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Tag Content
UUCD2 ID IUUC-Cja-018985
UUCD1 version UUC-CaJ-00728
Ensembl Protein ID ENSCJAP00000029455.2
UniProt Accession F7HL79; F7HL79_CALJA
Genbank Protein ID JAB17119.1; JAB28944.1; JAB45258.1
Protein Name E3 ubiquitin-protein ligase SMURF1 isoform 1
Genbank Nucleotide ID ACFV01126973; GAMR01004988; GAMP01007497
Gene Name SMURF1
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
ENSCJAG00000015970.2 ENSCJAT00000031115.2 ENSCJAP00000029446.2
ENSCJAG00000015970.2 ENSCJAT00000031126.2 ENSCJAP00000029455.2
Status Unreviewed
Classification
Family E-Value Score Start End
E3 activity/HECT 3.70e-127 425.3 421 756
Active Site
Position(s) Description Evidence
725 Glycyl thioester intermediate {ECO:0000256|PIRSR:PIRSR001569-1,
ECO:0000256|PROSITE-ProRule:PRU00104}
Domain Profile

   E3 activity/HECT
   S: 2    ksdlkkrlevefvgEegldlgGvtreflallskelqnpdlglflysendketlqpnpdsglknpehlklFeflGrllgkalqdgrlldl 90
           ++dlkkrl+v+f+gEegld+gGv+re+l+ll++e+ np++glf+ys ++ ++lq+npds + np+hl++F+f+Gr++g+a+++g++++ 
   Q: 421  PKDLKKRLMVKFRGEEGLDYGGVAREWLYLLCHEMLNPYYGLFQYSTDNIYMLQINPDSSI-NPDHLSYFHFVGRIMGLAVFHGHYING 508
           689*********************************************************9.89************************* PP
   S: 91   plsksfyklllgkklsledleevdpelykslkeikenaesdieelgldltfsvseeilgetkeeeLkpgGenipVtneNkeeYvklvve 179
            ++ +fyk+llgk+++l+dle+vdpel+ksl +i+en   di+   ld tf+v+++ +g + ++eLkp+G+n+pVt+eNk+eYv+l+v+
   Q: 509  GFTVPFYKQLLGKPIQLSDLESVDPELHKSLVWILEN---DITPV-LDHTFCVEHNAFGRILQHELKPNGRNVPVTEENKKEYVRLYVN 593
           ***********************************99...9***8.******************************************* PP
   S: 180  yrlkegikeqveafreGfneviplellslFteeelellicGeeeidvedlkketkykggytedspaiqwFwevleefsseerkafLqFv 268
           +r+ +gi+ q+ a+++Gfne+ip++ll+ F+++elel+i G ++id++d+k++t+ k+ + +ds+ ++wFw+++e f++e r+++LqFv
   Q: 594  WRFMRGIEAQFLALQKGFNELIPQHLLKPFDQKELELIIGGLDKIDLNDWKSNTRLKH-CVADSNIVRWFWQAVETFDEERRARLLQFV 681
           ********************************************************99.****************************** PP
   S: 269  TgssrlPlgGfaelk.......prlfvirk.dasddrlPssnTCfnyLkLPeYsskeilkekLlyAieetkgFel 335
           Tgs r+Pl+Gf++l+       prlf+i+  da++d+lP+++TCfn++++P+Y+s+e+l+ekLl+A+eet gF +
   Q: 682  TGSTRVPLQGFKALQgstgaagPRLFTIHLiDANTDNLPKAHTCFNRIDIPPYESYEKLYEKLLTAVEETCGFAV 756
           ******************************99999**************************************76 PP
   
Organism Callithrix jacchus
Protein Sequence
(Fasta)
MSNPGTRRNG SSIKIRLTVL CAKNLAKKDF FRLPDPFAKI VVDGSGQCHS TDTVKNTLDP 60
KWNQHYDLYV GKTDSITISV WNHKKIHKKQ GAGFLGCVRL LSNAISRLKD TGYQRLDLCK 120
It may take some time, please wait.

Protein Fasta Sequence


>IUUC-Cja-018985|E3,HECT|Callithrix jacchus
Please wait for a moment...
Nucleotide Sequence
(Fasta)
CGGCGGAAGA GGCGAGAGGC GGCGGACGTC CGGGCTATGA GGTGGGTGGA GGAGGAGGCG 60
GTTGCTCGGG ACTGAGCTCG GCTGGGAAGA GCGAGGGTCA GGGCACAGCA GCGAGCGCCG 120
It may take some time, please wait.

Nucleotide Fasta Sequence


>IUUC-Cja-018985|E3,HECT|Callithrix jacchus
Please wait for a moment...
Sequence Source Ensembl
Keyword

KW-0181--Complete proteome
KW-0436--Ligase
KW-1185--Reference proteome
KW-0808--Transferase
KW-0833--Ubl conjugation pathway
Interpro

IPR000008--C2_dom
IPR000569--HECT_dom
IPR001202--WW_dom
PROSITE

PS50004--C2
PS50237--HECT
PS01159--WW_DOMAIN_1
PS50020--WW_DOMAIN_2
Pfam

PF00168--C2
PF00632--HECT
PF00397--WW
SMART

SM00239--C2
SM00119--HECTc
SM00456--WW
Gene Ontology

GO:0070062--C:extracellular exosome
GO:0005739--C:mitochondrion
GO:0005886--C:plasma membrane
GO:0016874--F:ligase activity
GO:0061630--F:ubiquitin protein ligase activity
GO:0030509--P:BMP signaling pathway
GO:0061736--P:engulfment of target by autophagosome
GO:0030279--P:negative regulation of ossification
GO:0030512--P:negative regulation of transforming growth factor beta receptor signaling pathway
GO:0061734--P:parkin-mediated stimulation of mitophagy in response to mitochondrial depolarization
GO:1903861--P:positive regulation of dendrite extension
GO:2000060--P:positive regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process
GO:0043161--P:proteasome-mediated ubiquitin-dependent protein catabolic process
GO:0006611--P:protein export from nucleus
GO:0034394--P:protein localization to cell surface
GO:0000209--P:protein polyubiquitination
GO:0071211--P:protein targeting to vacuole involved in autophagy
GO:0042787--P:protein ubiquitination involved in ubiquitin-dependent protein catabolic process
GO:0032801--P:receptor catabolic process
GO:0061753--P:substrate localization to autophagosome
GO:0030579--P:ubiquitin-dependent SMAD protein catabolic process
KEGG cjc:100392632
Orthology
iUUCD ID Species Identity E-value Score
IUUC-Aml-001459 Ailuropoda melanoleuca 89.96 0.00e+00 1407.00
IUUC-Apl-004155 Anas platyrhynchos 93.40 0.00e+00 1454.00
IUUC-Aca-005238 Anolis carolinensis 92.37 0.00e+00 1428.00
IUUC-Ame-010901 Astyanax mexicanus 87.99 0.00e+00 1378.00
IUUC-Bta-013221 Bos taurus 88.22 0.00e+00 1344.00
IUUC-Cfa-020568 Canis familiaris 96.68 0.00e+00 1501.00
IUUC-Cpo-022531 Cavia porcellus 99.08 0.00e+00 1564.00
IUUC-Csa-024145 Chlorocebus sabaeus 95.90 0.00e+00 1496.00
IUUC-Cho-024963 Choloepus hoffmanni 80.85 0.00e+00 982.00
IUUC-Dre-028341 Danio rerio 88.67 0.00e+00 1392.00
IUUC-Dno-029705 Dasypus novemcinctus 97.87 0.00e+00 1506.00
IUUC-Dme-031740 Drosophila melanogaster 72.28 5.00e-175 608.00
IUUC-Eca-034125 Equus caballus 99.32 0.00e+00 1531.00
IUUC-Fca-035905 Felis catus 94.53 0.00e+00 1446.00
IUUC-Fal-037336 Ficedula albicollis 93.14 0.00e+00 1407.00
IUUC-Gmo-039486 Gadus morhua 76.71 0.00e+00 858.00
IUUC-Gga-040218 Gallus gallus 95.26 0.00e+00 1487.00
IUUC-Gac-041707 Gasterosteus aculeatus 82.22 0.00e+00 1276.00
IUUC-Ggo-045408 Gorilla gorilla 93.37 0.00e+00 1423.00
IUUC-Hsa-045878 Homo sapiens 99.60 0.00e+00 1572.00
IUUC-Itr-048317 Ictidomys tridecemlineatus 98.38 0.00e+00 1513.00
IUUC-Loc-052628 Lepisosteus oculatus 83.29 0.00e+00 1365.00
IUUC-Laf-053644 Loxodonta africana 90.12 0.00e+00 1389.00
IUUC-Mcc-055479 Macaca mulatta 88.38 0.00e+00 1347.00
IUUC-Mga-059723 Meleagris gallopavo 89.95 0.00e+00 1391.00
IUUC-Mdo-063005 Monodelphis domestica 94.85 0.00e+00 1484.00
IUUC-Mmu-063634 Mus musculus 95.38 0.00e+00 1469.00
IUUC-Mpu-065898 Mustela putorius furo 95.03 0.00e+00 1449.00
IUUC-Mlu-067584 Myotis lucifugus 98.12 0.00e+00 1525.00
IUUC-Nle-069033 Nomascus leucogenys 99.59 0.00e+00 1535.00
IUUC-Ont-072265 Oreochromis niloticus 84.76 0.00e+00 1326.00
IUUC-Oan-073621 Ornithorhynchus anatinus 88.45 0.00e+00 1424.00
IUUC-Ocu-073960 Oryctolagus cuniculus 97.84 0.00e+00 1500.00
IUUC-Oga-088579 Otolemur garnettii 99.60 0.00e+00 1571.00
IUUC-Oar-090396 Ovis aries 95.96 0.00e+00 1414.00
IUUC-Ptr-091624 Pan troglodytes 99.60 0.00e+00 1572.00
IUUC-Pan-092479 Papio anubis 99.59 0.00e+00 1536.00
IUUC-Pfo-097203 Poecilia formosa 82.25 0.00e+00 1289.00
IUUC-Pab-097540 Pongo abelii 99.45 0.00e+00 1499.00
IUUC-Pca-100379 Procavia capensis 73.59 0.00e+00 650.00
IUUC-Rno-105396 Rattus norvegicus 95.51 0.00e+00 1472.00
IUUC-Sha-107216 Sarcophilus harrisii 94.81 0.00e+00 1477.00
IUUC-Sar-113250 Sorex araneus 96.85 0.00e+00 832.00
IUUC-Ssc-116413 Sus scrofa 92.98 0.00e+00 1417.00
IUUC-Tgu-116723 Taeniopygia guttata 93.67 0.00e+00 1420.00
IUUC-Tru-117843 Takifugu rubripes 80.25 0.00e+00 1271.00
IUUC-Tsy-119455 Tarsius syrichta 99.29 0.00e+00 1439.00
IUUC-Tni-120037 Tetraodon nigroviridis 81.75 0.00e+00 1228.00
IUUC-Tbe-127879 Tupaia belangeri 85.23 0.00e+00 1261.00
IUUC-Ttr-128423 Tursiops truncatus 97.56 0.00e+00 1444.00
IUUC-Xtr-132237 Xenopus tropicalis 87.89 0.00e+00 1389.00
Created Date 25-Jun-2017

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