iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEO
DNA & RNA Element
miRTarBase	TRANSFAC	RAID2
Protein-protein Interaction
IID
Post-translational Modifications (PTMs)
dbPAF	PhosphositePlus
Protein Expression/Proteomics
GPMDB

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 activity/RING/RING	3.30e-06	27.9	18	57
ULD/UDP/UFD/RAWUL	1.90e-29	102.4	132	224

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

E3 activity/RING/RING

   S: 1    CaiCledfkdgplvlpCgHvfhadClqkwpglknssskefrCPlCr 46
           C +C   f d + +  C H f+++C+ ++        ++ +CP+C+
   Q: 18   CVLCGGYFIDATTIIECLHSFCKTCIVRY------LETSKYCPICD 57
           ********99999****************......**********5 PP

ULD/UDP/UFD/RAWUL

   S: 2    slsLeplesnkakddsk........lkkkylrcsarltVkhlkkflaeklklsssyevdllcedevLednetLeeikyifiwkkegpLv 82
           sls+e+++ ++ +++          ++k+ylrc+a+ltV+hl+kfl++k+++++++++d+++e+e+L+d++tL++i+yi++w+++gpL+
   Q: 132  SLSIEFFHPSRSDRKVTkekpkeevNDKRYLRCPAALTVMHLRKFLRSKMDIPNTFQIDVMYEEEPLKDYYTLMDIAYIYTWRRNGPLP 220
           5666666555555544355566777**************************************************************** PP
   S: 83   LqYr 86
           L+Yr
   Q: 221  LKYR 224
           ***9 PP

Organism

Rattus norvegicus

Protein Sequence
(Fasta)

MHRTTRIKIT ELNPHLMCVL CGGYFIDATT IIECLHSFCK TCIVRYLETS KYCPICDVQV 60
HKTRPLLNIR SDKTLQDIVY KLVPGLFKNE MKRRRDFYAA HPSADAANGS NEDRGEVADE 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

CGCACGCCCG CAGAGGCTGG GCTCGGCCAG CTCCGCGCAG AGTTGCAGCG GTGGCTGGAT 60
GCCAAGTGTA AGTGTAAGTT GCTATGGAAA CCCCAACAGA GGCGAGTTCC GAATCCGGAA 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-1185--Reference proteome

Interpro

IPR032443--RAWUL
IPR001841--Znf_RING
IPR013083--Znf_RING/FYVE/PHD
IPR017907--Znf_RING_CS

PROSITE

PS00518--ZF_RING_1
PS50089--ZF_RING_2

Pfam

PF16207--RAWUL

SMART

SM00184--RING

Gene Ontology

GO:0000792--C:heterochromatin
GO:0016604--C:nuclear body
GO:0031519--C:PcG protein complex
GO:0000151--C:ubiquitin ligase complex
GO:1990841--F:promoter-specific chromatin binding
GO:0000978--F:RNA polymerase II core promoter proximal region sequence-specific DNA binding
GO:0097027--F:ubiquitin-protein transferase activator activity
GO:0008270--F:zinc ion binding
GO:0007420--P:brain development
GO:0071549--P:cellular response to dexamethasone stimulus
GO:0071347--P:cellular response to interleukin-1
GO:0006306--P:DNA methylation
GO:0048704--P:embryonic skeletal system morphogenesis
GO:0016573--P:histone acetylation
GO:0016574--P:histone ubiquitination
GO:0006959--P:humoral immune response
GO:0001701--P:in utero embryonic development
GO:2001234--P:negative regulation of apoptotic signaling pathway
GO:0000122--P:negative regulation of transcription from RNA polymerase II promoter
GO:0030890--P:positive regulation of B cell proliferation
GO:0033092--P:positive regulation of immature T cell proliferation in thymus
GO:2000011--P:regulation of adaxial/abaxial pattern formation
GO:0021903--P:rostrocaudal neural tube patterning
GO:0048103--P:somatic stem cell division

KEGG

rno:307151

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Ata-000603	Aegilops tauschii	38.10	5.00e-12	65.50
IUUC-Aml-001498	Ailuropoda melanoleuca	95.40	7.00e-163	566.00
IUUC-Apl-004208	Anas platyrhynchos	88.89	9.00e-128	449.00
IUUC-Aca-004661	Anolis carolinensis	79.14	6.00e-134	470.00
IUUC-Ath-007649	Arabidopsis thaliana	42.50	3.00e-12	66.60
IUUC-Ame-010610	Astyanax mexicanus	72.04	1.00e-135	476.00
IUUC-Bta-012606	Bos taurus	93.87	3.00e-160	557.00
IUUC-Cja-019482	Callithrix jacchus	94.90	7.00e-171	592.00
IUUC-Cfa-020482	Canis familiaris	95.40	7.00e-163	566.00
IUUC-Cpo-022061	Cavia porcellus	94.27	4.00e-170	590.00
IUUC-Csa-024102	Chlorocebus sabaeus	94.59	1.00e-171	596.00
IUUC-Cho-025081	Choloepus hoffmanni	76.31	2.00e-104	371.00
IUUC-Cin-025612	Ciona intestinalis	49.77	2.00e-52	199.00
IUUC-Dre-027929	Danio rerio	78.40	2.00e-140	491.00
IUUC-Dno-029797	Dasypus novemcinctus	92.99	1.00e-175	608.00
IUUC-Dor-030256	Dipodomys ordii	95.51	5.00e-164	570.00
IUUC-Dme-031904	Drosophila melanogaster	44.25	4.00e-52	200.00
IUUC-Ete-033148	Echinops telfairi	64.41	2.00e-81	295.00
IUUC-Eca-033318	Equus caballus	94.48	6.00e-161	560.00
IUUC-Eeu-034547	Erinaceus europaeus	81.21	2.00e-139	488.00
IUUC-Fca-035866	Felis catus	94.79	1.00e-161	561.00
IUUC-Fal-036660	Ficedula albicollis	90.49	6.00e-153	533.00
IUUC-Gmo-039341	Gadus morhua	80.23	1.00e-122	432.00
IUUC-Gga-040611	Gallus gallus	90.13	3.00e-158	550.00
IUUC-Gac-041888	Gasterosteus aculeatus	70.71	2.00e-125	441.00
IUUC-Gma-042798	Glycine max	39.02	5.00e-12	65.50
IUUC-Ggo-045027	Gorilla gorilla	94.59	1.00e-170	591.00
IUUC-Hsa-045665	Homo sapiens	94.79	2.00e-171	595.00
IUUC-Itr-049045	Ictidomys tridecemlineatus	94.23	2.00e-170	591.00
IUUC-Lch-049714	Latimeria chalumnae	84.36	6.00e-160	556.00
IUUC-Loc-052161	Lepisosteus oculatus	80.73	5.00e-142	496.00
IUUC-Laf-054108	Loxodonta africana	92.45	9.00e-168	582.00
IUUC-Mcc-055562	Macaca mulatta	94.79	2.00e-171	595.00
IUUC-Meu-056709	Macropus eugenii	92.64	6.00e-163	566.00
IUUC-Mtr-058158	Medicago truncatula	43.42	3.00e-10	57.80
IUUC-Mga-060104	Meleagris gallopavo	85.94	4.00e-112	397.00
IUUC-Mmr-061191	Microcebus murinus	94.79	1.00e-171	595.00
IUUC-Mdo-062711	Monodelphis domestica	87.77	4.00e-144	503.00
IUUC-Mmu-064255	Mus musculus	95.83	8.00e-164	569.00
IUUC-Mpu-066466	Mustela putorius furo	94.79	1.00e-161	561.00
IUUC-Mlu-067622	Myotis lucifugus	94.59	2.00e-170	591.00
IUUC-Nle-069253	Nomascus leucogenys	94.79	2.00e-171	595.00
IUUC-Opr-070511	Ochotona princeps	94.17	1.00e-168	585.00
IUUC-Ont-072177	Oreochromis niloticus	81.78	3.00e-126	444.00
IUUC-Oan-073336	Ornithorhynchus anatinus	92.33	1.00e-160	558.00
IUUC-Ocu-074113	Oryctolagus cuniculus	93.63	5.00e-162	563.00
IUUC-Oni-082398	Oryza nivara	42.25	9.00e-12	65.10
IUUC-Ola-087057	Oryzias latipes	82.64	9.00e-120	422.00
IUUC-Oga-088346	Otolemur garnettii	94.59	1.00e-170	591.00
IUUC-Oar-089843	Ovis aries	93.87	3.00e-160	557.00
IUUC-Ptr-090486	Pan troglodytes	94.59	1.00e-170	591.00
IUUC-Pan-092667	Papio anubis	94.30	4.00e-150	524.00
IUUC-Psi-093469	Pelodiscus sinensis	90.80	1.00e-162	565.00
IUUC-Pma-094481	Petromyzon marinus	74.88	6.00e-91	326.00
IUUC-Ppa-095811	Physcomitrella patens	41.38	4.00e-10	59.70
IUUC-Pfo-097156	Poecilia formosa	77.03	4.00e-128	451.00
IUUC-Pab-097670	Pongo abelii	94.59	1.00e-170	591.00
IUUC-Pop-099100	Populus trichocarpa	37.65	1.00e-12	67.40
IUUC-Pva-102800	Pteropus vampyrus	94.59	1.00e-170	591.00
IUUC-Sha-106747	Sarcophilus harrisii	92.33	2.00e-154	538.00
IUUC-Sar-113416	Sorex araneus	94.27	5.00e-170	590.00
IUUC-Ssc-115864	Sus scrofa	94.59	1.00e-170	592.00
IUUC-Tgu-116851	Taeniopygia guttata	89.55	1.00e-128	452.00
IUUC-Tru-117698	Takifugu rubripes	82.93	3.00e-122	431.00
IUUC-Tsy-119590	Tarsius syrichta	94.59	2.00e-170	591.00
IUUC-Tni-120170	Tetraodon nigroviridis	81.78	1.00e-125	442.00
IUUC-Tae-123760	Triticum aestivum	37.21	6.00e-12	65.50
IUUC-Tur-126396	Triticum urartu	37.21	6.00e-12	65.10
IUUC-Tbe-127790	Tupaia belangeri	94.27	4.00e-170	590.00
IUUC-Ttr-129316	Tursiops truncatus	94.17	2.00e-169	587.00
IUUC-Vpa-130669	Vicugna pacos	94.48	7.00e-161	559.00
IUUC-Xtr-131912	Xenopus tropicalis	83.49	2.00e-142	498.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence