iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

UUCD2 ID

IUUC-Cfa-020226

UUCD1 version

Ensembl Protein ID

UniProt Accession

Genbank Protein ID

Protein Name

Uncharacterized protein

Genbank Nucleotide ID

AAEX03009940

Gene Name

SOCS2

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSCAFG00000006180.3	ENSCAFT00000009997.3	ENSCAFP00000009276.3

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 adaptor/Cullin RING/ECS/SOCS_VHL_BC-box	7.90e-16	58.0	153	197

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

E3 adaptor/Cullin RING/ECS/SOCS_VHL_BC-box

   S: 4    lwllrseprSLqhLCRlaIrrclgsqrlkaidkLPLPksLkdYLlyedyq 53
           +++l ++ ++LqhLCRl+I++c+g+     i++LPLP +LkdYL+++++q
   Q: 153  TKPLYTSAPPLQHLCRLTINKCTGT-----IWGLPLPTRLKDYLEEYKFQ 197
           678999*******************.....8***************9886 PP

Organism

Canis familiaris

Protein Sequence
(Fasta)

MTLRCLEPSG NGAEGTPSQW GPAGPAEEPT PEAARLAKAL RELSHTGWYW GNMTVNEAKE 60
KLKEAPEGTF LIRDSSHSDY LLTISVKTSA GPTNLRIEYQ DGKFRLDSII CVKSKLKQFD 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

GCAAACTGTG GGTGACCGCG CTTGCGGGGG ACTTGGCCAT CCGTGCACTG GGACCTGGGG 60
AGGAAGAACC AGAAGCACCC CAACCTCCCC GCCTCCAGCA TTTCGGATCC CCCGCAGGGA 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-1185--Reference proteome

Interpro

IPR000980--SH2
IPR028410--SOCS2
IPR001496--SOCS_box

PROSITE

PS50001--SH2
PS50225--SOCS

Pfam

PF00017--SH2
PF07525--SOCS_box

PRINTS

PR00401--SH2DOMAIN

SMART

SM00252--SH2
SM00253--SOCS
SM00969--SOCS_box

Gene Ontology

GO:0005737--C:cytoplasm
GO:0004860--F:protein kinase inhibitor activity
GO:0019221--P:cytokine-mediated signaling pathway
GO:0060396--P:growth hormone receptor signaling pathway
GO:0035556--P:intracellular signal transduction
GO:0046627--P:negative regulation of insulin receptor signaling pathway
GO:0046426--P:negative regulation of JAK-STAT cascade
GO:0006469--P:negative regulation of protein kinase activity
GO:0016567--P:protein ubiquitination
GO:0001558--P:regulation of cell growth
GO:0032355--P:response to estradiol

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-002075	Ailuropoda melanoleuca	95.94	7.00e-105	372.00
IUUC-Apl-003484	Anas platyrhynchos	78.95	4.00e-71	259.00
IUUC-Aca-004253	Anolis carolinensis	71.78	4.00e-71	260.00
IUUC-Ath-007106	Arabidopsis thaliana	35.59	2.60e-02	33.10
IUUC-Ame-011267	Astyanax mexicanus	62.05	3.00e-58	217.00
IUUC-Bta-013183	Bos taurus	95.43	8.00e-100	355.00
IUUC-Bra-017915	Brassica rapa	33.90	5.10e-02	32.00
IUUC-Cja-018862	Callithrix jacchus	94.42	2.00e-98	350.00
IUUC-Cpo-022414	Cavia porcellus	94.42	4.00e-102	363.00
IUUC-Csa-023758	Chlorocebus sabaeus	93.91	2.00e-101	361.00
IUUC-Cho-024471	Choloepus hoffmanni	86.09	1.00e-70	258.00
IUUC-Dre-028288	Danio rerio	56.02	6.00e-62	229.00
IUUC-Dno-029036	Dasypus novemcinctus	94.42	8.00e-104	369.00
IUUC-Dor-030447	Dipodomys ordii	98.00	5.00e-86	309.00
IUUC-Ete-033023	Echinops telfairi	92.39	6.00e-107	379.00
IUUC-Fca-036469	Felis catus	95.94	1.00e-99	355.00
IUUC-Fal-036642	Ficedula albicollis	73.91	5.00e-70	256.00
IUUC-Gmo-039331	Gadus morhua	60.58	8.00e-35	138.00
IUUC-Gga-040809	Gallus gallus	77.22	2.00e-72	263.00
IUUC-Gac-041398	Gasterosteus aculeatus	59.88	1.00e-58	218.00
IUUC-Ggo-045341	Gorilla gorilla	94.92	1.00e-98	351.00
IUUC-Hsa-046557	Homo sapiens	94.42	6.00e-110	389.00
IUUC-Itr-049013	Ictidomys tridecemlineatus	81.64	4.00e-91	327.00
IUUC-Lch-050160	Latimeria chalumnae	62.42	5.00e-50	189.00
IUUC-Loc-051825	Lepisosteus oculatus	61.90	3.00e-59	221.00
IUUC-Laf-053560	Loxodonta africana	93.91	2.00e-96	344.00
IUUC-Mcc-055890	Macaca mulatta	93.91	2.00e-97	347.00
IUUC-Meu-056218	Macropus eugenii	79.70	1.00e-93	335.00
IUUC-Mga-059755	Meleagris gallopavo	69.78	4.00e-71	260.00
IUUC-Mmr-061387	Microcebus murinus	95.43	1.00e-102	365.00
IUUC-Mdo-062383	Monodelphis domestica	81.22	5.00e-94	336.00
IUUC-Mmu-063443	Mus musculus	92.89	3.00e-99	353.00
IUUC-Mpu-066459	Mustela putorius furo	95.43	3.00e-99	353.00
IUUC-Mlu-068040	Myotis lucifugus	95.43	4.00e-105	373.00
IUUC-Nle-069016	Nomascus leucogenys	90.36	4.00e-96	343.00
IUUC-Opr-071087	Ochotona princeps	88.32	1.00e-101	361.00
IUUC-Ont-072340	Oreochromis niloticus	59.30	7.00e-58	216.00
IUUC-Oan-073443	Ornithorhynchus anatinus	79.70	6.00e-90	322.00
IUUC-Ocu-074539	Oryctolagus cuniculus	94.97	2.00e-99	354.00
IUUC-Ola-087004	Oryzias latipes	59.87	2.00e-54	204.00
IUUC-Oga-088438	Otolemur garnettii	93.91	2.00e-101	361.00
IUUC-Oar-089932	Ovis aries	96.45	2.00e-100	358.00
IUUC-Ptr-091037	Pan troglodytes	94.92	1.00e-98	351.00
IUUC-Pan-092767	Papio anubis	94.42	4.00e-98	350.00
IUUC-Psi-093099	Pelodiscus sinensis	77.22	4.00e-73	266.00
IUUC-Pma-094671	Petromyzon marinus	44.09	2.00e-36	145.00
IUUC-Pfo-097073	Poecilia formosa	49.74	5.00e-54	203.00
IUUC-Pab-098319	Pongo abelii	94.42	1.00e-103	368.00
IUUC-Pca-101117	Procavia capensis	92.89	3.00e-98	350.00
IUUC-Pva-102117	Pteropus vampyrus	94.92	3.00e-97	347.00
IUUC-Rno-105913	Rattus norvegicus	92.39	2.00e-98	352.00
IUUC-Sha-106500	Sarcophilus harrisii	81.22	3.00e-93	333.00
IUUC-Ssc-115252	Sus scrofa	96.95	4.00e-105	373.00
IUUC-Tgu-117524	Taeniopygia guttata	75.95	1.00e-69	254.00
IUUC-Tsy-119335	Tarsius syrichta	93.33	5.00e-83	299.00
IUUC-Tni-120263	Tetraodon nigroviridis	53.48	3.00e-55	207.00
IUUC-Tbe-127915	Tupaia belangeri	94.92	3.00e-96	343.00
IUUC-Ttr-128372	Tursiops truncatus	96.45	2.00e-104	370.00
IUUC-Vpa-130422	Vicugna pacos	99.33	2.00e-87	313.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence