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Basic Information Integrated Annotations
Tag Content
iUUCD ID IUUC-Hsa-046039
UUCD1 version UUC-HoS-00204
Ensembl Protein ID ENSP00000327994.2
UniProt Accession Q86XT4; Q86XT3; TRI50_HUMAN
Genbank Protein ID AAL91071.1; AAL91072.1; ENSP00000327994
Protein Name E3 ubiquitin-protein ligase TRIM50; RING-type E3 ubiquitin transferase TRIM50; Tripartite motif-containing protein 50
Genbank Nucleotide ID AY081948; AY081949; AC073841
Gene Name TRIM50; TRIM50A
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
ENSG00000146755.10 ENST00000333149.6 ENSP00000327994.2
Annotation
Cancer Mutation
TCGAICGCCOSMICCGAP
IntOGen
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEOArrayExpressTCGAICGC
COSMICTHPA
DNA & RNA Element
UTRdbmiRTarBasemicroRNATRANSFAC
TargetScanRepTarmiRcodeRAID2
Protein-protein Interaction
IIDiRefIndexPINAHINT
MenthaInWeb_IM
Disease-associated Information
OMIM
Post-translational Modifications (PTMs)
dbPAFPhosphositePlusBioGRID
DNA Methylation
TCGAICGCCOSMIC
Protein Expression/Proteomics
THPAGPMDB
Status Reviewed
Details
Family Domain References (PMIDs)
E3 activity/RING/RING RING 18398435; 24308962
Classification
Family E-value Score Start End
E3 activity/RING/U-box 2.70e-08 35.4 12 77
E3 activity/RING/RING 3.90e-07 32.1 16 57
Active Site
Position(s) Description Evidence
N/A N/A N/A
Domain Profile

   E3 activity/RING/U-box
   S: 4    eeflCpIslelMrdPvvlpsGitydrssI...ekwlasggktcPvtrqplteedlvPnltlrrliqa 67
           + + CpI le++++P +l++G++y + ++     +l+   + cPv+rq ++ ++  Pn +l r+i+a
   Q: 12   DRLQCPICLEVFKEPLMLQCGHSYCKGCLvslSCHLDAELR-CPVCRQAVDGSSSLPNVSLARVIEA 77
           5689*********************9876111567788877.**********************987 PP
   

   E3 activity/RING/RING
   S: 1    CaiCledfkdgplvlpCgHvfhadClqkwpglknssskefrCPlCr 46
           C+iCle fk+ pl l+CgH +++ Cl   + l++    e rCP+Cr
   Q: 16   CPICLEVFKE-PLMLQCGHSYCKGCL---VSLSCHLDAELRCPVCR 57
           ********99.999************...677999**********8 PP
   
Organism Homo sapiens
Functional Description
(View)

Functional Description


     E3 ubiquitin-protein ligase.
 E3 ubiquitin-protein ligase.
Protein Sequence
(Fasta)
MAWQVSLPEL EDRLQCPICL EVFKEPLMLQ CGHSYCKGCL VSLSCHLDAE LRCPVCRQAV 60
DGSSSLPNVS LARVIEALRL PGDPEPKVCV HHRNPLSLFC EKDQELICGL CGLLGSHQHH 120
It may take some time, please wait.

Protein Fasta Sequence


>IUUC-Hsa-046039|E3,RING;E3,U-box|Homo sapiens
Please wait for a moment...
Nucleotide Sequence
(Fasta)
AGAGCATGAT GGGGCACGCG CGGTAGCGCG AGGCGGGGCA TGTAACCATA GCGTGCGGGT 60
CATGATGAGG CACGGACGTG GGGGGTTAGG TGGGGCACGT AATTGGAGCT CGCGGGGCAG 120
It may take some time, please wait.

Nucleotide Fasta Sequence


>IUUC-Hsa-046039|E3,RING;E3,U-box|Homo sapiens
Please wait for a moment...
Sequence Source Ensembl
Keyword

KW-0025--Alternative splicing
KW-0175--Coiled coil
KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0479--Metal-binding
KW-0621--Polymorphism
KW-1185--Reference proteome
KW-0808--Transferase
KW-0832--Ubl conjugation
KW-0833--Ubl conjugation pathway
KW-0862--Zinc
KW-0863--Zinc-finger
Interpro

IPR001870--B30.2/SPRY
IPR003879--Butyrophylin
IPR013320--ConA-like_dom
IPR006574--PRY
IPR003877--SPRY_dom
IPR027370--Znf-RING_LisH
IPR000315--Znf_B-box
IPR001841--Znf_RING
IPR013083--Znf_RING/FYVE/PHD
IPR017907--Znf_RING_CS
PROSITE

PS50188--B302_SPRY
PS50119--ZF_BBOX
PS00518--ZF_RING_1
PS50089--ZF_RING_2
Pfam

PF13765--PRY
PF00622--SPRY
PF00643--zf-B_box
PF13445--zf-RING_UBOX
PRINTS

PR01407--BUTYPHLNCDUF
SMART

SM00336--BBOX
SM00589--PRY
SM00184--RING
SM00449--SPRY
Gene Ontology

GO:0005829--C:cytosol
GO:0042802--F:identical protein binding
GO:0016740--F:transferase activity
GO:0008270--F:zinc ion binding
KEGG hsa:135892
Orthology
iUUCD ID Species Identity E-value Score
IUUC-Aml-001406 Ailuropoda melanoleuca 90.76 0.00e+00 886.00
IUUC-Apl-004051 Anas platyrhynchos 62.28 2.00e-176 612.00
IUUC-Ame-010964 Astyanax mexicanus 53.91 2.00e-154 538.00
IUUC-Bta-012642 Bos taurus 91.47 0.00e+00 888.00
IUUC-Cja-019011 Callithrix jacchus 93.56 0.00e+00 874.00
IUUC-Cfa-020270 Canis familiaris 89.53 0.00e+00 884.00
IUUC-Cpo-022458 Cavia porcellus 89.96 0.00e+00 880.00
IUUC-Csa-023478 Chlorocebus sabaeus 97.34 0.00e+00 948.00
IUUC-Cne-027043 Cryptococcus neoformans 50.00 6.00e-06 45.40
IUUC-Cme-027278 Cyanidioschyzon merolae 45.76 3.00e-08 54.30
IUUC-Dno-028894 Dasypus novemcinctus 89.68 0.00e+00 859.00
IUUC-Dor-030228 Dipodomys ordii 85.38 0.00e+00 738.00
IUUC-Eca-033497 Equus caballus 91.58 0.00e+00 894.00
IUUC-Eeu-034910 Erinaceus europaeus 76.33 6.00e-134 469.00
IUUC-Fca-036164 Felis catus 90.97 0.00e+00 893.00
IUUC-Gga-040573 Gallus gallus 56.12 8.00e-98 351.00
IUUC-Ggo-044471 Gorilla gorilla 99.18 0.00e+00 960.00
IUUC-Itr-048897 Ictidomys tridecemlineatus 89.59 0.00e+00 854.00
IUUC-Lch-050638 Latimeria chalumnae 56.68 3.00e-164 571.00
IUUC-Loc-051971 Lepisosteus oculatus 54.74 3.00e-152 531.00
IUUC-Laf-054291 Loxodonta africana 90.62 0.00e+00 874.00
IUUC-Mcc-055708 Macaca mulatta 97.34 0.00e+00 947.00
IUUC-Meu-056670 Macropus eugenii 72.05 3.00e-141 495.00
IUUC-Mla-059039 Melampsora laricipopulina 48.15 1.00e-08 54.30
IUUC-Mga-059415 Meleagris gallopavo 60.78 6.00e-177 613.00
IUUC-Mmr-061410 Microcebus murinus 93.12 0.00e+00 871.00
IUUC-Mmu-064094 Mus musculus 89.13 0.00e+00 861.00
IUUC-Mpu-065781 Mustela putorius furo 89.12 0.00e+00 868.00
IUUC-Mlu-067974 Myotis lucifugus 90.41 0.00e+00 877.00
IUUC-Nle-069000 Nomascus leucogenys 97.95 0.00e+00 956.00
IUUC-Opr-071216 Ochotona princeps 90.70 5.00e-116 411.00
IUUC-Ocu-074859 Oryctolagus cuniculus 88.60 0.00e+00 852.00
IUUC-Oga-088285 Otolemur garnettii 90.35 0.00e+00 889.00
IUUC-Oar-090161 Ovis aries 82.38 0.00e+00 785.00
IUUC-Ptr-091672 Pan troglodytes 99.18 0.00e+00 962.00
IUUC-Pan-092870 Papio anubis 97.54 0.00e+00 949.00
IUUC-Psi-093742 Pelodiscus sinensis 65.82 0.00e+00 654.00
IUUC-Pab-098034 Pongo abelii 98.77 0.00e+00 960.00
IUUC-Pca-100115 Procavia capensis 81.21 4.00e-70 258.00
IUUC-Pva-103234 Pteropus vampyrus 91.04 0.00e+00 882.00
IUUC-Rno-105163 Rattus norvegicus 88.49 0.00e+00 842.00
IUUC-Sha-106575 Sarcophilus harrisii 63.71 2.00e-154 538.00
IUUC-Ssc-115600 Sus scrofa 91.17 0.00e+00 891.00
IUUC-Tbe-128151 Tupaia belangeri 92.93 3.00e-98 350.00
IUUC-Ttr-128947 Tursiops truncatus 90.55 0.00e+00 872.00
Created Date 25-Jun-2017

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