iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

UUCD2 ID

IUUC-Tni-120781

UUCD1 version

UUC-TeN-00761

Ensembl Protein ID

ENSTNIP00000017123.1

UniProt Accession

H3D9D2; H3D9D2_TETNG

Protein Name

Uncharacterized protein

Gene Name

SMURF2

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSTNIG00000014114.1	ENSTNIT00000017339.1	ENSTNIP00000017123.1
ENSTNIG00000014114.1	ENSTNIT00000000070.1	ENSTNIP00000003099.1

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 activity/HECT	1.20e-127	426.1	312	644

Active Site

Position(s)	Description	Evidence
613	Glycyl thioester intermediate	{ECO:0000256\|PIRSR:PIRSR001569-1, ECO:0000256\|PROSITE-ProRule:PRU00104}

Domain Profile

E3 activity/HECT

   S: 2    ksdlkkrlevefvgEegldlgGvtreflallskelqnpdlglflysendketlqpnpdsglknpehlklFeflGrllgkalqdgrlldl 90
           ++dl krl+++f+gEegld+gGv+re+l+lls+e+ np++glf+y+ +d +tlq+npds + npehl++F+f+Gr++g+a+++g+++d 
   Q: 312  PKDLWKRLMIKFRGEEGLDYGGVAREWLYLLSHEMLNPYYGLFQYTRDDIYTLQINPDSAV-NPEHLSYFHFVGRIMGMAVFHGHYIDG 399
           678999*****************************************************98.89************************* PP
   S: 91   plsksfyklllgkklsledleevdpelykslkeikenaesdieelgldltfsvseeilgetkeeeLkpgGenipVtneNkeeYvklvve 179
            ++ +fyk+llgk+++l+d+e+vdp+ly+sl +i++n   di+   ld tf+v+++ +ge+ ++eLkp+G++i+V ++ k+eYv+l+v+
   Q: 400  GFTLPFYKQLLGKSITLDDMESVDPDLYNSLVWILDN---DITGV-LDHTFCVEHNAYGEIIQHELKPNGKTISVSEDTKKEYVRLYVN 484
           ***********************************99...9***8.******************************************* PP
   S: 180  yrlkegikeqveafreGfneviplellslFteeelellicGeeeidvedlkketkykggytedspaiqwFwevleefsseerkafLqFv 268
           +r+  gi+ q+ a+++Gfnevip++ll++F+e+elel++cG  +id++d+k++t+ k+ +t+ds+ ++wFw+++e+f++e r+++LqFv
   Q: 485  WRFLHGIEAQFLALQKGFNEVIPQHLLKSFDEKELELIVCGLGKIDISDWKANTRLKH-CTPDSNIVKWFWKAVESFDEERRARLLQFV 572
           ********************************************************99.****************************** PP
   S: 269  TgssrlPlgGfaelk....prlfvirk.dasddrlPssnTCfnyLkLPeYsskeilkekLlyAieetkgFel 335
           Tgssr+Pl+Gf++l+    prlf+i++ da++++lP+++TCfn++++P+Y+ +e+l++kLl+Aieet gF +
   Q: 573  TGSSRVPLQGFKALQgaagPRLFTIHQiDANTNNLPKAHTCFNRIDIPPYEGYEKLYDKLLTAIEETCGFAV 644
           ***************************99999**************************************76 PP

Organism

Tetraodon nigroviridis

Protein Sequence
(Fasta)

QRLDLNKLGP NDNDTVRGQI VVSLQSRDRI GSGGPVVDCS RLFDNDLPDG WEERRTASGR 60
IQYLNHITRT TQWERPTRPA SEYSSPSGRP LSCVVDENTP VMTPVNGAEA SVPPGEQRIQ 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

CAGAGACTGG ATTTAAATAA ACTCGGCCCC AATGACAACG ACACCGTGAG AGGACAAATA 60
GTTGGTAAGA AACACACGCT TTTCTGTCTG GCCTTATTTC TTTTATTGTG CATTTTATGT 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-1185--Reference proteome
KW-0808--Transferase
KW-0833--Ubl conjugation pathway

Interpro

IPR000569--HECT_dom
IPR001202--WW_dom

PROSITE

PS50237--HECT
PS01159--WW_DOMAIN_1
PS50020--WW_DOMAIN_2

Pfam

PF00632--HECT
PF00397--WW

SMART

SM00119--HECTc
SM00456--WW

Gene Ontology

GO:0004842--F:ubiquitin-protein transferase activity

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001305	Ailuropoda melanoleuca	89.30	0.00e+00	1185.00
IUUC-Apl-003513	Anas platyrhynchos	89.92	0.00e+00	1199.00
IUUC-Aca-005358	Anolis carolinensis	90.85	0.00e+00	1203.00
IUUC-Ame-011320	Astyanax mexicanus	88.45	0.00e+00	1193.00
IUUC-Bta-013399	Bos taurus	89.46	0.00e+00	1185.00
IUUC-Cja-019355	Callithrix jacchus	89.77	0.00e+00	1189.00
IUUC-Cpo-022200	Cavia porcellus	89.46	0.00e+00	1187.00
IUUC-Cho-024804	Choloepus hoffmanni	93.53	3.00e-177	614.00
IUUC-Cin-025126	Ciona intestinalis	62.18	0.00e+00	776.00
IUUC-Dre-027650	Danio rerio	90.02	0.00e+00	1228.00
IUUC-Dno-029534	Dasypus novemcinctus	89.30	0.00e+00	1182.00
IUUC-Ete-032715	Echinops telfairi	84.19	0.00e+00	1098.00
IUUC-Eca-033580	Equus caballus	89.46	0.00e+00	1185.00
IUUC-Eeu-034945	Erinaceus europaeus	88.89	0.00e+00	1117.00
IUUC-Fca-036047	Felis catus	90.84	0.00e+00	968.00
IUUC-Fal-037275	Ficedula albicollis	90.39	0.00e+00	1202.00
IUUC-Gga-041060	Gallus gallus	86.36	0.00e+00	1122.00
IUUC-Gac-041983	Gasterosteus aculeatus	96.28	0.00e+00	1301.00
IUUC-Hsa-046726	Homo sapiens	89.61	0.00e+00	1183.00
IUUC-Itr-048042	Ictidomys tridecemlineatus	90.84	0.00e+00	969.00
IUUC-Lch-050026	Latimeria chalumnae	90.54	0.00e+00	1188.00
IUUC-Loc-051760	Lepisosteus oculatus	86.73	0.00e+00	1179.00
IUUC-Laf-053753	Loxodonta africana	89.61	0.00e+00	1186.00
IUUC-Mcc-054815	Macaca mulatta	89.61	0.00e+00	1183.00
IUUC-Meu-056436	Macropus eugenii	74.16	0.00e+00	912.00
IUUC-Mmr-060806	Microcebus murinus	89.46	0.00e+00	1186.00
IUUC-Mdo-062805	Monodelphis domestica	89.61	0.00e+00	1186.00
IUUC-Mmu-064034	Mus musculus	89.92	0.00e+00	1187.00
IUUC-Mpu-066762	Mustela putorius furo	89.46	0.00e+00	1187.00
IUUC-Mlu-066981	Myotis lucifugus	89.30	0.00e+00	1183.00
IUUC-Nle-069804	Nomascus leucogenys	89.61	0.00e+00	1185.00
IUUC-Opr-070591	Ochotona princeps	84.03	0.00e+00	1095.00
IUUC-Ont-072243	Oreochromis niloticus	93.52	0.00e+00	1291.00
IUUC-Oan-072699	Ornithorhynchus anatinus	87.75	0.00e+00	1187.00
IUUC-Ocu-074913	Oryctolagus cuniculus	89.46	0.00e+00	1184.00
IUUC-Ola-087161	Oryzias latipes	86.30	0.00e+00	1096.00
IUUC-Oga-089116	Otolemur garnettii	85.58	0.00e+00	1125.00
IUUC-Oar-089366	Ovis aries	89.46	0.00e+00	1186.00
IUUC-Ptr-091382	Pan troglodytes	89.61	0.00e+00	1183.00
IUUC-Psi-093298	Pelodiscus sinensis	89.46	0.00e+00	1179.00
IUUC-Pfo-096142	Poecilia formosa	92.25	0.00e+00	1251.00
IUUC-Pab-098682	Pongo abelii	89.61	0.00e+00	1184.00
IUUC-Pca-100516	Procavia capensis	85.17	4.00e-175	608.00
IUUC-Pva-102754	Pteropus vampyrus	88.06	0.00e+00	1151.00
IUUC-Rno-105600	Rattus norvegicus	89.92	0.00e+00	1188.00
IUUC-Sha-107144	Sarcophilus harrisii	89.30	0.00e+00	1181.00
IUUC-Sar-113122	Sorex araneus	83.10	0.00e+00	1070.00
IUUC-Tgu-117112	Taeniopygia guttata	89.92	0.00e+00	1189.00
IUUC-Tru-118497	Takifugu rubripes	98.46	0.00e+00	1295.00
IUUC-Tsy-118819	Tarsius syrichta	87.68	0.00e+00	852.00
IUUC-Tbe-127371	Tupaia belangeri	84.33	0.00e+00	1000.00
IUUC-Ttr-129305	Tursiops truncatus	82.52	0.00e+00	999.00
IUUC-Vpa-130591	Vicugna pacos	78.76	0.00e+00	1001.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence