iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

UUCD2 ID

IUUC-Ptr-091368

UUCD1 version

UUC-PaT-00050

Ensembl Protein ID

ENSPTRP00000058085.1

UniProt Accession

H2RCZ6; H2RCZ6_PANTR

Genbank Protein ID

JAA26326.1; JAA35489.1

Protein Name

Hect domain and RLD 4

Genbank Nucleotide ID

AACZ03073012; GABE01009250

Gene Name

HERC4

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSPTRG00000002549.5	ENSPTRT00000066506.1	ENSPTRP00000058085.1

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 activity/HECT	8.20e-101	337.7	733	1056

Active Site

Position(s)	Description	Evidence
1025	Glycyl thioester intermediate	{ECO:0000256\|PROSITE-ProRule:PRU00104}

Domain Profile

E3 activity/HECT

   S: 4    dlkkrlevefvgEegldlgGvtreflallskelqnpdlglflysendketlqpnpdsglknpehlklFeflGrllgkalqdgrlldl 90
           d kk l+v fvgE+++d+gGv +ef+ l+++el +p++g+f+y e+++  ++ +++      e  +lF+++G+++g+a+++  ++dl
   Q: 733  DYKKPLKVIFVGEDAVDAGGVRKEFFLLIMRELLDPKYGMFRYYEDSRLIWFSDKTF-----EDSDLFHLIGVICGLAIYNFTIVDL 814
           78999***********************************************88877.....689********************** PP
   S: 91   plsksfyklllgkklsledleevdpelykslkeikenaesdieelgldltfsvseeilgetkeeeLkpgGenipVtneNkeeYvklv 177
           +++ ++yk+ll+kk sl+dl+e++p++ +s+++++++ e+diee+ ++l+f+++ e++g t+++eL+ +G+++ V+++N++e+v+++
   Q: 815  HFPLALYKKLLKKKPSLDDLKELMPDVGRSMQQLLDYPEDDIEET-FCLNFTITVENFGATEVKELVLNGADTAVNKQNRQEFVDAY 900
           ***************************************9**998.***************************************** PP
   S: 178  veyrlkegikeqveafreGfneviplellslFteeelellicGeeeidvedlkketkykggytedspaiqwFwevleefsseerkaf 264
           v+y++++++++ ++af++Gf++v+  ++l lF+++el+ ++ G++++d+++l+k+t+ykg+y +++p+i+ Fwev++e+  e++k+f
   Q: 901  VDYIFNKSVASLFDAFHAGFHKVCGGKVLLLFQPNELQAMVIGNTNYDWKELEKNTEYKGEYWAEHPTIKIFWEVFHELPLEKKKQF 987
           *************************************************************************************** PP
   S: 265  LqFvTgssrlPlgGfaelkprlfvirk.dasddrlPssnTCfnyLkLPeYsskeilkekLlyAieetkgFel 335
           L F+Tgs+r+P+ G+++lk    vi+   + ++ lP s+TCfn+L+LP+Y++ke+l++kL+ Ai++++gF+l
   Q: 988  LLFLTGSDRIPILGMKSLK---LVIQStGGGEEYLPVSHTCFNLLDLPKYTEKETLRSKLIQAIDHNEGFSL 1056
           *******************...7777758889**************************************86 PP

Organism

Pan troglodytes

Protein Sequence
(Fasta)

MLCWGNASFG QLGLGGIDEE IVLEPRKSDF FINKRVRDVG CGLRHTVFVL DDGTVYTCGC 60
NDLGQLGHEK SRKKPEQVVA LDAQNIVAVS CGEAHTLALN DKGQVYAWGL DSDGQLGLVG 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

TTCCGGCCAG CCCCTCCCCC GCCTCCCTCG CGTGGCCACC TCCCCCTCTG CCTTCTCCTA 60
CCCAGTCTCT TCCCCAACTC TCCCCACCCC TCGTGCTCTC CTCCCCGCTT GCCTCCCGTT 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-1185--Reference proteome
KW-0677--Repeat
KW-0808--Transferase
KW-0833--Ubl conjugation pathway

Interpro

IPR000569--HECT_dom
IPR009091--RCC1/BLIP-II
IPR000408--Reg_chr_condens

PROSITE

PS50237--HECT
PS00626--RCC1_2
PS50012--RCC1_3

Pfam

PF00632--HECT
PF00415--RCC1

PRINTS

PR00633--RCCNDNSATION

SMART

SM00119--HECTc

Gene Ontology

GO:0005829--C:cytosol
GO:0001650--C:fibrillar center
GO:0004842--F:ubiquitin-protein transferase activity
GO:0007283--P:spermatogenesis

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001666	Ailuropoda melanoleuca	98.11	0.00e+00	2013.00
IUUC-Apl-003295	Anas platyrhynchos	88.47	0.00e+00	1878.00
IUUC-Aca-004336	Anolis carolinensis	86.23	0.00e+00	1821.00
IUUC-Ame-010768	Astyanax mexicanus	73.16	0.00e+00	1571.00
IUUC-Bta-013279	Bos taurus	97.73	0.00e+00	2006.00
IUUC-Bdi-014791	Brachypodium distachyon	37.29	4.00e-52	198.00
IUUC-Cel-018150	Caenorhabditis elegans	35.01	1.00e-149	524.00
IUUC-Cja-019023	Callithrix jacchus	98.58	0.00e+00	2022.00
IUUC-Cfa-021074	Canis familiaris	98.30	0.00e+00	2018.00
IUUC-Cpo-021461	Cavia porcellus	95.94	0.00e+00	1959.00
IUUC-Csa-024261	Chlorocebus sabaeus	99.05	0.00e+00	2033.00
IUUC-Cho-024513	Choloepus hoffmanni	78.05	0.00e+00	1491.00
IUUC-Cin-025232	Ciona intestinalis	42.72	0.00e+00	813.00
IUUC-Dre-028829	Danio rerio	74.81	0.00e+00	1562.00
IUUC-Dno-029445	Dasypus novemcinctus	95.16	0.00e+00	1627.00
IUUC-Dor-030158	Dipodomys ordii	97.36	0.00e+00	880.00
IUUC-Dme-032103	Drosophila melanogaster	45.07	0.00e+00	894.00
IUUC-Ete-033072	Echinops telfairi	86.57	0.00e+00	1726.00
IUUC-Eca-033317	Equus caballus	95.93	0.00e+00	1964.00
IUUC-Eeu-035098	Erinaceus europaeus	48.07	0.00e+00	690.00
IUUC-Fca-035682	Felis catus	97.73	0.00e+00	1998.00
IUUC-Fal-036969	Ficedula albicollis	87.42	0.00e+00	1853.00
IUUC-Gmo-038671	Gadus morhua	74.04	0.00e+00	1571.00
IUUC-Gga-041174	Gallus gallus	88.36	0.00e+00	1878.00
IUUC-Gac-042600	Gasterosteus aculeatus	73.96	0.00e+00	1513.00
IUUC-Gma-043616	Glycine max	37.18	4.00e-52	198.00
IUUC-Ggo-044589	Gorilla gorilla	99.62	0.00e+00	2070.00
IUUC-Hsa-046772	Homo sapiens	99.62	0.00e+00	2067.00
IUUC-Itr-048311	Ictidomys tridecemlineatus	55.86	0.00e+00	1109.00
IUUC-Lch-050147	Latimeria chalumnae	80.79	0.00e+00	1434.00
IUUC-Loc-052684	Lepisosteus oculatus	80.89	0.00e+00	1709.00
IUUC-Laf-053844	Loxodonta africana	97.63	0.00e+00	2000.00
IUUC-Mcc-055531	Macaca mulatta	96.76	0.00e+00	2017.00
IUUC-Meu-056274	Macropus eugenii	48.26	4.00e-142	499.00
IUUC-Mtr-058277	Medicago truncatula	36.81	1.00e-52	200.00
IUUC-Mga-060151	Meleagris gallopavo	87.78	0.00e+00	1565.00
IUUC-Mmr-060954	Microcebus murinus	98.39	0.00e+00	2016.00
IUUC-Mdo-062246	Monodelphis domestica	92.46	0.00e+00	1778.00
IUUC-Mmu-063369	Mus musculus	96.40	0.00e+00	1989.00
IUUC-Mpu-065936	Mustela putorius furo	97.56	0.00e+00	1849.00
IUUC-Mlu-067326	Myotis lucifugus	97.54	0.00e+00	1973.00
IUUC-Nle-069453	Nomascus leucogenys	98.68	0.00e+00	2011.00
IUUC-Opr-070891	Ochotona princeps	48.53	0.00e+00	904.00
IUUC-Ont-071720	Oreochromis niloticus	74.72	0.00e+00	1570.00
IUUC-Oan-073464	Ornithorhynchus anatinus	92.97	0.00e+00	1798.00
IUUC-Ocu-074207	Oryctolagus cuniculus	96.05	0.00e+00	1854.00
IUUC-Olo-080768	Oryza longistaminata	37.86	4.00e-53	202.00
IUUC-Ome-081908	Oryza meridionalis	33.94	2.00e-47	183.00
IUUC-Ola-086762	Oryzias latipes	74.34	0.00e+00	1535.00
IUUC-Oga-088435	Otolemur garnettii	98.39	0.00e+00	2018.00
IUUC-Oar-089233	Ovis aries	97.73	0.00e+00	2007.00
IUUC-Pan-092300	Papio anubis	99.05	0.00e+00	2033.00
IUUC-Psi-093406	Pelodiscus sinensis	89.88	0.00e+00	1897.00
IUUC-Pma-094113	Petromyzon marinus	71.53	0.00e+00	1138.00
IUUC-Ppa-095354	Physcomitrella patens	32.38	4.00e-147	515.00
IUUC-Pfo-097021	Poecilia formosa	73.51	0.00e+00	1580.00
IUUC-Pab-098327	Pongo abelii	99.62	0.00e+00	2066.00
IUUC-Pca-101075	Procavia capensis	96.28	0.00e+00	823.00
IUUC-Pva-102909	Pteropus vampyrus	86.57	0.00e+00	1699.00
IUUC-Rno-105457	Rattus norvegicus	97.16	0.00e+00	2008.00
IUUC-Sha-106632	Sarcophilus harrisii	93.76	0.00e+00	1954.00
IUUC-Sar-113679	Sorex araneus	88.19	0.00e+00	1150.00
IUUC-Ssc-115473	Sus scrofa	56.01	0.00e+00	1112.00
IUUC-Tgu-116849	Taeniopygia guttata	83.44	0.00e+00	1742.00
IUUC-Tru-118206	Takifugu rubripes	72.89	0.00e+00	1471.00
IUUC-Tsy-119521	Tarsius syrichta	83.63	0.00e+00	1617.00
IUUC-Tni-120233	Tetraodon nigroviridis	72.14	0.00e+00	1461.00
IUUC-Tbe-127941	Tupaia belangeri	87.97	0.00e+00	1157.00
IUUC-Ttr-128926	Tursiops truncatus	97.76	0.00e+00	1182.00
IUUC-Vpa-130448	Vicugna pacos	97.16	0.00e+00	1994.00
IUUC-Xtr-132719	Xenopus tropicalis	70.79	0.00e+00	1387.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence