iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

iUUCD ID

IUUC-Ptr-091476

Ensembl Protein ID

ENSPTRP00000005961.4

UniProt Accession

H2Q397; H2Q397_PANTR

Genbank Protein ID

JAA00833.1; JAA17351.1; JAA30014.1

Protein Name

Tumor susceptibility gene 101

Genbank Nucleotide ID

AACZ03078885; GABF01004794; GABD01003086

Gene Name

TSG101

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSPTRG00000003424.5	ENSPTRT00000006464.4	ENSPTRP00000005961.4

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E2/UEV	2.10e-45	154.1	2	146
UBD/UBC-like/UBD_UEV	1.80e-68	228.8	2	145

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

E2/UEV

   S: 1    avseselkvvvpr......nfrlleeleegekglgdgtvsygldDgddilllsltgtIigpertayegrIyqlklfvgkkYPekPPtv. 82
           avses+lk++v++      ++r+++++++ +k+l+++++sy+++Dg++++l++ltgtI++p+r+++ ++I +++l++ ++YP++PP++ 
   Q: 2    AVSESQLKKMVSKykyrdlTVRETVNVITLYKDLKPVLDSYVFNDGSSRELMNLTGTIPVPYRGNT-YNI-PICLWLLDTYPYNPPICf 88
           799***************************************************************.***.****************** PP
   S: 83   ...rfsskinmaevndsnGvvdpralpvLanWkreysievvlvqlkkellskenrklqqPp 140
              ++s++i++ +++d+nG++   +lp+L++Wk+++s+++ l+q++++++++e++++++P 
   Q: 89   vkpTSSMTIKTGKHVDANGKI---YLPYLHEWKHPQSDLLGLIQVMIVVFGDEPPVFSRPI 146
           *********************...************************************5 PP

UBD/UBC-like/UBD_UEV

   S: 1    AvsesslkkvpskykdkrltvrellnliesykslkpktasfvlnDgesreLlrltGtipvpergitynipiilwlletYPekPPfvsvk 89
           Avses+lkk++skyk+++ltvre++n+i+ yk+lkp+++s+v+nDg+sreL++ltGtipvp+rg+tynipi+lwll+tYP++PP+++vk
   Q: 2    AVSESQLKKMVSKYKYRDLTVRETVNVITLYKDLKPVLDSYVFNDGSSRELMNLTGTIPVPYRGNTYNIPICLWLLDTYPYNPPICFVK 90
           89*************************************************************************************** PP
   S: 90   ekidmntikssnehvdpnGkialpvLhkWknpasnlvelvqelivllskeppklsrp 146
           ++++m tik++ +hvd+nGki+lp+Lh+Wk+p+s+l+ l+q++iv++++epp++srp
   Q: 91   PTSSM-TIKTG-KHVDANGKIYLPYLHEWKHPQSDLLGLIQVMIVVFGDEPPVFSRP 145
           *****.*****.*******************************************98 PP

Organism

Pan troglodytes

Protein Sequence
(Fasta)

MAVSESQLKK MVSKYKYRDL TVRETVNVIT LYKDLKPVLD SYVFNDGSSR ELMNLTGTIP 60
VPYRGNTYNI PICLWLLDTY PYNPPICFVK PTSSMTIKTG KHVDANGKIY LPYLHEWKHP 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

GAAGCGGAAG TGGTGTGTTG GTGCCGACTT CCTGTTGTTT GAGGCCGGGT TGGGGGTGTG 60
CGATTGTGTG GGACGGTCTG GGGCAGCCCA GCAGCGGCTG ACCCTCTGCC TGCGGGGAAG 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0175--Coiled coil
KW-0181--Complete proteome
KW-1185--Reference proteome

Interpro

IPR017916--SB_dom
IPR016135--UBQ-conjugating_enzyme/RWD
IPR008883--UEV_N

PROSITE

PS51312--SB
PS51322--UEV

Pfam

PF05743--UEV
PF09454--Vps23_core

Gene Ontology

GO:0005829--C:cytosol
GO:0005769--C:early endosome
GO:0000813--C:ESCRT I complex
GO:0070062--C:extracellular exosome
GO:0005770--C:late endosome
GO:0005730--C:nucleolus
GO:0005886--C:plasma membrane
GO:0003714--F:transcription corepressor activity
GO:0046790--F:virion binding
GO:0007050--P:cell cycle arrest
GO:0006464--P:cellular protein modification process
GO:1990182--P:exosomal secretion
GO:0030216--P:keratinocyte differentiation
GO:0008285--P:negative regulation of cell proliferation
GO:0042059--P:negative regulation of epidermal growth factor receptor signaling pathway
GO:0045892--P:negative regulation of transcription, DNA-templated
GO:1903543--P:positive regulation of exosomal secretion
GO:2000397--P:positive regulation of ubiquitin-dependent endocytosis
GO:1903774--P:positive regulation of viral budding via host ESCRT complex
GO:1902188--P:positive regulation of viral release from host cell
GO:0015031--P:protein transport
GO:0001558--P:regulation of cell growth
GO:1903551--P:regulation of extracellular exosome assembly
GO:0043405--P:regulation of MAP kinase activity
GO:0043162--P:ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway
GO:0046755--P:viral budding

KEGG

ptr:451065

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Ata-001072	Aegilops tauschii	27.17	6.00e-27	114.00
IUUC-Aml-002415	Ailuropoda melanoleuca	97.70	0.00e+00	727.00
IUUC-Atr-002875	Amborella trichopoda	28.92	7.00e-35	141.00
IUUC-Apl-003473	Anas platyrhynchos	88.78	0.00e+00	681.00
IUUC-Aca-004573	Anolis carolinensis	90.82	0.00e+00	669.00
IUUC-Aly-006164	Arabidopsis lyrata	44.12	5.00e-22	98.60
IUUC-Ath-006575	Arabidopsis thaliana	44.12	5.00e-22	98.60
IUUC-Ago-007755	Ashbya gossypii	25.89	2.00e-05	43.50
IUUC-Acl-008218	Aspergillus clavatus	38.76	3.00e-25	110.00
IUUC-Afl-008597	Aspergillus flavus	39.10	2.00e-25	110.00
IUUC-Afu-009017	Aspergillus fumigatus	37.98	2.00e-23	103.00
IUUC-Ani-009468	Aspergillus nidulans	38.64	4.00e-21	96.30
IUUC-Ang-009755	Aspergillus niger	36.51	2.00e-22	100.00
IUUC-Aor-010072	Aspergillus oryzae	37.59	2.00e-25	110.00
IUUC-Ate-010400	Aspergillus terreus	37.98	8.00e-25	108.00
IUUC-Ame-011620	Astyanax mexicanus	80.00	0.00e+00	635.00
IUUC-Bgr-012136	Blumeria graminis	35.77	7.00e-24	105.00
IUUC-Bta-012557	Bos taurus	89.00	0.00e+00	719.00
IUUC-Bci-013881	Botrytis cinerea	38.35	3.00e-26	112.00
IUUC-Bdi-014325	Brachypodium distachyon	32.11	2.00e-14	73.20
IUUC-Bol-016308	Brassica oleracea	41.60	9.00e-27	115.00
IUUC-Bra-017605	Brassica rapa	41.13	8.00e-27	114.00
IUUC-Cel-018697	Caenorhabditis elegans	48.84	3.00e-37	149.00
IUUC-Cja-018963	Callithrix jacchus	92.58	0.00e+00	726.00
IUUC-Cfa-020472	Canis familiaris	97.70	0.00e+00	724.00
IUUC-Cpo-022001	Cavia porcellus	98.98	0.00e+00	732.00
IUUC-Cre-022918	Chlamydomonas reinhardtii	30.73	1.00e-33	137.00
IUUC-Csa-023959	Chlorocebus sabaeus	100.00	0.00e+00	711.00
IUUC-Cho-024389	Choloepus hoffmanni	56.36	2.00e-38	153.00
IUUC-Cin-025688	Ciona intestinalis	44.53	3.00e-99	355.00
IUUC-Cne-026904	Cryptococcus neoformans	30.56	2.00e-14	74.30
IUUC-Cme-027280	Cyanidioschyzon merolae	39.09	1.00e-17	84.00
IUUC-Dre-027913	Danio rerio	80.26	2.00e-174	605.00
IUUC-Dno-029672	Dasypus novemcinctus	97.95	0.00e+00	741.00
IUUC-Dor-030175	Dipodomys ordii	97.00	3.00e-93	334.00
IUUC-Dse-031375	Dothistroma septosporum	34.09	4.00e-23	102.00
IUUC-Dme-031736	Drosophila melanogaster	50.12	3.00e-99	355.00
IUUC-Ete-032343	Echinops telfairi	92.58	0.00e+00	694.00
IUUC-Eca-033926	Equus caballus	98.46	0.00e+00	733.00
IUUC-Eeu-034940	Erinaceus europaeus	90.28	0.00e+00	712.00
IUUC-Fca-035491	Felis catus	97.44	0.00e+00	709.00
IUUC-Fal-037508	Ficedula albicollis	91.58	0.00e+00	672.00
IUUC-Fox-037937	Fusarium oxysporum	32.31	3.00e-21	96.70
IUUC-Fso-038091	Fusarium solani	36.03	5.00e-25	108.00
IUUC-Gmo-039427	Gadus morhua	77.95	6.00e-170	589.00
IUUC-Ggr-039724	Gaeumannomyces graminis	37.31	5.00e-25	108.00
IUUC-Gga-040998	Gallus gallus	88.49	0.00e+00	696.00
IUUC-Gac-041356	Gasterosteus aculeatus	80.72	0.00e+00	636.00
IUUC-Gma-043566	Glycine max	39.68	3.00e-25	109.00
IUUC-Ggo-044967	Gorilla gorilla	100.00	0.00e+00	711.00
IUUC-Hsa-046686	Homo sapiens	100.00	0.00e+00	711.00
IUUC-Hvu-047430	Hordeum vulgare	27.17	8.00e-27	114.00
IUUC-Itr-047929	Ictidomys tridecemlineatus	98.21	8.00e-110	389.00
IUUC-Kpa-049287	Komagataella pastoris	30.41	8.00e-16	78.20
IUUC-Lch-050597	Latimeria chalumnae	86.73	0.00e+00	672.00
IUUC-Lpe-051090	Leersia perrieri	38.02	2.00e-20	93.20
IUUC-Loc-052399	Lepisosteus oculatus	78.77	9.00e-177	612.00
IUUC-Lma-053249	Leptosphaeria maculans	29.82	1.00e-13	71.60
IUUC-Laf-053766	Loxodonta africana	98.47	0.00e+00	731.00
IUUC-Mcc-055641	Macaca mulatta	100.00	0.00e+00	711.00
IUUC-Meu-055919	Macropus eugenii	89.88	3.00e-168	584.00
IUUC-Mor-056970	Magnaporthe oryzae	38.46	5.00e-24	105.00
IUUC-Mpo-057345	Magnaporthe poae	36.92	8.00e-23	101.00
IUUC-Mtr-058436	Medicago truncatula	38.10	8.00e-26	111.00
IUUC-Mla-059037	Melampsora laricipopulina	34.93	2.00e-25	110.00
IUUC-Mga-059263	Meleagris gallopavo	87.79	0.00e+00	669.00
IUUC-Mvi-060463	Microbotryum violaceum	30.20	2.00e-17	84.30
IUUC-Mmr-060915	Microcebus murinus	98.21	0.00e+00	724.00
IUUC-Mdo-062449	Monodelphis domestica	94.12	0.00e+00	686.00
IUUC-Mmu-063151	Mus musculus	94.63	0.00e+00	699.00
IUUC-Mac-065581	Musa acuminata	36.43	7.00e-22	97.80
IUUC-Mpu-066621	Mustela putorius furo	97.70	0.00e+00	727.00
IUUC-Mlu-067336	Myotis lucifugus	97.95	0.00e+00	709.00
IUUC-Nfi-068530	Neosartorya fischeri	38.76	2.00e-23	103.00
IUUC-Ncr-068785	Neurospora crassa	36.03	1.00e-24	107.00
IUUC-Nle-069972	Nomascus leucogenys	100.00	0.00e+00	711.00
IUUC-Opr-071150	Ochotona princeps	68.80	9.00e-123	432.00
IUUC-Ont-071366	Oreochromis niloticus	81.28	0.00e+00	632.00
IUUC-Oan-073290	Ornithorhynchus anatinus	93.91	4.00e-105	373.00
IUUC-Ocu-074351	Oryctolagus cuniculus	99.23	0.00e+00	733.00
IUUC-Oba-075338	Oryza barthii	37.14	2.00e-11	63.20
IUUC-Obr-076135	Oryza brachyantha	37.19	3.00e-20	92.80
IUUC-Ogl-077182	Oryza glaberrima	36.28	3.00e-17	82.80
IUUC-Ogu-078281	Oryza glumaepatula	37.19	3.00e-20	92.80
IUUC-Oin-079068	Oryza indica	36.28	7.00e-17	82.00
IUUC-Olo-080460	Oryza longistaminata	35.80	1.00e-08	52.80
IUUC-Ome-081781	Oryza meridionalis	25.61	5.00e-18	85.50
IUUC-Oni-082517	Oryza nivara	26.36	1.00e-20	94.00
IUUC-Opu-084101	Oryza punctata	36.28	2.00e-17	82.80
IUUC-Oru-084556	Oryza rufipogon	36.84	3.00e-17	82.80
IUUC-Osa-086264	Oryza sativa	36.28	3.00e-17	82.80
IUUC-Ola-087252	Oryzias latipes	93.29	3.00e-69	253.00
IUUC-Olu-087610	Ostreococcus lucimarinus	26.67	7.00e-15	74.70
IUUC-Oga-088304	Otolemur garnettii	97.95	0.00e+00	725.00
IUUC-Oar-089734	Ovis aries	89.00	0.00e+00	719.00
IUUC-Pan-092341	Papio anubis	100.00	0.00e+00	711.00
IUUC-Psi-093470	Pelodiscus sinensis	92.99	0.00e+00	669.00
IUUC-Pma-094143	Petromyzon marinus	64.84	3.00e-135	474.00
IUUC-Pno-095069	Phaeosphaeria nodorum	31.93	2.00e-14	73.90
IUUC-Ppa-095933	Physcomitrella patens	29.09	5.00e-37	148.00
IUUC-Pfo-096321	Poecilia formosa	80.26	4.00e-173	600.00
IUUC-Pab-098527	Pongo abelii	99.43	0.00e+00	631.00
IUUC-Pop-099323	Populus trichocarpa	27.53	5.00e-37	148.00
IUUC-Pca-101044	Procavia capensis	79.54	2.00e-157	548.00
IUUC-Ppe-101458	Prunus persica	41.67	4.00e-27	115.00
IUUC-Pva-103014	Pteropus vampyrus	87.47	4.00e-172	597.00
IUUC-Pgr-103615	Puccinia graminis	36.09	2.00e-20	94.00
IUUC-Ptt-103826	Puccinia triticina	40.20	2.00e-16	80.50
IUUC-Pte-104171	Pyrenophora teres	35.29	2.00e-21	97.40
IUUC-Pyt-104433	Pyrenophora triticirepentis	33.01	2.00e-10	60.50
IUUC-Rno-105957	Rattus norvegicus	93.61	0.00e+00	693.00
IUUC-Sce-106262	Saccharomyces cerevisiae	27.34	2.00e-10	60.10
IUUC-Sha-107607	Sarcophilus harrisii	95.13	7.00e-174	602.00
IUUC-Spo-108175	Schizosaccharomyces pombe	30.56	1.20e-02	34.70
IUUC-Ssl-108672	Sclerotinia sclerotiorum	35.29	2.00e-25	110.00
IUUC-Smo-108973	Selaginella moellendorffii	39.47	6.00e-21	94.70
IUUC-Sly-111373	Solanum lycopersicum	36.51	1.00e-23	103.00
IUUC-Stu-112844	Solanum tuberosum	35.71	8.00e-23	101.00
IUUC-Sar-113653	Sorex araneus	85.82	1.00e-178	619.00
IUUC-Sbi-114390	Sorghum bicolor	35.54	3.00e-20	92.80
IUUC-Sre-115200	Sporisorium reilianum	38.36	5.00e-24	106.00
IUUC-Ssc-115888	Sus scrofa	98.24	2.00e-112	397.00
IUUC-Tgu-117506	Taeniopygia guttata	84.88	0.00e+00	686.00
IUUC-Tru-118063	Takifugu rubripes	79.03	6.00e-170	590.00
IUUC-Tsy-118851	Tarsius syrichta	74.71	8.00e-144	502.00
IUUC-Tni-120010	Tetraodon nigroviridis	78.83	1.00e-168	585.00
IUUC-Tca-121182	Theobroma cacao	38.89	3.00e-22	99.40
IUUC-Tre-122040	Trichoderma reesei	36.15	7.00e-22	98.60
IUUC-Tvi-122660	Trichoderma virens	39.71	8.00e-26	111.00
IUUC-Tae-124561	Triticum aestivum	27.17	6.00e-27	114.00
IUUC-Tur-126651	Triticum urartu	37.40	8.00e-21	94.40
IUUC-Tme-127184	Tuber melanosporum	47.32	1.00e-25	111.00
IUUC-Tbe-127894	Tupaia belangeri	82.00	5.00e-89	320.00
IUUC-Ttr-128264	Tursiops truncatus	89.00	0.00e+00	701.00
IUUC-Uma-129407	Ustilago maydis	36.99	1.00e-24	107.00
IUUC-Vda-130002	Verticillium dahliae	30.82	5.00e-16	79.00
IUUC-Vpa-130156	Vicugna pacos	96.50	4.00e-96	344.00
IUUC-Vvi-131479	Vitis vinifera	41.23	1.00e-23	103.00
IUUC-Xtr-132332	Xenopus tropicalis	81.68	6.00e-64	235.00
IUUC-Xma-133186	Xiphophorus maculatus	77.69	2.00e-173	601.00
IUUC-Yli-134500	Yarrowia lipolytica	33.55	9.00e-13	67.80
IUUC-Zma-135391	Zea mays	36.13	6.00e-20	91.70

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence