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Basic Information Integrated Annotations
Tag Content
iUUCD ID IUUC-Cel-018478
Ensembl Protein ID T26E3.3a.1
UniProt Accession Q9NAN2; Q1ZXS2; Q9XY93; PAR6_CAEEL
Genbank Protein ID AAD15926.1; CAB61018.2; CAJ85768.1
Protein Name Partitioning defective protein 6
Genbank Nucleotide ID AF070968; Z82053; Z82053
Gene Name par-6; T26E3.3
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
WBGene00003921 T26E3.3a.1 T26E3.3a.1
Annotation
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEO
DNA & RNA Element
microRNARAID2
Protein-protein Interaction
IIDiRefIndexPINAMentha
Post-translational Modifications (PTMs)
dbPAFdbPTMPhospho.ELMPHOSIDA
Protein Expression/Proteomics
GPMDB
Status Unreviewed
Classification
Family Identity E-Value Score Source Orthology
ULD/UDP/UFD/PB1 56.92 2.00e-76 283.00 IUUC-Hsa-045815
Active Site
Position(s) Description Evidence
N/A N/A N/A
Organism Caenorhabditis elegans
Functional Description
(View)

Functional Description


     Necessary for apicobasal and anterior-posterior asymmetries associated with cell adhesion and gastrulation during the first few cell cycles of embryogenesis (PubMed:8898226). Required for localizing/ maintaining par-3 at the cell periphery (PubMed:9834192, PubMed:8898226). Regulates mes-1 expression and/or localization pattern during early embryogenesis (PubMed:11003841). Acts together with par-3 and pkc-3 in maintaining epithelial cell polarity in the distal spermatheca (PubMed:13129846, PubMed:15151982). Plays a role in endosome and Golgi body positioning (PubMed:22634595).
 Necessary for apicobasal and anterior-posterior asymmetries associated with cell adhesion and gastrulation during the first few cell cycles of embryogenesis (PubMed:8898226). Required for localizing/ maintaining par-3 at the cell periphery (PubMed:9834192, PubMed:8898226). Regulates mes-1 expression and/or localization pattern during early embryogenesis (PubMed:11003841). Acts together with par-3 and pkc-3 in maintaining epithelial cell polarity in the distal spermatheca (PubMed:13129846, PubMed:15151982). Plays a role in endosome and Golgi body positioning (PubMed:22634595).
Protein Sequence
(Fasta)
MSYNGSYHQN HHSTLQVKSK FDSEWRRFSI PMHSASGVSY DGFRSLVEKL HHLESVQFTL 60
CYNSTGGDLL PITNDDNLRK SFESARPLLR LLIQRRGESW EEKYGYGTDS DKRWKGISSL 120
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Protein Fasta Sequence


>IUUC-Cel-018478|ULD,PB1|Caenorhabditis elegans
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Nucleotide Sequence
(Fasta)
CCGAAAAAAT CGATATTTCC CACGAAAATT GTGCATTATT TCCGGCTCAA CGCGGAGCTG 60
CACCTGTAAC TTGTAATTGT GAGTTTTAAT TTGCGAAAAT CATAATTTTT CAGCTTAAAA 120
It may take some time, please wait.

Nucleotide Fasta Sequence


>IUUC-Cel-018478|ULD,PB1|Caenorhabditis elegans
Please wait for a moment...
Sequence Source Ensembl
Keyword

KW-0025--Alternative splicing
KW-0130--Cell adhesion
KW-0131--Cell cycle
KW-0132--Cell division
KW-0965--Cell junction
KW-1003--Cell membrane
KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0217--Developmental protein
KW-0221--Differentiation
KW-0278--Fertilization
KW-0306--Gastrulation
KW-0334--Gonadal differentiation
KW-0472--Membrane
KW-1185--Reference proteome
KW-0796--Tight junction
Interpro

IPR000270--PB1_dom
IPR001478--PDZ
PROSITE

PS51745--PB1
PS50106--PDZ
Pfam

PF00564--PB1
PF00595--PDZ
SMART

SM00666--PB1
SM00228--PDZ
Gene Ontology

GO:0005923--C:bicellular tight junction
GO:0005938--C:cell cortex
GO:0005737--C:cytoplasm
GO:0016021--C:integral component of membrane
GO:0005886--C:plasma membrane
GO:0005080--F:protein kinase C binding
GO:0017048--F:Rho GTPase binding
GO:0007155--P:cell adhesion
GO:0030154--P:cell differentiation
GO:0051301--P:cell division
GO:0040001--P:establishment of mitotic spindle localization
GO:0007163--P:establishment or maintenance of cell polarity
GO:0007369--P:gastrulation
GO:0008406--P:gonad development
GO:0007506--P:gonadal mesoderm development
GO:0009949--P:polarity specification of anterior/posterior axis
GO:0007338--P:single fertilization
KEGG cel:CELE_T26E3.3
Orthology
iUUCD ID Species Identity E-value Score
IUUC-Aml-001436 Ailuropoda melanoleuca 56.98 2.00e-77 280.00
IUUC-Apl-003829 Anas platyrhynchos 54.23 2.00e-70 258.00
IUUC-Aca-004789 Anolis carolinensis 57.20 2.00e-75 274.00
IUUC-Ame-011428 Astyanax mexicanus 59.92 4.00e-76 276.00
IUUC-Bta-012518 Bos taurus 57.77 1.00e-77 281.00
IUUC-Cja-019906 Callithrix jacchus 56.54 5.00e-75 273.00
IUUC-Cfa-020182 Canis familiaris 57.83 1.00e-75 276.00
IUUC-Cpo-021968 Cavia porcellus 60.33 6.00e-78 283.00
IUUC-Csa-023165 Chlorocebus sabaeus 57.25 1.00e-77 281.00
IUUC-Cho-024608 Choloepus hoffmanni 54.15 1.00e-69 255.00
IUUC-Cin-025213 Ciona intestinalis 55.51 3.00e-66 244.00
IUUC-Csv-025825 Ciona savignyi 54.69 3.00e-67 247.00
IUUC-Dre-028158 Danio rerio 58.87 2.00e-73 268.00
IUUC-Dno-028998 Dasypus novemcinctus 55.77 9.00e-76 275.00
IUUC-Dor-030206 Dipodomys ordii 56.92 2.00e-77 281.00
IUUC-Dme-031864 Drosophila melanogaster 62.96 4.00e-73 266.00
IUUC-Ete-032289 Echinops telfairi 55.98 8.00e-75 272.00
IUUC-Eca-033390 Equus caballus 57.25 2.00e-76 277.00
IUUC-Eeu-034442 Erinaceus europaeus 51.52 2.00e-65 241.00
IUUC-Fca-035382 Felis catus 57.43 3.00e-76 277.00
IUUC-Fal-037480 Ficedula albicollis 58.52 2.00e-70 258.00
IUUC-Gmo-039039 Gadus morhua 52.59 3.00e-68 250.00
IUUC-Gga-040274 Gallus gallus 58.90 4.00e-73 266.00
IUUC-Gac-041720 Gasterosteus aculeatus 59.76 1.00e-76 278.00
IUUC-Ggo-044974 Gorilla gorilla 57.25 1.00e-77 282.00
IUUC-Hsa-045815 Homo sapiens 57.25 8.00e-78 282.00
IUUC-Itr-047961 Ictidomys tridecemlineatus 60.17 4.00e-75 273.00
IUUC-Lch-050235 Latimeria chalumnae 59.59 3.00e-76 277.00
IUUC-Loc-052534 Lepisosteus oculatus 59.84 6.00e-75 273.00
IUUC-Laf-054157 Loxodonta africana 56.92 3.00e-77 280.00
IUUC-Mcc-054932 Macaca mulatta 57.25 2.00e-76 277.00
IUUC-Meu-056725 Macropus eugenii 57.20 8.00e-74 269.00
IUUC-Mga-059223 Meleagris gallopavo 58.01 6.00e-70 256.00
IUUC-Mvi-060532 Microbotryum violaceum 27.08 1.90e+00 26.20
IUUC-Mmr-061600 Microcebus murinus 57.25 1.00e-78 285.00
IUUC-Mdo-062981 Monodelphis domestica 56.63 3.00e-77 280.00
IUUC-Mmu-063392 Mus musculus 60.34 4.00e-75 273.00
IUUC-Mpu-066720 Mustela putorius furo 56.92 4.00e-77 280.00
IUUC-Mlu-067104 Myotis lucifugus 51.18 9.00e-73 265.00
IUUC-Nle-070003 Nomascus leucogenys 57.31 4.00e-77 280.00
IUUC-Opr-070932 Ochotona princeps 50.99 2.00e-64 238.00
IUUC-Ont-071750 Oreochromis niloticus 58.40 5.00e-77 280.00
IUUC-Oan-073018 Ornithorhynchus anatinus 57.32 5.00e-77 280.00
IUUC-Ocu-074524 Oryctolagus cuniculus 56.13 8.00e-76 275.00
IUUC-Ola-086459 Oryzias latipes 59.04 4.00e-76 277.00
IUUC-Oga-089103 Otolemur garnettii 57.37 3.00e-77 280.00
IUUC-Oar-090055 Ovis aries 58.17 7.00e-78 283.00
IUUC-Ptr-090642 Pan troglodytes 56.32 2.00e-74 271.00
IUUC-Pan-092904 Papio anubis 57.25 8.00e-78 282.00
IUUC-Psi-094040 Pelodiscus sinensis 59.34 2.00e-76 278.00
IUUC-Pfo-097463 Poecilia formosa 61.07 8.00e-78 282.00
IUUC-Pab-097709 Pongo abelii 56.86 2.00e-77 280.00
IUUC-Pca-100345 Procavia capensis 56.54 7.00e-77 279.00
IUUC-Pva-102267 Pteropus vampyrus 56.54 2.00e-77 280.00
IUUC-Rno-105280 Rattus norvegicus 60.17 5.00e-75 273.00
IUUC-Sha-106608 Sarcophilus harrisii 55.17 3.00e-73 267.00
IUUC-Sar-113368 Sorex araneus 56.81 2.00e-73 267.00
IUUC-Ssc-115590 Sus scrofa 58.02 8.00e-72 262.00
IUUC-Tgu-117002 Taeniopygia guttata 58.08 4.00e-70 256.00
IUUC-Tru-117906 Takifugu rubripes 59.92 2.00e-78 284.00
IUUC-Tsy-119156 Tarsius syrichta 53.94 5.00e-69 253.00
IUUC-Tni-120078 Tetraodon nigroviridis 55.23 1.00e-68 251.00
IUUC-Tbe-127843 Tupaia belangeri 60.00 2.00e-73 267.00
IUUC-Ttr-128847 Tursiops truncatus 55.86 2.00e-75 274.00
IUUC-Vpa-130278 Vicugna pacos 55.56 4.00e-73 266.00
IUUC-Xtr-132550 Xenopus tropicalis 55.04 5.00e-71 259.00
Created Date 25-Jun-2017

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