iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

UUCD2 ID

IUUC-Mlu-067011

UUCD1 version

Ensembl Protein ID

UniProt Accession

Genbank Protein ID

Protein Name

Uncharacterized protein

Genbank Nucleotide ID

AAPE02011308

Gene Name

G2E3

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSMLUG00000000531.2	ENSMLUT00000000531.2	ENSMLUP00000000482.2

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 activity/HECT	5.80e-39	134.4	387	694

Active Site

Position(s)	Description	Evidence
664	Glycyl thioester intermediate	{ECO:0000256\|PROSITE-ProRule:PRU00104}

Domain Profile

E3 activity/HECT

   S: 7    krlevefvgEe...gldlgGvtreflallskelqnpdlglflysendketlqpnpdsglknpehlklFeflGrllgkalqdgrlldlpl 92
           + +ev +v+E+   g++++G+++efl+ll+++l+n+   lf  + + +++l+ n+++      ++++++ +G++l+++l +g + + ++
   Q: 387  YTIEVAYVNENdnfGTEHPGSKQEFLSLLMQHLENSP--LF--EGSLSKNLSLNSQAL-----KENHYYEAGKMLAISLAHGGPSPGFF 466
           678999***98888*********************99..56..677777888888885.....67899999****************** PP
   S: 93   sksfyklllgkklsledleevdpelyks.lkeikenaesdieelgldltfsvseeilgetkeeeLkpgGenipVtneNkeeYvklvvey 180
           sk+++++l+  +   e++  + +++ ++ + +i+ +  ++ ++  +dl++      ++e++++  + g+ +i    ++k+   k+++ y
   Q: 467  SKTLFNCLVFGP---ENTFPTLDDVSDFdVAQILIRI-NSATNV-ADLNSI-----MNECYNYLELIGCLRIITSLSDKYLLAKDILAY 545
           ********9997...4544444555555577777663.344443.677765.....999****99************************ PP
   S: 181  rlkegikeqveafreGfneviplellslFteeelellicGeeeidvedlkketkykggytedspaiqwFwevl.eefsseerkafLq.. 266
           ++ ++++  +e+f++G++++  le+++ + e   ++++++ e++++++l++  + +  + ++s     Fw+ + +++++ + ++ L+  
   Q: 546  HVIKRVQAPFESFKQGLKTLGVLEKIQTYPEAFYSIFCHKPENLSAKMLRDLFTVHT-CDAQSL---GFWNSYlQAVEDGKSATTLEdi 630
           **************************************************9655533.444444...6777655777777776666666 PP
   S: 267  ..FvTgssrlPlgGfaelkprlfvirkdasddrlPssnTCfnyLkLPeYsskeilkekLlyAieetkgFe 334
             F+Tg++++P++Gf++ + ++ +++      ++P  n+C n+L LP  +++++++ek+ + i++t ++e
   Q: 631  liFATGCNSIPPAGFKPTP-SVECLHM-----DFPVGNKCNNCLALPITNTYKEFQEKMDFSIRNTLRLE 694
           66****************9.9999999.....********************************987665 PP

Organism

Myotis lucifugus

Protein Sequence
(Fasta)

MKINQVTHGL SACVFCRKND DCPNKYGEKK INEKWNLTVH YYCLLMSSGI WQRGKEEEGV 60
YGFLIEDIRK EVNRASKLKC CVCKKSGASI GCVAPRCKRS YHFPCGLQRE CIFQFTGNFA 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

AGTAAAATGA ATGAAAATAA ACCAAGTGAC TCACGGACTC TCGGTAAGTG ACAGTATTTA 60
AAATATTTTC AAATATAATT TAAAATATTT TACTCATGCT TTTTTATAAT AAATCTCTTC 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-0479--Metal-binding
KW-1185--Reference proteome
KW-0808--Transferase
KW-0833--Ubl conjugation pathway
KW-0862--Zinc
KW-0863--Zinc-finger

Interpro

IPR034732--EPHD
IPR000569--HECT_dom
IPR019786--Zinc_finger_PHD-type_CS
IPR011011--Znf_FYVE_PHD
IPR001965--Znf_PHD
IPR013083--Znf_RING/FYVE/PHD

PROSITE

PS51805--EPHD
PS50237--HECT
PS01359--ZF_PHD_1

Pfam

PF00632--HECT

SMART

SM00119--HECTc
SM00249--PHD

Gene Ontology

GO:0004842--F:ubiquitin-protein transferase activity
GO:0008270--F:zinc ion binding

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001501	Ailuropoda melanoleuca	91.35	0.00e+00	1337.00
IUUC-Apl-003763	Anas platyrhynchos	59.46	0.00e+00	847.00
IUUC-Aca-004328	Anolis carolinensis	60.79	0.00e+00	857.00
IUUC-Ame-011288	Astyanax mexicanus	40.46	1.00e-161	563.00
IUUC-Bta-012496	Bos taurus	86.44	0.00e+00	1267.00
IUUC-Cja-019756	Callithrix jacchus	87.57	0.00e+00	1285.00
IUUC-Cfa-020806	Canis familiaris	89.12	0.00e+00	1330.00
IUUC-Cpo-022519	Cavia porcellus	84.44	0.00e+00	1231.00
IUUC-Csa-023957	Chlorocebus sabaeus	89.05	0.00e+00	1312.00
IUUC-Cho-024375	Choloepus hoffmanni	81.24	0.00e+00	1163.00
IUUC-Cin-025325	Ciona intestinalis	42.40	3.00e-64	238.00
IUUC-Csv-026262	Ciona savignyi	43.00	2.00e-68	253.00
IUUC-Dre-027829	Danio rerio	40.57	5.00e-153	534.00
IUUC-Dno-029362	Dasypus novemcinctus	87.01	0.00e+00	1274.00
IUUC-Dor-030710	Dipodomys ordii	81.41	0.00e+00	1207.00
IUUC-Dse-031248	Dothistroma septosporum	40.38	3.00e-03	37.40
IUUC-Dme-031692	Drosophila melanogaster	34.72	9.00e-42	164.00
IUUC-Ete-032282	Echinops telfairi	78.21	0.00e+00	1099.00
IUUC-Eca-033963	Equus caballus	91.07	0.00e+00	1336.00
IUUC-Eeu-035029	Erinaceus europaeus	86.00	0.00e+00	1261.00
IUUC-Fca-036229	Felis catus	91.50	0.00e+00	1347.00
IUUC-Fal-037015	Ficedula albicollis	57.40	0.00e+00	854.00
IUUC-Gmo-039715	Gadus morhua	40.16	3.00e-78	285.00
IUUC-Gga-040298	Gallus gallus	58.55	0.00e+00	887.00
IUUC-Gac-041444	Gasterosteus aculeatus	38.87	2.00e-139	489.00
IUUC-Ggo-045456	Gorilla gorilla	88.90	0.00e+00	1306.00
IUUC-Hsa-046297	Homo sapiens	88.26	0.00e+00	1317.00
IUUC-Itr-047897	Ictidomys tridecemlineatus	86.08	0.00e+00	905.00
IUUC-Lch-050287	Latimeria chalumnae	66.14	2.00e-104	373.00
IUUC-Loc-052839	Lepisosteus oculatus	58.00	4.00e-32	129.00
IUUC-Laf-053581	Loxodonta africana	86.69	0.00e+00	1273.00
IUUC-Mcc-055615	Macaca mulatta	89.05	0.00e+00	1313.00
IUUC-Meu-056753	Macropus eugenii	46.84	2.00e-123	436.00
IUUC-Mga-059902	Meleagris gallopavo	58.55	0.00e+00	890.00
IUUC-Mmr-061522	Microcebus murinus	89.53	0.00e+00	1323.00
IUUC-Mdo-063022	Monodelphis domestica	64.18	0.00e+00	878.00
IUUC-Mmu-063609	Mus musculus	76.92	0.00e+00	1151.00
IUUC-Mpu-066656	Mustela putorius furo	88.83	0.00e+00	1336.00
IUUC-Nle-069949	Nomascus leucogenys	88.90	0.00e+00	1307.00
IUUC-Opr-071224	Ochotona princeps	81.58	5.00e-127	448.00
IUUC-Ont-072174	Oreochromis niloticus	36.48	1.00e-134	474.00
IUUC-Oan-072712	Ornithorhynchus anatinus	66.43	0.00e+00	952.00
IUUC-Ocu-073776	Oryctolagus cuniculus	88.47	0.00e+00	1293.00
IUUC-Ola-087247	Oryzias latipes	37.78	8.00e-131	461.00
IUUC-Oga-088094	Otolemur garnettii	85.15	0.00e+00	1201.00
IUUC-Oar-090248	Ovis aries	86.72	0.00e+00	1270.00
IUUC-Ptr-090634	Pan troglodytes	89.19	0.00e+00	1313.00
IUUC-Pan-092876	Papio anubis	89.19	0.00e+00	1314.00
IUUC-Psi-093580	Pelodiscus sinensis	60.98	0.00e+00	869.00
IUUC-Pma-094295	Petromyzon marinus	52.78	8.00e-73	266.00
IUUC-Pfo-096351	Poecilia formosa	37.43	4.00e-144	505.00
IUUC-Pab-097596	Pongo abelii	89.63	0.00e+00	1316.00
IUUC-Pca-100309	Procavia capensis	80.12	0.00e+00	1167.00
IUUC-Pva-102526	Pteropus vampyrus	94.98	0.00e+00	878.00
IUUC-Rno-105432	Rattus norvegicus	80.06	0.00e+00	1181.00
IUUC-Sha-107089	Sarcophilus harrisii	65.21	0.00e+00	999.00
IUUC-Sar-113667	Sorex araneus	67.20	0.00e+00	945.00
IUUC-Ssc-116200	Sus scrofa	89.19	0.00e+00	1310.00
IUUC-Tgu-116467	Taeniopygia guttata	56.89	0.00e+00	847.00
IUUC-Tru-117690	Takifugu rubripes	38.57	2.00e-154	539.00
IUUC-Tsy-119481	Tarsius syrichta	87.30	0.00e+00	892.00
IUUC-Tni-119669	Tetraodon nigroviridis	37.20	3.00e-134	472.00
IUUC-Tbe-127241	Tupaia belangeri	82.31	0.00e+00	1124.00
IUUC-Ttr-129057	Tursiops truncatus	90.28	0.00e+00	1011.00
IUUC-Vpa-130685	Vicugna pacos	86.87	0.00e+00	1239.00
IUUC-Xtr-132555	Xenopus tropicalis	52.49	0.00e+00	733.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence