iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

UUCD2 ID

IUUC-Ptr-090989

UUCD1 version

Ensembl Protein ID

UniProt Accession

Genbank Protein ID

Protein Name

Uncharacterized protein

Genbank Nucleotide ID

AACZ03113102

Gene Name

RNF125

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSPTRG00000009954.2	ENSPTRT00000018271.2	ENSPTRP00000016922.2

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 activity/RING/RING	3.60e-09	37.0	37	76
E3 activity/RING/U-box	1.30e-10	41.2	33	98

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

E3 activity/RING/RING

   S: 1    CaiCledfkdgplvlpCgHvfhadCl.qkwpglknssskefrCPlCr 46
           Ca+Cle + + p+ ++CgHvf+++C+   +      ++++++CP+Cr
   Q: 37   CAVCLEVLHQ-PVRTRCGHVFCRSCIaTSL------KNNKWTCPYCR 76
           ********99.777***********95555......**********8 PP

E3 activity/RING/U-box

   S: 4    eeflCpIslelMrdPvvlpsGitydrssIekwlasggktcPvtrqplteedlvPnltlrrliqawc 69
             f C++ le+ ++Pv + +G+++ rs+I+  l++++ tcP +r+ l +e +    + +r+ +++ 
   Q: 33   TSFDCAVCLEVLHQPVRTRCGHVFCRSCIATSLKNNKWTCPYCRAYLPSEGVPATDVAKRMKSEYK 98
           579******************************99999**********999999999999999986 PP

Organism

Pan troglodytes

Protein Sequence
(Fasta)

MGSVLSTDSG KSAPASATAR ALERRRDPEL PVTSFDCAVC LEVLHQPVRT RCGHVFCRSC 60
IATSLKNNKW TCPYCRAYLP SEGVPATDVA KRMKSEYKNC AECDTLVCLS EMRAHIRTCQ 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

ACTTCTGACA GTGGGGAAAG CAGCTGTGTG TGATAGCTTG GAAGGTTTAC TGCTGCCTCA 60
AGTCCTCTTC TCTGCAGTTG AGGTTTCAGG TTTCAATCCT CCCAATACCA CAAGACAGAG 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-1185--Reference proteome

Interpro

IPR008598--Di19_Zn_binding_dom
IPR034734--ZF_C2HC_RNF
IPR001841--Znf_RING
IPR013083--Znf_RING/FYVE/PHD
IPR017907--Znf_RING_CS

PROSITE

PS51803--ZF_C2HC_RNF
PS00518--ZF_RING_1
PS50089--ZF_RING_2

Pfam

PF05605--zf-Di19

SMART

SM00184--RING

Gene Ontology

GO:0000139--C:Golgi membrane
GO:0005622--C:intracellular
GO:0034098--C:VCP-NPL4-UFD1 AAA ATPase complex
GO:0031624--F:ubiquitin conjugating enzyme binding
GO:0061630--F:ubiquitin protein ligase activity
GO:0008270--F:zinc ion binding
GO:0039536--P:negative regulation of RIG-I signaling pathway
GO:0032480--P:negative regulation of type I interferon production
GO:0032436--P:positive regulation of proteasomal ubiquitin-dependent protein catabolic process
GO:0000209--P:protein polyubiquitination
GO:0042787--P:protein ubiquitination involved in ubiquitin-dependent protein catabolic process

KEGG

ptr:743809

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001992	Ailuropoda melanoleuca	92.24	5.00e-128	449.00
IUUC-Aca-004839	Anolis carolinensis	63.48	2.00e-67	247.00
IUUC-Bta-012827	Bos taurus	90.48	5.00e-125	439.00
IUUC-Cja-018794	Callithrix jacchus	93.97	8.00e-129	452.00
IUUC-Cfa-021234	Canis familiaris	91.38	5.00e-119	419.00
IUUC-Cpo-022412	Cavia porcellus	80.60	8.00e-109	385.00
IUUC-Csa-023406	Chlorocebus sabaeus	97.41	7.00e-133	465.00
IUUC-Cho-024427	Choloepus hoffmanni	77.40	3.00e-76	276.00
IUUC-Dno-030085	Dasypus novemcinctus	92.67	2.00e-128	451.00
IUUC-Dor-030911	Dipodomys ordii	69.83	4.00e-76	277.00
IUUC-Ete-032469	Echinops telfairi	85.34	1.00e-118	418.00
IUUC-Eca-034352	Equus caballus	93.97	9.00e-130	455.00
IUUC-Eeu-034889	Erinaceus europaeus	78.02	3.00e-102	363.00
IUUC-Fca-036116	Felis catus	92.67	6.00e-121	426.00
IUUC-Hsa-046518	Homo sapiens	99.57	1.00e-135	474.00
IUUC-Itr-048344	Ictidomys tridecemlineatus	96.61	8.00e-101	358.00
IUUC-Laf-053363	Loxodonta africana	91.88	2.00e-126	444.00
IUUC-Meu-056101	Macropus eugenii	78.20	3.00e-95	340.00
IUUC-Mdo-062046	Monodelphis domestica	75.54	1.00e-100	358.00
IUUC-Mmu-063184	Mus musculus	86.43	1.00e-59	221.00
IUUC-Mpu-065708	Mustela putorius furo	90.09	7.00e-125	439.00
IUUC-Mlu-067561	Myotis lucifugus	90.96	2.00e-95	340.00
IUUC-Nle-069665	Nomascus leucogenys	95.33	1.00e-119	421.00
IUUC-Opr-070301	Ochotona princeps	79.31	1.00e-105	375.00
IUUC-Ocu-074562	Oryctolagus cuniculus	93.65	1.00e-67	247.00
IUUC-Opu-083381	Oryza punctata	39.74	6.00e-09	53.10
IUUC-Oga-088958	Otolemur garnettii	94.40	1.00e-130	457.00
IUUC-Oar-089541	Ovis aries	92.61	3.00e-97	346.00
IUUC-Pan-092372	Papio anubis	96.55	4.00e-132	462.00
IUUC-Pab-098718	Pongo abelii	82.76	2.00e-106	377.00
IUUC-Pca-100453	Procavia capensis	90.52	2.00e-124	437.00
IUUC-Pva-102931	Pteropus vampyrus	93.53	2.00e-121	427.00
IUUC-Rno-105771	Rattus norvegicus	85.41	2.00e-100	358.00
IUUC-Sha-107557	Sarcophilus harrisii	75.11	3.00e-106	377.00
IUUC-Sar-113435	Sorex araneus	93.65	2.00e-67	247.00
IUUC-Ssc-116388	Sus scrofa	92.24	5.00e-128	449.00
IUUC-Tsy-119439	Tarsius syrichta	93.79	2.00e-98	350.00
IUUC-Tbe-127417	Tupaia belangeri	66.67	1.00e-69	255.00
IUUC-Ttr-129212	Tursiops truncatus	92.24	4.00e-128	450.00
IUUC-Vpa-130153	Vicugna pacos	91.81	1.00e-127	447.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence