iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Basic Information

Integrated Annotations

Tag

Content

iUUCD ID

IUUC-Rno-106063

Ensembl Protein ID

ENSRNOP00000062130.2

UniProt Accession

Q62625; Q6XVN7; MLP3B_RAT

Genbank Protein ID

AAA20645.1; AAP42561.1; AAQ94605.1; AAH58144.1; AAH83556.1

Protein Name

Microtubule-associated proteins 1A/1B light chain 3B; Autophagy-related protein LC3 B; Autophagy-related ubiquitin-like modifier LC3 B; MAP1 light chain 3-like protein 2; MAP1A/MAP1B light chain 3 B; Microtubule-associated protein 1 light chain 3 beta

Genbank Nucleotide ID

U05784; AY206669; AY392036; BC058144; BC083556

Gene Name

Map1lc3b; Map1alc3; Map1lc3

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSRNOG00000017905.8	ENSRNOT00000051352.6	ENSRNOP00000049421.3
ENSRNOG00000017905.8	ENSRNOT00000067141.2	ENSRNOP00000062130.2

Annotation

Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEO	ArrayExpress
DNA & RNA Element
microRNA	TRANSFAC	RAID2
Protein-protein Interaction
IID	iRefIndex	PINA	Mentha
Protein 3D Structure
PDB	MMDB
Protein Expression/Proteomics
GPMDB

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
ULD/UBL/ATG8	3.10e-48	162.6	15	120

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

ULD/UBL/ATG8

   S: 1    krkeevekirdkfpdkiPvivekakkeki.peldkkkylvPsdltvgqlvkiirkrlqlraedalfllvnn.slvsvsatlaeiyeeek 87
           +r+e+v+ ir+++p+kiPvi+e++k+ek+ p+ldk+k+lvP+++++++l+kiir+rlql+a++a+fllvn  s+vsvs++++e+ye+e+
   Q: 15   QRVEDVRLIREQHPTKIPVIIERYKGEKQlPVLDKTKFLVPDHVNMSELIKIIRRRLQLNANQAFFLLVNGhSMVSVSTPISEVYESER 103
           699*************************99****************************************99***************** PP
   S: 88   dedgflyvayaseetfG 104
           dedgfly++yas+etfG
   Q: 104  DEDGFLYMVYASQETFG 120
           ****************9 PP

Organism

Rattus norvegicus

Functional Description
(View)

Ubiquitin-like modifier involved in formation of autophagosomal vacuoles (autophagosomes). Plays a role in mitophagy which contributes to regulate mitochondrial quantity and quality by eliminating the mitochondria to a basal level to fulfill cellular energy requirements and preventing excess ROS production. Whereas LC3s are involved in elongation of the phagophore membrane, the GABARAP/GATE-16 subfamily is essential for a later stage in autophagosome maturation. Promotes primary ciliogenesis by removing OFD1 from centriolar satellites via the autophagic pathway.

Protein Sequence
(Fasta)

MPSEKTFKQR RSFEQRVEDV RLIREQHPTK IPVIIERYKG EKQLPVLDKT KFLVPDHVNM 60
SELIKIIRRR LQLNANQAFF LLVNGHSMVS VSTPISEVYE SERDEDGFLY MVYASQETFG 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

CTTCAGATAA AAATTGGGGT ATTTGAAAGA AATGGTGGCA CTCTGCACAG GGCTATTGGA 60
AATGGAAATT AGATGCTATG GGAGTCAGTC TCTGAGTCCC TCAAAAATCT AAAAGCAGAA 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0002--3D-structure
KW-0025--Alternative splicing
KW-0072--Autophagy
KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0968--Cytoplasmic vesicle
KW-0206--Cytoskeleton
KW-0903--Direct protein sequencing
KW-0449--Lipoprotein
KW-0472--Membrane
KW-0493--Microtubule
KW-0597--Phosphoprotein
KW-1185--Reference proteome
KW-0833--Ubl conjugation pathway

Interpro

IPR004241--Atg8-like
IPR029071--Ubiquitin-rel_dom

Pfam

PF02991--Atg8

Gene Ontology

GO:0000421--C:autophagosome membrane
GO:0030424--C:axon
GO:0005737--C:cytoplasm
GO:0031410--C:cytoplasmic vesicle
GO:0030425--C:dendrite
GO:0012505--C:endomembrane system
GO:0005874--C:microtubule
GO:0005875--C:microtubule associated complex
GO:0043025--C:neuronal cell body
GO:0008017--F:microtubule binding
GO:0019904--F:protein domain specific binding
GO:0015631--F:tubulin binding
GO:0006914--P:autophagy
GO:0032092--P:positive regulation of protein binding

KEGG

rno:64862

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001523	Ailuropoda melanoleuca	94.44	2.00e-66	243.00
IUUC-Apl-004007	Anas platyrhynchos	89.08	4.00e-59	219.00
IUUC-Aca-004678	Anolis carolinensis	93.10	4.00e-61	226.00
IUUC-Bta-013149	Bos taurus	95.20	9.00e-68	248.00
IUUC-Cja-019405	Callithrix jacchus	96.00	2.00e-68	250.00
IUUC-Cfa-020120	Canis familiaris	95.24	1.00e-66	244.00
IUUC-Cpo-021922	Cavia porcellus	98.33	3.00e-67	246.00
IUUC-Csa-023961	Chlorocebus sabaeus	96.00	2.00e-68	250.00
IUUC-Cho-024909	Choloepus hoffmanni	87.27	2.00e-52	196.00
IUUC-Cin-025249	Ciona intestinalis	76.86	4.00e-54	202.00
IUUC-Dre-028586	Danio rerio	95.00	4.00e-65	239.00
IUUC-Dno-029506	Dasypus novemcinctus	96.00	1.00e-67	248.00
IUUC-Dor-030793	Dipodomys ordii	95.16	1.00e-67	248.00
IUUC-Ete-032996	Echinops telfairi	99.06	5.00e-59	218.00
IUUC-Eca-034195	Equus caballus	95.20	8.00e-68	248.00
IUUC-Fca-035717	Felis catus	93.81	4.00e-58	216.00
IUUC-Fal-037169	Ficedula albicollis	88.33	3.00e-60	223.00
IUUC-Gmo-038732	Gadus morhua	87.90	9.00e-64	234.00
IUUC-Gga-041131	Gallus gallus	92.80	1.00e-66	244.00
IUUC-Gac-041441	Gasterosteus aculeatus	91.74	3.00e-64	236.00
IUUC-Ggo-044417	Gorilla gorilla	96.40	2.00e-60	223.00
IUUC-Hsa-046160	Homo sapiens	96.00	2.00e-68	250.00
IUUC-Itr-048601	Ictidomys tridecemlineatus	93.75	5.00e-58	215.00
IUUC-Lch-050631	Latimeria chalumnae	92.00	6.00e-66	242.00
IUUC-Loc-052865	Lepisosteus oculatus	95.00	1.00e-65	241.00
IUUC-Laf-053756	Loxodonta africana	94.44	3.00e-66	242.00
IUUC-Mcc-054698	Macaca mulatta	96.00	2.00e-68	250.00
IUUC-Meu-056702	Macropus eugenii	83.20	2.00e-57	213.00
IUUC-Mga-059558	Meleagris gallopavo	86.40	8.00e-61	224.00
IUUC-Mdo-062675	Monodelphis domestica	95.20	9.00e-68	248.00
IUUC-Mmu-063150	Mus musculus	99.20	1.00e-70	257.00
IUUC-Mpu-066210	Mustela putorius furo	83.21	6.00e-63	232.00
IUUC-Mlu-067216	Myotis lucifugus	80.56	5.00e-62	229.00
IUUC-Nle-069962	Nomascus leucogenys	96.00	2.00e-68	250.00
IUUC-Opr-070758	Ochotona princeps	99.06	4.00e-59	219.00
IUUC-Ont-072582	Oreochromis niloticus	92.62	1.00e-64	238.00
IUUC-Oan-072816	Ornithorhynchus anatinus	89.43	2.00e-60	224.00
IUUC-Ocu-073918	Oryctolagus cuniculus	88.52	1.00e-58	218.00
IUUC-Oga-088260	Otolemur garnettii	96.00	4.00e-68	249.00
IUUC-Oar-090154	Ovis aries	95.20	9.00e-68	248.00
IUUC-Ptr-091009	Pan troglodytes	96.00	2.00e-68	250.00
IUUC-Pan-091694	Papio anubis	96.00	2.00e-68	250.00
IUUC-Psi-093327	Pelodiscus sinensis	92.86	1.00e-58	217.00
IUUC-Pma-094489	Petromyzon marinus	85.00	4.00e-58	215.00
IUUC-Pfo-096338	Poecilia formosa	89.17	3.00e-61	226.00
IUUC-Pab-098381	Pongo abelii	96.75	1.00e-67	248.00
IUUC-Pca-100621	Procavia capensis	94.40	3.00e-67	246.00
IUUC-Pva-102563	Pteropus vampyrus	95.20	9.00e-68	248.00
IUUC-Sha-107561	Sarcophilus harrisii	93.86	7.00e-60	222.00
IUUC-Sar-113048	Sorex araneus	95.51	6.00e-47	177.00
IUUC-Ssc-116253	Sus scrofa	95.20	9.00e-68	248.00
IUUC-Tgu-117120	Taeniopygia guttata	95.04	3.00e-66	243.00
IUUC-Tru-118140	Takifugu rubripes	94.17	2.00e-64	237.00
IUUC-Tsy-118793	Tarsius syrichta	94.64	1.00e-59	220.00
IUUC-Tbe-127594	Tupaia belangeri	94.59	5.00e-59	218.00
IUUC-Ttr-128932	Tursiops truncatus	95.20	9.00e-68	248.00
IUUC-Vpa-130747	Vicugna pacos	95.50	9.00e-60	221.00
IUUC-Xtr-132757	Xenopus tropicalis	94.35	2.00e-66	243.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence