iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

iUUCD ID

IUUC-Aor-010053

Ensembl Protein ID

BAE61024

UniProt Accession

Q2UBP1; RSP5_ASPOR

Genbank Protein ID

BAE61024.1

Protein Name

Probable E3 ubiquitin-protein ligase hulA; HECT ubiquitin ligase A; HECT-type E3 ubiquitin transferase hulA

Genbank Nucleotide ID

AP007161

Gene Name

hulA; AO090012000923

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
AO090012000923	BAE61024	BAE61024

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 activity/HECT	4.60e-110	367.4	1	298

Active Site

Position(s)	Description	Evidence
784	Glycyl thioester intermediate	{ECO:0000255\|PROSITE-ProRule:PRU00104}

Domain Profile

E3 activity/HECT

   S: 36   lqnpdlglflysendketlqpnpdsglknpehlklFeflGrllgkalqdgrlldlplsksfyklllgkklsledleevdpelykslkeikenaesdieelg 136
           ++np ++lf+ys+ d++tlq+np+sg+ npehl++F+f+Gr++g+a++++r+ld ++  +fyk++l+kk+sl+d+e vd++l+++l++ ++n   die + 
   Q: 1    MFNPFYCLFEYSAHDNYTLQINPHSGV-NPEHLNYFKFIGRVVGLAIFHRRFLDSFFIGAFYKMMLRKKVSLQDMEGVDEDLHRNLTWTLDN---DIEGI- 96
           79************************9.89************************************************************99...9***9. PP
   S: 137  ldltfsvseeilgetkeeeLkpgGenipVtneNkeeYvklvveyrlkegikeqveafreGfneviplellslFteeelellicGeeeidvedlkketkykg 237
           ++ltf v++e++ge+++ +LkpgG++ipVtneNk eYv+lv+e+++ ++++eq++af +Gfne+ip +l+++F+e+elelli G ++idv+d+kk+t y+g
   Q: 97   IELTFAVDDEKFGERRTIDLKPGGRDIPVTNENKGEYVELVTEWKIVKRVEEQFNAFMSGFNELIPADLVNVFDERELELLIGGIADIDVDDWKKHTDYRG 197
           ***************************************************************************************************76 PP
   S: 238  gytedspaiqwFwevleefsseerkafLqFvTgssrlPlgGfaelk....prlfvirkdasddrlPssnTCfnyLkLPeYsskeilkekLlyAieetkgFe 334
            y+e++++iq+Fw++++ +++e+++++LqF+Tg+sr+P++Gf++l+    pr+f+i+k++++  lP+s+TCfn+L+LP+Y++ ++l++kL +A+eet gF+
   Q: 198  -YQESDEVIQNFWKIVRTWDAEQKSRLLQFTTGTSRIPVNGFKDLQgsdgPRRFTIEKSGDPGALPKSHTCFNRLDLPPYKTNDVLEHKLSIAVEETLGFG 297
           .***************************************************************************************************8 PP
   S: 335  l 335
           +
   Q: 298  Q 298
           6 PP

Organism

Aspergillus oryzae

Functional Description
(View)

E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. Probably involved in the regulatory network controlling carbon source utilization.

Protein Sequence
(Fasta)

MFNPFYCLFE YSAHDNYTLQ INPHSGVNPE HLNYFKFIGR VVGLAIFHRR FLDSFFIGAF 60
YKMMLRKKVS LQDMEGVDED LHRNLTWTLD NDIEGIIELT FAVDDEKFGE RRTIDLKPGG 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

ATGTTTAACC CCTTCTATTG TCTTTTCGAA TACTCCGCAC ATGATAATTA TACCCTGCAA 60
ATTAATCCTC ATTCGGGCGT TAATCCGGAG CATCTGAACT ACTTCAAGTT CATTGGACGT 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-1185--Reference proteome
KW-0677--Repeat
KW-0808--Transferase
KW-0833--Ubl conjugation pathway

Interpro

IPR000008--C2_dom
IPR024928--E3_ub_ligase_SMURF1
IPR000569--HECT_dom
IPR001202--WW_dom

PROSITE

PS50004--C2
PS50237--HECT
PS01159--WW_DOMAIN_1
PS50020--WW_DOMAIN_2

Pfam

PF00168--C2
PF00632--HECT
PF00397--WW

SMART

SM00239--C2
SM00119--HECTc
SM00456--WW

Gene Ontology

GO:0005737--C:cytoplasm
GO:0004842--F:ubiquitin-protein transferase activity

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001314	Ailuropoda melanoleuca	58.05	1.00e-101	362.00
IUUC-Apl-003893	Anas platyrhynchos	57.38	1.00e-99	355.00
IUUC-Aca-005338	Anolis carolinensis	52.00	6.00e-94	337.00
IUUC-Ago-007742	Ashbya gossypii	76.59	5.00e-141	493.00
IUUC-Acl-008273	Aspergillus clavatus	96.99	2.00e-176	610.00
IUUC-Afl-008713	Aspergillus flavus	100.00	0.00e+00	625.00
IUUC-Afu-009103	Aspergillus fumigatus	96.32	7.00e-176	608.00
IUUC-Ani-009259	Aspergillus nidulans	96.32	5.00e-174	602.00
IUUC-Ang-009738	Aspergillus niger	97.66	1.00e-176	611.00
IUUC-Ate-010529	Aspergillus terreus	97.99	2.00e-177	613.00
IUUC-Ame-010810	Astyanax mexicanus	57.72	2.00e-100	358.00
IUUC-Bgr-012148	Blumeria graminis	76.92	1.00e-143	501.00
IUUC-Bta-012679	Bos taurus	58.05	1.00e-101	362.00
IUUC-Bci-013785	Botrytis cinerea	78.93	3.00e-146	510.00
IUUC-Cel-018299	Caenorhabditis elegans	52.33	9.00e-93	332.00
IUUC-Cja-018732	Callithrix jacchus	58.05	1.00e-101	362.00
IUUC-Cfa-021226	Canis familiaris	58.05	2.00e-101	362.00
IUUC-Cpo-021671	Cavia porcellus	58.05	1.00e-101	362.00
IUUC-Csa-023344	Chlorocebus sabaeus	58.05	2.00e-101	361.00
IUUC-Cho-024695	Choloepus hoffmanni	52.33	6.00e-94	337.00
IUUC-Cin-025157	Ciona intestinalis	56.38	1.00e-99	355.00
IUUC-Csv-026256	Ciona savignyi	50.67	2.00e-93	334.00
IUUC-Cgl-026642	Colletotrichum gloeosporioides	77.33	1.00e-140	492.00
IUUC-Cne-026849	Cryptococcus neoformans	76.25	3.00e-140	490.00
IUUC-Dre-027770	Danio rerio	57.38	4.00e-100	357.00
IUUC-Dno-029466	Dasypus novemcinctus	58.05	2.00e-101	362.00
IUUC-Dor-030138	Dipodomys ordii	57.72	1.00e-100	358.00
IUUC-Dse-031241	Dothistroma septosporum	81.94	5.00e-152	529.00
IUUC-Dme-032166	Drosophila melanogaster	55.85	9.00e-97	346.00
IUUC-Ete-033145	Echinops telfairi	57.05	5.00e-99	353.00
IUUC-Eca-033445	Equus caballus	58.05	1.00e-101	362.00
IUUC-Eeu-035247	Erinaceus europaeus	58.05	2.00e-101	362.00
IUUC-Fca-036384	Felis catus	56.04	3.00e-98	351.00
IUUC-Fal-037604	Ficedula albicollis	57.38	7.00e-100	357.00
IUUC-Fox-037774	Fusarium oxysporum	78.67	1.00e-143	501.00
IUUC-Fso-038393	Fusarium solani	78.33	6.00e-143	499.00
IUUC-Gmo-039674	Gadus morhua	57.38	3.00e-100	358.00
IUUC-Ggr-040107	Gaeumannomyces graminis	78.00	6.00e-142	496.00
IUUC-Gga-041276	Gallus gallus	57.72	4.00e-100	357.00
IUUC-Gac-042020	Gasterosteus aculeatus	57.72	3.00e-100	358.00
IUUC-Ggo-045332	Gorilla gorilla	58.05	3.00e-101	361.00
IUUC-Hsa-045968	Homo sapiens	58.05	2.00e-101	361.00
IUUC-Itr-048462	Ictidomys tridecemlineatus	58.05	2.00e-102	363.00
IUUC-Kpa-049273	Komagataella pastoris	77.93	1.00e-142	498.00
IUUC-Lch-050443	Latimeria chalumnae	57.05	5.00e-100	357.00
IUUC-Loc-052662	Lepisosteus oculatus	56.71	3.00e-97	348.00
IUUC-Laf-053850	Loxodonta africana	58.05	2.00e-101	362.00
IUUC-Mcc-055821	Macaca mulatta	58.05	2.00e-101	362.00
IUUC-Meu-056897	Macropus eugenii	55.99	2.00e-93	335.00
IUUC-Mor-057097	Magnaporthe oryzae	77.33	1.00e-141	494.00
IUUC-Mpo-057442	Magnaporthe poae	78.00	2.00e-142	498.00
IUUC-Mla-058996	Melampsora laricipopulina	74.25	9.00e-137	479.00
IUUC-Mga-059362	Meleagris gallopavo	56.71	7.00e-98	350.00
IUUC-Mvi-060395	Microbotryum violaceum	73.91	1.00e-137	482.00
IUUC-Mmr-061061	Microcebus murinus	55.70	3.00e-98	352.00
IUUC-Mdo-062173	Monodelphis domestica	58.05	3.00e-101	361.00
IUUC-Mmu-064136	Mus musculus	58.05	1.00e-101	362.00
IUUC-Mpu-066765	Mustela putorius furo	58.05	2.00e-101	362.00
IUUC-Mlu-067565	Myotis lucifugus	58.39	6.00e-102	363.00
IUUC-Nfi-068427	Neosartorya fischeri	95.99	1.00e-175	608.00
IUUC-Ncr-068918	Neurospora crassa	77.93	1.00e-142	498.00
IUUC-Nle-069070	Nomascus leucogenys	57.91	1.00e-100	359.00
IUUC-Opr-071044	Ochotona princeps	58.05	2.00e-101	362.00
IUUC-Ont-072044	Oreochromis niloticus	57.38	3.00e-100	357.00
IUUC-Oan-073019	Ornithorhynchus anatinus	56.04	2.00e-97	348.00
IUUC-Ocu-074160	Oryctolagus cuniculus	58.05	1.00e-101	362.00
IUUC-Ola-087467	Oryzias latipes	56.71	3.00e-99	354.00
IUUC-Oga-088460	Otolemur garnettii	58.05	2.00e-101	362.00
IUUC-Oar-090198	Ovis aries	58.05	1.00e-101	362.00
IUUC-Ptr-090939	Pan troglodytes	58.05	2.00e-101	361.00
IUUC-Pan-092284	Papio anubis	58.05	3.00e-101	361.00
IUUC-Psi-093645	Pelodiscus sinensis	58.39	3.00e-102	364.00
IUUC-Pma-094364	Petromyzon marinus	57.53	2.00e-99	354.00
IUUC-Pno-095118	Phaeosphaeria nodorum	84.62	5.00e-156	543.00
IUUC-Pfo-096768	Poecilia formosa	58.19	2.00e-101	361.00
IUUC-Pab-098088	Pongo abelii	58.05	2.00e-101	362.00
IUUC-Pca-100568	Procavia capensis	54.36	2.00e-92	332.00
IUUC-Pva-102354	Pteropus vampyrus	58.05	2.00e-101	361.00
IUUC-Pgr-103620	Puccinia graminis	73.91	3.00e-135	474.00
IUUC-Ptt-103806	Puccinia triticina	73.68	8.00e-102	362.00
IUUC-Pte-104016	Pyrenophora teres	83.95	5.00e-154	536.00
IUUC-Pyt-104550	Pyrenophora triticirepentis	83.95	5.00e-154	536.00
IUUC-Rno-105318	Rattus norvegicus	58.05	1.00e-101	362.00
IUUC-Sce-106289	Saccharomyces cerevisiae	75.92	2.00e-140	491.00
IUUC-Sha-107482	Sarcophilus harrisii	57.48	4.00e-100	357.00
IUUC-Sja-107941	Schizosaccharomyces japonicus	69.57	3.00e-130	457.00
IUUC-Spo-108171	Schizosaccharomyces pombe	73.58	1.00e-137	481.00
IUUC-Ssl-108514	Sclerotinia sclerotiorum	79.26	1.00e-146	511.00
IUUC-Sar-113761	Sorex araneus	51.33	1.00e-92	332.00
IUUC-Sre-114929	Sporisorium reilianum	73.58	4.00e-137	480.00
IUUC-Ssc-115950	Sus scrofa	58.05	7.00e-102	363.00
IUUC-Tgu-117130	Taeniopygia guttata	57.38	6.00e-100	357.00
IUUC-Tru-118610	Takifugu rubripes	57.72	1.00e-100	358.00
IUUC-Tsy-119492	Tarsius syrichta	58.05	4.00e-100	357.00
IUUC-Tni-120113	Tetraodon nigroviridis	57.53	2.00e-99	355.00
IUUC-Tre-122203	Trichoderma reesei	79.33	2.00e-144	504.00
IUUC-Tvi-122595	Trichoderma virens	79.33	2.00e-144	504.00
IUUC-Tme-126897	Tuber melanosporum	80.27	3.00e-144	503.00
IUUC-Tbe-127408	Tupaia belangeri	54.29	8.00e-89	320.00
IUUC-Ttr-128235	Tursiops truncatus	58.05	5.00e-101	360.00
IUUC-Uma-129332	Ustilago maydis	73.58	6.00e-130	456.00
IUUC-Vda-129753	Verticillium dahliae	76.67	4.00e-140	490.00
IUUC-Vpa-130503	Vicugna pacos	56.04	2.00e-98	352.00
IUUC-Xtr-132859	Xenopus tropicalis	57.05	2.00e-100	358.00
IUUC-Xma-133797	Xiphophorus maculatus	58.05	6.00e-102	363.00
IUUC-Yli-134668	Yarrowia lipolytica	81.27	2.00e-147	514.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence