iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Basic Information

Integrated Annotations

Tag

Content

UUCD2 ID

IUUC-Mmu-064139

UUCD1 version

UUC-MuM-00893

Ensembl Protein ID

ENSMUSP00000004120.2

UniProt Accession

Q9CR14; Q3TGY2; Q9D017; FANCL_MOUSE

Genbank Protein ID

AAN64921.1; BAB25772.1; BAB27674.1; BAB27820.1; BAB27906.1; BAB31039.1; BAC36123.1; BAE40416.1; AAH66181.1; AAH32876.1

Protein Name

E3 ubiquitin-protein ligase FANCL; Fanconi anemia group L protein homolog; Proliferation of germ cells protein; RING-type E3 ubiquitin transferase FANCL

Genbank Nucleotide ID

AF513619; AK008605; AK011520; AK011752; AK011903; AK018018; AK076017; AK168538; BC066181; BC032876

Gene Name

Fancl; Phf9; Pog

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSMUSG00000004018.9	ENSMUST00000004120.8	ENSMUSP00000004120.2
ENSMUSG00000004018.9	ENSMUST00000109509.7	ENSMUSP00000105135.1
ENSMUSG00000004018.9	ENSMUST00000136830.1	ENSMUSP00000117073.1
ENSMUSG00000004018.9	ENSMUST00000134445.1	ENSMUSP00000119873.1

Annotation

Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEO	ArrayExpress	GXD
DNA & RNA Element
AREsite	circBase	microRNA	TRANSFAC
RepTar	miRNAMap	RAID2
Protein-protein Interaction
IID	iRefIndex	Mentha
Protein Expression/Proteomics
GPMDB

Status

Unreviewed

Classification

Family	Identity	E-Value	Score	Source Orthology
E3 activity/RING/RING	65.42	3.00e-136	481.00	IUUC-Gga-040220
E3 activity/RING/RING	79.41	4.00e-169	592.00	IUUC-Hsa-046788

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Organism

Mus musculus

Functional Description
(View)

Ubiquitin ligase protein that mediates monoubiquitination of FANCD2, a key step in the DNA damage pathway. Also mediates monoubiquitination of FANCI. May stimulate the ubiquitin release from UBE2W. May be required for proper primordial germ cell proliferation in the embryonic stage, whereas it is probably not needed for spermatogonial proliferation after birth.

Protein Sequence
(Fasta)

MDEAEASLLR HFPLLLPQNR EKTVYEGFIS AQGSDFHLRI VLPKDLQLKK ARLLCSLQLK 60
NILNEYHQVV QQRMKHSPDL MSFMMELKMI LEVALKNKQE LCVQPPSCSF CKDLLTEIGA 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

AGTGCTGACA ACACTGCAAT CTGAGTCACA TTTTGAGAAA GTCTTATCAT ACTGGTTCTC 60
CAAAAACACT TAAATTGTGA TTCATAACAG TAGCAAAATT ACGGTTACAA AGAAGCAACA 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0025--Alternative splicing
KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0227--DNA damage
KW-0234--DNA repair
KW-0479--Metal-binding
KW-0539--Nucleus
KW-1185--Reference proteome
KW-0808--Transferase
KW-0832--Ubl conjugation
KW-0833--Ubl conjugation pathway
KW-0862--Zinc
KW-0863--Zinc-finger

Interpro

IPR026848--Fancl
IPR026850--FANCL_C
IPR019162--FancL_WD-rpt_cont_dom
IPR013083--Znf_RING/FYVE/PHD

Pfam

PF11793--FANCL_C
PF09765--WD-3

Gene Ontology

GO:0005737--C:cytoplasm
GO:0043240--C:Fanconi anaemia nuclear complex
GO:0043231--C:intracellular membrane-bounded organelle
GO:0016604--C:nuclear body
GO:0005635--C:nuclear envelope
GO:0046872--F:metal ion binding
GO:0061630--F:ubiquitin protein ligase activity
GO:0031625--F:ubiquitin protein ligase binding
GO:0004842--F:ubiquitin-protein transferase activity
GO:0006974--P:cellular response to DNA damage stimulus
GO:0006281--P:DNA repair
GO:0007276--P:gamete generation
GO:0006513--P:protein monoubiquitination
GO:0042127--P:regulation of cell proliferation

KEGG

mmu:67030

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Ata-000947	Aegilops tauschii	34.83	1.00e-28	121.00
IUUC-Aml-002195	Ailuropoda melanoleuca	79.58	3.00e-180	624.00
IUUC-Atr-002781	Amborella trichopoda	30.83	2.00e-51	196.00
IUUC-Apl-004169	Anas platyrhynchos	65.53	9.00e-141	493.00
IUUC-Aca-004265	Anolis carolinensis	66.67	3.00e-150	524.00
IUUC-Aly-005687	Arabidopsis lyrata	33.81	3.00e-46	178.00
IUUC-Ath-007450	Arabidopsis thaliana	34.75	2.00e-47	182.00
IUUC-Ame-011485	Astyanax mexicanus	57.88	3.00e-131	461.00
IUUC-Bta-012445	Bos taurus	79.14	1.00e-170	592.00
IUUC-Bol-015164	Brassica oleracea	34.17	7.00e-47	181.00
IUUC-Bra-017917	Brassica rapa	35.25	8.00e-49	187.00
IUUC-Cja-019671	Callithrix jacchus	78.89	1.00e-179	622.00
IUUC-Cfa-020724	Canis familiaris	77.31	4.00e-172	597.00
IUUC-Cpo-022262	Cavia porcellus	79.68	0.00e+00	631.00
IUUC-Cre-022596	Chlamydomonas reinhardtii	54.90	5.00e-13	68.90
IUUC-Csa-023404	Chlorocebus sabaeus	79.68	0.00e+00	626.00
IUUC-Cho-024948	Choloepus hoffmanni	69.23	5.00e-149	520.00
IUUC-Cin-025665	Ciona intestinalis	33.99	3.00e-62	232.00
IUUC-Csv-026047	Ciona savignyi	33.24	1.00e-62	233.00
IUUC-Cme-027255	Cyanidioschyzon merolae	27.88	2.00e-41	163.00
IUUC-Dre-027613	Danio rerio	56.20	3.00e-129	454.00
IUUC-Dno-029829	Dasypus novemcinctus	79.52	4.00e-178	617.00
IUUC-Dor-031075	Dipodomys ordii	68.28	2.00e-141	494.00
IUUC-Dme-031934	Drosophila melanogaster	26.37	8.00e-15	74.70
IUUC-Eca-033981	Equus caballus	79.07	1.00e-165	575.00
IUUC-Eeu-034830	Erinaceus europaeus	73.39	3.00e-162	564.00
IUUC-Fca-036219	Felis catus	79.73	8.00e-179	619.00
IUUC-Fal-037306	Ficedula albicollis	62.43	9.00e-138	483.00
IUUC-Gmo-039666	Gadus morhua	45.04	4.00e-88	317.00
IUUC-Gga-040220	Gallus gallus	65.42	3.00e-149	521.00
IUUC-Gac-042420	Gasterosteus aculeatus	52.32	1.00e-111	396.00
IUUC-Ggo-044566	Gorilla gorilla	78.36	3.00e-178	617.00
IUUC-Hsa-046788	Homo sapiens	79.41	5.00e-180	623.00
IUUC-Hvu-047570	Hordeum vulgare	36.36	4.00e-50	191.00
IUUC-Itr-047954	Ictidomys tridecemlineatus	79.74	0.00e+00	634.00
IUUC-Lch-050066	Latimeria chalumnae	65.47	6.00e-144	503.00
IUUC-Loc-052217	Lepisosteus oculatus	63.66	1.00e-141	496.00
IUUC-Mcc-055354	Macaca mulatta	79.95	0.00e+00	629.00
IUUC-Meu-056714	Macropus eugenii	66.76	3.00e-127	447.00
IUUC-Mga-060000	Meleagris gallopavo	62.64	3.00e-139	488.00
IUUC-Mmr-061723	Microcebus murinus	81.07	0.00e+00	640.00
IUUC-Mdo-062984	Monodelphis domestica	75.20	5.00e-172	597.00
IUUC-Mac-065662	Musa acuminata	32.25	1.00e-46	180.00
IUUC-Mpu-066812	Mustela putorius furo	79.58	0.00e+00	626.00
IUUC-Mlu-067545	Myotis lucifugus	78.93	3.00e-180	624.00
IUUC-Nle-069513	Nomascus leucogenys	70.34	1.00e-154	539.00
IUUC-Opr-070501	Ochotona princeps	67.65	9.00e-143	499.00
IUUC-Ont-072646	Oreochromis niloticus	56.22	6.00e-121	427.00
IUUC-Oan-073161	Ornithorhynchus anatinus	70.97	3.00e-159	554.00
IUUC-Ocu-074746	Oryctolagus cuniculus	78.36	7.00e-172	596.00
IUUC-Obr-076053	Oryza brachyantha	37.50	5.00e-52	198.00
IUUC-Ogl-077717	Oryza glaberrima	35.04	2.00e-42	166.00
IUUC-Oin-079089	Oryza indica	36.46	2.00e-51	195.00
IUUC-Ome-081316	Oryza meridionalis	34.30	2.00e-46	179.00
IUUC-Oni-082916	Oryza nivara	33.45	3.00e-44	172.00
IUUC-Opu-083751	Oryza punctata	36.96	2.00e-52	199.00
IUUC-Osa-085519	Oryza sativa	36.82	4.00e-52	198.00
IUUC-Ola-086369	Oryzias latipes	56.76	5.00e-132	464.00
IUUC-Oga-088349	Otolemur garnettii	78.67	0.00e+00	626.00
IUUC-Oar-090434	Ovis aries	79.14	3.00e-170	590.00
IUUC-Ptr-090459	Pan troglodytes	77.84	4.00e-176	610.00
IUUC-Pan-092544	Papio anubis	76.80	1.00e-171	595.00
IUUC-Psi-093343	Pelodiscus sinensis	63.66	5.00e-138	483.00
IUUC-Pma-094525	Petromyzon marinus	54.35	6.00e-114	404.00
IUUC-Ppa-095236	Physcomitrella patens	38.48	6.00e-74	271.00
IUUC-Pfo-096567	Poecilia formosa	58.87	3.00e-130	457.00
IUUC-Pab-098472	Pongo abelii	79.14	5.00e-180	623.00
IUUC-Pca-100979	Procavia capensis	70.43	7.00e-83	300.00
IUUC-Ppe-101756	Prunus persica	31.47	1.00e-46	180.00
IUUC-Pva-102760	Pteropus vampyrus	78.19	2.00e-166	578.00
IUUC-Pgr-103278	Puccinia graminis	42.86	1.00e-04	39.70
IUUC-Rno-105013	Rattus norvegicus	91.47	0.00e+00	722.00
IUUC-Sha-107358	Sarcophilus harrisii	74.49	5.00e-158	550.00
IUUC-Sit-110352	Setaria italica	38.38	1.00e-54	206.00
IUUC-Sly-111509	Solanum lycopersicum	35.29	2.00e-52	198.00
IUUC-Sar-113212	Sorex araneus	71.24	8.00e-149	520.00
IUUC-Sbi-114129	Sorghum bicolor	37.50	2.00e-50	192.00
IUUC-Sre-115047	Sporisorium reilianum	30.77	1.00e-04	42.00
IUUC-Ssc-116109	Sus scrofa	77.13	2.00e-144	504.00
IUUC-Tgu-117065	Taeniopygia guttata	63.69	4.00e-145	507.00
IUUC-Tru-117934	Takifugu rubripes	56.49	9.00e-129	453.00
IUUC-Tsy-119196	Tarsius syrichta	73.02	3.00e-153	534.00
IUUC-Tni-120320	Tetraodon nigroviridis	55.23	9.00e-122	429.00
IUUC-Tca-121021	Theobroma cacao	31.94	7.00e-50	190.00
IUUC-Tae-123568	Triticum aestivum	36.79	9.00e-51	193.00
IUUC-Tur-126008	Triticum urartu	38.31	4.00e-48	184.00
IUUC-Tbe-127837	Tupaia belangeri	63.27	5.00e-124	437.00
IUUC-Ttr-129133	Tursiops truncatus	72.46	3.00e-158	550.00
IUUC-Vpa-130296	Vicugna pacos	73.78	2.00e-149	521.00
IUUC-Vvi-131575	Vitis vinifera	37.80	4.00e-13	67.80
IUUC-Xtr-131991	Xenopus tropicalis	56.45	8.00e-124	436.00
IUUC-Xma-133080	Xiphophorus maculatus	58.65	6.00e-130	457.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence