iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

iUUCD ID

IUUC-Mpu-066687

Ensembl Protein ID

ENSMPUP00000000011.1

UniProt Accession

M3XLR1; M3XLR1_MUSPF

Genbank Protein ID

ENSMPUP00000000011

Protein Name

Ubiquitinyl hydrolase 1

Genbank Nucleotide ID

AEYP01089293

Gene Name

USP22

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSMPUG00000000011.1	ENSMPUT00000000011.1	ENSMPUP00000000011.1

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
DUB/USP	5.10e-92	308.6	175	519

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

DUB/USP

   S: 2    GlkNlgNtCYmNSvLQcLsnipelrelllekkkeklneenpkepkgellkslqklfeelw.kskkkavsprellkalkkeaeefsgyeq 89
           Gl NlgNtC+mN+++Q+L+++p lr+++l+ ++++++ +   +p+ +l++++ +lf+e   +++++   p +ll+ +++ a+++ gyeq
   Q: 175  GLINLGNTCFMNCIVQALTHTPLLRDFFLS-DRHRCEMQ---SPSSCLVCEMSSLFQEQFySGHRSPHIPYKLLHLVWTHARHLAGYEQ 259
           9*****************************.99999875...78************9987799999*********************** PP
   S: 90   qDaqEflaflldqleeelkkeknkpkeeeeeedkselsdeaeekkkkknkslisdlFqgqlksqikclecdnvssreepfldlslpvpg 178
           qDa+Efl   ld l++++k                  ++ ++ +++++ +++i+++F g l+s+++c+ c+ vs++ +pf+d+sl++pg
   Q: 260  QDAHEFLIAALDVLHRHCKG----------------DDNGKKANNPNHCNCIIDQIFTGGLQSDVTCQVCHGVSTTIDPFWDISLDLPG 332
           ******************22................22335677899999*************************************** PP
   S: 179  keetkke....................slqdcLesftkeeelegenkyycekckkkqeaekklklkklPevLilhLkRfsfseeqksre 247
           +++   +                    +l+dcL+ ft++e+l ++ k++c+ c+++qe++k+l++kklP v ++hLkRf  +++ k r+
   Q: 333  SSTPFWPlspgsegsvvngeshvagttTLTDCLRRFTRPEHLGSSAKIKCSGCHSYQESTKQLTMKKLPIVACFHLKRF--EHSAKLRR 419
           **87777************************************************************************..5666899* PP
   S: 248  kinkkvefpleLdlspfcts............peekqkekkkYeLiavvvHsGslssGHYvayvknekgkWllfdDskVtevkeeevle 324
           ki+++v+fpleLd++pf++s            p+++ ++++kY+L+avv+H+G+l+sGHY+++++++k++W+++dD  +t+ + e+vl 
   Q: 420  KITTYVSFPLELDMTPFMASskesrmngqyqqPTDSLNNDNKYSLFAVVNHQGTLESGHYTSFIRQHKDQWFKCDDAIITKASIEDVLD 508
           ********************5555555555554445555************************************************** PP
   S: 325  etgstaYvlfYkrr 338
              s++Y+lfY+++
   Q: 509  ---SEGYLLFYHKQ 519
           ...********985 PP

Organism

Mustela putorius furo

Protein Sequence
(Fasta)

FARPGPLLRL FAAELRTPPG CSHLSSFKVD NWKQNLRAIY QCFVWSGTAE ARKRKAKSCV 60
CHVCGVHLNR LHSCLHCVFF GCFTKKHIHE HAKSKRHNLA IELMYGGIYC FLCHDYIYDK 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

TTTGCAAGGC CCGGCCCGTT GCTCCGCCTC TTTGCGGCAG AGCTCAGGCC AGTGCAAACC 60
GGTTCAGTGC CCCGACGGAC TGTCCGCGTC GCCCAATCCT CCACTGCCCC CCGCCTCCGC 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-0378--Hydrolase
KW-0479--Metal-binding
KW-0645--Protease
KW-1185--Reference proteome
KW-0788--Thiol protease
KW-0833--Ubl conjugation pathway
KW-0862--Zinc
KW-0863--Zinc-finger

Interpro

IPR001394--Peptidase_C19_UCH
IPR018200--USP_CS
IPR028889--USP_dom
IPR013083--Znf_RING/FYVE/PHD
IPR001607--Znf_UBP

PROSITE

PS00972--USP_1
PS00973--USP_2
PS50235--USP_3
PS50271--ZF_UBP

Pfam

PF00443--UCH
PF02148--zf-UBP

Gene Ontology

GO:0000124--C:SAGA complex
GO:0010485--F:H4 histone acetyltransferase activity
GO:0030374--F:ligand-dependent nuclear receptor transcription coactivator activity
GO:0004843--F:thiol-dependent ubiquitin-specific protease activity
GO:0008270--F:zinc ion binding
GO:0016578--P:histone deubiquitination
GO:0016574--P:histone ubiquitination
GO:0045931--P:positive regulation of mitotic cell cycle
GO:0045893--P:positive regulation of transcription, DNA-templated
GO:0006511--P:ubiquitin-dependent protein catabolic process

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Ata-000393	Aegilops tauschii	38.29	2.00e-64	241.00
IUUC-Aml-001343	Ailuropoda melanoleuca	96.37	0.00e+00	1051.00
IUUC-Atr-002653	Amborella trichopoda	37.62	8.00e-99	354.00
IUUC-Apl-003433	Anas platyrhynchos	92.16	0.00e+00	941.00
IUUC-Aca-005347	Anolis carolinensis	88.15	0.00e+00	994.00
IUUC-Ago-007811	Ashbya gossypii	30.58	1.00e-53	204.00
IUUC-Acl-008124	Aspergillus clavatus	30.37	4.00e-58	218.00
IUUC-Afl-008464	Aspergillus flavus	32.77	8.00e-54	204.00
IUUC-Afu-008912	Aspergillus fumigatus	30.93	2.00e-55	210.00
IUUC-Ani-009168	Aspergillus nidulans	32.09	5.00e-57	215.00
IUUC-Ang-009694	Aspergillus niger	31.65	6.00e-56	211.00
IUUC-Aor-010035	Aspergillus oryzae	34.83	4.00e-38	151.00
IUUC-Ate-010382	Aspergillus terreus	32.05	1.00e-51	196.00
IUUC-Ame-011253	Astyanax mexicanus	84.96	0.00e+00	827.00
IUUC-Bgr-012150	Blumeria graminis	31.48	3.00e-48	186.00
IUUC-Bta-013303	Bos taurus	96.88	0.00e+00	1045.00
IUUC-Bci-013604	Botrytis cinerea	32.70	6.00e-57	214.00
IUUC-Bdi-014171	Brachypodium distachyon	35.49	1.00e-75	277.00
IUUC-Cja-019283	Callithrix jacchus	97.88	0.00e+00	875.00
IUUC-Cfa-021239	Canis familiaris	98.73	0.00e+00	976.00
IUUC-Cpo-022354	Cavia porcellus	94.47	0.00e+00	1035.00
IUUC-Csa-023145	Chlorocebus sabaeus	95.61	0.00e+00	1049.00
IUUC-Cho-024938	Choloepus hoffmanni	94.83	5.00e-65	241.00
IUUC-Cin-025109	Ciona intestinalis	56.88	1.00e-119	422.00
IUUC-Csv-026214	Ciona savignyi	55.28	5.00e-173	600.00
IUUC-Cne-027085	Cryptococcus neoformans	32.32	5.00e-62	232.00
IUUC-Dre-027433	Danio rerio	92.96	0.00e+00	920.00
IUUC-Dno-030095	Dasypus novemcinctus	96.38	0.00e+00	957.00
IUUC-Dor-030481	Dipodomys ordii	95.38	7.00e-99	354.00
IUUC-Dse-031415	Dothistroma septosporum	30.76	3.00e-61	229.00
IUUC-Dme-032074	Drosophila melanogaster	51.80	1.00e-137	482.00
IUUC-Ete-033175	Echinops telfairi	77.95	0.00e+00	702.00
IUUC-Eca-033736	Equus caballus	98.09	0.00e+00	965.00
IUUC-Eeu-034814	Erinaceus europaeus	92.54	1.00e-126	446.00
IUUC-Fca-035861	Felis catus	98.72	0.00e+00	972.00
IUUC-Fal-037645	Ficedula albicollis	92.45	0.00e+00	927.00
IUUC-Fox-038046	Fusarium oxysporum	31.68	4.00e-55	209.00
IUUC-Fso-038321	Fusarium solani	33.56	4.00e-55	208.00
IUUC-Gmo-038474	Gadus morhua	94.26	2.00e-171	595.00
IUUC-Gga-040624	Gallus gallus	91.05	0.00e+00	1007.00
IUUC-Gac-042197	Gasterosteus aculeatus	85.52	0.00e+00	919.00
IUUC-Gma-042897	Glycine max	33.51	6.00e-84	305.00
IUUC-Ggo-044409	Gorilla gorilla	95.80	0.00e+00	1052.00
IUUC-Hsa-046521	Homo sapiens	95.61	0.00e+00	1050.00
IUUC-Hvu-047739	Hordeum vulgare	38.84	6.00e-69	254.00
IUUC-Itr-048375	Ictidomys tridecemlineatus	96.49	0.00e+00	1037.00
IUUC-Kpa-049135	Komagataella pastoris	35.19	2.00e-68	253.00
IUUC-Lch-050537	Latimeria chalumnae	93.11	0.00e+00	1010.00
IUUC-Lpe-050969	Leersia perrieri	38.28	4.00e-72	265.00
IUUC-Loc-052765	Lepisosteus oculatus	82.71	0.00e+00	901.00
IUUC-Lma-053105	Leptosphaeria maculans	33.53	4.00e-66	245.00
IUUC-Laf-053571	Loxodonta africana	97.02	0.00e+00	959.00
IUUC-Mcc-055166	Macaca mulatta	95.61	0.00e+00	1049.00
IUUC-Mor-057103	Magnaporthe oryzae	31.18	7.00e-56	211.00
IUUC-Mpo-057621	Magnaporthe poae	32.31	1.00e-55	211.00
IUUC-Mtr-057894	Medicago truncatula	37.19	3.00e-84	305.00
IUUC-Mga-059709	Meleagris gallopavo	92.16	0.00e+00	941.00
IUUC-Mmr-060988	Microcebus murinus	95.80	0.00e+00	1047.00
IUUC-Mdo-063065	Monodelphis domestica	93.90	0.00e+00	1018.00
IUUC-Mmu-063829	Mus musculus	95.42	0.00e+00	1047.00
IUUC-Nfi-068423	Neosartorya fischeri	30.93	2.00e-55	210.00
IUUC-Ncr-068809	Neurospora crassa	30.06	3.00e-58	219.00
IUUC-Nle-069261	Nomascus leucogenys	91.79	0.00e+00	994.00
IUUC-Opr-070469	Ochotona princeps	79.48	0.00e+00	682.00
IUUC-Ont-071961	Oreochromis niloticus	88.30	0.00e+00	959.00
IUUC-Oan-073565	Ornithorhynchus anatinus	85.60	0.00e+00	910.00
IUUC-Ocu-074435	Oryctolagus cuniculus	95.69	0.00e+00	1017.00
IUUC-Obr-076652	Oryza brachyantha	41.84	5.00e-74	271.00
IUUC-Ogl-077910	Oryza glaberrima	36.02	1.00e-77	283.00
IUUC-Ogu-078479	Oryza glumaepatula	36.02	1.00e-77	284.00
IUUC-Oin-079697	Oryza indica	39.80	2.00e-75	276.00
IUUC-Olo-080811	Oryza longistaminata	41.38	5.00e-53	201.00
IUUC-Ome-081706	Oryza meridionalis	36.02	5.00e-77	282.00
IUUC-Oni-083070	Oryza nivara	35.61	1.00e-77	283.00
IUUC-Opu-083605	Oryza punctata	40.33	6.00e-67	247.00
IUUC-Oru-084522	Oryza rufipogon	36.02	1.00e-77	283.00
IUUC-Osa-085351	Oryza sativa	39.51	9.00e-76	277.00
IUUC-Ola-086743	Oryzias latipes	87.84	0.00e+00	749.00
IUUC-Olu-087695	Ostreococcus lucimarinus	31.27	2.00e-49	189.00
IUUC-Oga-089131	Otolemur garnettii	92.78	0.00e+00	1035.00
IUUC-Oar-089319	Ovis aries	98.08	0.00e+00	964.00
IUUC-Ptr-090783	Pan troglodytes	94.47	0.00e+00	967.00
IUUC-Pan-092927	Papio anubis	95.42	0.00e+00	1048.00
IUUC-Psi-093670	Pelodiscus sinensis	91.26	0.00e+00	942.00
IUUC-Pma-094323	Petromyzon marinus	70.39	0.00e+00	717.00
IUUC-Pfo-096462	Poecilia formosa	88.91	0.00e+00	978.00
IUUC-Pab-097612	Pongo abelii	95.80	0.00e+00	1050.00
IUUC-Pte-104340	Pyrenophora teres	32.34	1.00e-59	223.00
IUUC-Pyt-104782	Pyrenophora triticirepentis	33.94	1.00e-65	243.00
IUUC-Rno-105247	Rattus norvegicus	95.42	0.00e+00	1048.00
IUUC-Sce-106247	Saccharomyces cerevisiae	31.61	4.00e-51	195.00
IUUC-Sha-107538	Sarcophilus harrisii	95.85	2.00e-124	437.00
IUUC-Sja-107656	Schizosaccharomyces japonicus	34.48	4.00e-66	245.00
IUUC-Ssl-108531	Sclerotinia sclerotiorum	31.71	2.00e-53	203.00
IUUC-Sbi-114205	Sorghum bicolor	35.27	2.00e-79	290.00
IUUC-Tgu-116938	Taeniopygia guttata	95.11	0.00e+00	950.00
IUUC-Tru-117622	Takifugu rubripes	87.81	0.00e+00	977.00
IUUC-Tsy-119431	Tarsius syrichta	85.50	0.00e+00	809.00
IUUC-Tni-120661	Tetraodon nigroviridis	90.06	0.00e+00	987.00
IUUC-Tre-122139	Trichoderma reesei	33.33	2.00e-54	206.00
IUUC-Tvi-122599	Trichoderma virens	32.74	2.00e-55	209.00
IUUC-Tae-125608	Triticum aestivum	35.69	5.00e-85	308.00
IUUC-Tme-127115	Tuber melanosporum	36.35	3.00e-80	292.00
IUUC-Uma-129455	Ustilago maydis	33.58	1.00e-32	134.00
IUUC-Xtr-132444	Xenopus tropicalis	90.25	0.00e+00	999.00
IUUC-Xma-133514	Xiphophorus maculatus	90.49	0.00e+00	993.00
IUUC-Yli-134357	Yarrowia lipolytica	30.33	7.00e-48	184.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence