iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEO	ArrayExpress
DNA & RNA Element
TRANSFAC	RAID2
Protein-protein Interaction
IID
Post-translational Modifications (PTMs)
dbPAF	PhosphositePlus	UniProt
Protein Expression/Proteomics
GPMDB

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
DUB/USP	4.50e-82	276.3	111	410

Active Site

Position(s)	Description	Evidence
119	Nucleophile	ECO:0000255\|PROSITE-ProRule:PRU10092, ECO:0000255\|PROSITE-ProRule:PRU10093}
370	Proton acceptor	ECO:0000255\|PROSITE-ProRule:PRU10092, ECO:0000255\|PROSITE-ProRule:PRU10093}

Domain Profile

DUB/USP

   S: 2    GlkNlgNtCYmNSvLQcLsnipelrellle.kkkeklneenpkepkgellkslqklfeelwkskkkavsprellkalkkeaeefsgyeq 89
           Gl+NlgNtC+ N++LQcL+ +p+l++++l+ ++++++++     +  ++++++q+ +++ +++   +++p  +++ ++++a++f+  +q
   Q: 111  GLQNLGNTCFANAALQCLTYTPPLANYMLShEHSKTCHA-----EGFCMMCTMQTHITQALSNPGDVIKPMFVINEMRRIARHFRFGNQ 194
           9*****************************445555544.....578****************************************** PP
   S: 90   qDaqEflaflldqleeelkkeknkpkeeeeeedkselsdeaeekkkkknkslisdlFqgqlksqikclecdnvssreepfldlslpvpg 178
           +Da+Efl++ +d++++++                  l+ +++ + +++ ++l+ ++F+g l+s++kcl+c+ vs +++p ld++l+++ 
   Q: 195  EDAHEFLQYTVDAMQKAC------------------LNGSNKLDRHTQATTLVCQIFGGYLRSRVKCLNCKGVSDTFDPYLDITLEIKA 265
           ******************..................3344567789999**************************************** PP
   S: 179  keetkkeslqdcLesftkeeelegenkyycekckkkqeaekklklkklPevLilhLkRfsfseeqksrekinkkvefpleLdlspfcts 267
            +     s++++Le+f+k+e+l+gen y+c+kckk + a+k++++++ ++vL++ LkRf    ++    ki k v++p+ Ld++p++++
   Q: 266  AQ-----SVTKALEQFVKPEQLDGENSYKCSKCKKMVPASKRFTIHRSSNVLTISLKRF----ANFTGGKIAKDVKYPEYLDIRPYMSQ 345
           **.....9***************************************************....668889******************** PP
   S: 268  peekqkekkkYeLiavvvHsG.slssGHYvayvknekgkWllfdDskVtevkeeevleetgstaYvlfYkr 337
           p+ +   + +Y L+av+vH+G +++ GHY++y+k ++g W++++Ds V++++  +vl+   ++aYvlfY r
   Q: 346  PNGE---PIIYVLYAVLVHTGfNCHAGHYFCYIKASNGLWYQMNDSIVSTSDIRSVLN---QQAYVLFYIR 410
           9977...8**************************************************...********87 PP

Organism

Rattus norvegicus

Functional Description
(View)

Deubiquitinating enzyme which may play an important role during spermatogenesis.

Protein Sequence
(Fasta)

MTIVDKTEPS DPSTCQNQPG SSEAVSPEDM DTGSASWGAV SSISDVSNHT LSLGPVPGAV 60
VYNNSSVPEK SKPSPPKDQV LGDGIAPPQK VLFPSEKICL KWQQSHRVGA GLQNLGNTCF 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

CAGGGTTGAA AAATGACCAT AGTTGACAAA ACTGAACCTT CAGACCCATC AACCTGTCAG 60
AACCAGCCTG GCAGTTCTGA GGCGGTCTCA CCTGAAGACA TGGACACAGG CTCTGCCAGC 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-0221--Differentiation
KW-0378--Hydrolase
KW-0597--Phosphoprotein
KW-0645--Protease
KW-1185--Reference proteome
KW-0744--Spermatogenesis
KW-0788--Thiol protease
KW-0833--Ubl conjugation pathway

Interpro

IPR001394--Peptidase_C19_UCH
IPR018200--USP_CS
IPR028889--USP_dom

PROSITE

PS00972--USP_1
PS00973--USP_2
PS50235--USP_3

Pfam

PF00443--UCH

Gene Ontology

GO:0004843--F:thiol-dependent ubiquitin-specific protease activity
GO:0030154--P:cell differentiation
GO:0016579--P:protein deubiquitination
GO:0007283--P:spermatogenesis
GO:0006511--P:ubiquitin-dependent protein catabolic process

KEGG

rno:288482

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Ata-000401	Aegilops tauschii	38.91	2.00e-70	261.00
IUUC-Aml-002303	Ailuropoda melanoleuca	65.59	0.00e+00	1285.00
IUUC-Atr-003102	Amborella trichopoda	47.23	8.00e-86	312.00
IUUC-Apl-003459	Anas platyrhynchos	54.64	0.00e+00	692.00
IUUC-Aca-004440	Anolis carolinensis	52.88	0.00e+00	963.00
IUUC-Aly-006389	Arabidopsis lyrata	43.14	1.00e-77	284.00
IUUC-Ath-006710	Arabidopsis thaliana	42.81	2.00e-77	283.00
IUUC-Ago-007836	Ashbya gossypii	26.61	3.00e-34	140.00
IUUC-Ame-011358	Astyanax mexicanus	70.59	0.00e+00	664.00
IUUC-Bta-012803	Bos taurus	67.28	0.00e+00	1485.00
IUUC-Bol-015996	Brassica oleracea	43.65	6.00e-83	302.00
IUUC-Bra-016634	Brassica rapa	43.65	3.00e-83	303.00
IUUC-Cja-019199	Callithrix jacchus	68.00	0.00e+00	1465.00
IUUC-Cfa-020597	Canis familiaris	69.80	0.00e+00	1558.00
IUUC-Cpo-021945	Cavia porcellus	67.18	0.00e+00	1545.00
IUUC-Csa-023485	Chlorocebus sabaeus	68.40	0.00e+00	1444.00
IUUC-Cho-024575	Choloepus hoffmanni	60.29	0.00e+00	1139.00
IUUC-Dre-028442	Danio rerio	54.71	0.00e+00	659.00
IUUC-Dno-029673	Dasypus novemcinctus	69.24	0.00e+00	1646.00
IUUC-Dor-030518	Dipodomys ordii	58.11	3.00e-117	416.00
IUUC-Ete-033088	Echinops telfairi	55.54	0.00e+00	923.00
IUUC-Eca-033579	Equus caballus	68.70	0.00e+00	1566.00
IUUC-Eeu-034511	Erinaceus europaeus	51.17	0.00e+00	854.00
IUUC-Fca-035792	Felis catus	66.44	0.00e+00	1451.00
IUUC-Fal-037075	Ficedula albicollis	43.20	0.00e+00	794.00
IUUC-Gga-040504	Gallus gallus	55.08	0.00e+00	723.00
IUUC-Gac-042176	Gasterosteus aculeatus	64.02	1.00e-154	541.00
IUUC-Gma-044075	Glycine max	48.53	2.00e-86	313.00
IUUC-Ggo-044798	Gorilla gorilla	64.13	0.00e+00	1252.00
IUUC-Hsa-046072	Homo sapiens	68.50	0.00e+00	1439.00
IUUC-Hvu-047620	Hordeum vulgare	41.54	7.00e-74	272.00
IUUC-Itr-048078	Ictidomys tridecemlineatus	73.40	0.00e+00	1774.00
IUUC-Lch-049867	Latimeria chalumnae	66.48	0.00e+00	929.00
IUUC-Loc-052621	Lepisosteus oculatus	64.53	0.00e+00	687.00
IUUC-Laf-054330	Loxodonta africana	84.35	0.00e+00	1177.00
IUUC-Mcc-054900	Macaca mulatta	93.37	0.00e+00	749.00
IUUC-Meu-056877	Macropus eugenii	45.55	3.00e-164	573.00
IUUC-Mga-059501	Meleagris gallopavo	41.39	0.00e+00	720.00
IUUC-Mvi-060547	Microbotryum violaceum	43.72	1.00e-81	297.00
IUUC-Mmr-060864	Microcebus murinus	69.84	0.00e+00	1646.00
IUUC-Mdo-062395	Monodelphis domestica	58.72	0.00e+00	1397.00
IUUC-Mmu-064236	Mus musculus	91.94	0.00e+00	2248.00
IUUC-Mpu-065822	Mustela putorius furo	69.45	0.00e+00	1575.00
IUUC-Mlu-067091	Myotis lucifugus	67.68	0.00e+00	1434.00
IUUC-Nle-069004	Nomascus leucogenys	67.61	0.00e+00	1465.00
IUUC-Opr-071170	Ochotona princeps	57.20	0.00e+00	1041.00
IUUC-Ont-071832	Oreochromis niloticus	61.68	0.00e+00	649.00
IUUC-Oan-073711	Ornithorhynchus anatinus	55.27	0.00e+00	1211.00
IUUC-Ocu-074596	Oryctolagus cuniculus	92.13	0.00e+00	1014.00
IUUC-Oga-088641	Otolemur garnettii	69.07	0.00e+00	1589.00
IUUC-Oar-089760	Ovis aries	68.05	0.00e+00	1167.00
IUUC-Ptr-091445	Pan troglodytes	68.13	0.00e+00	1461.00
IUUC-Pan-092484	Papio anubis	68.18	0.00e+00	1412.00
IUUC-Psi-093277	Pelodiscus sinensis	51.61	0.00e+00	1066.00
IUUC-Pma-094651	Petromyzon marinus	38.24	6.00e-58	217.00
IUUC-Pfo-096469	Poecilia formosa	64.13	0.00e+00	651.00
IUUC-Pab-097794	Pongo abelii	66.38	0.00e+00	1342.00
IUUC-Ppe-101678	Prunus persica	46.58	2.00e-82	301.00
IUUC-Pva-103238	Pteropus vampyrus	64.25	0.00e+00	1337.00
IUUC-Sha-106713	Sarcophilus harrisii	58.77	0.00e+00	1424.00
IUUC-Smo-108763	Selaginella moellendorffii	48.05	2.00e-81	295.00
IUUC-Sar-113340	Sorex araneus	78.67	0.00e+00	1060.00
IUUC-Tgu-117149	Taeniopygia guttata	44.32	0.00e+00	796.00
IUUC-Tru-117776	Takifugu rubripes	65.42	6.00e-178	618.00
IUUC-Tsy-118974	Tarsius syrichta	67.88	0.00e+00	1572.00
IUUC-Tni-120774	Tetraodon nigroviridis	66.45	8.00e-174	603.00
IUUC-Tca-120936	Theobroma cacao	46.25	3.00e-85	310.00
IUUC-Tbe-128006	Tupaia belangeri	64.98	4.00e-126	446.00
IUUC-Ttr-128764	Tursiops truncatus	58.02	0.00e+00	1219.00
IUUC-Vvi-131535	Vitis vinifera	46.96	4.00e-87	316.00
IUUC-Xtr-132544	Xenopus tropicalis	57.21	0.00e+00	643.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence