iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

iUUCD ID

IUUC-Bta-012690

Ensembl Protein ID

ENSBTAP00000006241.5

UniProt Accession

A3KMV1; SHKB1_BOVIN

Genbank Protein ID

AAI33280.1

Protein Name

SH3KBP1-binding protein 1

Genbank Nucleotide ID

BC133279

Gene Name

SHKBP1

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSBTAG00000004755.5	ENSBTAT00000006241.5	ENSBTAP00000006241.5

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 adaptor/Cullin RING/DCX/DWD	1.50e-06	28.5	429	461
E3 adaptor/Cullin RING/BCR/BTB_Other: BTB	3.80e-09	36.9	22	85

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

E3 adaptor/Cullin RING/DCX/DWD

   S: 2    Htdsvtclafsd.tllvsGsdDgtikvWDlrtg 33
           H ++vt + +s+ +l+++++d + ++ W+++++
   Q: 429  HRSPVTKIMLSEkHLISVCADSNHVRTWSVTRF 461
           99******9988566677888899*****9976 PP

E3 adaptor/Cullin RING/BCR/BTB_Other: BTB

   S: 4    ilvvggeeffahkivLaas.SsvFyalflmele.esksklmveikdvqpevfrallkFlYtgkld 66
            l+vgg++f++ + +L+    s+F++l+++  +  +++++ + i+ ++p+vf  +l+Fl+t++ld
   Q: 22   HLNVGGKRFSTSRQTLTWIpDSFFSSLLSGRIStLKDETGAIFID-RDPTVFAPILNFLRTKELD 85
           69****************99*************9999********.*****************98 PP

Organism

Bos taurus

Functional Description
(View)

Inhibits CBL-SH3KBP1 complex mediated down-regulation of EGFR signaling by sequestration of SH3KBP1. Binds to SH3KBP1 and prevents its interaction with CBL and inhibits translocation of SH3KBP1 to EGFR containing vesicles upon EGF stimulation.

Protein Sequence
(Fasta)

MAAAAPAVDG VPGRGPPGEV IHLNVGGKRF STSRQTLTWI PDSFFSSLLS GRISTLKDET 60
GAIFIDRDPT VFAPILNFLR TKELDPRGVH GSSLLHEAQF YGLTPLVRRL QLLEELDRSS 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

AGCCCGGGGG CCATGGCGGC CGCGGCCCCT GCAGTCGACG GGGTCCCAGG TCGGGGGCCT 60
CCCGGAGAGG TGATTCATCT GAATGTGGGA GGCAAGAGGT GAGTGTAAGA GTTTCTTGAG 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0007--Acetylation
KW-0181--Complete proteome
KW-0458--Lysosome
KW-0597--Phosphoprotein
KW-1185--Reference proteome
KW-0677--Repeat
KW-0853--WD repeat

Interpro

IPR000210--BTB/POZ_dom
IPR011333--SKP1/BTB/POZ
IPR003131--T1-type_BTB
IPR015943--WD40/YVTN_repeat-like_dom
IPR017986--WD40_repeat_dom

PROSITE

PS50097--BTB
PS00678--WD_REPEATS_1

Pfam

PF02214--BTB_2

SMART

SM00225--BTB

Gene Ontology

GO:0045742--P:positive regulation of epidermal growth factor receptor signaling pathway
GO:0051260--P:protein homooligomerization

KEGG

bta:512402

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-002379	Ailuropoda melanoleuca	94.32	0.00e+00	1149.00
IUUC-Aca-004906	Anolis carolinensis	75.33	0.00e+00	966.00
IUUC-Ath-006820	Arabidopsis thaliana	38.54	6.00e-09	55.50
IUUC-Acl-008201	Aspergillus clavatus	28.04	7.00e-04	38.50
IUUC-Afl-008739	Aspergillus flavus	29.52	8.00e-05	39.30
IUUC-Ame-011252	Astyanax mexicanus	68.36	0.00e+00	874.00
IUUC-Bci-013656	Botrytis cinerea	36.89	5.00e-10	57.80
IUUC-Bra-017048	Brassica rapa	40.62	5.00e-04	39.30
IUUC-Cja-018763	Callithrix jacchus	94.46	0.00e+00	1269.00
IUUC-Cfa-020543	Canis familiaris	94.19	0.00e+00	1171.00
IUUC-Cpo-021962	Cavia porcellus	92.33	0.00e+00	1189.00
IUUC-Dre-027729	Danio rerio	75.00	0.00e+00	971.00
IUUC-Dno-028972	Dasypus novemcinctus	91.72	0.00e+00	1056.00
IUUC-Dor-030553	Dipodomys ordii	94.39	0.00e+00	1107.00
IUUC-Eca-033315	Equus caballus	96.93	0.00e+00	1176.00
IUUC-Eeu-035311	Erinaceus europaeus	93.35	0.00e+00	1014.00
IUUC-Fca-036552	Felis catus	94.18	0.00e+00	1197.00
IUUC-Fso-038119	Fusarium solani	31.97	2.00e-06	47.00
IUUC-Gmo-039368	Gadus morhua	75.54	0.00e+00	907.00
IUUC-Gac-041846	Gasterosteus aculeatus	68.68	0.00e+00	951.00
IUUC-Hsa-045915	Homo sapiens	95.33	0.00e+00	1255.00
IUUC-Itr-048663	Ictidomys tridecemlineatus	96.64	0.00e+00	1156.00
IUUC-Loc-051959	Lepisosteus oculatus	67.43	0.00e+00	972.00
IUUC-Laf-054452	Loxodonta africana	86.75	0.00e+00	1036.00
IUUC-Mcc-055544	Macaca mulatta	92.79	0.00e+00	1206.00
IUUC-Meu-056159	Macropus eugenii	89.36	0.00e+00	1055.00
IUUC-Mmr-061709	Microcebus murinus	96.16	0.00e+00	1204.00
IUUC-Mdo-062553	Monodelphis domestica	84.15	0.00e+00	1070.00
IUUC-Mmu-063367	Mus musculus	92.76	0.00e+00	1181.00
IUUC-Mpu-066614	Mustela putorius furo	95.47	0.00e+00	1152.00
IUUC-Nle-069872	Nomascus leucogenys	90.52	0.00e+00	1140.00
IUUC-Opr-070600	Ochotona princeps	83.52	0.00e+00	981.00
IUUC-Ont-071375	Oreochromis niloticus	74.80	0.00e+00	948.00
IUUC-Oga-088526	Otolemur garnettii	95.74	0.00e+00	1217.00
IUUC-Oar-089898	Ovis aries	97.82	0.00e+00	1205.00
IUUC-Ptr-091353	Pan troglodytes	91.37	0.00e+00	1182.00
IUUC-Pan-091730	Papio anubis	92.99	0.00e+00	1196.00
IUUC-Pfo-097224	Poecilia formosa	67.45	0.00e+00	955.00
IUUC-Pab-098142	Pongo abelii	91.99	0.00e+00	1167.00
IUUC-Pca-100847	Procavia capensis	84.80	0.00e+00	996.00
IUUC-Ppe-101673	Prunus persica	36.46	5.00e-10	58.90
IUUC-Pva-102652	Pteropus vampyrus	97.52	0.00e+00	1207.00
IUUC-Rno-104907	Rattus norvegicus	91.76	0.00e+00	1192.00
IUUC-Stu-112164	Solanum tuberosum	39.45	5.00e-10	58.90
IUUC-Sar-113577	Sorex araneus	81.17	0.00e+00	937.00
IUUC-Tru-118507	Takifugu rubripes	70.49	0.00e+00	977.00
IUUC-Tni-120814	Tetraodon nigroviridis	71.69	0.00e+00	946.00
IUUC-Tre-121919	Trichoderma reesei	31.36	1.00e-06	47.80
IUUC-Tvi-122427	Trichoderma virens	33.07	1.00e-06	48.10
IUUC-Vda-129852	Verticillium dahliae	32.84	1.00e-04	40.80
IUUC-Xtr-132155	Xenopus tropicalis	71.79	0.00e+00	974.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence