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Basic Information Integrated Annotations
Tag Content
UUCD2 ID IUUC-Hsa-046120
UUCD1 version UUC-HoS-00839
Ensembl Protein ID ENSP00000341342.3
UniProt Accession Q8WZ60; B2RB31; D3DNS8; Q8N5I1; Q8N892; KLHL6_HUMAN
Genbank Protein ID BAC04957.1; BAG37078.1; EAW78324.1; EAW78325.1; AAH32348.1; AAL35594.1
Protein Name Kelch-like protein 6
Genbank Nucleotide ID AK097125; AK314473; AC092960; CH471052; BC032348; AF441792
Gene Name KLHL6
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
ENSG00000172578.11 ENST00000341319.7 ENSP00000341342.3
Annotation
Cancer Mutation
TCGAICGCCOSMICCGAP
IntOGen
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEOArrayExpressTCGAICGC
COSMICTHPAHPM
DNA & RNA Element
UTRdbAREsiteCircNetmiRTarBase
microRNATRANSFACTargetScanRepTar
miRNAMapmiRcodeRAID2
Protein-protein Interaction
IIDiRefIndexHINTMentha
InWeb_IM
Disease-associated Variation
ClinVarGWASdbOMIM
Post-translational Modifications (PTMs)
CPLMdbPAFPhosphositePlusdbPTM
BioGRIDmUbiSiDa
DNA Methylation
TCGAICGCCOSMIC
Protein Expression/Proteomics
THPAGPMDB
Status Unreviewed
Classification
Family E-Value Score Start End
E3 adaptor/Cullin RING/BCR/BTB_3-box: BTB 5.80e-19 69.9 72 135
E3 adaptor/Cullin RING/BCR/BTB_3-box: 3-box 7.30e-11 41.2 171 201
Active Site
Position(s) Description Evidence
N/A N/A N/A
Domain Profile

   E3 adaptor/Cullin RING/BCR/BTB_3-box: BTB
   S: 1    aDvilvvggeeffahkivLaasSsvFyalflmeleesksklmveikdvqpevfrallkFlYtgkl 65
           +Dvil+v+ +ef++h++vLaa+S +F+a+f ++l+e+  ++++ ik+v++e + +ll++ Yt+k+
   Q: 72   TDVILCVDIQEFSCHRVVLAAASNYFRAMFCNDLKEKY-EKRIIIKGVDAETMHTLLDYTYTSKA 135
           7***********************************97.***********************987 PP
   

   E3 adaptor/Cullin RING/BCR/BTB_3-box: 3-box
   S: 1    leNclgilrfAdlydcpdLkdaaldfilkhF 31
           +eNc+gilr+Ad+++++ Lk++++++i+++F
   Q: 171  PENCVGILRLADTHSLDSLKKQVQSYIIQNF 201
           89***************************** PP
   
Organism Homo sapiens
Functional Description
(View)

Functional Description


     Involved in B-lymphocyte antigen receptor signaling and germinal center formation.
 Involved in B-lymphocyte antigen receptor signaling and germinal center formation.
Protein Sequence
(Fasta)
MLMAGQRGAW TMGDVVEKSL EGPLAPSTDE PSQKTGDLVE ILNGEKVKFD DAGLSLILQN 60
GLETLRMENA LTDVILCVDI QEFSCHRVVL AAASNYFRAM FCNDLKEKYE KRIIIKGVDA 120
It may take some time, please wait.

Protein Fasta Sequence


>IUUC-Hsa-046120|E3,BTB_3-box|Homo sapiens
Please wait for a moment...
Nucleotide Sequence
(Fasta)
GGGCCTGCCT GACACTTGGG CGCTCCTTCA GTCTCGATGT TGATGGCAGG ACAAAGGGGC 60
GCCTGGACCA TGGGTGATGT GGTCGAGAAG AGTTTGGAAG GGCCCCTGGC ACCTTCTACA 120
It may take some time, please wait.

Nucleotide Fasta Sequence


>IUUC-Hsa-046120|E3,BTB_3-box|Homo sapiens
Please wait for a moment...
Sequence Source Ensembl
Keyword

KW-0181--Complete proteome
KW-0880--Kelch repeat
KW-0621--Polymorphism
KW-1185--Reference proteome
KW-0677--Repeat
Interpro

IPR011705--BACK
IPR017096--BTB-kelch_protein
IPR000210--BTB/POZ_dom
IPR015915--Kelch-typ_b-propeller
IPR006652--Kelch_1
IPR029851--KLHL6
IPR011333--SKP1/BTB/POZ
PROSITE

PS50097--BTB
Pfam

PF07707--BACK
PF00651--BTB
PF01344--Kelch_1
SMART

SM00875--BACK
SM00225--BTB
SM00612--Kelch
Gene Ontology

GO:0005737--C:cytoplasm
GO:0005634--C:nucleus
GO:0003700--F:transcription factor activity, sequence-specific DNA binding
GO:0000976--F:transcription regulatory region sequence-specific DNA binding
GO:0050853--P:B cell receptor signaling pathway
GO:0002467--P:germinal center formation
GO:0045893--P:positive regulation of transcription, DNA-templated
GO:0006357--P:regulation of transcription from RNA polymerase II promoter
KEGG hsa:89857
Orthology
iUUCD ID Species Identity E-value Score
IUUC-Aml-001509 Ailuropoda melanoleuca 98.07 0.00e+00 1275.00
IUUC-Apl-003490 Anas platyrhynchos 85.41 0.00e+00 1110.00
IUUC-Aca-005136 Anolis carolinensis 82.16 0.00e+00 1065.00
IUUC-Ame-010886 Astyanax mexicanus 66.77 0.00e+00 828.00
IUUC-Bta-013473 Bos taurus 96.62 0.00e+00 1231.00
IUUC-Cja-018888 Callithrix jacchus 98.36 0.00e+00 1256.00
IUUC-Cpo-021761 Cavia porcellus 88.51 0.00e+00 1112.00
IUUC-Csa-023206 Chlorocebus sabaeus 99.84 0.00e+00 1293.00
IUUC-Cin-025367 Ciona intestinalis 40.79 2.00e-132 466.00
IUUC-Csv-026076 Ciona savignyi 41.21 7.00e-126 444.00
IUUC-Dre-027948 Danio rerio 73.22 0.00e+00 902.00
IUUC-Dno-030045 Dasypus novemcinctus 96.93 0.00e+00 1258.00
IUUC-Dor-030839 Dipodomys ordii 88.89 0.00e+00 1124.00
IUUC-Ete-033161 Echinops telfairi 93.15 1.00e-160 560.00
IUUC-Eca-033608 Equus caballus 96.78 0.00e+00 1233.00
IUUC-Eeu-034640 Erinaceus europaeus 94.92 0.00e+00 1211.00
IUUC-Fca-036065 Felis catus 96.94 0.00e+00 1263.00
IUUC-Fal-036949 Ficedula albicollis 85.83 0.00e+00 1092.00
IUUC-Gmo-039661 Gadus morhua 58.12 5.00e-175 607.00
IUUC-Gga-040740 Gallus gallus 84.26 0.00e+00 1097.00
IUUC-Gac-042413 Gasterosteus aculeatus 61.35 0.00e+00 782.00
IUUC-Ggo-045167 Gorilla gorilla 99.84 0.00e+00 1294.00
IUUC-Itr-047926 Ictidomys tridecemlineatus 97.26 0.00e+00 1263.00
IUUC-Lch-049709 Latimeria chalumnae 79.32 0.00e+00 1036.00
IUUC-Loc-052239 Lepisosteus oculatus 77.70 0.00e+00 973.00
IUUC-Laf-054511 Loxodonta africana 96.23 0.00e+00 1232.00
IUUC-Mcc-055109 Macaca mulatta 99.84 0.00e+00 1289.00
IUUC-Meu-056522 Macropus eugenii 74.79 6.00e-104 371.00
IUUC-Mga-060012 Meleagris gallopavo 82.39 0.00e+00 1068.00
IUUC-Mmr-061364 Microcebus murinus 97.26 0.00e+00 1264.00
IUUC-Mdo-063033 Monodelphis domestica 82.95 0.00e+00 1016.00
IUUC-Mmu-063880 Mus musculus 94.67 0.00e+00 1193.00
IUUC-Mlu-068233 Myotis lucifugus 96.46 0.00e+00 1230.00
IUUC-Opr-070638 Ochotona princeps 95.54 0.00e+00 890.00
IUUC-Ont-071960 Oreochromis niloticus 61.58 0.00e+00 785.00
IUUC-Oan-073406 Ornithorhynchus anatinus 83.77 0.00e+00 1075.00
IUUC-Ocu-074612 Oryctolagus cuniculus 96.45 0.00e+00 1248.00
IUUC-Ola-087181 Oryzias latipes 59.19 0.00e+00 761.00
IUUC-Oga-088955 Otolemur garnettii 96.78 0.00e+00 1256.00
IUUC-Oar-089682 Ovis aries 96.62 0.00e+00 1231.00
IUUC-Ptr-090969 Pan troglodytes 99.84 0.00e+00 1293.00
IUUC-Pan-092289 Papio anubis 99.84 0.00e+00 1293.00
IUUC-Psi-093279 Pelodiscus sinensis 85.20 0.00e+00 1115.00
IUUC-Pab-097957 Pongo abelii 100.00 0.00e+00 952.00
IUUC-Pca-100619 Procavia capensis 93.06 0.00e+00 1220.00
IUUC-Pva-102533 Pteropus vampyrus 96.59 0.00e+00 755.00
IUUC-Rno-106111 Rattus norvegicus 94.83 0.00e+00 1224.00
IUUC-Sha-106716 Sarcophilus harrisii 83.63 0.00e+00 1070.00
IUUC-Tgu-116839 Taeniopygia guttata 85.25 0.00e+00 1105.00
IUUC-Tru-117792 Takifugu rubripes 60.13 0.00e+00 759.00
IUUC-Tsy-119609 Tarsius syrichta 91.75 4.00e-164 571.00
IUUC-Tni-119682 Tetraodon nigroviridis 60.10 0.00e+00 763.00
IUUC-Tme-127039 Tuber melanosporum 31.37 3.00e-12 68.20
IUUC-Tbe-127961 Tupaia belangeri 91.31 0.00e+00 1121.00
IUUC-Ttr-128917 Tursiops truncatus 95.78 0.00e+00 1048.00
IUUC-Vpa-130721 Vicugna pacos 97.64 0.00e+00 866.00
Created Date 25-Jun-2017

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