iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

UUCD2 ID

IUUC-Ggo-045408

UUCD1 version

UUC-GoG-00676

Ensembl Protein ID

ENSGGOP00000016907.1

UniProt Accession

G3RM93; G3RM93_GORGO

Protein Name

Uncharacterized protein

Gene Name

SMURF1

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSGGOG00000011481.2	ENSGGOT00000011532.2	ENSGGOP00000011203.2
ENSGGOG00000011481.2	ENSGGOT00000031936.1	ENSGGOP00000016907.1

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 activity/HECT	3.20e-100	336.2	420	751

Active Site

Position(s)	Description	Evidence
720	Glycyl thioester intermediate	{ECO:0000256\|PIRSR:PIRSR001569-1, ECO:0000256\|PROSITE-ProRule:PRU00104}

Domain Profile

E3 activity/HECT

   S: 2    ksdlkkrlevefvgEegldlgGvtreflallskelqnpdlglflysendketlqpnpdsglknpehlklFeflGrllgkalqdgrlldl 90
           ++dlkkrl+v+f+gEegld+gGv+re+l+ll++e+ np++glf+ys ++ ++lq+npds + np+hl++F+f+Gr++g+a+++g++++ 
   Q: 420  PKDLKKRLMVKFRGEEGLDYGGVAREWLYLLCHEMLNPYYGLFQYSTDNIYMLQINPDSSI-NPDHLSYFHFVGRIMGLAVFHGHYING 507
           689*********************************************************9.89************************* PP
   S: 91   plsksfyklllgkklsledleevdpelykslkeikenaesdieelgldltfsvseeilgetkeeeLkpgGenipVtneNkeeYvklvve 179
            ++ +fyk+llgk+++l+dle+vdpel+ksl +i+en   di+   ld tf+v+++ +g + ++eLkp+G+n+pVt+eNk+eYv+l+v+
   Q: 508  GFTVPFYKQLLGKPIQLSDLESVDPELHKSLVWILEN---DITPV-LDHTFCVEHNAFGRILQHELKPNGRNVPVTEENKKEYVRLYVN 592
           ***********************************99...9***8.******************************************* PP
   S: 180  yrlkegikeqveafreGfneviplellslFteeelellicGeeeidvedlkketkykggytedspaiqwFwevleefsseerkafLqFv 268
           +r+ +gi+ q+ a+++Gfne+ip++ll+ F+++ele +  G+e+++++ ++  ++    +t +s    +F+++  + ++  r++     
   Q: 593  WRFMRGIEAQFLALQKGFNELIPQHLLKPFDQKELENIAGGKEQLSWSGWSGRQRLPA-FTVQSVIQVYFIQA--AYDQLRRCRKADVE 678
           ******************************************************9977.67666666688887..56777777777888 PP
   S: 269  TgssrlPlgGfaelk.......prlfvirk.dasddrlPssnTCfnyLkLPeYsskeilkekLlyAieetkgFel 335
           Tg++  P +Gf + +       prlf+i+  da++d+lP+++TCfn++++P+Y+s+e+l+ekLl+A+eet gF +
   Q: 679  TGRK--PKRGFCSASgstgaagPRLFTIHLiDANTDNLPKAHTCFNRIDIPPYESYEKLYEKLLTAVEETCGFAV 751
           9999..************************99999**************************************76 PP

Organism

Gorilla gorilla

Protein Sequence
(Fasta)

YGNLVFNANL SNFSLFLVLC AKNLAKKDFF RLPDPFAKIV VDGSGQCHST DTVKNTLDPK 60
WNQHYDLYVG KTDSITISVW NHKKIHKKQG AGFLGCVRLL SNAISRLKDT GYQRLDLCKL 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

TTGATCCCAN NNNNNNNNNN NNNNNNNNNN NNNNNNNNNN NNNNNNNNNN NNNNNNNNNN 60
NNNNNNNNNN NNNNNNNNNN NNNNTCTCTT AAAAAAAAAA AAGTATATTG ATCAACCCAT 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-1185--Reference proteome
KW-0732--Signal
KW-0808--Transferase
KW-0833--Ubl conjugation pathway

Interpro

IPR000008--C2_dom
IPR000569--HECT_dom
IPR001202--WW_dom

PROSITE

PS50004--C2
PS50237--HECT
PS01159--WW_DOMAIN_1
PS50020--WW_DOMAIN_2

Pfam

PF00168--C2
PF00632--HECT
PF00397--WW

SMART

SM00239--C2
SM00119--HECTc
SM00456--WW

Gene Ontology

GO:0070062--C:extracellular exosome
GO:0005739--C:mitochondrion
GO:0005886--C:plasma membrane
GO:0061630--F:ubiquitin protein ligase activity
GO:0030509--P:BMP signaling pathway
GO:0061736--P:engulfment of target by autophagosome
GO:0030279--P:negative regulation of ossification
GO:0030512--P:negative regulation of transforming growth factor beta receptor signaling pathway
GO:0061734--P:parkin-mediated stimulation of mitophagy in response to mitochondrial depolarization
GO:1903861--P:positive regulation of dendrite extension
GO:2000060--P:positive regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process
GO:0043161--P:proteasome-mediated ubiquitin-dependent protein catabolic process
GO:0006611--P:protein export from nucleus
GO:0034394--P:protein localization to cell surface
GO:0000209--P:protein polyubiquitination
GO:0071211--P:protein targeting to vacuole involved in autophagy
GO:0042787--P:protein ubiquitination involved in ubiquitin-dependent protein catabolic process
GO:0032801--P:receptor catabolic process
GO:0061753--P:substrate localization to autophagosome
GO:0030579--P:ubiquitin-dependent SMAD protein catabolic process

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001459	Ailuropoda melanoleuca	84.73	0.00e+00	1295.00
IUUC-Apl-004155	Anas platyrhynchos	88.42	0.00e+00	1340.00
IUUC-Aca-005238	Anolis carolinensis	87.06	0.00e+00	1310.00
IUUC-Ame-010901	Astyanax mexicanus	82.16	0.00e+00	1235.00
IUUC-Bta-013221	Bos taurus	83.21	0.00e+00	1258.00
IUUC-Cja-018985	Callithrix jacchus	93.37	0.00e+00	1423.00
IUUC-Cfa-020568	Canis familiaris	91.90	0.00e+00	1383.00
IUUC-Cpo-022531	Cavia porcellus	92.42	0.00e+00	1410.00
IUUC-Csa-024145	Chlorocebus sabaeus	89.72	0.00e+00	1348.00
IUUC-Cho-024963	Choloepus hoffmanni	80.85	0.00e+00	982.00
IUUC-Cin-025126	Ciona intestinalis	56.66	0.00e+00	830.00
IUUC-Csv-026339	Ciona savignyi	56.83	0.00e+00	834.00
IUUC-Dre-028341	Danio rerio	82.86	0.00e+00	1249.00
IUUC-Dno-029705	Dasypus novemcinctus	91.94	0.00e+00	1389.00
IUUC-Dor-030314	Dipodomys ordii	98.17	5.00e-129	454.00
IUUC-Ete-032924	Echinops telfairi	89.87	0.00e+00	946.00
IUUC-Eca-034125	Equus caballus	92.69	0.00e+00	1411.00
IUUC-Eeu-034945	Erinaceus europaeus	64.55	0.00e+00	919.00
IUUC-Fca-035905	Felis catus	88.68	0.00e+00	1338.00
IUUC-Fal-037336	Ficedula albicollis	87.48	0.00e+00	1299.00
IUUC-Gmo-039486	Gadus morhua	72.92	0.00e+00	798.00
IUUC-Gga-040218	Gallus gallus	89.07	0.00e+00	1339.00
IUUC-Gac-041707	Gasterosteus aculeatus	76.97	0.00e+00	1144.00
IUUC-Hsa-045878	Homo sapiens	93.78	0.00e+00	1428.00
IUUC-Itr-048317	Ictidomys tridecemlineatus	91.88	0.00e+00	1396.00
IUUC-Lch-050026	Latimeria chalumnae	66.24	0.00e+00	1008.00
IUUC-Loc-052628	Lepisosteus oculatus	77.64	0.00e+00	1222.00
IUUC-Laf-053644	Loxodonta africana	84.27	0.00e+00	1280.00
IUUC-Mcc-055479	Macaca mulatta	82.00	0.00e+00	1198.00
IUUC-Meu-056436	Macropus eugenii	51.80	0.00e+00	716.00
IUUC-Mga-059723	Meleagris gallopavo	84.16	0.00e+00	1278.00
IUUC-Mmr-060806	Microcebus murinus	67.01	0.00e+00	1019.00
IUUC-Mdo-063005	Monodelphis domestica	89.04	0.00e+00	1342.00
IUUC-Mmu-063634	Mus musculus	88.90	0.00e+00	1319.00
IUUC-Mpu-065898	Mustela putorius furo	89.61	0.00e+00	1339.00
IUUC-Mlu-067584	Myotis lucifugus	91.91	0.00e+00	1424.00
IUUC-Nle-069033	Nomascus leucogenys	93.78	0.00e+00	1428.00
IUUC-Opr-070591	Ochotona princeps	63.26	0.00e+00	934.00
IUUC-Ont-072265	Oreochromis niloticus	79.81	0.00e+00	1196.00
IUUC-Oan-073621	Ornithorhynchus anatinus	84.17	0.00e+00	1312.00
IUUC-Ocu-073960	Oryctolagus cuniculus	91.36	0.00e+00	1381.00
IUUC-Ola-086597	Oryzias latipes	70.13	0.00e+00	1051.00
IUUC-Oga-088579	Otolemur garnettii	93.23	0.00e+00	1419.00
IUUC-Oar-090396	Ovis aries	89.26	0.00e+00	1327.00
IUUC-Ptr-091624	Pan troglodytes	93.78	0.00e+00	1428.00
IUUC-Pan-092479	Papio anubis	93.65	0.00e+00	1458.00
IUUC-Psi-093298	Pelodiscus sinensis	67.10	0.00e+00	1018.00
IUUC-Pma-094354	Petromyzon marinus	59.92	0.00e+00	870.00
IUUC-Pfo-097203	Poecilia formosa	77.14	0.00e+00	1157.00
IUUC-Pab-097540	Pongo abelii	93.34	0.00e+00	1357.00
IUUC-Pca-100379	Procavia capensis	68.61	2.00e-170	592.00
IUUC-Pva-102754	Pteropus vampyrus	65.80	0.00e+00	981.00
IUUC-Rno-105396	Rattus norvegicus	89.04	0.00e+00	1322.00
IUUC-Sha-107216	Sarcophilus harrisii	88.93	0.00e+00	1360.00
IUUC-Sar-113250	Sorex araneus	87.41	0.00e+00	731.00
IUUC-Ssc-116413	Sus scrofa	88.53	0.00e+00	1326.00
IUUC-Tgu-116723	Taeniopygia guttata	87.87	0.00e+00	1312.00
IUUC-Tru-117843	Takifugu rubripes	75.36	0.00e+00	1140.00
IUUC-Tsy-119455	Tarsius syrichta	92.35	0.00e+00	1321.00
IUUC-Tni-120037	Tetraodon nigroviridis	76.90	0.00e+00	1114.00
IUUC-Tbe-127879	Tupaia belangeri	78.73	0.00e+00	1142.00
IUUC-Ttr-128423	Tursiops truncatus	91.19	0.00e+00	1349.00
IUUC-Vpa-130591	Vicugna pacos	61.17	0.00e+00	897.00
IUUC-Xtr-132237	Xenopus tropicalis	83.38	0.00e+00	1265.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence