iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

iUUCD ID

IUUC-Aca-004391

Ensembl Protein ID

ENSACAP00000014343.2

UniProt Accession

H9GLA2; H9GLA2_ANOCA

Protein Name

Tyrosine-protein kinase

Gene Name

CSK

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSACAG00000014477.3	ENSACAT00000014636.3	ENSACAP00000014343.2

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
UBD/SH3	4.30e-11	42.6	13	67

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

UBD/SH3

   S: 5    kvqvlydyeaqnddeLtlkkGdvvlviekeeqdegWlkgvkelegkrGlfPenFvek 61
            +++ y++ ++ d +L++ kGdv+++i   ++d +W k+ ++  g++G++P+n+v+k
   Q: 13   ECIAKYNFHGTADQDLSFSKGDVLTII-SVTKDPNWYKA-RNKVGREGIIPANYVQK 67
           68999**********************.99*********.59*************87 PP

Organism

Anolis carolinensis

Protein Sequence
(Fasta)

MSGVQAVWPS GTECIAKYNF HGTADQDLSF SKGDVLTIIS VTKDPNWYKA RNKVGREGII 60
PANYVQKREG VKAGIKLSLM PWFHGKITRE QAERLLYPPE TGLFLVREST NYPGDYTLCV 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

CTCCCAGGTC TGCTCTCTGA AGAGCAAGGC ATGGGAGGAG TGTGCAGGAA CGGGACTGGC 60
CTGTAGGTGG CGCGCCGCCC TTCCCTGGCC AGGGAGGGAG TGTGCTCGGC CCCGCGCATG 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0067--ATP-binding
KW-0181--Complete proteome
KW-0418--Kinase
KW-0547--Nucleotide-binding
KW-1185--Reference proteome
KW-0728--SH3 domain
KW-0808--Transferase
KW-0829--Tyrosine-protein kinase

Interpro

IPR011009--Kinase-like_dom
IPR000719--Prot_kinase_dom
IPR017441--Protein_kinase_ATP_BS
IPR001245--Ser-Thr/Tyr_kinase_cat_dom
IPR000980--SH2
IPR001452--SH3_domain
IPR008266--Tyr_kinase_AS
IPR020635--Tyr_kinase_cat_dom

PROSITE

PS00107--PROTEIN_KINASE_ATP
PS50011--PROTEIN_KINASE_DOM
PS00109--PROTEIN_KINASE_TYR
PS50001--SH2
PS50002--SH3

Pfam

PF07714--Pkinase_Tyr
PF00017--SH2
PF00018--SH3_1

PRINTS

PR00401--SH2DOMAIN
PR00452--SH3DOMAIN
PR00109--TYRKINASE

SMART

SM00252--SH2
SM00326--SH3
SM00219--TyrKc

Gene Ontology

GO:0005911--C:cell-cell junction
GO:0070062--C:extracellular exosome
GO:0031234--C:extrinsic component of cytoplasmic side of plasma membrane
GO:0005524--F:ATP binding
GO:0004715--F:non-membrane spanning protein tyrosine kinase activity
GO:0005102--F:receptor binding
GO:0034332--P:adherens junction organization
GO:0030154--P:cell differentiation
GO:0007417--P:central nervous system development
GO:0045087--P:innate immune response
GO:0008285--P:negative regulation of cell proliferation
GO:0042997--P:negative regulation of Golgi to plasma membrane protein transport
GO:0038083--P:peptidyl-tyrosine autophosphorylation
GO:0042127--P:regulation of cell proliferation
GO:0001817--P:regulation of cytokine production
GO:0060368--P:regulation of Fc receptor mediated stimulatory signaling pathway
GO:0007169--P:transmembrane receptor protein tyrosine kinase signaling pathway

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Bdi-014440	Brachypodium distachyon	32.26	3.00e-19	90.50
IUUC-Cin-025513	Ciona intestinalis	54.36	6.00e-145	506.00
IUUC-Csv-025899	Ciona savignyi	50.94	2.00e-137	482.00
IUUC-Fal-037215	Ficedula albicollis	94.44	0.00e+00	890.00
IUUC-Gmo-039103	Gadus morhua	84.65	0.00e+00	794.00
IUUC-Gga-040506	Gallus gallus	94.67	0.00e+00	889.00
IUUC-Loc-052586	Lepisosteus oculatus	88.00	0.00e+00	842.00
IUUC-Meu-056387	Macropus eugenii	94.22	0.00e+00	889.00
IUUC-Mtr-058657	Medicago truncatula	28.35	2.00e-19	91.30
IUUC-Mga-060040	Meleagris gallopavo	93.05	0.00e+00	863.00
IUUC-Mdo-061871	Monodelphis domestica	93.56	0.00e+00	885.00
IUUC-Ont-072457	Oreochromis niloticus	83.97	0.00e+00	791.00
IUUC-Ola-087366	Oryzias latipes	85.65	0.00e+00	791.00
IUUC-Oga-087928	Otolemur garnettii	93.11	0.00e+00	876.00
IUUC-Pfo-096126	Poecilia formosa	83.30	0.00e+00	788.00
IUUC-Sha-106987	Sarcophilus harrisii	94.00	0.00e+00	890.00
IUUC-Sbi-114754	Sorghum bicolor	29.69	6.00e-20	91.30
IUUC-Tru-118712	Takifugu rubripes	81.55	0.00e+00	771.00
IUUC-Tni-119856	Tetraodon nigroviridis	82.17	0.00e+00	779.00
IUUC-Xtr-132763	Xenopus tropicalis	83.59	0.00e+00	795.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence