iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Basic Information

Integrated Annotations

Tag

Content

UUCD2 ID

IUUC-Rno-105285

UUCD1 version

Ensembl Protein ID

UniProt Accession

Genbank Protein ID

Protein Name

Autoimmune regulator; Autoimmune regulator (Autoimmune polyendocrinopathy candidiasis ectodermal dystrophy) (Predicted), isoform CRA_a

Genbank Nucleotide ID

AC109383

Gene Name

Aire; Aire_predicted; rCG_60778

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSRNOG00000001213.5	ENSRNOT00000001611.4	ENSRNOP00000001611.3

Annotation

Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEO
DNA & RNA Element
TRANSFAC
Protein-protein Interaction
IID
Protein Expression/Proteomics
GPMDB

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 activity/RING/PHD	4.10e-14	52.9	295	339

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

E3 activity/RING/PHD

   S: 2    kvClvCgeggedekslveCekCrewfHpaClklsveeelpnsekwiCpkCr 52
           + C+vC++gge    l++C+ C ++fH aCl+++  +e p+   w C+ C 
   Q: 295  DECAVCHDGGE----LICCDGCPRAFHLACLSPP-LQEIPSGL-WRCSCCL 339
           57*********....*******************.*******7.*****95 PP

Organism

Rattus norvegicus

Protein Sequence
(Fasta)

MAGGDGMLRR LLRLHRTEIA VAIDSAFPLL HALADHDVVP EDKFQETLRL KEKEGCPQAF 60
HALLSWLLTR DSGAILDFWR VLFKDYNLER YSRLHTILDG FPKDVDLSQP RKGRKPLAGP 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

GAACGCAAGC GCGCGGGGGG CCAGCAGGGG GCGCCGAAGC GCAGACCCTG TCTGGAGGAT 60
GGCTGGTGGG GATGGGATGC TGCGCCGCCT GCTGAGGCTG CACCGCACCG AGATCGCAGT 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-0479--Metal-binding
KW-1185--Reference proteome
KW-0862--Zinc
KW-0863--Zinc-finger

Interpro

IPR008087--AIRE
IPR004865--HSR_dom
IPR000770--SAND_dom
IPR010919--SAND_dom-like
IPR019786--Zinc_finger_PHD-type_CS
IPR011011--Znf_FYVE_PHD
IPR001965--Znf_PHD
IPR019787--Znf_PHD-finger
IPR013083--Znf_RING/FYVE/PHD

PROSITE

PS51414--HSR
PS50864--SAND
PS01359--ZF_PHD_1
PS50016--ZF_PHD_2

Pfam

PF03172--HSR
PF00628--PHD

PRINTS

PR01711--AIREGULATOR

SMART

SM00249--PHD
SM00258--SAND

Gene Ontology

GO:0005737--C:cytoplasm
GO:0016604--C:nuclear body
GO:0005634--C:nucleus
GO:0003682--F:chromatin binding
GO:0042393--F:histone binding
GO:0000977--F:RNA polymerase II regulatory region sequence-specific DNA binding
GO:0003712--F:transcription cofactor activity
GO:0045182--F:translation regulator activity
GO:0008270--F:zinc ion binding
GO:0002509--P:central tolerance induction to self antigen
GO:0032602--P:chemokine production
GO:0006959--P:humoral immune response
GO:0006955--P:immune response
GO:0045060--P:negative thymic T cell selection
GO:0002458--P:peripheral T cell tolerance induction
GO:0045944--P:positive regulation of transcription from RNA polymerase II promoter
GO:2000410--P:regulation of thymocyte migration
GO:0097536--P:thymus epithelium morphogenesis

KEGG

rno:294328

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001612	Ailuropoda melanoleuca	71.04	5.00e-178	617.00
IUUC-Aca-004543	Anolis carolinensis	66.13	3.00e-23	99.40
IUUC-Bta-012988	Bos taurus	70.97	0.00e+00	671.00
IUUC-Bdi-014663	Brachypodium distachyon	61.70	3.00e-13	71.60
IUUC-Cja-019486	Callithrix jacchus	58.81	2.00e-85	308.00
IUUC-Cfa-021069	Canis familiaris	69.26	5.00e-170	590.00
IUUC-Cpo-021649	Cavia porcellus	66.19	1.00e-156	546.00
IUUC-Csa-023960	Chlorocebus sabaeus	68.90	2.00e-162	565.00
IUUC-Dre-028583	Danio rerio	40.18	2.00e-57	216.00
IUUC-Dno-029869	Dasypus novemcinctus	57.40	5.00e-118	417.00
IUUC-Dor-030263	Dipodomys ordii	84.76	2.00e-45	176.00
IUUC-Dse-031258	Dothistroma septosporum	42.59	1.00e-09	59.30
IUUC-Ete-032778	Echinops telfairi	86.73	8.00e-47	181.00
IUUC-Eca-034328	Equus caballus	69.31	1.00e-172	599.00
IUUC-Fca-035400	Felis catus	66.18	7.00e-163	566.00
IUUC-Fal-036644	Ficedula albicollis	51.92	2.00e-71	263.00
IUUC-Ggo-045250	Gorilla gorilla	69.23	2.00e-170	592.00
IUUC-Hsa-046603	Homo sapiens	69.61	2.00e-170	592.00
IUUC-Hvu-047073	Hordeum vulgare	58.70	4.00e-13	70.90
IUUC-Itr-048977	Ictidomys tridecemlineatus	70.66	2.00e-167	582.00
IUUC-Lch-050310	Latimeria chalumnae	41.17	1.00e-95	343.00
IUUC-Loc-052508	Lepisosteus oculatus	39.04	4.00e-93	335.00
IUUC-Laf-054028	Loxodonta africana	63.78	7.00e-154	537.00
IUUC-Mcc-054935	Macaca mulatta	68.16	5.00e-172	597.00
IUUC-Mga-059318	Meleagris gallopavo	40.24	8.00e-51	194.00
IUUC-Mmr-061557	Microcebus murinus	56.96	7.00e-126	444.00
IUUC-Mdo-062475	Monodelphis domestica	52.03	1.00e-127	450.00
IUUC-Mmu-063994	Mus musculus	88.77	0.00e+00	913.00
IUUC-Mpu-066347	Mustela putorius furo	68.51	0.00e+00	653.00
IUUC-Mlu-068239	Myotis lucifugus	58.93	2.00e-89	322.00
IUUC-Nle-069544	Nomascus leucogenys	88.89	7.00e-25	107.00
IUUC-Opr-071199	Ochotona princeps	70.73	5.00e-70	258.00
IUUC-Ont-072571	Oreochromis niloticus	29.39	5.00e-45	175.00
IUUC-Oan-073739	Ornithorhynchus anatinus	53.38	1.00e-141	496.00
IUUC-Ogl-077865	Oryza glaberrima	56.52	2.00e-12	68.60
IUUC-Olo-080499	Oryza longistaminata	50.88	2.00e-12	69.30
IUUC-Opu-083209	Oryza punctata	56.52	3.00e-12	68.60
IUUC-Ola-086528	Oryzias latipes	34.57	5.00e-41	162.00
IUUC-Oga-088353	Otolemur garnettii	71.40	0.00e+00	662.00
IUUC-Oar-090065	Ovis aries	70.98	3.00e-147	514.00
IUUC-Ptr-091347	Pan troglodytes	69.42	3.00e-163	568.00
IUUC-Pan-092423	Papio anubis	68.82	2.00e-172	598.00
IUUC-Psi-093798	Pelodiscus sinensis	52.62	9.00e-132	463.00
IUUC-Pfo-096145	Poecilia formosa	34.12	4.00e-31	129.00
IUUC-Pab-098369	Pongo abelii	76.60	7.00e-117	414.00
IUUC-Pca-100537	Procavia capensis	62.83	6.00e-162	563.00
IUUC-Pva-102639	Pteropus vampyrus	69.84	2.00e-167	582.00
IUUC-Sha-107159	Sarcophilus harrisii	49.72	1.00e-127	450.00
IUUC-Spo-108017	Schizosaccharomyces pombe	25.86	1.00e-13	71.20
IUUC-Sit-110355	Setaria italica	60.42	1.00e-12	69.30
IUUC-Sbi-113930	Sorghum bicolor	60.42	1.00e-12	69.30
IUUC-Ssc-115773	Sus scrofa	69.09	0.00e+00	642.00
IUUC-Tgu-116922	Taeniopygia guttata	48.54	1.00e-68	253.00
IUUC-Tru-118263	Takifugu rubripes	32.12	9.00e-58	217.00
IUUC-Tsy-119270	Tarsius syrichta	66.53	6.00e-90	324.00
IUUC-Tni-120138	Tetraodon nigroviridis	28.80	6.00e-55	208.00
IUUC-Tca-121757	Theobroma cacao	56.60	2.00e-13	72.80
IUUC-Tae-124715	Triticum aestivum	31.47	2.00e-13	72.40
IUUC-Tme-127204	Tuber melanosporum	55.32	2.00e-14	75.10
IUUC-Tbe-128077	Tupaia belangeri	67.58	0.00e+00	657.00
IUUC-Ttr-128781	Tursiops truncatus	74.03	5.00e-69	255.00
IUUC-Xma-133054	Xiphophorus maculatus	31.35	1.00e-57	217.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence