iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

UUCD2 ID

IUUC-Laf-054383

UUCD1 version

UUC-LoA-00395

Ensembl Protein ID

ENSLAFP00000009697.4

UniProt Accession

G3T7U0; G3T7U0_LOXAF

Protein Name

Uncharacterized protein

Gene Name

ITCH

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSLAFG00000011603.4	ENSLAFT00000011605.4	ENSLAFP00000009697.4

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 activity/HECT	3.20e-136	454.5	532	864

Active Site

Position(s)	Description	Evidence
833	Glycyl thioester intermediate	{ECO:0000256\|PIRSR:PIRSR001569-1, ECO:0000256\|PROSITE-ProRule:PRU00104}

Domain Profile

E3 activity/HECT

   S: 2    ksdlkkrlevefvgEegldlgGvtreflallskelqnpdlglflysendketlqpnpdsglknpehlklFeflGrllgkalqdgrlldl 90
           ++dl++rl+v f gEegld+gGv+re+++lls+e+ np+++lf+y  +d+++lq+np+s++ np+hlk+F+f+Gr++++al++g+++d+
   Q: 532  PQDLRRRLWVIFPGEEGLDYGGVAREWFFLLSHEVLNPMYCLFEYAGKDNYCLQINPASYI-NPDHLKYFRFIGRFIAMALFHGKFIDT 619
           689*********************************************************9.89************************* PP
   S: 91   plsksfyklllgkklsledleevdpelykslkeikenaesdieelgldltfsvseeilgetkeeeLkpgGenipVtneNkeeYvklvve 179
            +s +fyk++l+k++ l+dle++dpe+y+sl ++ken   +iee+gl++ fsv++eilge+k+++Lkp+G ni Vt+eNkeeY++ v+e
   Q: 620  GFSLPFYKRILNKPVGLKDLESIDPEFYNSLIWVKEN---NIEECGLEMYFSVDKEILGEIKSHDLKPNGGNILVTEENKEEYIRMVAE 705
           ***********************************99...9************************************************ PP
   S: 180  yrlkegikeqveafreGfneviplellslFteeelellicGeeeidvedlkketkykggytedspaiqwFwevleefsseerkafLqFv 268
           +rl +g++eq++af eGfne++p++ l++F+++ele+l+cG++eid++d+++++ y++ yt++s++i wFw++++e+++e+r ++LqFv
   Q: 706  WRLSRGVEEQTQAFFEGFNEILPQQYLQYFDAKELEVLLCGMQEIDLNDWQRHAIYRH-YTRTSKQIMWFWQFVKEIDNEKRMRLLQFV 793
           ********************************************************99.****************************** PP
   S: 269  TgssrlPlgGfaelk....prlfvirkdasddrlPssnTCfnyLkLPeYsskeilkekLlyAieetkgFel 335
           Tg++rlP+gGfa+l+    p++f+i+k +++++lP+s+TCfn+L+LP+Y+s+e+lkekLl+Aieet+gF++
   Q: 794  TGTCRLPVGGFADLMgsngPQKFCIEKVGKENWLPRSHTCFNRLDLPPYKSYEQLKEKLLFAIEETEGFGQ 864
           *********************************************************************96 PP

Organism

Loxodonta africana

Protein Sequence
(Fasta)

IGGMSDSGSQ LGSMGSLTMK SQLQITVISA KLKENKKNWF GPSPYVEVTV DGQSKKTEKC 60
NNTNSPKWKQ PLTVIVTPVS KLHFRVWSHQ TLKSDVLLGT AALDIYETLK SNNMKLEEVV 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

ATTGGTGGTA TGTCTGACAG TGGATCACAA CTTGGTTCAA TGGGTAGCCT GACCATGAAA 60
TCACAACTTC AAATCACTGG TAAGTCTTAG AAAAGATCTA CTACTCTACT TTTTTTCCCC 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-1185--Reference proteome
KW-0808--Transferase
KW-0833--Ubl conjugation pathway

Interpro

IPR000008--C2_dom
IPR024928--E3_ub_ligase_SMURF1
IPR000569--HECT_dom
IPR001202--WW_dom

PROSITE

PS50004--C2
PS50237--HECT
PS01159--WW_DOMAIN_1
PS50020--WW_DOMAIN_2

Pfam

PF00168--C2
PF00632--HECT
PF00397--WW

SMART

SM00239--C2
SM00119--HECTc
SM00456--WW

Gene Ontology

GO:0005938--C:cell cortex
GO:0031410--C:cytoplasmic vesicle
GO:0070062--C:extracellular exosome
GO:0005654--C:nucleoplasm
GO:0005886--C:plasma membrane
GO:0016874--F:ligase activity
GO:0043021--F:ribonucleoprotein complex binding
GO:0061630--F:ubiquitin protein ligase activity
GO:0046642--P:negative regulation of alpha-beta T cell proliferation
GO:0043066--P:negative regulation of apoptotic process
GO:0050687--P:negative regulation of defense response to virus
GO:0046329--P:negative regulation of JNK cascade
GO:0032088--P:negative regulation of NF-kappaB transcription factor activity
GO:0045732--P:positive regulation of protein catabolic process
GO:0002669--P:positive regulation of T cell anergy
GO:0035519--P:protein K29-linked ubiquitination
GO:0070936--P:protein K48-linked ubiquitination
GO:0070534--P:protein K63-linked ubiquitination
GO:0042787--P:protein ubiquitination involved in ubiquitin-dependent protein catabolic process
GO:0090085--P:regulation of protein deubiquitination

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-002302	Ailuropoda melanoleuca	97.64	0.00e+00	1632.00
IUUC-Apl-003752	Anas platyrhynchos	84.20	0.00e+00	1461.00
IUUC-Aca-005338	Anolis carolinensis	82.33	0.00e+00	1446.00
IUUC-Ago-007742	Ashbya gossypii	48.88	9.00e-163	567.00
IUUC-Ame-010601	Astyanax mexicanus	87.56	0.00e+00	1116.00
IUUC-Bta-012782	Bos taurus	97.56	0.00e+00	1602.00
IUUC-Cja-018899	Callithrix jacchus	93.13	0.00e+00	1572.00
IUUC-Cfa-020648	Canis familiaris	96.47	0.00e+00	1599.00
IUUC-Cpo-022073	Cavia porcellus	97.80	0.00e+00	1652.00
IUUC-Csa-023252	Chlorocebus sabaeus	97.33	0.00e+00	1649.00
IUUC-Cho-024695	Choloepus hoffmanni	90.37	0.00e+00	1627.00
IUUC-Cgl-026642	Colletotrichum gloeosporioides	47.54	8.00e-156	544.00
IUUC-Cne-026849	Cryptococcus neoformans	47.63	5.00e-159	555.00
IUUC-Dre-028451	Danio rerio	75.83	0.00e+00	1308.00
IUUC-Dno-029884	Dasypus novemcinctus	97.22	0.00e+00	1675.00
IUUC-Eca-033793	Equus caballus	97.69	0.00e+00	1661.00
IUUC-Eeu-034716	Erinaceus europaeus	93.01	0.00e+00	889.00
IUUC-Fca-035605	Felis catus	97.41	0.00e+00	1659.00
IUUC-Fal-037126	Ficedula albicollis	84.11	0.00e+00	1458.00
IUUC-Fso-038393	Fusarium solani	47.21	4.00e-154	538.00
IUUC-Gmo-038596	Gadus morhua	80.20	0.00e+00	1007.00
IUUC-Gga-040832	Gallus gallus	83.77	0.00e+00	1478.00
IUUC-Gac-041658	Gasterosteus aculeatus	86.99	0.00e+00	1124.00
IUUC-Ggo-044535	Gorilla gorilla	94.45	0.00e+00	1620.00
IUUC-Hsa-046564	Homo sapiens	93.58	0.00e+00	1636.00
IUUC-Itr-048918	Ictidomys tridecemlineatus	96.29	0.00e+00	1578.00
IUUC-Kpa-049273	Komagataella pastoris	49.23	7.00e-164	570.00
IUUC-Lch-050454	Latimeria chalumnae	77.87	0.00e+00	1405.00
IUUC-Loc-052647	Lepisosteus oculatus	74.53	0.00e+00	1357.00
IUUC-Mcc-055532	Macaca mulatta	97.33	0.00e+00	1650.00
IUUC-Mga-059661	Meleagris gallopavo	83.88	0.00e+00	1467.00
IUUC-Mmr-061135	Microcebus murinus	97.45	0.00e+00	1674.00
IUUC-Mdo-062505	Monodelphis domestica	87.92	0.00e+00	1510.00
IUUC-Mmu-063375	Mus musculus	95.83	0.00e+00	1605.00
IUUC-Mpu-066203	Mustela putorius furo	97.88	0.00e+00	1635.00
IUUC-Mlu-067837	Myotis lucifugus	97.34	0.00e+00	1657.00
IUUC-Nle-069244	Nomascus leucogenys	96.41	0.00e+00	1627.00
IUUC-Opr-070585	Ochotona princeps	91.69	0.00e+00	1593.00
IUUC-Ont-071798	Oreochromis niloticus	88.10	0.00e+00	1144.00
IUUC-Ocu-074298	Oryctolagus cuniculus	97.69	0.00e+00	1644.00
IUUC-Ola-086526	Oryzias latipes	85.57	0.00e+00	1124.00
IUUC-Oga-088167	Otolemur garnettii	90.53	0.00e+00	1523.00
IUUC-Oar-090316	Ovis aries	81.25	0.00e+00	1209.00
IUUC-Ptr-090819	Pan troglodytes	92.79	0.00e+00	1598.00
IUUC-Pan-092454	Papio anubis	97.34	0.00e+00	1657.00
IUUC-Psi-093319	Pelodiscus sinensis	83.29	0.00e+00	1441.00
IUUC-Pfo-097346	Poecilia formosa	84.18	0.00e+00	1103.00
IUUC-Pab-097580	Pongo abelii	86.82	0.00e+00	1477.00
IUUC-Pca-100923	Procavia capensis	79.81	0.00e+00	1379.00
IUUC-Pva-103209	Pteropus vampyrus	96.06	0.00e+00	1594.00
IUUC-Rno-104924	Rattus norvegicus	95.16	0.00e+00	1613.00
IUUC-Sha-107175	Sarcophilus harrisii	89.31	0.00e+00	1512.00
IUUC-Sja-107941	Schizosaccharomyces japonicus	45.11	1.00e-160	560.00
IUUC-Spo-108171	Schizosaccharomyces pombe	50.53	1.00e-162	566.00
IUUC-Sar-113761	Sorex araneus	86.46	0.00e+00	1490.00
IUUC-Tgu-116632	Taeniopygia guttata	81.04	0.00e+00	1336.00
IUUC-Tru-118442	Takifugu rubripes	88.75	0.00e+00	1120.00
IUUC-Tsy-119198	Tarsius syrichta	90.60	0.00e+00	1531.00
IUUC-Tni-120168	Tetraodon nigroviridis	86.52	0.00e+00	1057.00
IUUC-Tbe-127756	Tupaia belangeri	78.18	0.00e+00	1315.00
IUUC-Ttr-128504	Tursiops truncatus	91.25	0.00e+00	1199.00
IUUC-Vpa-130103	Vicugna pacos	82.96	0.00e+00	1409.00
IUUC-Xtr-132885	Xenopus tropicalis	76.57	0.00e+00	1379.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence