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Basic Information Integrated Annotations
Tag Content
UUCD2 ID IUUC-Mmu-064262
UUCD1 version UUC-MuM-00083
Ensembl Protein ID ENSMUSP00000030584.4
UniProt Accession A2A7Q9; A0AUN9; Q7TT05; RN19B_MOUSE
Genbank Protein ID CAM19707.1; AAH52529.1; AAI17808.1
Protein Name E3 ubiquitin-protein ligase RNF19B; IBR domain-containing protein 3; Natural killer lytic-associated molecule; RING finger protein 19B
Genbank Nucleotide ID AL606977; BC052529; BC117807
Gene Name Rnf19b; Ibrdc3; Nklam
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
ENSMUSG00000028793.15 ENSMUST00000130803.2 ENSMUSP00000121004.1
ENSMUSG00000028793.15 ENSMUST00000168461.7 ENSMUSP00000131373.1
ENSMUSG00000028793.15 ENSMUST00000030584.10 ENSMUSP00000030584.4
Annotation
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEOArrayExpressGXD
DNA & RNA Element
AREsitemicroRNATRANSFACRAID2
Protein-protein Interaction
IID
Post-translational Modifications (PTMs)
dbPAFPhosphositePlusPHOSIDA
Protein Expression/Proteomics
GPMDB
Status Unreviewed
Classification
Family E-Value Score Start End
E3 activity/RBR 1.60e-53 182.2 116 315
Active Site
Position(s) Description Evidence
299 N/A {ECO:0000250|UniProtKB:Q9Y4X5}
Domain Profile

   E3 activity/RBR
   S: 1    CkvCllelsveeltvlleCehtfCkeClkqylelkikegqvteiscpaaecpekleeseikellveeelykryekllleevveadaalkw 90
           C++Cl++l++e+++ ll+C h+ C++Cl++yl+l+i+e++ + iscp  ec+e+l++++i+ ll+++ l+++ye+++l++++++d++++w
   Q: 116  CPLCLVRLPPERAPRLLSCPHRSCRDCLRHYLRLEISESR-VPISCP--ECSERLNPHDIRLLLADPPLMHKYEEFMLRRYLASDPDCRW 202
           ****************************************.9*****..89*************************************** PP
   S: 91   cpapdCslvvllekea..eklevecekcgkefCveCkeewHeglsCkelkeklakteeek......eeaeskelleanskkCpkCkvyie 172
           cpapdC ++v++  +a  +kl++e+e+c++efC++Ck++wH++++C+++++++a+t + +       ++ +++  ++++k+Cp+C++yi+
   Q: 203  CPAPDCGYAVIAYGCAscPKLTCEREGCQTEFCYHCKQIWHPNQTCDMARQQRAQTLRVRtkhtsgLSYGQESGPADDIKPCPRCSAYII 292
           *************999899************************************99988888888888899999*************** PP
   S: 173  k..negCnhmtCakCkaefCwlC 193
           k  +++CnhmtCa C++efCwlC
   Q: 293  KmnDGSCNHMTCAVCGCEFCWLC 315
           997889***************** PP
   
Organism Mus musculus
Functional Description
(View)

Functional Description


     E3 ubiquitin-protein ligase which accepts ubiquitin from E2 ubiquitin-conjugating enzymes UBE2L3 and UBE2L6 in the form of a thioester and then directly transfers the ubiquitin to targeted substrates, such as UCKL1. Involved in the cytolytic activity of natural killer cells and cytotoxic T-cells (By similarity).
 E3 ubiquitin-protein ligase which accepts ubiquitin from E2 ubiquitin-conjugating enzymes UBE2L3 and UBE2L6 in the form of a thioester and then directly transfers the ubiquitin to targeted substrates, such as UCKL1. Involved in the cytolytic activity of natural killer cells and cytotoxic T-cells (By similarity).
Protein Sequence
(Fasta)
MGSEKDSESP RSTSLHAAAP DPKCRSGGRR RRLTFHSVFS ASARGRRART KPQAEPPPPA 60
APPPPPPPAP APVEAQAPPV EALPSEPAAE AEAEAVAAGP EEDEAAEGGG AEEVECPLCL 120
It may take some time, please wait.

Protein Fasta Sequence


>IUUC-Mmu-064262|E3,RBR|Mus musculus
Please wait for a moment...
Nucleotide Sequence
(Fasta)
ATGGGCTCCG AGAAGGACTC CGAGTCGCCG CGCTCCACCT CGCTCCATGC GGCCGCCCCC 60
GACCCTAAGT GCCGCAGCGG CGGCCGGCGC CGGCGCCTCA CCTTCCACAG CGTCTTCTCC 120
It may take some time, please wait.

Nucleotide Fasta Sequence


>IUUC-Mmu-064262|E3,RBR|Mus musculus
Please wait for a moment...
Sequence Source Ensembl
Keyword

KW-1064--Adaptive immunity
KW-0181--Complete proteome
KW-0391--Immunity
KW-0472--Membrane
KW-0479--Metal-binding
KW-1185--Reference proteome
KW-0677--Repeat
KW-0808--Transferase
KW-0812--Transmembrane
KW-1133--Transmembrane helix
KW-0833--Ubl conjugation pathway
KW-0862--Zinc
KW-0863--Zinc-finger
Interpro

IPR016150--Casein_kin_II_reg-sub_b-sht
IPR031127--E3_UB_ligase_RBR
IPR002867--IBR_dom
IPR001841--Znf_RING
IPR013083--Znf_RING/FYVE/PHD
PROSITE

PS50089--ZF_RING_2
Pfam

PF01485--IBR
SMART

SM00647--IBR
SM00184--RING
Gene Ontology

GO:0044194--C:cytolytic granule
GO:0005829--C:cytosol
GO:0016021--C:integral component of membrane
GO:0000151--C:ubiquitin ligase complex
GO:0031624--F:ubiquitin conjugating enzyme binding
GO:0061630--F:ubiquitin protein ligase activity
GO:0004842--F:ubiquitin-protein transferase activity
GO:0008270--F:zinc ion binding
GO:0002250--P:adaptive immune response
GO:0072643--P:interferon-gamma secretion
GO:0042267--P:natural killer cell mediated cytotoxicity
GO:0032436--P:positive regulation of proteasomal ubiquitin-dependent protein catabolic process
GO:0000209--P:protein polyubiquitination
GO:0042787--P:protein ubiquitination involved in ubiquitin-dependent protein catabolic process
Orthology
iUUCD ID Species Identity E-value Score
IUUC-Aml-002183 Ailuropoda melanoleuca 93.90 0.00e+00 1050.00
IUUC-Apl-003468 Anas platyrhynchos 90.23 0.00e+00 835.00
IUUC-Aca-004324 Anolis carolinensis 87.52 0.00e+00 947.00
IUUC-Ame-011813 Astyanax mexicanus 66.43 0.00e+00 681.00
IUUC-Bta-013135 Bos taurus 95.62 0.00e+00 1102.00
IUUC-Cja-019264 Callithrix jacchus 85.88 0.00e+00 955.00
IUUC-Cpo-022502 Cavia porcellus 95.26 0.00e+00 965.00
IUUC-Cho-025032 Choloepus hoffmanni 73.77 0.00e+00 712.00
IUUC-Dre-028769 Danio rerio 60.85 0.00e+00 752.00
IUUC-Dor-030551 Dipodomys ordii 96.98 3.00e-119 422.00
IUUC-Ete-033008 Echinops telfairi 81.19 0.00e+00 775.00
IUUC-Eca-033267 Equus caballus 95.20 0.00e+00 904.00
IUUC-Fca-035520 Felis catus 95.39 0.00e+00 899.00
IUUC-Fal-037090 Ficedula albicollis 88.98 0.00e+00 745.00
IUUC-Gga-041229 Gallus gallus 89.26 0.00e+00 733.00
IUUC-Gac-041619 Gasterosteus aculeatus 68.52 0.00e+00 726.00
IUUC-Hsa-045958 Homo sapiens 95.77 0.00e+00 1100.00
IUUC-Itr-048425 Ictidomys tridecemlineatus 96.32 0.00e+00 966.00
IUUC-Lch-049552 Latimeria chalumnae 75.04 0.00e+00 927.00
IUUC-Loc-051738 Lepisosteus oculatus 67.11 0.00e+00 775.00
IUUC-Laf-054252 Loxodonta africana 92.16 0.00e+00 924.00
IUUC-Meu-055920 Macropus eugenii 91.04 0.00e+00 925.00
IUUC-Mga-059587 Meleagris gallopavo 88.78 0.00e+00 786.00
IUUC-Mdo-061985 Monodelphis domestica 91.61 0.00e+00 1067.00
IUUC-Mpu-066101 Mustela putorius furo 95.37 0.00e+00 1095.00
IUUC-Mlu-067347 Myotis lucifugus 93.47 0.00e+00 902.00
IUUC-Ont-071298 Oreochromis niloticus 68.63 0.00e+00 745.00
IUUC-Oan-073219 Ornithorhynchus anatinus 88.29 0.00e+00 855.00
IUUC-Ocu-073792 Oryctolagus cuniculus 92.51 0.00e+00 871.00
IUUC-Ola-086499 Oryzias latipes 68.46 0.00e+00 753.00
IUUC-Oga-088812 Otolemur garnettii 95.42 0.00e+00 1050.00
IUUC-Oar-090353 Ovis aries 94.43 0.00e+00 965.00
IUUC-Psi-092988 Pelodiscus sinensis 88.70 0.00e+00 827.00
IUUC-Pfo-096268 Poecilia formosa 64.57 0.00e+00 742.00
IUUC-Pca-100597 Procavia capensis 94.05 0.00e+00 891.00
IUUC-Pva-102542 Pteropus vampyrus 81.79 0.00e+00 845.00
IUUC-Sha-106512 Sarcophilus harrisii 90.84 0.00e+00 1030.00
IUUC-Sar-113233 Sorex araneus 93.09 0.00e+00 862.00
IUUC-Ssc-115781 Sus scrofa 95.28 0.00e+00 1151.00
IUUC-Tgu-117384 Taeniopygia guttata 95.45 0.00e+00 773.00
IUUC-Tru-117919 Takifugu rubripes 67.65 0.00e+00 729.00
IUUC-Tsy-119275 Tarsius syrichta 91.38 0.00e+00 889.00
IUUC-Tbe-127335 Tupaia belangeri 100.00 0.00e+00 671.00
IUUC-Ttr-128554 Tursiops truncatus 94.24 0.00e+00 892.00
IUUC-Vpa-130407 Vicugna pacos 89.25 0.00e+00 906.00
IUUC-Xtr-132325 Xenopus tropicalis 85.34 0.00e+00 724.00
Created Date 25-Jun-2017

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