iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

iUUCD ID

IUUC-Mdo-063030

Ensembl Protein ID

ENSMODP00000000300.2

UniProt Accession

F6WR53; F6WR53_MONDO

Protein Name

Tyrosine-protein kinase

Gene Name

SRC

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSMODG00000000247.3	ENSMODT00000000304.2	ENSMODP00000000300.2

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
UBD/SH3	3.60e-11	43.0	85	156

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

UBD/SH3

   S: 5    kvqvlydyeaqnddeLtlkkGdvvlvi...............ekeeqdegWlkgvkelegkrGlfPenFvek 61
           ++ +lydye+ ++ +L++kkG+ ++++                  + +++W+ + + ++g+ G +P+n+v+ 
   Q: 85   TFVALYDYESRTETDLSFKKGERLQIVnntrkvdvsqtwftfRWLQREGDWWLAHSLTTGQTGYIPSNYVAP 156
           5789***********************98888887666666555678999999999*************975 PP

Organism

Monodelphis domestica

Protein Sequence
(Fasta)

MGSSKSKPKD PSQRRRSLEP TESVLHSGFS ISQTPNKASA PDTHRTPNPP FGTTAPEPKL 60
FGGFNTSDTV TSPQRSGPLA GGVTTFVALY DYESRTETDL SFKKGERLQI VNNTRKVDVS 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

CTGAGAACAT CTGGGCCTCC CCTTACCCCC AGCCCTGTGG GTCAGGGACT GAGCCAGGTA 60
AGAGAATTTT TCAACCATAT AAAGTCATTT CAGTCAGGAC AATGGAGAGA TGAGATCCTT 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0067--ATP-binding
KW-0181--Complete proteome
KW-0418--Kinase
KW-0547--Nucleotide-binding
KW-1185--Reference proteome
KW-0728--SH3 domain
KW-0808--Transferase
KW-0829--Tyrosine-protein kinase

Interpro

IPR011009--Kinase-like_dom
IPR000719--Prot_kinase_dom
IPR017441--Protein_kinase_ATP_BS
IPR001245--Ser-Thr/Tyr_kinase_cat_dom
IPR000980--SH2
IPR001452--SH3_domain
IPR008266--Tyr_kinase_AS
IPR020635--Tyr_kinase_cat_dom

PROSITE

PS00107--PROTEIN_KINASE_ATP
PS50011--PROTEIN_KINASE_DOM
PS00109--PROTEIN_KINASE_TYR
PS50001--SH2
PS50002--SH3

Pfam

PF07714--Pkinase_Tyr
PF00017--SH2
PF14604--SH3_9

PRINTS

PR00401--SH2DOMAIN
PR00452--SH3DOMAIN
PR00109--TYRKINASE

SMART

SM00252--SH2
SM00326--SH3
SM00219--TyrKc

Gene Ontology

GO:0005884--C:actin filament
GO:0005901--C:caveola
GO:0005829--C:cytosol
GO:0070062--C:extracellular exosome
GO:0031234--C:extrinsic component of cytoplasmic side of plasma membrane
GO:0005770--C:late endosome
GO:0005764--C:lysosome
GO:0005743--C:mitochondrial inner membrane
GO:0005634--C:nucleus
GO:0048471--C:perinuclear region of cytoplasm
GO:0002102--C:podosome
GO:0032587--C:ruffle membrane
GO:0005524--F:ATP binding
GO:0070851--F:growth factor receptor binding
GO:0020037--F:heme binding
GO:0051427--F:hormone receptor binding
GO:0004715--F:non-membrane spanning protein tyrosine kinase activity
GO:0086098--P:angiotensin-activated signaling pathway involved in heart process
GO:0045453--P:bone resorption
GO:0060444--P:branching involved in mammary gland duct morphogenesis
GO:0007155--P:cell adhesion
GO:0016477--P:cell migration
GO:0071498--P:cellular response to fluid shear stress
GO:0036120--P:cellular response to platelet-derived growth factor stimulus
GO:0034614--P:cellular response to reactive oxygen species
GO:0007417--P:central nervous system development
GO:0007173--P:epidermal growth factor receptor signaling pathway
GO:0030900--P:forebrain development
GO:0045087--P:innate immune response
GO:0007229--P:integrin-mediated signaling pathway
GO:0030520--P:intracellular estrogen receptor signaling pathway
GO:0035556--P:intracellular signal transduction
GO:2000811--P:negative regulation of anoikis
GO:0043154--P:negative regulation of cysteine-type endopeptidase activity involved in apoptotic process
GO:2001237--P:negative regulation of extrinsic apoptotic signaling pathway
GO:2001243--P:negative regulation of intrinsic apoptotic signaling pathway
GO:0051902--P:negative regulation of mitochondrial depolarization
GO:0032463--P:negative regulation of protein homooligomerization
GO:0051974--P:negative regulation of telomerase activity
GO:0032211--P:negative regulation of telomere maintenance via telomerase
GO:0048477--P:oogenesis
GO:0036035--P:osteoclast development
GO:0038083--P:peptidyl-tyrosine autophosphorylation
GO:0048008--P:platelet-derived growth factor receptor signaling pathway
GO:0090263--P:positive regulation of canonical Wnt signaling pathway
GO:0010634--P:positive regulation of epithelial cell migration
GO:0070374--P:positive regulation of ERK1 and ERK2 cascade
GO:2000394--P:positive regulation of lamellipodium morphogenesis
GO:0050731--P:positive regulation of peptidyl-tyrosine phosphorylation
GO:0071803--P:positive regulation of podosome assembly
GO:0051897--P:positive regulation of protein kinase B signaling
GO:1900182--P:positive regulation of protein localization to nucleus
GO:0010954--P:positive regulation of protein processing
GO:0071902--P:positive regulation of protein serine/threonine kinase activity
GO:0051057--P:positive regulation of small GTPase mediated signal transduction
GO:0050847--P:progesterone receptor signaling pathway
GO:0031648--P:protein destabilization
GO:2001286--P:regulation of caveolin-mediated endocytosis
GO:0051726--P:regulation of cell cycle
GO:0060491--P:regulation of cell projection assembly
GO:0042127--P:regulation of cell proliferation
GO:0022407--P:regulation of cell-cell adhesion
GO:2000641--P:regulation of early endosome to late endosome transport
GO:0033146--P:regulation of intracellular estrogen receptor signaling pathway
GO:0071801--P:regulation of podosome assembly
GO:0043393--P:regulation of protein binding
GO:0070555--P:response to interleukin-1
GO:0043149--P:stress fiber assembly
GO:0034446--P:substrate adhesion-dependent cell spreading
GO:0007179--P:transforming growth factor beta receptor signaling pathway
GO:0060065--P:uterus development

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001713	Ailuropoda melanoleuca	90.60	0.00e+00	1028.00
IUUC-Aca-004237	Anolis carolinensis	91.45	0.00e+00	1037.00
IUUC-Ame-011887	Astyanax mexicanus	77.46	0.00e+00	876.00
IUUC-Bta-012982	Bos taurus	89.09	0.00e+00	1025.00
IUUC-Cja-019995	Callithrix jacchus	91.50	0.00e+00	1040.00
IUUC-Cfa-020060	Canis familiaris	90.42	0.00e+00	1030.00
IUUC-Cpo-021557	Cavia porcellus	88.97	0.00e+00	1000.00
IUUC-Csa-023711	Chlorocebus sabaeus	91.50	0.00e+00	1038.00
IUUC-Dre-028491	Danio rerio	81.01	0.00e+00	879.00
IUUC-Dno-029651	Dasypus novemcinctus	92.18	0.00e+00	1046.00
IUUC-Ete-033170	Echinops telfairi	94.03	0.00e+00	911.00
IUUC-Eca-033970	Equus caballus	86.96	0.00e+00	957.00
IUUC-Fca-036113	Felis catus	90.42	0.00e+00	1030.00
IUUC-Fal-036785	Ficedula albicollis	94.18	0.00e+00	1073.00
IUUC-Gga-040899	Gallus gallus	92.73	0.00e+00	1056.00
IUUC-Gac-042332	Gasterosteus aculeatus	79.17	0.00e+00	887.00
IUUC-Ggo-044829	Gorilla gorilla	78.48	0.00e+00	852.00
IUUC-Hsa-046192	Homo sapiens	91.68	0.00e+00	1041.00
IUUC-Itr-049014	Ictidomys tridecemlineatus	91.67	0.00e+00	1035.00
IUUC-Lch-049892	Latimeria chalumnae	85.64	0.00e+00	965.00
IUUC-Loc-052812	Lepisosteus oculatus	80.54	0.00e+00	896.00
IUUC-Laf-053977	Loxodonta africana	91.68	0.00e+00	1046.00
IUUC-Mcc-055159	Macaca mulatta	93.49	0.00e+00	1071.00
IUUC-Mga-060135	Meleagris gallopavo	94.36	0.00e+00	1075.00
IUUC-Mmr-061168	Microcebus murinus	93.49	0.00e+00	1074.00
IUUC-Mmu-063893	Mus musculus	91.85	0.00e+00	1048.00
IUUC-Mpu-066411	Mustela putorius furo	90.42	0.00e+00	1030.00
IUUC-Mlu-068139	Myotis lucifugus	90.43	0.00e+00	1035.00
IUUC-Nle-070178	Nomascus leucogenys	88.97	0.00e+00	980.00
IUUC-Ont-072130	Oreochromis niloticus	80.25	0.00e+00	911.00
IUUC-Ocu-074403	Oryctolagus cuniculus	90.25	0.00e+00	1019.00
IUUC-Ola-086527	Oryzias latipes	79.54	0.00e+00	904.00
IUUC-Oga-088493	Otolemur garnettii	91.50	0.00e+00	1039.00
IUUC-Oar-090279	Ovis aries	89.43	0.00e+00	1027.00
IUUC-Ptr-091050	Pan troglodytes	91.68	0.00e+00	1041.00
IUUC-Pan-091862	Papio anubis	90.42	0.00e+00	1024.00
IUUC-Psi-093071	Pelodiscus sinensis	92.55	0.00e+00	1054.00
IUUC-Pfo-096578	Poecilia formosa	81.32	0.00e+00	922.00
IUUC-Pab-097902	Pongo abelii	93.85	0.00e+00	1075.00
IUUC-Pva-103176	Pteropus vampyrus	78.12	0.00e+00	855.00
IUUC-Rno-105847	Rattus norvegicus	91.86	0.00e+00	1045.00
IUUC-Sha-107539	Sarcophilus harrisii	95.45	0.00e+00	1088.00
IUUC-Stu-112331	Solanum tuberosum	32.40	8.00e-23	102.00
IUUC-Ssc-115762	Sus scrofa	90.34	0.00e+00	1042.00
IUUC-Tru-117849	Takifugu rubripes	80.25	0.00e+00	879.00
IUUC-Tni-120843	Tetraodon nigroviridis	79.54	0.00e+00	902.00
IUUC-Ttr-128702	Tursiops truncatus	85.90	0.00e+00	964.00
IUUC-Xtr-132291	Xenopus tropicalis	84.84	0.00e+00	938.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence