iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEO	ArrayExpress
DNA & RNA Element
microRNA	RAID2
Protein-protein Interaction
IID	iRefIndex	Mentha
Post-translational Modifications (PTMs)
dbPAF	PHOSIDA
Protein Expression/Proteomics
GPMDB

Status

Reviewed

Details

Family	Domain	References (PMIDs)
E3 activity/HECT	HECT	18519643

Classification

Family	E-value	Score	Start	End
E3 activity/HECT	4.50e-118	394.5	2288	2727

Active Site

Position(s)	Description	Evidence
2696	Glycyl thioester intermediate	{ECO:0000256\|PROSITE-ProRule:PRU00104}

Domain Profile

E3 activity/HECT

   S: 4    dlkkrlevefvgEegldlgGvtreflallskelqnpdlglflysen..dketlqpnpdsglknp.........................ehlklFe 72
           ++k++levef++Eeg++l G+t+ef+al+++e+q++dl+++l++++  +++++++++++g+++p                         ++lk+F+
   Q: 2288 NRKSVLEVEFLDEEGTGL-GPTLEFYALVAAEIQRSDLCMWLCDDDlgEDTENSTQSAEGNSKPvgyyvnrrehgifpaplpqnseiceNVLKYFW 2382
           6799**************.***************************99999**********999******************************** PP
   S: 73   flGrllgkalqdgrlldlplsksfykll................................................lgkklsledleevdpelyks 120
           f+G++++k+lqd+rl+d+pls+sf++ll                                                +g  lsle+l+e+dp++y++
   Q: 2383 FFGVFVAKVLQDMRLVDIPLSTSFLQLLchnkvlsrnlqkvisdrrngdlsvvsedsdivetctkllrtdsnksnaFGGILSLENLKEIDPTRYQF 2478
           ****************************6666666666666666666666666666666666555555554444444447**************** PP
   S: 121  lkeikena........es........................dieelgldltfsvseeilgetkeeeLkpgGenipVtneNkeeYvklvveyrlke 184
           l+e++++         ++                        ++e+l+l++t+ +s++i+g+t++e L+p+G++++Vt++N+e+Y++l+++++l++
   Q: 2479 LQEMQNLLlrkqsiefDDtisaekkhelinelklqtqnglevSLEDLALTFTYLPSSSIYGYTQAE-LLPNGSSVNVTIDNLEAYCELLMNFILQD 2573
           *****9987765555500566666777788888888889966777777777777*******99998.***************************** PP
   S: 185  gikeqveafreGfneviplellslFteeelellicGeeeidvedlkket..ky...kggytedspaiqwFwevleefsseerkafLqFvTgssrlP 275
           gi++q++af++Gfnev+pl++l++Ft++e +++icGe   +++++++e+  +y   k gy++dsp++q+F++vl ++s +erkafLqF+Tg+s+lP
   Q: 2574 GIAQQMKAFSDGFNEVFPLKKLAAFTPSEARMMICGE---QFPHWSREDiiSYtepKLGYNKDSPGFQRFVNVLLSMSGDERKAFLQFTTGCSSLP 2666
           *************************************...9999999988877888**************************************** PP
   S: 276  lgGfaelkprlfvirk.dasddrlPssnTCfnyLkLPeYsskeilkekLlyAieetkgFels 336
           +gG+a+l+prl+v+rk da   ++Ps+nTC++yLkLP+Y+++ei+ke+Ll+A++e kgF+l+
   Q: 2667 PGGLANLHPRLTVVRKvDAGVGSYPSVNTCVHYLKLPDYPTEEIMKERLLTATKE-KGFHLN 2727
           ****************99999**********************************.****86 PP

Organism

Drosophila melanogaster

Protein Sequence
(Fasta)

MGDVDPETLL EWLSMGQGDE RDMQLIALEQ LCMLLLMSDN VDRCFESCPP RTFLPALCKI 60
FLDELAPENV LEVTARAITY YLDVSAECTR RIVSIDGAIK AICNHLVVAD LSSRTSRDLA 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

ACATGTAATC TCTATAATCA ATTTTCGAGC TGTGCTGCTA GATATTTGTG TGAATAAAAA 60
TAGTGTTGTG TATTGAGTAA TTGTTAAAAA GCTTTAATAA GCAGCTTTAA AAAAGAGTGC 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0040--ANK repeat
KW-0181--Complete proteome
KW-1267--Proteomics identification
KW-1185--Reference proteome
KW-0808--Transferase
KW-0833--Ubl conjugation pathway

Interpro

IPR002110--Ankyrin_rpt
IPR020683--Ankyrin_rpt-contain_dom
IPR011989--ARM-like
IPR016024--ARM-type_fold
IPR008979--Galactose-bd-like
IPR000569--HECT_dom
IPR010606--Mib_Herc2
IPR012919--SUN_dom

PROSITE

PS50297--ANK_REP_REGION
PS50088--ANK_REPEAT
PS50237--HECT
PS51416--MIB_HERC2

Pfam

PF12796--Ank_2
PF00632--HECT
PF06701--MIB_HERC2
PF07738--Sad1_UNC

SMART

SM00248--ANK
SM00119--HECTc

Gene Ontology

GO:0005634--C:nucleus
GO:0046872--F:metal ion binding
GO:0004842--F:ubiquitin-protein transferase activity
GO:0042787--P:protein ubiquitination involved in ubiquitin-dependent protein catabolic process

KEGG

dme:Dmel_CG5604

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Ata-000750	Aegilops tauschii	35.00	2.00e-85	310.00
IUUC-Aml-001987	Ailuropoda melanoleuca	59.76	0.00e+00	1577.00
IUUC-Atr-002821	Amborella trichopoda	34.33	4.00e-87	316.00
IUUC-Apl-003493	Anas platyrhynchos	59.67	0.00e+00	1582.00
IUUC-Aca-004521	Anolis carolinensis	59.59	0.00e+00	1573.00
IUUC-Aly-005962	Arabidopsis lyrata	33.75	3.00e-85	310.00
IUUC-Ath-006636	Arabidopsis thaliana	33.81	3.00e-85	310.00
IUUC-Ago-007875	Ashbya gossypii	29.57	9.00e-59	221.00
IUUC-Acl-008242	Aspergillus clavatus	31.43	1.00e-78	288.00
IUUC-Afl-008736	Aspergillus flavus	31.07	1.00e-75	278.00
IUUC-Afu-008812	Aspergillus fumigatus	31.12	1.00e-80	295.00
IUUC-Ani-009407	Aspergillus nidulans	31.19	2.00e-72	267.00
IUUC-Ang-009763	Aspergillus niger	29.71	3.00e-71	263.00
IUUC-Aor-009941	Aspergillus oryzae	31.07	3.00e-75	276.00
IUUC-Ate-010459	Aspergillus terreus	31.06	5.00e-68	253.00
IUUC-Ame-011258	Astyanax mexicanus	59.54	0.00e+00	1541.00
IUUC-Bgr-012265	Blumeria graminis	30.54	2.00e-81	297.00
IUUC-Bta-012835	Bos taurus	59.66	0.00e+00	1577.00
IUUC-Bci-013890	Botrytis cinerea	34.15	3.00e-78	287.00
IUUC-Bdi-014961	Brachypodium distachyon	33.12	1.00e-84	308.00
IUUC-Bol-015942	Brassica oleracea	34.50	5.00e-89	322.00
IUUC-Bra-016849	Brassica rapa	34.35	8.00e-89	322.00
IUUC-Cel-018153	Caenorhabditis elegans	44.20	1.00e-180	627.00
IUUC-Cja-019174	Callithrix jacchus	59.30	0.00e+00	1565.00
IUUC-Cfa-021115	Canis familiaris	59.30	0.00e+00	1541.00
IUUC-Cpo-022382	Cavia porcellus	55.52	0.00e+00	1421.00
IUUC-Csa-023230	Chlorocebus sabaeus	59.59	0.00e+00	1577.00
IUUC-Cho-024711	Choloepus hoffmanni	53.11	0.00e+00	692.00
IUUC-Cin-025342	Ciona intestinalis	47.65	0.00e+00	1215.00
IUUC-Csv-026031	Ciona savignyi	48.53	0.00e+00	1295.00
IUUC-Cgl-026716	Colletotrichum gloeosporioides	31.43	8.00e-80	292.00
IUUC-Cne-026857	Cryptococcus neoformans	31.94	9.00e-68	252.00
IUUC-Dre-027435	Danio rerio	60.37	0.00e+00	1592.00
IUUC-Dno-029954	Dasypus novemcinctus	59.44	0.00e+00	1567.00
IUUC-Dor-030734	Dipodomys ordii	57.17	0.00e+00	906.00
IUUC-Dse-031444	Dothistroma septosporum	30.30	2.00e-77	284.00
IUUC-Ete-033192	Echinops telfairi	65.05	4.00e-144	504.00
IUUC-Eca-033434	Equus caballus	59.66	0.00e+00	1580.00
IUUC-Eeu-035031	Erinaceus europaeus	54.37	6.00e-109	387.00
IUUC-Fca-035998	Felis catus	58.89	0.00e+00	1529.00
IUUC-Fal-037468	Ficedula albicollis	58.56	0.00e+00	1570.00
IUUC-Fox-038035	Fusarium oxysporum	31.45	1.00e-78	286.00
IUUC-Fso-038320	Fusarium solani	31.51	5.00e-80	292.00
IUUC-Gmo-038495	Gadus morhua	61.81	0.00e+00	969.00
IUUC-Ggr-040057	Gaeumannomyces graminis	31.01	2.00e-79	291.00
IUUC-Gga-040736	Gallus gallus	59.66	0.00e+00	1573.00
IUUC-Gac-041777	Gasterosteus aculeatus	59.23	0.00e+00	1560.00
IUUC-Gma-043048	Glycine max	34.38	2.00e-85	310.00
IUUC-Ggo-044677	Gorilla gorilla	56.72	0.00e+00	1467.00
IUUC-Hsa-045879	Homo sapiens	59.59	0.00e+00	1577.00
IUUC-Hvu-047775	Hordeum vulgare	35.10	1.00e-85	311.00
IUUC-Itr-048664	Ictidomys tridecemlineatus	59.59	0.00e+00	1578.00
IUUC-Kpa-049098	Komagataella pastoris	31.26	1.00e-61	231.00
IUUC-Lch-050444	Latimeria chalumnae	58.99	0.00e+00	1516.00
IUUC-Lpe-051017	Leersia perrieri	31.26	3.00e-84	306.00
IUUC-Loc-051986	Lepisosteus oculatus	59.67	0.00e+00	1519.00
IUUC-Lma-052990	Leptosphaeria maculans	33.57	2.00e-83	304.00
IUUC-Laf-054230	Loxodonta africana	59.43	0.00e+00	1555.00
IUUC-Mcc-054787	Macaca mulatta	59.59	0.00e+00	1577.00
IUUC-Meu-056502	Macropus eugenii	51.86	5.00e-157	549.00
IUUC-Mor-057054	Magnaporthe oryzae	31.26	6.00e-78	286.00
IUUC-Mpo-057417	Magnaporthe poae	30.84	1.00e-79	291.00
IUUC-Mtr-057849	Medicago truncatula	34.03	1.00e-87	318.00
IUUC-Mga-059409	Meleagris gallopavo	57.54	0.00e+00	1210.00
IUUC-Mvi-060507	Microbotryum violaceum	32.22	4.00e-88	320.00
IUUC-Mmr-061667	Microcebus murinus	59.35	0.00e+00	1568.00
IUUC-Mdo-061960	Monodelphis domestica	60.03	0.00e+00	1590.00
IUUC-Mmu-063941	Mus musculus	59.83	0.00e+00	1585.00
IUUC-Mac-064675	Musa acuminata	33.88	9.00e-81	294.00
IUUC-Mpu-065939	Mustela putorius furo	59.59	0.00e+00	1577.00
IUUC-Mlu-068112	Myotis lucifugus	59.76	0.00e+00	1577.00
IUUC-Nfi-068482	Neosartorya fischeri	31.12	3.00e-79	290.00
IUUC-Ncr-068906	Neurospora crassa	33.55	9.00e-79	288.00
IUUC-Nle-069001	Nomascus leucogenys	59.59	0.00e+00	1577.00
IUUC-Opr-071222	Ochotona princeps	56.38	0.00e+00	1314.00
IUUC-Ont-072101	Oreochromis niloticus	58.93	0.00e+00	1597.00
IUUC-Oan-072814	Ornithorhynchus anatinus	59.76	0.00e+00	1576.00
IUUC-Ocu-074011	Oryctolagus cuniculus	59.59	0.00e+00	1575.00
IUUC-Oba-075380	Oryza barthii	33.16	2.00e-75	277.00
IUUC-Obr-076904	Oryza brachyantha	30.38	2.00e-79	291.00
IUUC-Ogl-077055	Oryza glaberrima	31.10	1.00e-81	298.00
IUUC-Ogu-078892	Oryza glumaepatula	33.33	1.00e-75	278.00
IUUC-Oin-079256	Oryza indica	30.83	3.00e-79	290.00
IUUC-Olo-080343	Oryza longistaminata	31.14	7.00e-80	292.00
IUUC-Ome-081422	Oryza meridionalis	31.00	1.00e-78	288.00
IUUC-Oni-083047	Oryza nivara	33.51	9.00e-77	281.00
IUUC-Opu-083641	Oryza punctata	32.92	8.00e-73	268.00
IUUC-Oru-084439	Oryza rufipogon	33.63	6.00e-76	278.00
IUUC-Osa-085972	Oryza sativa	31.20	6.00e-81	294.00
IUUC-Ola-086412	Oryzias latipes	59.43	0.00e+00	1556.00
IUUC-Olu-087871	Ostreococcus lucimarinus	33.05	7.00e-70	257.00
IUUC-Oar-089668	Ovis aries	59.66	0.00e+00	1576.00
IUUC-Ptr-090517	Pan troglodytes	59.52	0.00e+00	1568.00
IUUC-Pan-091849	Papio anubis	56.84	0.00e+00	1469.00
IUUC-Psi-093390	Pelodiscus sinensis	59.18	0.00e+00	1537.00
IUUC-Pma-094628	Petromyzon marinus	55.73	0.00e+00	1034.00
IUUC-Pno-094891	Phaeosphaeria nodorum	33.61	1.00e-83	304.00
IUUC-Ppa-095264	Physcomitrella patens	31.68	2.00e-86	313.00
IUUC-Pfo-097075	Poecilia formosa	59.89	0.00e+00	1584.00
IUUC-Pab-098176	Pongo abelii	59.59	0.00e+00	1577.00
IUUC-Pop-099190	Populus trichocarpa	33.12	1.00e-86	315.00
IUUC-Pca-101123	Procavia capensis	64.16	0.00e+00	725.00
IUUC-Ppe-101284	Prunus persica	34.03	7.00e-88	318.00
IUUC-Pva-103008	Pteropus vampyrus	60.67	0.00e+00	1041.00
IUUC-Pte-104346	Pyrenophora teres	33.28	2.00e-80	293.00
IUUC-Pyt-104508	Pyrenophora triticirepentis	33.77	1.00e-81	298.00
IUUC-Rno-105885	Rattus norvegicus	59.66	0.00e+00	1578.00
IUUC-Sce-106273	Saccharomyces cerevisiae	30.65	6.00e-54	206.00
IUUC-Sha-107048	Sarcophilus harrisii	59.74	0.00e+00	1576.00
IUUC-Ssl-108560	Sclerotinia sclerotiorum	33.98	1.00e-79	291.00
IUUC-Smo-108776	Selaginella moellendorffii	33.39	2.00e-84	307.00
IUUC-Sit-110717	Setaria italica	32.35	3.00e-87	317.00
IUUC-Sly-111469	Solanum lycopersicum	31.99	4.00e-87	316.00
IUUC-Stu-112896	Solanum tuberosum	33.82	2.00e-73	269.00
IUUC-Sar-113071	Sorex araneus	58.38	0.00e+00	841.00
IUUC-Sbi-114313	Sorghum bicolor	32.03	4.00e-87	316.00
IUUC-Ssc-115963	Sus scrofa	59.66	0.00e+00	1577.00
IUUC-Tgu-117488	Taeniopygia guttata	62.42	0.00e+00	923.00
IUUC-Tru-118626	Takifugu rubripes	59.72	0.00e+00	1592.00
IUUC-Tsy-119504	Tarsius syrichta	53.28	0.00e+00	1138.00
IUUC-Tni-119877	Tetraodon nigroviridis	59.49	0.00e+00	1582.00
IUUC-Tca-121779	Theobroma cacao	34.13	5.00e-86	312.00
IUUC-Tre-122195	Trichoderma reesei	31.31	1.00e-78	288.00
IUUC-Tvi-122650	Trichoderma virens	31.67	5.00e-76	279.00
IUUC-Tae-125432	Triticum aestivum	31.72	2.00e-85	311.00
IUUC-Tur-126295	Triticum urartu	35.00	4.00e-85	309.00
IUUC-Tme-126964	Tuber melanosporum	31.85	5.00e-80	293.00
IUUC-Tbe-127602	Tupaia belangeri	66.37	0.00e+00	730.00
IUUC-Ttr-128394	Tursiops truncatus	54.72	0.00e+00	711.00
IUUC-Vda-129725	Verticillium dahliae	33.33	6.00e-79	289.00
IUUC-Vpa-130280	Vicugna pacos	59.66	0.00e+00	1578.00
IUUC-Vvi-131147	Vitis vinifera	34.33	2.00e-85	311.00
IUUC-Xtr-131787	Xenopus tropicalis	58.47	0.00e+00	1556.00
IUUC-Xma-133497	Xiphophorus maculatus	59.03	0.00e+00	812.00
IUUC-Zma-135657	Zea mays	31.95	2.00e-87	317.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence