iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSDARG00000099199.1	ENSDART00000170500.1	ENSDARP00000135733.1
ENSDARG00000099199.1	ENSDART00000162186.1	ENSDARP00000130100.1

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 activity/HECT	2.10e-129	432.6	534	866

Active Site

Position(s)	Description	Evidence
835	Glycyl thioester intermediate	{ECO:0000256\|PIRSR:PIRSR001569-1, ECO:0000256\|PROSITE-ProRule:PRU00104}

Domain Profile

E3 activity/HECT

   S: 2    ksdlkkrlevefvgEegldlgGvtreflallskelqnpdlglflysendketlqpnpdsglknpehlklFeflGrllgkalqdgrlldl 90
           ++dl++rl++ f gEegld+gGv+re+++lls+e+ np+++lf+y  +d+++lq+np+s++ np+hlk+F+f+Gr++++al++g+++d+
   Q: 534  AQDLRRRLWIIFPGEEGLDYGGVAREWFFLLSHEVLNPMYCLFEYAGKDNYCLQINPASYI-NPDHLKYFKFIGRFIAMALFHGKFIDT 621
           689*********************************************************9.89************************* PP
   S: 91   plsksfyklllgkklsledleevdpelykslkeikenaesdieelgldltfsvseeilgetkeeeLkpgGenipVtneNkeeYvklvve 179
            +s +fyk++l+k+l+l+dle++dpe+y+sl +ik+n   +iee+gl++ fsv++eilge++++eLkp+G ni+Vt+eNkeeY++lv+e
   Q: 622  GFSLPFYKRILNKPLTLKDLESIDPEFYNSLIWIKDN---NIEECGLEMFFSVDKEILGEVSTHELKPDGGNIQVTEENKEEYIRLVAE 707
           ***********************************99...9************************************************ PP
   S: 180  yrlkegikeqveafreGfneviplellslFteeelellicGeeeidvedlkketkykggytedspaiqwFwevleefsseerkafLqFv 268
           +rl +g++eq++af eGfnev+p++ l++F+++ele+++cG++eid++d++++t y++ yt++s++i wFw++++e+++e+r ++LqFv
   Q: 708  WRLSRGVEEQTQAFFEGFNEVLPQQYLQYFDAKELEVMLCGMQEIDLNDWQRNTIYRH-YTSSSKQIMWFWQFIKEMDNEKRMRLLQFV 795
           ********************************************************99.****************************** PP
   S: 269  TgssrlPlgGfaelk....prlfvirkdasddrlPssnTCfnyLkLPeYsskeilkekLlyAieetkgFel 335
           Tg++rlP+gGfa+l+    p++f+i+k +++++lP+s+TC n ++ P Y+++ +l ++L+ Aieet+gF++
   Q: 796  TGTCRLPVGGFADLMgsngPQKFCIEKVGKENWLPRSHTCLNPIENPMYQKYAQLMDRLMXAIEETEGFGQ 866
           *********************************************************************96 PP

Organism

Danio rerio

Protein Sequence
(Fasta)

MACSVAKAAP ANGFPMKAQL QIMVISAKLK ENKKNWFGPS PYVEVCVDGQ SKKTEKCNNT 60
HSPKWKQSFA VIVTPFSKLI FRVWSHQTLK SDLLLGVATL DISETLKSHD MKICEVVQTL 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

AAGATGGCGG AAGTTCATTC CTGATCTGAG CCGGAGTCTC TCGGTACGGA TTCGGTAATA 60
AAACTCTCCG AGGACTGATC GGTTTCGGCT TCACGACTCA CATCCGACCC GCCGGCAAAT 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-1267--Proteomics identification
KW-1185--Reference proteome
KW-0808--Transferase
KW-0833--Ubl conjugation pathway

Interpro

IPR000008--C2_dom
IPR024928--E3_ub_ligase_SMURF1
IPR000569--HECT_dom
IPR001202--WW_dom

PROSITE

PS50004--C2
PS50237--HECT
PS01159--WW_DOMAIN_1
PS50020--WW_DOMAIN_2

Pfam

PF00168--C2
PF00632--HECT
PF00397--WW

SMART

SM00239--C2
SM00119--HECTc
SM00456--WW

Gene Ontology

GO:0004842--F:ubiquitin-protein transferase activity
GO:0048920--P:posterior lateral line neuromast primordium migration

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-002302	Ailuropoda melanoleuca	75.15	0.00e+00	1294.00
IUUC-Apl-003752	Anas platyrhynchos	75.03	0.00e+00	1300.00
IUUC-Aca-005338	Anolis carolinensis	72.15	0.00e+00	1281.00
IUUC-Cfa-020648	Canis familiaris	74.07	0.00e+00	1260.00
IUUC-Cpo-022073	Cavia porcellus	74.08	0.00e+00	1302.00
IUUC-Csa-023252	Chlorocebus sabaeus	73.27	0.00e+00	1291.00
IUUC-Cho-024695	Choloepus hoffmanni	69.89	0.00e+00	1242.00
IUUC-Dno-029884	Dasypus novemcinctus	73.27	0.00e+00	1302.00
IUUC-Eca-033793	Equus caballus	74.08	0.00e+00	1296.00
IUUC-Fca-035605	Felis catus	75.29	0.00e+00	1311.00
IUUC-Fal-037126	Ficedula albicollis	74.49	0.00e+00	1302.00
IUUC-Gga-040832	Gallus gallus	74.41	0.00e+00	1306.00
IUUC-Gac-041658	Gasterosteus aculeatus	78.56	0.00e+00	1382.00
IUUC-Ggo-044535	Gorilla gorilla	71.72	0.00e+00	1267.00
IUUC-Hsa-046564	Homo sapiens	71.19	0.00e+00	1287.00
IUUC-Lch-050454	Latimeria chalumnae	74.57	0.00e+00	1320.00
IUUC-Loc-052647	Lepisosteus oculatus	76.77	0.00e+00	1392.00
IUUC-Laf-054383	Loxodonta africana	73.96	0.00e+00	1304.00
IUUC-Mcc-055532	Macaca mulatta	73.39	0.00e+00	1291.00
IUUC-Mga-059661	Meleagris gallopavo	74.52	0.00e+00	1300.00
IUUC-Mmr-061135	Microcebus murinus	75.57	0.00e+00	1315.00
IUUC-Mdo-062505	Monodelphis domestica	75.99	0.00e+00	1298.00
IUUC-Mpu-066203	Mustela putorius furo	75.38	0.00e+00	1295.00
IUUC-Mlu-067837	Myotis lucifugus	74.19	0.00e+00	1295.00
IUUC-Nle-069244	Nomascus leucogenys	73.19	0.00e+00	1286.00
IUUC-Ont-071822	Oreochromis niloticus	77.60	0.00e+00	1399.00
IUUC-Oga-088167	Otolemur garnettii	70.02	0.00e+00	1200.00
IUUC-Ptr-090819	Pan troglodytes	70.17	0.00e+00	1246.00
IUUC-Pan-092454	Papio anubis	73.39	0.00e+00	1291.00
IUUC-Psi-093319	Pelodiscus sinensis	73.10	0.00e+00	1246.00
IUUC-Pab-097580	Pongo abelii	64.22	0.00e+00	1107.00
IUUC-Pca-100923	Procavia capensis	66.17	0.00e+00	1055.00
IUUC-Pva-103209	Pteropus vampyrus	73.27	0.00e+00	1243.00
IUUC-Rno-104924	Rattus norvegicus	73.09	0.00e+00	1295.00
IUUC-Sha-107175	Sarcophilus harrisii	74.01	0.00e+00	1296.00
IUUC-Tgu-116632	Taeniopygia guttata	72.95	0.00e+00	1201.00
IUUC-Tru-118442	Takifugu rubripes	86.57	0.00e+00	1149.00
IUUC-Tsy-119198	Tarsius syrichta	67.78	0.00e+00	1164.00
IUUC-Tni-120168	Tetraodon nigroviridis	91.34	0.00e+00	1112.00
IUUC-Tre-122203	Trichoderma reesei	42.38	2.00e-147	516.00
IUUC-Tbe-127756	Tupaia belangeri	62.10	0.00e+00	975.00
IUUC-Ttr-128504	Tursiops truncatus	66.86	0.00e+00	899.00
IUUC-Xtr-132885	Xenopus tropicalis	69.20	0.00e+00	1243.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence