iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEO	ArrayExpress
DNA & RNA Element
microRNA	RAID2
Protein-protein Interaction
IID	iRefIndex	Mentha
Protein Expression/Proteomics
GPMDB

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 activity/RING/RING	1.50e-07	31.9	125	166

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

E3 activity/RING/RING

   S: 1    CaiCledfkdgplvlpCgHvfhadClqkwpglknssskefrCPlCr 46
           C iCl+  kd  +v  CgH+f+  Cl++w        ++ +CP+C+
   Q: 125  CNICLDTAKD-AVVSMCGHLFCWPCLHQW---LLTRPNRKLCPVCK 166
           99********.77799*************...44599999*****7 PP

Organism

Drosophila melanogaster

Protein Sequence
(Fasta)

MEEPKSVPTA ELPSTSTGAS SSSSTLSNNV SYDKIAWTRD ITEPLAEESS TSQLRPLGTS 60
IPTNSTASEL KKSNTSYSFT GDYLSGGNKA DLKGGYPFGG TDTDTKANEK DKEKEHTADD 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

AGGTATCGTC AGTGCAGTTG TTTTGAGGTG CTAAGACGTC AATTGATAAA TTCCCAATTT 60
TACCGTAACA TAACACACTT GTCCACACAA TCAATTTAGC AACATTCTCT GATTCGGTTT 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-0472--Membrane
KW-1267--Proteomics identification
KW-1185--Reference proteome
KW-0812--Transmembrane
KW-1133--Transmembrane helix

Interpro

IPR001841--Znf_RING
IPR013083--Znf_RING/FYVE/PHD
IPR017907--Znf_RING_CS

PROSITE

PS00518--ZF_RING_1
PS50089--ZF_RING_2

SMART

SM00184--RING

Gene Ontology

GO:0036513--C:Derlin-1 retrotranslocation complex
GO:0016021--C:integral component of membrane
GO:1904264--F:ubiquitin protein ligase activity involved in ERAD pathway
GO:0044390--F:ubiquitin-like protein conjugating enzyme binding
GO:0004842--F:ubiquitin-protein transferase activity
GO:0008270--F:zinc ion binding
GO:0071712--P:ER-associated misfolded protein catabolic process
GO:0016567--P:protein ubiquitination
GO:0042787--P:protein ubiquitination involved in ubiquitin-dependent protein catabolic process

KEGG

dme:Dmel_CG8974

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Ata-001042	Aegilops tauschii	52.27	2.00e-24	104.00
IUUC-Aml-001875	Ailuropoda melanoleuca	57.86	3.00e-39	154.00
IUUC-Atr-002444	Amborella trichopoda	48.98	9.00e-25	105.00
IUUC-Apl-003744	Anas platyrhynchos	79.71	7.00e-33	131.00
IUUC-Aca-004254	Anolis carolinensis	63.86	2.00e-30	124.00
IUUC-Aly-006065	Arabidopsis lyrata	53.76	3.00e-26	110.00
IUUC-Ath-007267	Arabidopsis thaliana	53.76	5.00e-26	110.00
IUUC-Ame-011667	Astyanax mexicanus	53.85	5.00e-34	136.00
IUUC-Bta-012734	Bos taurus	57.86	4.00e-39	153.00
IUUC-Bdi-014841	Brachypodium distachyon	53.01	1.00e-23	103.00
IUUC-Bol-016132	Brassica oleracea	47.71	7.00e-26	109.00
IUUC-Bra-017631	Brassica rapa	47.71	7.00e-26	109.00
IUUC-Cel-018228	Caenorhabditis elegans	37.61	3.00e-37	147.00
IUUC-Cja-019136	Callithrix jacchus	57.86	5.00e-39	152.00
IUUC-Cfa-020308	Canis familiaris	57.86	3.00e-39	154.00
IUUC-Cpo-021347	Cavia porcellus	57.23	4.00e-39	152.00
IUUC-Cre-022829	Chlamydomonas reinhardtii	54.35	4.00e-26	108.00
IUUC-Csa-023755	Chlorocebus sabaeus	57.86	1.00e-39	154.00
IUUC-Cin-025364	Ciona intestinalis	44.00	1.00e-09	56.20
IUUC-Cgl-026743	Colletotrichum gloeosporioides	40.74	2.00e-08	52.80
IUUC-Cme-027164	Cyanidioschyzon merolae	50.77	9.00e-18	83.20
IUUC-Dre-028094	Danio rerio	55.97	4.00e-38	149.00
IUUC-Dno-029402	Dasypus novemcinctus	57.86	3.00e-39	154.00
IUUC-Dor-030373	Dipodomys ordii	57.86	3.00e-39	154.00
IUUC-Ete-032786	Echinops telfairi	57.86	2.00e-39	154.00
IUUC-Eca-034261	Equus caballus	57.86	3.00e-39	154.00
IUUC-Eeu-034614	Erinaceus europaeus	49.69	7.00e-28	115.00
IUUC-Fca-036049	Felis catus	57.86	3.00e-39	154.00
IUUC-Fal-037085	Ficedula albicollis	57.23	9.00e-39	152.00
IUUC-Fso-038195	Fusarium solani	37.31	1.00e-10	60.50
IUUC-Gmo-039369	Gadus morhua	75.71	2.00e-31	127.00
IUUC-Gga-040514	Gallus gallus	57.23	1.00e-38	151.00
IUUC-Gac-041719	Gasterosteus aculeatus	54.72	8.00e-36	142.00
IUUC-Gma-043898	Glycine max	53.41	8.00e-26	109.00
IUUC-Ggo-044504	Gorilla gorilla	57.86	3.00e-39	154.00
IUUC-Hsa-045707	Homo sapiens	57.86	3.00e-39	154.00
IUUC-Hvu-047487	Hordeum vulgare	47.62	5.00e-24	103.00
IUUC-Itr-048343	Ictidomys tridecemlineatus	57.86	2.00e-39	154.00
IUUC-Lch-050658	Latimeria chalumnae	59.12	1.00e-38	151.00
IUUC-Lpe-051034	Leersia perrieri	51.65	4.00e-24	103.00
IUUC-Loc-052118	Lepisosteus oculatus	54.27	2.00e-36	144.00
IUUC-Laf-054438	Loxodonta africana	57.50	2.00e-39	154.00
IUUC-Mcc-054641	Macaca mulatta	54.09	6.00e-32	129.00
IUUC-Meu-055984	Macropus eugenii	60.00	1.00e-27	114.00
IUUC-Mpo-057431	Magnaporthe poae	39.58	2.00e-09	56.60
IUUC-Mtr-058107	Medicago truncatula	53.85	8.00e-26	109.00
IUUC-Mga-059554	Meleagris gallopavo	57.23	1.00e-38	151.00
IUUC-Mvi-060316	Microbotryum violaceum	49.15	8.00e-13	66.60
IUUC-Mmr-061662	Microcebus murinus	52.47	5.00e-30	123.00
IUUC-Mdo-062774	Monodelphis domestica	57.86	3.00e-39	154.00
IUUC-Mmu-063372	Mus musculus	57.50	7.00e-39	152.00
IUUC-Mac-065390	Musa acuminata	50.00	4.00e-25	107.00
IUUC-Mpu-066033	Mustela putorius furo	57.50	2.00e-39	157.00
IUUC-Mlu-067254	Myotis lucifugus	57.86	3.00e-39	154.00
IUUC-Nle-069850	Nomascus leucogenys	57.86	3.00e-39	154.00
IUUC-Opr-070197	Ochotona princeps	55.97	2.00e-37	147.00
IUUC-Ont-071950	Oreochromis niloticus	56.41	1.00e-37	147.00
IUUC-Oan-073480	Ornithorhynchus anatinus	57.86	3.00e-39	154.00
IUUC-Ocu-073878	Oryctolagus cuniculus	59.75	4.00e-42	162.00
IUUC-Ogl-077553	Oryza glaberrima	49.46	1.00e-25	108.00
IUUC-Ogu-078463	Oryza glumaepatula	49.46	2.00e-25	108.00
IUUC-Oin-080177	Oryza indica	49.46	2.00e-25	108.00
IUUC-Olo-080296	Oryza longistaminata	52.44	2.00e-23	102.00
IUUC-Ome-081605	Oryza meridionalis	51.14	3.00e-25	107.00
IUUC-Oni-082458	Oryza nivara	49.46	4.00e-25	108.00
IUUC-Opu-083362	Oryza punctata	51.65	2.00e-24	105.00
IUUC-Oru-084757	Oryza rufipogon	51.14	2.00e-25	108.00
IUUC-Ola-086800	Oryzias latipes	54.72	2.00e-35	141.00
IUUC-Olu-087623	Ostreococcus lucimarinus	50.88	9.00e-15	72.40
IUUC-Oga-088197	Otolemur garnettii	56.71	4.00e-40	156.00
IUUC-Oar-090284	Ovis aries	63.03	4.00e-41	159.00
IUUC-Ptr-091106	Pan troglodytes	57.86	3.00e-39	154.00
IUUC-Pan-092671	Papio anubis	57.86	1.00e-39	154.00
IUUC-Psi-093323	Pelodiscus sinensis	57.86	3.00e-39	153.00
IUUC-Ppa-095474	Physcomitrella patens	46.90	5.00e-26	110.00
IUUC-Pfo-096943	Poecilia formosa	53.75	3.00e-35	140.00
IUUC-Pab-097845	Pongo abelii	57.86	3.00e-39	154.00
IUUC-Pop-098889	Populus trichocarpa	45.61	7.00e-27	112.00
IUUC-Pca-100319	Procavia capensis	62.81	5.00e-42	162.00
IUUC-Ppe-102011	Prunus persica	44.64	6.00e-26	109.00
IUUC-Pva-102298	Pteropus vampyrus	57.86	3.00e-39	153.00
IUUC-Rno-105293	Rattus norvegicus	57.86	1.00e-39	155.00
IUUC-Sha-107361	Sarcophilus harrisii	57.86	1.00e-39	154.00
IUUC-Smo-109663	Selaginella moellendorffii	57.14	5.00e-25	105.00
IUUC-Sit-110376	Setaria italica	39.86	9.00e-25	106.00
IUUC-Sly-111255	Solanum lycopersicum	45.67	4.00e-25	107.00
IUUC-Stu-112117	Solanum tuberosum	45.90	6.00e-24	102.00
IUUC-Sar-113669	Sorex araneus	76.09	1.00e-18	84.00
IUUC-Ssc-116228	Sus scrofa	57.86	3.00e-39	154.00
IUUC-Tgu-116886	Taeniopygia guttata	57.23	9.00e-39	152.00
IUUC-Tru-118679	Takifugu rubripes	54.93	1.00e-18	84.70
IUUC-Tsy-119615	Tarsius syrichta	59.40	2.00e-42	163.00
IUUC-Tni-120909	Tetraodon nigroviridis	51.12	2.00e-37	147.00
IUUC-Tre-122215	Trichoderma reesei	36.76	9.00e-11	61.20
IUUC-Tae-124870	Triticum aestivum	52.27	4.00e-24	103.00
IUUC-Tur-126198	Triticum urartu	52.38	2.00e-23	101.00
IUUC-Tbe-127360	Tupaia belangeri	79.17	1.00e-33	134.00
IUUC-Ttr-129044	Tursiops truncatus	57.86	3.00e-39	154.00
IUUC-Vda-129983	Verticillium dahliae	43.40	4.00e-09	53.50
IUUC-Vpa-130365	Vicugna pacos	57.23	3.00e-38	150.00
IUUC-Vvi-131449	Vitis vinifera	51.61	8.00e-26	109.00
IUUC-Xtr-132608	Xenopus tropicalis	56.90	3.00e-34	136.00
IUUC-Xma-133333	Xiphophorus maculatus	53.46	3.00e-34	137.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence