.0 836 876
Active Site
Position(s) Description Evidence
N/A N/A N/A
Domain Profile

   E3 activity/RING/PHD
   S: 3    vClvCgeggedekslveCekCrewfHpaClklsveeelpnsekwiCpkCr 52
           +C vC +gg+    l++Ce C  +fHp+Cl+++    +p+ + w+C++Cr
   Q: 836  WCFVCSKGGS----LLCCESCPAAFHPDCLNIE----MPDGS-WFCNDCR 876
           8*********....*******************....9***8.******8 PP
   
Organism Gorilla gorilla
Protein Sequence
(Fasta)
MEFSIKQSPL SVQSVVKCIK MKQAPEILGS ANGKTPSCEV NRECSVFLSK AQLSSSLQEG 60
VMQKFNGHDA LPFIPADKLK DLTSRVFNGE PGAHDAKLRF ESQEMKGIGT PPNTTPIKNG 120
It may take some time, please wait.

Protein Fasta Sequence


>IUUC-Ggo-044643|E3,PHD|Gorilla gorilla
Please wait for a moment...
Nucleotide Sequence
(Fasta)
TGGTCTCGAA CTTCTGACCT TGTGATCTGC TCGCCTCAGC CTCCCAAAGT GCTGGGATTA 60
CAGGCATGAG CCACCGTGCC TGTCCTAGAA CCACTGGTAA CTCTTAACTG GTAATTTTTG 120
It may take some time, please wait.

Nucleotide Fasta Sequence


>IUUC-Ggo-044643|E3,PHD|Gorilla gorilla
Please wait for a moment...
Sequence Source Ensembl
Keyword

KW-0181--Complete proteome
KW-0238--DNA-binding
KW-0479--Metal-binding
KW-0489--Methyltransferase
KW-0539--Nucleus
KW-1185--Reference proteome
KW-0949--S-adenosyl-L-methionine
KW-0808--Transferase
KW-0862--Zinc
KW-0863--Zinc-finger
Interpro

IPR006560--AWS_dom
IPR009071--HMG_box_dom
IPR003616--Post-SET_dom
IPR000313--PWWP_dom
IPR001214--SET_dom
IPR019786--Zinc_finger_PHD-type_CS
IPR011011--Znf_FYVE_PHD
IPR001965--Znf_PHD
IPR019787--Znf_PHD-finger
IPR001841--Znf_RING
IPR013083--Znf_RING/FYVE/PHD
PROSITE

PS51215--AWS
PS50118--HMG_BOX_2
PS50868--POST_SET
PS50812--PWWP
PS50280--SET
PS01359--ZF_PHD_1
PS50016--ZF_PHD_2
PS50089--ZF_RING_2
Pfam

PF00505--HMG_box
PF00855--PWWP
PF00856--SET
SMART

SM00570--AWS
SM00398--HMG
SM00249--PHD
SM00508--PostSET
SM00293--PWWP
SM00184--RING
SM00317--SET
Gene Ontology

GO:0005634--C:nucleus
GO:0003682--F:chromatin binding
GO:0018024--F:histone-lysine N-methyltransferase activity
GO:0043565--F:sequence-specific DNA binding
GO:0008270--F:zinc ion binding
GO:0003289--P:atrial septum primum morphogenesis
GO:0003290--P:atrial septum secundum morphogenesis
GO:0060348--P:bone development
GO:0010452--P:histone H3-K36 methylation
GO:0034770--P:histone H4-K20 methylation
GO:0003149--P:membranous septum morphogenesis
GO:0000122--P:negative regulation of transcription from RNA polymerase II promoter
GO:0048298--P:positive regulation of isotype switching to IgA isotypes
GO:2001032--P:regulation of double-strand break repair via nonhomologous end joining
GO:0070201--P:regulation of establishment of protein localization
Orthology
iUUCD ID Species Identity E-value Score
IUUC-Ata-000229 Aegilops tauschii 54.17 1.00e-03 39.70
IUUC-Aml-002181 Ailuropoda melanoleuca 92.41 0.00e+00 2437.00
IUUC-Apl-003677 Anas platyrhynchos 80.77 0.00e+00 2143.00
IUUC-Aca-004278 Anolis carolinensis 75.53 0.00e+00 1409.00
IUUC-Ame-011932 Astyanax mexicanus 61.01 0.00e+00 1029.00
IUUC-Bta-012522 Bos taurus 86.18 0.00e+00 2266.00
IUUC-Bra-017864 Brassica rapa 30.82 4.00e-13 71.20
IUUC-Cja-018908 Callithrix jacchus 98.28 0.00e+00 2516.00
IUUC-Cfa-020894 Canis familiaris 91.49 0.00e+00 2480.00
IUUC-Cpo-021982 Cavia porcellus 89.41 0.00e+00 2379.00
IUUC-Csa-023807 Chlorocebus sabaeus 98.28 0.00e+00 2533.00
IUUC-Cho-024405 Choloepus hoffmanni 73.44 0.00e+00 724.00
IUUC-Csv-026298 Ciona savignyi 39.29 9.00e-58 217.00
IUUC-Dre-027492 Danio rerio 71.61 0.00e+00 1066.00
IUUC-Dno-030020 Dasypus novemcinctus 87.16 0.00e+00 2070.00
IUUC-Dor-031103 Dipodomys ordii 84.50 0.00e+00 2152.00
IUUC-Dme-032193 Drosophila melanogaster 42.21 6.00e-119 422.00
IUUC-Ete-032488 Echinops telfairi 81.63 0.00e+00 2133.00
IUUC-Eca-034066 Equus caballus 92.84 0.00e+00 2493.00
IUUC-Eeu-035199 Erinaceus europaeus 70.97 0.00e+00 756.00
IUUC-Fca-035434 Felis catus 87.14 0.00e+00 1994.00
IUUC-Fal-037113 Ficedula albicollis 78.77 0.00e+00 2153.00
IUUC-Gmo-039686 Gadus morhua 70.62 0.00e+00 1017.00
IUUC-Gga-040273 Gallus gallus 78.94 0.00e+00 2117.00
IUUC-Gac-042123 Gasterosteus aculeatus 51.05 0.00e+00 1260.00
IUUC-Hsa-046380 Homo sapiens 99.63 0.00e+00 2563.00
IUUC-Itr-048658 Ictidomys tridecemlineatus 93.26 0.00e+00 1448.00
IUUC-Lch-050217 Latimeria chalumnae 66.94 0.00e+00 1745.00
IUUC-Lpe-051201 Leersia perrieri 28.48 1.00e-10 61.60
IUUC-Loc-052766 Lepisosteus oculatus 58.96 0.00e+00 1287.00
IUUC-Laf-053780 Loxodonta africana 89.49 0.00e+00 2422.00
IUUC-Mcc-054928 Macaca mulatta 98.58 0.00e+00 2573.00
IUUC-Meu-056184 Macropus eugenii 75.36 0.00e+00 790.00
IUUC-Mga-059576 Meleagris gallopavo 79.66 0.00e+00 2123.00
IUUC-Mmr-061045 Microcebus murinus 92.92 0.00e+00 2479.00
IUUC-Mdo-062576 Monodelphis domestica 83.02 0.00e+00 2213.00
IUUC-Mmu-063640 Mus musculus 90.98 0.00e+00 2379.00
IUUC-Mac-065303 Musa acuminata 29.22 3.00e-11 63.90
IUUC-Mpu-066512 Mustela putorius furo 92.21 0.00e+00 2422.00
IUUC-Mlu-067280 Myotis lucifugus 80.46 0.00e+00 1103.00
IUUC-Nle-069896 Nomascus leucogenys 99.45 0.00e+00 2461.00
IUUC-Opr-070842 Ochotona princeps 62.92 0.00e+00 932.00
IUUC-Ont-072197 Oreochromis niloticus 73.44 0.00e+00 1039.00
IUUC-Oan-072724 Ornithorhynchus anatinus 78.99 0.00e+00 1369.00
IUUC-Ocu-074758 Oryctolagus cuniculus 89.78 0.00e+00 2319.00
IUUC-Ogl-077641 Oryza glaberrima 27.91 6.00e-10 58.20
IUUC-Ogu-078898 Oryza glumaepatula 27.91 8.00e-10 57.80
IUUC-Oin-079557 Oryza indica 27.91 7.00e-10 57.80
IUUC-Olo-080702 Oryza longistaminata 41.47 3.00e-45 177.00
IUUC-Opu-083371 Oryza punctata 41.88 1.00e-46 182.00
IUUC-Osa-085353 Oryza sativa 27.91 6.00e-10 58.20
IUUC-Oga-088702 Otolemur garnettii 92.19 0.00e+00 2137.00
IUUC-Oar-089736 Ovis aries 81.14 0.00e+00 1990.00
IUUC-Ptr-091055 Pan troglodytes 99.48 0.00e+00 2561.00
IUUC-Pan-092752 Papio anubis 99.61 0.00e+00 1477.00
IUUC-Psi-093620 Pelodiscus sinensis 80.40 0.00e+00 2156.00
IUUC-Pfo-097464 Poecilia formosa 50.86 0.00e+00 1222.00
IUUC-Pab-098051 Pongo abelii 99.40 0.00e+00 2594.00
IUUC-Pop-099927 Populus trichocarpa 28.96 6.00e-12 66.20
IUUC-Pca-100273 Procavia capensis 89.19 0.00e+00 2361.00
IUUC-Pva-102473 Pteropus vampyrus 79.28 0.00e+00 1961.00
IUUC-Rno-105056 Rattus norvegicus 90.47 0.00e+00 2375.00
IUUC-Sha-107494 Sarcophilus harrisii 83.87 0.00e+00 2203.00
IUUC-Sar-113310 Sorex araneus 91.02 0.00e+00 1885.00
IUUC-Sbi-114581 Sorghum bicolor 35.19 6.00e-10 58.20
IUUC-Ssc-116344 Sus scrofa 85.91 0.00e+00 2269.00
IUUC-Tgu-116786 Taeniopygia guttata 80.45 0.00e+00 2152.00
IUUC-Tru-117638 Takifugu rubripes 51.13 0.00e+00 1250.00
IUUC-Tsy-118937 Tarsius syrichta 97.07 0.00e+00 1566.00
IUUC-Tni-120452 Tetraodon nigroviridis 54.00 0.00e+00 1184.00
IUUC-Tae-125237 Triticum aestivum 31.51 1.00e-07 50.10
IUUC-Tbe-127291 Tupaia belangeri 88.39 0.00e+00 1533.00
IUUC-Ttr-129017 Tursiops truncatus 83.58 0.00e+00 1785.00
IUUC-Xtr-132673 Xenopus tropicalis 67.32 0.00e+00 1779.00
Created Date 25-Jun-2017

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