iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

iUUCD ID

IUUC-Mpu-066608

Ensembl Protein ID

ENSMPUP00000007438.1

UniProt Accession

M3Y7Y1; M3Y7Y1_MUSPF

Genbank Protein ID

ENSMPUP00000007438

Protein Name

E3 ubiquitin-protein ligase

Genbank Nucleotide ID

AEYP01015946

Gene Name

WWP2

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSMPUG00000007494.1	ENSMPUT00000007558.1	ENSMPUP00000007438.1

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 activity/HECT	7.50e-126	420.0	538	871

Active Site

Position(s)	Description	Evidence
840	Glycyl thioester intermediate	{ECO:0000256\|PIRSR:PIRSR001569-1, ECO:0000256\|PROSITE-ProRule:PRU00104}

Domain Profile

E3 activity/HECT

   S: 2    ksdlkkrlevefvgEegldlgGvtreflallskelqnpdlglflysendketlqpnpdsglknpehlklFeflGrllgkalqdgrlldl 90
           ++dl++rl++ ++gEegld+gG++re+++lls+e+ np+++lf+y  +++++lq+np+s + np+hl +F+f+Gr++++al++g+++d+
   Q: 538  PYDLRRRLYIIMRGEEGLDYGGIAREWFFLLSHEVLNPMYCLFEYAGKNNYCLQINPASSI-NPDHLTYFRFIGRFIAMALYHGKFIDT 625
           6799********************************************************9.89************************* PP
   S: 91   plsksfyklllgk.klsledleevdpelykslkeikenaesdieelgldltfsvseeilgetkeeeLkpgGenipVtneNkeeYvklvv 178
            ++ +fyk++l+k + +l++          +l +iken   ++ee+gl+l f ++ eilg+++++eLk+gGe+i+Vt+eNk+eY+ l++
   Q: 626  GFTLPFYKRMLNKrPRQLQNSLHASGRGPVQLLWIKEN---NLEECGLELYFIQDMEILGKVTTHELKEGGESIRVTEENKDEYIMLLT 711
           *************4445555555555555558899988...9*********************************************** PP
   S: 179  eyrlkegikeqveafreGfneviplellslFteeelellicGeeeidvedlkketkykggytedspaiqwFwevleefsseerkafLqF 267
           ++r+++g++eq++af +Gfnev ple+l++F+e+elel++cG++eid++d++k+t y++ yt++s++iqwFw+v++e+++e+r ++LqF
   Q: 712  DWRFTRGVEEQTKAFLDGFNEVAPLEWLRYFDEKELELMLCGMQEIDMSDWQKNTIYRH-YTKNSKQIQWFWQVVKEMDNEKRIRLLQF 799
           *********************************************************99.***************************** PP
   S: 268  vTgssrlPlgGfaelk....prlfvirkdasddrlPssnTCfnyLkLPeYsskeilkekLlyAieetkgFel 335
           vTg++rlP+gGfael     p++f+i + +++++lP+s+TCfn+L+LP+Y+s+e+lkekLlyAieet+gF++
   Q: 800  VTGTCRLPVGGFAELIgsngPQKFCIDRVGKETWLPRSHTCFNRLDLPPYKSYEQLKEKLLYAIEETEGFGQ 871
           **********************************************************************96 PP

Organism

Mustela putorius furo

Protein Sequence
(Fasta)

MASASSSRAG VALPFEKSQL TLKVVSAKPK VHNRQPRINS FVEVAVDGLP SETKKTGKRI 60
GSSELLWNEI IILNVTAQSH LDLKVWSCHT LRNELLGTAS VNLSNVLKNN GGKMENTQLT 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

ATGGCATCTG CCAGCTCCAG CCGGGCAGGA GTGGCCCTGC CTTTTGAGAA GTCGCAGCTT 60
ACTTTGAAAG GTGAGTGGCA CCCTGGGAAA TGTTTTCTGT TTGAGGTCCA GCACAGTCTA 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-1185--Reference proteome
KW-0808--Transferase
KW-0833--Ubl conjugation pathway

Interpro

IPR000008--C2_dom
IPR024928--E3_ub_ligase_SMURF1
IPR000569--HECT_dom
IPR001202--WW_dom

PROSITE

PS50237--HECT
PS01159--WW_DOMAIN_1
PS50020--WW_DOMAIN_2

Pfam

PF00632--HECT
PF00397--WW

SMART

SM00239--C2
SM00119--HECTc
SM00456--WW

Gene Ontology

GO:0005737--C:cytoplasm
GO:0070062--C:extracellular exosome
GO:0016020--C:membrane
GO:0005634--C:nucleus
GO:0001190--F:transcriptional activator activity, RNA polymerase II transcription factor binding
GO:0061630--F:ubiquitin protein ligase activity
GO:0051224--P:negative regulation of protein transport
GO:0043433--P:negative regulation of sequence-specific DNA binding transcription factor activity
GO:0032410--P:negative regulation of transporter activity
GO:0043161--P:proteasome-mediated ubiquitin-dependent protein catabolic process
GO:0051865--P:protein autoubiquitination
GO:0070534--P:protein K63-linked ubiquitination
GO:0042391--P:regulation of membrane potential
GO:1901016--P:regulation of potassium ion transmembrane transporter activity

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001575	Ailuropoda melanoleuca	95.19	0.00e+00	1607.00
IUUC-Apl-003912	Anas platyrhynchos	73.80	0.00e+00	1178.00
IUUC-Aca-004291	Anolis carolinensis	78.62	0.00e+00	1385.00
IUUC-Bta-013231	Bos taurus	93.46	0.00e+00	1557.00
IUUC-Cja-019455	Callithrix jacchus	93.35	0.00e+00	1628.00
IUUC-Cfa-021017	Canis familiaris	95.30	0.00e+00	1592.00
IUUC-Cpo-021988	Cavia porcellus	93.35	0.00e+00	1610.00
IUUC-Csa-023549	Chlorocebus sabaeus	93.46	0.00e+00	1637.00
IUUC-Dre-028513	Danio rerio	88.81	0.00e+00	1093.00
IUUC-Dno-028976	Dasypus novemcinctus	93.70	0.00e+00	1624.00
IUUC-Dor-030176	Dipodomys ordii	89.50	0.00e+00	1444.00
IUUC-Eca-033949	Equus caballus	94.38	0.00e+00	1606.00
IUUC-Eeu-034529	Erinaceus europaeus	87.61	0.00e+00	1351.00
IUUC-Fca-036236	Felis catus	95.30	0.00e+00	1646.00
IUUC-Fal-036948	Ficedula albicollis	76.67	0.00e+00	1287.00
IUUC-Gmo-038842	Gadus morhua	86.09	0.00e+00	1028.00
IUUC-Gga-040617	Gallus gallus	77.73	0.00e+00	1368.00
IUUC-Gac-041338	Gasterosteus aculeatus	67.38	0.00e+00	1199.00
IUUC-Ggo-045278	Gorilla gorilla	93.92	0.00e+00	1642.00
IUUC-Hsa-046148	Homo sapiens	93.92	0.00e+00	1644.00
IUUC-Itr-047945	Ictidomys tridecemlineatus	94.96	0.00e+00	1080.00
IUUC-Lch-050663	Latimeria chalumnae	75.00	0.00e+00	1335.00
IUUC-Loc-052604	Lepisosteus oculatus	72.74	0.00e+00	1257.00
IUUC-Laf-053944	Loxodonta africana	93.92	0.00e+00	1624.00
IUUC-Mcc-055655	Macaca mulatta	93.58	0.00e+00	1637.00
IUUC-Meu-055953	Macropus eugenii	77.69	0.00e+00	1326.00
IUUC-Mga-060190	Meleagris gallopavo	78.27	0.00e+00	1374.00
IUUC-Mmr-060896	Microcebus murinus	93.54	0.00e+00	1580.00
IUUC-Mdo-062536	Monodelphis domestica	88.56	0.00e+00	1551.00
IUUC-Mmu-064017	Mus musculus	92.89	0.00e+00	1590.00
IUUC-Mlu-067623	Myotis lucifugus	93.12	0.00e+00	1595.00
IUUC-Nle-069496	Nomascus leucogenys	91.87	0.00e+00	1593.00
IUUC-Opr-071054	Ochotona princeps	82.26	0.00e+00	1383.00
IUUC-Ont-071279	Oreochromis niloticus	71.05	0.00e+00	1226.00
IUUC-Oan-073512	Ornithorhynchus anatinus	85.78	0.00e+00	1436.00
IUUC-Ocu-074271	Oryctolagus cuniculus	92.67	0.00e+00	1566.00
IUUC-Ola-087237	Oryzias latipes	67.34	0.00e+00	1176.00
IUUC-Oga-088164	Otolemur garnettii	94.27	0.00e+00	1635.00
IUUC-Oar-089698	Ovis aries	93.81	0.00e+00	1567.00
IUUC-Ptr-091306	Pan troglodytes	92.78	0.00e+00	1613.00
IUUC-Pan-092814	Papio anubis	90.62	0.00e+00	1562.00
IUUC-Pfo-096709	Poecilia formosa	70.61	0.00e+00	1228.00
IUUC-Pab-098494	Pongo abelii	88.11	0.00e+00	1548.00
IUUC-Pca-100596	Procavia capensis	81.37	0.00e+00	1324.00
IUUC-Pva-103154	Pteropus vampyrus	88.73	0.00e+00	1515.00
IUUC-Rno-104954	Rattus norvegicus	92.36	0.00e+00	1360.00
IUUC-Sha-106781	Sarcophilus harrisii	88.90	0.00e+00	1593.00
IUUC-Ssc-116307	Sus scrofa	85.07	0.00e+00	1443.00
IUUC-Tgu-116530	Taeniopygia guttata	73.55	0.00e+00	1131.00
IUUC-Tru-118287	Takifugu rubripes	86.49	0.00e+00	1025.00
IUUC-Tsy-119097	Tarsius syrichta	79.69	0.00e+00	1163.00
IUUC-Tni-120801	Tetraodon nigroviridis	67.74	0.00e+00	1155.00
IUUC-Tbe-127793	Tupaia belangeri	82.57	0.00e+00	1395.00
IUUC-Ttr-128275	Tursiops truncatus	89.33	0.00e+00	1508.00
IUUC-Xtr-132866	Xenopus tropicalis	80.95	0.00e+00	1105.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence