iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

UUCD2 ID

IUUC-Tni-120836

UUCD1 version

UUC-TeN-00742

Ensembl Protein ID

ENSTNIP00000018139.1

UniProt Accession

H3DC96; H3DC96_TETNG

Protein Name

Uncharacterized protein

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSTNIG00000015085.1	ENSTNIT00000018363.1	ENSTNIP00000018139.1
ENSTNIG00000015085.1	ENSTNIT00000000145.1	ENSTNIP00000001600.1

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 activity/HECT	2.50e-120	402.1	3031	3365
UBD/Alpha-Helix/UBA	4.70e-08	33.1	362	399

Active Site

Position(s)	Description	Evidence
3333	Glycyl thioester intermediate	{ECO:0000256\|PROSITE-ProRule:PRU00104}

Domain Profile

E3 activity/HECT

   S: 2    ksdlkkrlevefvgEegldlgGvtreflallskelqnpdlglflysendketlqpnpdsglknpehlklFeflGrllgkalqdgrll 88
           ++d+k+rl++ f+gEeg+d+gG+ re++  +s+e++np++ lf++s++d+ t+++np+s + np+hl++F+f+Gr+++ka++d+rll
   Q: 3031 PEDMKNRLYIVFEGEEGQDAGGLLREWYMIISREMFNPMYALFRTSPGDRVTYTINPSSHC-NPNHLSYFKFVGRVVAKAVYDNRLL 3116
           689********************************************************86.99*********************** PP
   S: 89   dlplsksfyklllgkklsledleevdpelykslkeikenaesdieelgldltfsvseeilgetkeeeLkpgGenipVtneNkeeYvk 175
           ++ +++sfyk++lgk++ + d+e+ d  +++ l +++en   d+++lg +ltfs++ +++g +++++Lkp+G+ni Vt+eNk+eYv+
   Q: 3117 ECYFTRSFYKHILGKSVRYTDMESEDYPFFQGLVYLLEN---DVSTLGYELTFSTEVQEFGVCEVRDLKPNGANILVTEENKKEYVH 3200
           *************************************99...********************************************* PP
   S: 176  lvveyrlkegikeqveafreGfneviplellslFteeelellicGeeeidvedlkketkykggytedspaiqwFwevleefsseerk 262
           lv++++++  i++q++af eGf+e+ip++l+s+Fte+elelli+G ++id++dlk++t+y++ y+++s +iqwFw++l++f++ +r+
   Q: 3201 LVCQMKMTGAIRKQLAAFLEGFYEIIPKRLISIFTEQELELLISGLPTIDIDDLKANTEYHK-YQSSSIQIQWFWRALRSFDQADRA 3286
           ************************************************************66.************************ PP
   S: 263  afLqFvTgssrlPlgGfaelk....prlfvirk.dasddrlPssnTCfnyLkLPeYsskeilkekLlyAieet.kgFel 335
           +fLqFvTg+s++Pl+Gf +l+     ++f+i++ d+s+drlPs++TCfn+L+LP Y+s+e+l+++Ll+Ai+e+ +gF+l
   Q: 3287 KFLQFVTGTSKVPLQGFSALEgmngIQKFQIHRdDRSTDRLPSAHTCFNQLDLPAYESYEKLRHMLLLAIQECsEGFGL 3365
           *********************99998999999988899***************************************97 PP

UBD/Alpha-Helix/UBA

   S: 3    dedkleqlveMGFdreealqaLraannnleaAveyLldg 41
           ++++l ql++MGF+re+al+aL++   + e A+eyLl++
   Q: 362  NQSQLTQLMDMGFSREHALEALLN-TSTMEQATEYLLTH 399
           799*********************.7***********98 PP

Organism

Tetraodon nigroviridis

Protein Sequence
(Fasta)

SLPPGCEFGQ ADMQKLVPKE EKPSSSTPAP AGFGAKRTAT GLLEGMGLDG DSLAPMETDE 60
PSATDPKTKS KLSPAMATRI KQIKPLLSAS SRLGRALAEL FGLLVKLCVG SPVRQRRSHH 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

AGTTTGCCTC CAGGCTGTGA GTTTGGCCAG GCAGACATGC AGAAACTAGT GCCCAAGGAA 60
GAGAAGCCAT CAAGCAGTAC TCCTGCACCT GCAGGCTTTG GTGCAAAGAG AACTGGTAAT 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0175--Coiled coil
KW-0181--Complete proteome
KW-1185--Reference proteome
KW-0808--Transferase
KW-0833--Ubl conjugation pathway

Interpro

IPR025527--DUF4414
IPR000569--HECT_dom
IPR015940--UBA
IPR009060--UBA-like
IPR004170--WWE-dom
IPR018123--WWE-dom_subgr

PROSITE

PS50237--HECT
PS50030--UBA
PS50918--WWE

Pfam

PF14377--DUF4414
PF00632--HECT
PF00627--UBA
PF02825--WWE

SMART

SM00119--HECTc
SM00165--UBA
SM00678--WWE

Gene Ontology

GO:0004842--F:ubiquitin-protein transferase activity
GO:0008270--F:zinc ion binding

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Ata-000627	Aegilops tauschii	46.24	7.00e-103	370.00
IUUC-Aml-001684	Ailuropoda melanoleuca	77.50	0.00e+00	1958.00
IUUC-Atr-003044	Amborella trichopoda	52.22	7.00e-123	436.00
IUUC-Apl-003729	Anas platyrhynchos	90.12	0.00e+00	653.00
IUUC-Aca-005263	Anolis carolinensis	78.43	0.00e+00	1955.00
IUUC-Aly-006083	Arabidopsis lyrata	55.10	4.00e-123	437.00
IUUC-Ath-007472	Arabidopsis thaliana	51.11	3.00e-123	438.00
IUUC-Ago-008005	Ashbya gossypii	47.60	5.00e-128	454.00
IUUC-Acl-008254	Aspergillus clavatus	45.42	6.00e-128	453.00
IUUC-Afl-008712	Aspergillus flavus	45.23	4.00e-129	456.00
IUUC-Afu-009022	Aspergillus fumigatus	45.04	2.00e-127	452.00
IUUC-Ani-009412	Aspergillus nidulans	45.99	2.00e-129	459.00
IUUC-Ang-009771	Aspergillus niger	45.04	9.00e-129	456.00
IUUC-Aor-010186	Aspergillus oryzae	44.42	2.00e-119	423.00
IUUC-Ate-010253	Aspergillus terreus	45.32	2.00e-128	456.00
IUUC-Ame-011067	Astyanax mexicanus	78.44	0.00e+00	2495.00
IUUC-Bgr-012043	Blumeria graminis	46.27	5.00e-134	474.00
IUUC-Bta-012813	Bos taurus	77.70	0.00e+00	1986.00
IUUC-Bci-013995	Botrytis cinerea	45.32	4.00e-132	468.00
IUUC-Bdi-014884	Brachypodium distachyon	51.52	4.00e-124	441.00
IUUC-Bol-016533	Brassica oleracea	58.33	2.00e-89	321.00
IUUC-Bra-016637	Brassica rapa	43.62	5.00e-120	427.00
IUUC-Cel-018179	Caenorhabditis elegans	59.38	9.00e-179	622.00
IUUC-Cja-018741	Callithrix jacchus	77.84	0.00e+00	1971.00
IUUC-Cfa-020083	Canis familiaris	77.50	0.00e+00	1968.00
IUUC-Cpo-021923	Cavia porcellus	77.70	0.00e+00	1951.00
IUUC-Cre-022900	Chlamydomonas reinhardtii	47.80	2.00e-114	405.00
IUUC-Csa-023853	Chlorocebus sabaeus	77.36	0.00e+00	1968.00
IUUC-Cho-024718	Choloepus hoffmanni	97.33	0.00e+00	800.00
IUUC-Cin-025627	Ciona intestinalis	34.36	0.00e+00	847.00
IUUC-Csv-025872	Ciona savignyi	72.22	0.00e+00	683.00
IUUC-Cgl-026647	Colletotrichum gloeosporioides	50.89	3.00e-131	464.00
IUUC-Cme-027267	Cyanidioschyzon merolae	51.55	4.00e-113	403.00
IUUC-Dre-028525	Danio rerio	85.73	0.00e+00	2102.00
IUUC-Dno-029680	Dasypus novemcinctus	77.35	0.00e+00	1922.00
IUUC-Dor-030902	Dipodomys ordii	76.22	0.00e+00	1001.00
IUUC-Dse-031197	Dothistroma septosporum	46.50	1.00e-132	469.00
IUUC-Dme-032122	Drosophila melanogaster	66.43	0.00e+00	753.00
IUUC-Ete-032690	Echinops telfairi	78.11	0.00e+00	1088.00
IUUC-Eca-033915	Equus caballus	76.97	0.00e+00	1959.00
IUUC-Eeu-034963	Erinaceus europaeus	87.73	0.00e+00	1336.00
IUUC-Fca-035824	Felis catus	77.63	0.00e+00	1972.00
IUUC-Fox-037756	Fusarium oxysporum	45.90	5.00e-132	467.00
IUUC-Fso-038464	Fusarium solani	46.95	1.00e-132	469.00
IUUC-Gmo-039073	Gadus morhua	86.58	0.00e+00	3316.00
IUUC-Ggr-039946	Gaeumannomyces graminis	45.04	1.00e-129	459.00
IUUC-Gga-040309	Gallus gallus	96.75	0.00e+00	645.00
IUUC-Gac-042430	Gasterosteus aculeatus	87.72	0.00e+00	4887.00
IUUC-Gma-044247	Glycine max	51.76	9.00e-124	439.00
IUUC-Ggo-044785	Gorilla gorilla	77.33	0.00e+00	1942.00
IUUC-Hsa-046879	Homo sapiens	77.40	0.00e+00	1943.00
IUUC-Hvu-047697	Hordeum vulgare	51.52	4.00e-124	441.00
IUUC-Itr-048430	Ictidomys tridecemlineatus	88.10	0.00e+00	1321.00
IUUC-Kpa-049228	Komagataella pastoris	47.89	1.00e-134	475.00
IUUC-Lch-050252	Latimeria chalumnae	72.45	0.00e+00	2237.00
IUUC-Lpe-051550	Leersia perrieri	50.69	3.00e-124	441.00
IUUC-Loc-052472	Lepisosteus oculatus	81.52	0.00e+00	2040.00
IUUC-Lma-053159	Leptosphaeria maculans	45.04	2.00e-129	459.00
IUUC-Laf-054154	Loxodonta africana	76.83	0.00e+00	1930.00
IUUC-Mcc-055085	Macaca mulatta	77.43	0.00e+00	1972.00
IUUC-Meu-056727	Macropus eugenii	77.86	0.00e+00	1554.00
IUUC-Mor-057201	Magnaporthe oryzae	46.20	2.00e-131	465.00
IUUC-Mpo-057597	Magnaporthe poae	45.16	2.00e-128	455.00
IUUC-Mtr-058088	Medicago truncatula	52.46	5.00e-124	441.00
IUUC-Mla-058888	Melampsora laricipopulina	49.75	1.00e-115	409.00
IUUC-Mvi-060320	Microbotryum violaceum	48.11	9.00e-117	416.00
IUUC-Mmr-060820	Microcebus murinus	77.16	0.00e+00	1946.00
IUUC-Mdo-062930	Monodelphis domestica	77.88	0.00e+00	1961.00
IUUC-Mmu-063601	Mus musculus	77.57	0.00e+00	1932.00
IUUC-Mac-065557	Musa acuminata	54.08	4.00e-116	414.00
IUUC-Mpu-066653	Mustela putorius furo	77.45	0.00e+00	1962.00
IUUC-Mlu-067418	Myotis lucifugus	77.87	0.00e+00	2013.00
IUUC-Nfi-068278	Neosartorya fischeri	45.23	4.00e-128	454.00
IUUC-Ncr-068813	Neurospora crassa	46.18	2.00e-132	468.00
IUUC-Nle-069418	Nomascus leucogenys	77.20	0.00e+00	1925.00
IUUC-Opr-070187	Ochotona princeps	80.07	0.00e+00	843.00
IUUC-Ont-071300	Oreochromis niloticus	90.05	0.00e+00	2303.00
IUUC-Oan-073046	Ornithorhynchus anatinus	72.77	0.00e+00	2919.00
IUUC-Ocu-074178	Oryctolagus cuniculus	70.68	0.00e+00	2192.00
IUUC-Oba-075757	Oryza barthii	50.69	1.00e-124	442.00
IUUC-Obr-076553	Oryza brachyantha	51.15	2.00e-124	442.00
IUUC-Ogl-077520	Oryza glaberrima	50.69	2.00e-124	442.00
IUUC-Ogu-078278	Oryza glumaepatula	50.69	1.00e-124	442.00
IUUC-Oin-079767	Oryza indica	50.69	2.00e-124	442.00
IUUC-Olo-080380	Oryza longistaminata	50.23	8.00e-123	436.00
IUUC-Ome-081925	Oryza meridionalis	50.23	6.00e-123	437.00
IUUC-Oni-082619	Oryza nivara	50.69	1.00e-124	442.00
IUUC-Opu-083684	Oryza punctata	50.23	6.00e-123	437.00
IUUC-Oru-084501	Oryza rufipogon	50.69	1.00e-124	442.00
IUUC-Osa-086251	Oryza sativa	50.69	6.00e-123	434.00
IUUC-Ola-087437	Oryzias latipes	89.06	0.00e+00	1195.00
IUUC-Olu-087813	Ostreococcus lucimarinus	50.25	1.00e-112	399.00
IUUC-Oga-088903	Otolemur garnettii	77.09	0.00e+00	1938.00
IUUC-Oar-090210	Ovis aries	77.36	0.00e+00	1962.00
IUUC-Ptr-090502	Pan troglodytes	77.40	0.00e+00	1942.00
IUUC-Pan-092368	Papio anubis	77.50	0.00e+00	1971.00
IUUC-Pma-094246	Petromyzon marinus	69.57	0.00e+00	901.00
IUUC-Pno-094871	Phaeosphaeria nodorum	49.55	9.00e-128	453.00
IUUC-Ppa-095657	Physcomitrella patens	50.90	8.00e-123	436.00
IUUC-Pfo-096232	Poecilia formosa	84.17	0.00e+00	2755.00
IUUC-Pab-098583	Pongo abelii	77.43	0.00e+00	1942.00
IUUC-Pop-099613	Populus trichocarpa	52.56	2.00e-125	444.00
IUUC-Pca-100310	Procavia capensis	66.50	0.00e+00	747.00
IUUC-Ppe-102109	Prunus persica	52.22	4.00e-124	441.00
IUUC-Pva-102116	Pteropus vampyrus	77.43	0.00e+00	2000.00
IUUC-Pgr-103465	Puccinia graminis	42.99	7.00e-123	437.00
IUUC-Ptt-103813	Puccinia triticina	40.88	2.00e-110	395.00
IUUC-Pte-104018	Pyrenophora teres	49.66	2.00e-126	448.00
IUUC-Pyt-104713	Pyrenophora triticirepentis	49.66	4.00e-126	447.00
IUUC-Rno-105889	Rattus norvegicus	68.27	0.00e+00	1611.00
IUUC-Sce-106449	Saccharomyces cerevisiae	44.91	5.00e-122	434.00
IUUC-Sha-106961	Sarcophilus harrisii	76.17	0.00e+00	1891.00
IUUC-Sja-107814	Schizosaccharomyces japonicus	45.40	2.00e-124	441.00
IUUC-Spo-108024	Schizosaccharomyces pombe	45.68	6.00e-125	443.00
IUUC-Smo-109640	Selaginella moellendorffii	49.89	5.00e-126	447.00
IUUC-Sit-110598	Setaria italica	51.99	9.00e-125	443.00
IUUC-Sly-111285	Solanum lycopersicum	51.00	1.00e-124	442.00
IUUC-Stu-112582	Solanum tuberosum	32.68	4.00e-56	213.00
IUUC-Sar-113291	Sorex araneus	75.92	0.00e+00	1925.00
IUUC-Sbi-114042	Sorghum bicolor	51.52	6.00e-124	440.00
IUUC-Sre-114958	Sporisorium reilianum	56.82	9.00e-132	463.00
IUUC-Ssc-115754	Sus scrofa	77.50	0.00e+00	1960.00
IUUC-Tru-118570	Takifugu rubripes	94.54	0.00e+00	2941.00
IUUC-Tsy-119159	Tarsius syrichta	76.65	0.00e+00	1542.00
IUUC-Tca-121479	Theobroma cacao	50.82	1.00e-121	432.00
IUUC-Tre-121909	Trichoderma reesei	52.71	2.00e-129	459.00
IUUC-Tvi-122370	Trichoderma virens	52.47	3.00e-129	457.00
IUUC-Tae-125214	Triticum aestivum	52.16	4.00e-123	436.00
IUUC-Tme-127172	Tuber melanosporum	46.08	8.00e-133	469.00
IUUC-Tbe-127506	Tupaia belangeri	72.89	0.00e+00	1119.00
IUUC-Ttr-129253	Tursiops truncatus	75.51	0.00e+00	1541.00
IUUC-Uma-129355	Ustilago maydis	47.64	7.00e-132	464.00
IUUC-Vda-129886	Verticillium dahliae	46.68	2.00e-134	474.00
IUUC-Vpa-130708	Vicugna pacos	75.78	0.00e+00	1587.00
IUUC-Vvi-131170	Vitis vinifera	50.56	5.00e-124	439.00
IUUC-Xtr-132123	Xenopus tropicalis	70.96	0.00e+00	3995.00
IUUC-Xma-133869	Xiphophorus maculatus	82.83	0.00e+00	2788.00
IUUC-Yli-134657	Yarrowia lipolytica	44.91	1.00e-124	442.00
IUUC-Zma-135570	Zea mays	51.52	6.00e-124	440.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence