iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

UUCD2 ID

IUUC-Xtr-132123

UUCD1 version

Ensembl Protein ID

UniProt Accession

Genbank Protein ID

Protein Name

Uncharacterized protein

Genbank Nucleotide ID

AAMC01094763

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSXETG00000030011.1	ENSXETT00000061581.1	ENSXETP00000060650.1

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 activity/HECT	7.40e-120	400.5	4033	4359
UBD/Alpha-Helix/UBA	5.20e-09	36.1	1320	1357

Active Site

Position(s)	Description	Evidence
4327	Glycyl thioester intermediate	{ECO:0000256\|PROSITE-ProRule:PRU00104}

Domain Profile

E3 activity/HECT

   S: 10   evefvgEegldlgGvtreflallskelqnpdlglflysendketlqpnpdsglknpehlklFeflGrllgkalqdgrlldlplsksf 96
           ++ f+gEeg+d+gG+ re++  +s+e++np++ lf++s++d+ t+++np+s + np+hl++F+f+Gr+++ka++d+rll++ +++sf
   Q: 4033 YIVFEGEEGQDAGGLLREWYMIISREMFNPMYALFRTSPGDRVTYTINPSSHC-NPNHLSYFKFVGRIVAKAVYDNRLLECYFTRSF 4118
           599************************************************86.99******************************* PP
   S: 97   yklllgkklsledleevdpelykslkeikenaesdieelgldltfsvseeilgetkeeeLkpgGenipVtneNkeeYvklvveyrlk 183
           yk++lgk++ + d+e+ d ++y+ l +++en   d+++lg dltfs++ +++g +++++Lkp+G+ni Vt+eNk+eYv+lv++++++
   Q: 4119 YKHILGKSVRYTDMESEDYHFYQGLVYLLEN---DVSTLGYDLTFSTEVQEFGVCEVRDLKPNGANILVTEENKKEYVHLVCQMKMT 4202
           *****************************99...***************************************************** PP
   S: 184  egikeqveafreGfneviplellslFteeelellicGeeeidvedlkketkykggytedspaiqwFwevleefsseerkafLqFvTg 270
             i++q++af eGf+e+ip++l+s+Fte+elelli+G ++id++dlk++t+y++ y+++s +iqwFw++l++f++ +r++fLqFvTg
   Q: 4203 GAIRKQLAAFLEGFYEIIPKRLISIFTEQELELLISGLPTIDIDDLKSNTEYHK-YQSNSIQIQWFWRALRSFDQADRAKFLQFVTG 4288
           ****************************************************66.******************************** PP
   S: 271  ssrlPlgGfaelk....prlfvirk.dasddrlPssnTCfnyLkLPeYsskeilkekLlyAieet.kgFel 335
           +s++Pl+Gfa+l+     ++f+i++ d+s+drlPs++TCfn+L+LP Y+s+e+l+++Ll+Ai+e+ +gF+l
   Q: 4289 TSKVPLQGFAALEgmngIQKFQIHRdDRSTDRLPSAHTCFNQLDLPAYESYEKLRHMLLLAIQECsEGFGL 4359
           *************99998999999988899***************************************97 PP

UBD/Alpha-Helix/UBA

   S: 3    dedkleqlveMGFdreealqaLraannnleaAveyLldg 41
           ++++l+ql++MGF+re+al+aL++   + e A+eyLl++
   Q: 1320 NQQQLQQLMDMGFTREHALEALLN-TSTMEQATEYLLTH 1357
           89**********************.7***********98 PP

Organism

Xenopus tropicalis

Protein Sequence
(Fasta)

MKVDRTKLKK TPTEAPADCR SLIDKLKVCS DEQLLLELQQ IKTWNIGKCE LYHWVDLLDR 60
FDGILADAGQ TVENMSWMLV CDRPEREQLK ALLLAVLNFT ALLIEYSFSR HLYSSIEHLT 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

AGTTACTAAG ACTCCAGCTA CCAAGTTTCA TCTTGTGAAT TGGGAGGCTA ACCTGGTATA 60
ATCTGAACTA CACTTGAGTC CTTTAGACTG TGTCTTTCAA TGCAGTTTTC CTCACCCCCG 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0175--Coiled coil
KW-0181--Complete proteome
KW-1185--Reference proteome
KW-0808--Transferase
KW-0833--Ubl conjugation pathway

Interpro

IPR011989--ARM-like
IPR016024--ARM-type_fold
IPR025527--DUF4414
IPR010309--E3_Ub_ligase_DUF908
IPR010314--E3_Ub_ligase_DUF913
IPR000569--HECT_dom
IPR015940--UBA
IPR009060--UBA-like
IPR004170--WWE-dom
IPR018123--WWE-dom_subgr

PROSITE

PS50237--HECT
PS50030--UBA
PS50918--WWE

Pfam

PF14377--DUF4414
PF06012--DUF908
PF06025--DUF913
PF00632--HECT
PF00627--UBA
PF02825--WWE

SMART

SM00119--HECTc
SM00165--UBA
SM00678--WWE

Gene Ontology

GO:0004842--F:ubiquitin-protein transferase activity
GO:0008270--F:zinc ion binding

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Ata-000627	Aegilops tauschii	38.10	5.00e-94	341.00
IUUC-Aml-001684	Ailuropoda melanoleuca	89.62	0.00e+00	3983.00
IUUC-Atr-003044	Amborella trichopoda	49.88	2.00e-112	402.00
IUUC-Apl-003729	Anas platyrhynchos	86.78	1.00e-178	618.00
IUUC-Aca-005263	Anolis carolinensis	88.79	0.00e+00	2984.00
IUUC-Aly-006083	Arabidopsis lyrata	49.46	2.00e-113	405.00
IUUC-Ath-007472	Arabidopsis thaliana	49.46	1.00e-113	406.00
IUUC-Ago-008005	Ashbya gossypii	44.28	1.00e-121	432.00
IUUC-Acl-008254	Aspergillus clavatus	45.15	3.00e-127	451.00
IUUC-Afl-008712	Aspergillus flavus	44.59	6.00e-129	455.00
IUUC-Afu-009022	Aspergillus fumigatus	45.10	2.00e-127	451.00
IUUC-Ani-009412	Aspergillus nidulans	45.34	4.00e-128	454.00
IUUC-Ang-009771	Aspergillus niger	45.66	3.00e-128	454.00
IUUC-Aor-010186	Aspergillus oryzae	43.76	6.00e-119	422.00
IUUC-Ate-010253	Aspergillus terreus	44.88	3.00e-128	455.00
IUUC-Ame-011067	Astyanax mexicanus	79.17	0.00e+00	3524.00
IUUC-Bgr-012043	Blumeria graminis	45.67	2.00e-130	462.00
IUUC-Bta-012813	Bos taurus	89.57	0.00e+00	4003.00
IUUC-Bci-013995	Botrytis cinerea	45.05	1.00e-128	456.00
IUUC-Bdi-014884	Brachypodium distachyon	49.19	2.00e-114	409.00
IUUC-Bol-016533	Brassica oleracea	57.97	8.00e-89	319.00
IUUC-Bra-016637	Brassica rapa	48.57	2.00e-111	398.00
IUUC-Cel-018179	Caenorhabditis elegans	58.48	1.00e-171	598.00
IUUC-Cja-018741	Callithrix jacchus	89.74	0.00e+00	3992.00
IUUC-Cfa-020083	Canis familiaris	87.94	0.00e+00	3964.00
IUUC-Cpo-021923	Cavia porcellus	89.51	0.00e+00	4336.00
IUUC-Cre-022900	Chlamydomonas reinhardtii	46.12	5.00e-107	380.00
IUUC-Csa-023853	Chlorocebus sabaeus	89.78	0.00e+00	3995.00
IUUC-Cho-024718	Choloepus hoffmanni	99.39	0.00e+00	710.00
IUUC-Cin-025627	Ciona intestinalis	41.53	0.00e+00	1873.00
IUUC-Csv-025824	Ciona savignyi	46.86	0.00e+00	1389.00
IUUC-Cgl-026647	Colletotrichum gloeosporioides	44.07	4.00e-128	454.00
IUUC-Cne-027095	Cryptococcus neoformans	38.75	9.00e-94	340.00
IUUC-Cme-027267	Cyanidioschyzon merolae	48.21	5.00e-105	376.00
IUUC-Dre-028525	Danio rerio	80.36	0.00e+00	3502.00
IUUC-Dno-029680	Dasypus novemcinctus	88.42	0.00e+00	3925.00
IUUC-Dor-030902	Dipodomys ordii	87.08	0.00e+00	1083.00
IUUC-Dse-031197	Dothistroma septosporum	45.28	5.00e-130	460.00
IUUC-Dme-032122	Drosophila melanogaster	64.74	0.00e+00	725.00
IUUC-Ete-032690	Echinops telfairi	79.59	0.00e+00	1112.00
IUUC-Eca-033915	Equus caballus	89.22	0.00e+00	3950.00
IUUC-Eeu-034963	Erinaceus europaeus	87.33	0.00e+00	2723.00
IUUC-Fca-035824	Felis catus	89.74	0.00e+00	3993.00
IUUC-Fox-037756	Fusarium oxysporum	44.60	2.00e-129	458.00
IUUC-Fso-038464	Fusarium solani	52.87	6.00e-129	457.00
IUUC-Gmo-039073	Gadus morhua	80.87	0.00e+00	3529.00
IUUC-Ggr-039946	Gaeumannomyces graminis	43.03	6.00e-125	444.00
IUUC-Gga-040309	Gallus gallus	98.38	0.00e+00	653.00
IUUC-Gac-042430	Gasterosteus aculeatus	81.23	0.00e+00	3622.00
IUUC-Gma-044247	Glycine max	50.35	1.00e-113	405.00
IUUC-Ggo-044785	Gorilla gorilla	89.49	0.00e+00	3957.00
IUUC-Hsa-046879	Homo sapiens	89.53	0.00e+00	3959.00
IUUC-Hvu-047697	Hordeum vulgare	42.11	6.00e-116	414.00
IUUC-Itr-048430	Ictidomys tridecemlineatus	88.68	0.00e+00	1332.00
IUUC-Kpa-049228	Komagataella pastoris	41.94	2.00e-129	458.00
IUUC-Lch-050252	Latimeria chalumnae	87.24	0.00e+00	3284.00
IUUC-Lpe-051550	Leersia perrieri	49.42	2.00e-114	408.00
IUUC-Loc-052472	Lepisosteus oculatus	81.60	0.00e+00	3634.00
IUUC-Lma-053159	Leptosphaeria maculans	42.63	9.00e-126	446.00
IUUC-Laf-054154	Loxodonta africana	88.83	0.00e+00	3963.00
IUUC-Mcc-055085	Macaca mulatta	88.17	0.00e+00	3940.00
IUUC-Meu-056727	Macropus eugenii	90.52	0.00e+00	1814.00
IUUC-Mor-057201	Magnaporthe oryzae	43.56	7.00e-126	447.00
IUUC-Mpo-057597	Magnaporthe poae	43.73	6.00e-124	440.00
IUUC-Mtr-058088	Medicago truncatula	50.81	6.00e-114	407.00
IUUC-Mla-058888	Melampsora laricipopulina	46.53	5.00e-105	374.00
IUUC-Mvi-060320	Microbotryum violaceum	41.49	4.00e-112	401.00
IUUC-Mmr-060820	Microcebus murinus	87.49	0.00e+00	3934.00
IUUC-Mdo-062930	Monodelphis domestica	87.76	0.00e+00	3930.00
IUUC-Mmu-063601	Mus musculus	89.33	0.00e+00	3896.00
IUUC-Mac-065557	Musa acuminata	49.31	5.00e-106	380.00
IUUC-Mpu-066653	Mustela putorius furo	87.56	0.00e+00	3853.00
IUUC-Mlu-067418	Myotis lucifugus	89.46	0.00e+00	4047.00
IUUC-Nfi-068278	Neosartorya fischeri	45.29	8.00e-128	453.00
IUUC-Ncr-068813	Neurospora crassa	45.16	1.00e-127	452.00
IUUC-Nle-069418	Nomascus leucogenys	89.28	0.00e+00	3931.00
IUUC-Opr-070187	Ochotona princeps	75.56	0.00e+00	763.00
IUUC-Ont-071300	Oreochromis niloticus	81.62	0.00e+00	3567.00
IUUC-Oan-073046	Ornithorhynchus anatinus	82.94	0.00e+00	4949.00
IUUC-Ocu-074178	Oryctolagus cuniculus	84.43	0.00e+00	6489.00
IUUC-Oba-075757	Oryza barthii	48.96	2.00e-114	409.00
IUUC-Obr-076553	Oryza brachyantha	42.40	4.00e-114	407.00
IUUC-Ogl-077520	Oryza glaberrima	49.18	3.00e-114	408.00
IUUC-Ogu-078278	Oryza glumaepatula	49.18	3.00e-114	408.00
IUUC-Oin-079767	Oryza indica	49.18	3.00e-114	408.00
IUUC-Olo-080380	Oryza longistaminata	48.73	1.00e-112	402.00
IUUC-Ome-081925	Oryza meridionalis	48.73	1.00e-112	402.00
IUUC-Oni-082619	Oryza nivara	49.18	3.00e-114	407.00
IUUC-Opu-083428	Oryza punctata	50.12	4.00e-110	394.00
IUUC-Oru-084501	Oryza rufipogon	49.18	2.00e-114	409.00
IUUC-Osa-086251	Oryza sativa	49.18	6.00e-113	401.00
IUUC-Ola-087437	Oryzias latipes	81.78	0.00e+00	2026.00
IUUC-Olu-087813	Ostreococcus lucimarinus	47.65	2.00e-98	352.00
IUUC-Oga-088903	Otolemur garnettii	89.16	0.00e+00	3964.00
IUUC-Oar-090210	Ovis aries	88.04	0.00e+00	3959.00
IUUC-Ptr-090502	Pan troglodytes	87.92	0.00e+00	2982.00
IUUC-Pan-092368	Papio anubis	88.17	0.00e+00	3011.00
IUUC-Pma-094246	Petromyzon marinus	73.97	0.00e+00	1258.00
IUUC-Pno-094871	Phaeosphaeria nodorum	49.89	5.00e-124	441.00
IUUC-Ppa-095657	Physcomitrella patens	47.79	2.00e-111	399.00
IUUC-Pfo-096232	Poecilia formosa	78.80	0.00e+00	3543.00
IUUC-Pab-098583	Pongo abelii	89.57	0.00e+00	3966.00
IUUC-Pop-099613	Populus trichocarpa	51.04	7.00e-116	413.00
IUUC-Pca-100310	Procavia capensis	78.04	0.00e+00	1530.00
IUUC-Ppe-102109	Prunus persica	49.88	8.00e-114	407.00
IUUC-Pva-102116	Pteropus vampyrus	89.45	0.00e+00	4013.00
IUUC-Pgr-103465	Puccinia graminis	41.65	4.00e-116	414.00
IUUC-Ptt-103813	Puccinia triticina	39.59	1.00e-103	372.00
IUUC-Pte-104018	Pyrenophora teres	49.66	1.00e-122	436.00
IUUC-Pyt-104713	Pyrenophora triticirepentis	49.66	1.00e-123	439.00
IUUC-Rno-105889	Rattus norvegicus	82.41	0.00e+00	3514.00
IUUC-Sce-106449	Saccharomyces cerevisiae	42.99	1.00e-118	422.00
IUUC-Sha-106961	Sarcophilus harrisii	86.67	0.00e+00	3893.00
IUUC-Sja-107814	Schizosaccharomyces japonicus	43.75	4.00e-118	421.00
IUUC-Spo-108024	Schizosaccharomyces pombe	43.94	1.00e-118	422.00
IUUC-Smo-109428	Selaginella moellendorffii	47.71	6.00e-117	417.00
IUUC-Sit-110598	Setaria italica	42.91	2.00e-115	411.00
IUUC-Sly-111285	Solanum lycopersicum	49.45	2.00e-115	412.00
IUUC-Sar-113291	Sorex araneus	84.34	0.00e+00	2452.00
IUUC-Sbi-114042	Sorghum bicolor	42.86	2.00e-115	412.00
IUUC-Sre-114958	Sporisorium reilianum	45.47	1.00e-129	456.00
IUUC-Ssc-115754	Sus scrofa	89.49	0.00e+00	3979.00
IUUC-Tru-118570	Takifugu rubripes	80.98	0.00e+00	3624.00
IUUC-Tsy-119159	Tarsius syrichta	91.44	0.00e+00	1795.00
IUUC-Tni-120836	Tetraodon nigroviridis	75.89	0.00e+00	1939.00
IUUC-Tca-121479	Theobroma cacao	48.84	4.00e-112	401.00
IUUC-Tre-121909	Trichoderma reesei	51.38	3.00e-124	441.00
IUUC-Tvi-122370	Trichoderma virens	51.15	5.00e-124	441.00
IUUC-Tae-125214	Triticum aestivum	41.12	9.00e-114	405.00
IUUC-Tme-127172	Tuber melanosporum	44.56	1.00e-131	466.00
IUUC-Tbe-127506	Tupaia belangeri	85.33	0.00e+00	1301.00
IUUC-Ttr-129253	Tursiops truncatus	81.34	0.00e+00	1919.00
IUUC-Uma-129355	Ustilago maydis	45.13	2.00e-129	455.00
IUUC-Vda-129886	Verticillium dahliae	45.73	5.00e-130	460.00
IUUC-Vpa-130708	Vicugna pacos	88.25	0.00e+00	3497.00
IUUC-Vvi-131170	Vitis vinifera	48.79	2.00e-114	407.00
IUUC-Xma-133869	Xiphophorus maculatus	83.82	0.00e+00	2141.00
IUUC-Yli-134657	Yarrowia lipolytica	43.63	5.00e-121	430.00
IUUC-Zma-135570	Zea mays	41.94	3.00e-117	418.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence