iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSCAFG00000014600.4	ENSCAFT00000023190.4	ENSCAFP00000021534.3
ENSCAFG00000014600.4	ENSCAFT00000043953.1	ENSCAFP00000037946.1

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 activity/RING/RING	5.00e-07	30.4	24	65

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

E3 activity/RING/RING

   S: 1    CaiCledfkdgplvlpCgHvfhadClqkwpglknssskefrCPlCr 46
           C+iCle +k+ p+++ C H+f++ C  k+    n+ ++  +CPlC+
   Q: 24   CPICLELIKE-PVSTKCDHIFCKFCMLKL---LNQRKGPSQCPLCK 65
           ********99.**************9666...68999********7 PP

Organism

Canis familiaris

Protein Sequence
(Fasta)

MDLSADRVEE VQNVLNAMQK ILECPICLEL IKEPVSTKCD HIFCKFCMLK LLNQRKGPSQ 60
CPLCKNDITK RSLQESTRFS QLVEELLKII HAFELDTGLQ FADSYNFSKK ENNSPEHLKE 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

ATGGATTTAT CTGCGGATCG TGTTGAAGAA GTACAAAATG TTCTTAATGC TATGCAGAAA 60
ATCTTAGAGT GTCCAATATG GTAAGTAGAC AGAAGAGTTT ATTACTTTAA GATCCTTCCC 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0175--Coiled coil
KW-0181--Complete proteome
KW-0479--Metal-binding
KW-1185--Reference proteome
KW-0862--Zinc
KW-0863--Zinc-finger

Interpro

IPR011364--BRCA1
IPR031099--BRCA1-associated
IPR025994--BRCA1_serine_dom
IPR001357--BRCT_dom
IPR018957--Znf_C3HC4_RING-type
IPR001841--Znf_RING
IPR013083--Znf_RING/FYVE/PHD
IPR017907--Znf_RING_CS

PROSITE

PS50172--BRCT
PS00518--ZF_RING_1
PS50089--ZF_RING_2

Pfam

PF00533--BRCT
PF12820--BRCT_assoc
PF00097--zf-C3HC4

PRINTS

PR00493--BRSTCANCERI

SMART

SM00292--BRCT
SM00184--RING

Gene Ontology

GO:0070531--C:BRCA1-A complex
GO:0031436--C:BRCA1-BARD1 complex
GO:0005737--C:cytoplasm
GO:0030529--C:intracellular ribonucleoprotein complex
GO:0000800--C:lateral element
GO:0005886--C:plasma membrane
GO:0003684--F:damaged DNA binding
GO:0003723--F:RNA binding
GO:0044212--F:transcription regulatory region DNA binding
GO:0004842--F:ubiquitin-protein transferase activity
GO:0008270--F:zinc ion binding
GO:0071681--P:cellular response to indole-3-methanol
GO:0071356--P:cellular response to tumor necrosis factor
GO:0007098--P:centrosome cycle
GO:0043009--P:chordate embryonic development
GO:0007059--P:chromosome segregation
GO:0006260--P:DNA replication
GO:0009048--P:dosage compensation by inactivation of X chromosome
GO:0000724--P:double-strand break repair via homologous recombination
GO:0031572--P:G2 DNA damage checkpoint
GO:0008630--P:intrinsic apoptotic signaling pathway in response to DNA damage
GO:1902042--P:negative regulation of extrinsic apoptotic signaling pathway via death domain receptors
GO:0045717--P:negative regulation of fatty acid biosynthetic process
GO:0035067--P:negative regulation of histone acetylation
GO:0051572--P:negative regulation of histone H3-K4 methylation
GO:0051573--P:negative regulation of histone H3-K9 methylation
GO:0033147--P:negative regulation of intracellular estrogen receptor signaling pathway
GO:2000378--P:negative regulation of reactive oxygen species metabolic process
GO:0045892--P:negative regulation of transcription, DNA-templated
GO:0045766--P:positive regulation of angiogenesis
GO:0071158--P:positive regulation of cell cycle arrest
GO:0045739--P:positive regulation of DNA repair
GO:0051571--P:positive regulation of histone H3-K4 methylation
GO:2000617--P:positive regulation of histone H3-K9 acetylation
GO:0051574--P:positive regulation of histone H3-K9 methylation
GO:2000620--P:positive regulation of histone H4-K16 acetylation
GO:0070512--P:positive regulation of histone H4-K20 methylation
GO:0031398--P:positive regulation of protein ubiquitination
GO:0045944--P:positive regulation of transcription from RNA polymerase II promoter
GO:0010575--P:positive regulation of vascular endothelial growth factor production
GO:0006301--P:postreplication repair
GO:0051865--P:protein autoubiquitination
GO:0085020--P:protein K6-linked ubiquitination
GO:0044030--P:regulation of DNA methylation
GO:0006349--P:regulation of gene expression by genetic imprinting
GO:0043627--P:response to estrogen
GO:0010212--P:response to ionizing radiation

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-002388	Ailuropoda melanoleuca	84.37	0.00e+00	3068.00
IUUC-Apl-003252	Anas platyrhynchos	38.84	2.00e-115	411.00
IUUC-Aca-004526	Anolis carolinensis	56.43	5.00e-77	282.00
IUUC-Ame-011720	Astyanax mexicanus	45.15	2.00e-55	211.00
IUUC-Bgr-011969	Blumeria graminis	40.74	9.00e-09	54.70
IUUC-Bta-013433	Bos taurus	71.89	0.00e+00	2499.00
IUUC-Cel-018208	Caenorhabditis elegans	33.70	4.00e-11	63.20
IUUC-Cja-019149	Callithrix jacchus	72.17	0.00e+00	2498.00
IUUC-Cpo-021583	Cavia porcellus	45.55	0.00e+00	1248.00
IUUC-Cre-022597	Chlamydomonas reinhardtii	30.59	7.00e-09	55.10
IUUC-Csa-024227	Chlorocebus sabaeus	75.76	7.00e-156	544.00
IUUC-Cho-024530	Choloepus hoffmanni	65.56	0.00e+00	1126.00
IUUC-Cin-025364	Ciona intestinalis	35.16	1.00e-15	77.40
IUUC-Csv-026245	Ciona savignyi	39.74	2.00e-13	68.90
IUUC-Dno-029247	Dasypus novemcinctus	69.48	0.00e+00	2013.00
IUUC-Dme-032032	Drosophila melanogaster	54.35	7.00e-11	58.50
IUUC-Ete-032472	Echinops telfairi	54.05	0.00e+00	1633.00
IUUC-Eca-033446	Equus caballus	78.22	0.00e+00	2824.00
IUUC-Eeu-034858	Erinaceus europaeus	61.02	0.00e+00	963.00
IUUC-Fca-035991	Felis catus	81.42	0.00e+00	2973.00
IUUC-Fal-036803	Ficedula albicollis	62.91	2.00e-81	298.00
IUUC-Gmo-038782	Gadus morhua	45.92	2.00e-46	181.00
IUUC-Gga-040969	Gallus gallus	59.91	1.00e-78	289.00
IUUC-Gac-042296	Gasterosteus aculeatus	45.62	1.00e-53	205.00
IUUC-Ggo-044740	Gorilla gorilla	71.27	0.00e+00	2414.00
IUUC-Hsa-046086	Homo sapiens	74.04	0.00e+00	2510.00
IUUC-Itr-048512	Ictidomys tridecemlineatus	69.86	0.00e+00	2480.00
IUUC-Lch-049789	Latimeria chalumnae	36.48	3.00e-90	327.00
IUUC-Loc-051952	Lepisosteus oculatus	50.20	6.00e-71	263.00
IUUC-Laf-053648	Loxodonta africana	71.12	0.00e+00	2407.00
IUUC-Mcc-055210	Macaca mulatta	73.46	0.00e+00	2593.00
IUUC-Meu-056342	Macropus eugenii	37.38	6.00e-130	459.00
IUUC-Mor-057034	Magnaporthe oryzae	40.82	2.00e-08	53.90
IUUC-Mpo-057316	Magnaporthe poae	41.30	4.00e-08	52.80
IUUC-Mga-060163	Meleagris gallopavo	54.07	9.00e-81	296.00
IUUC-Mmr-061402	Microcebus murinus	68.20	0.00e+00	791.00
IUUC-Mdo-062209	Monodelphis domestica	44.60	0.00e+00	1241.00
IUUC-Mmu-064003	Mus musculus	53.31	0.00e+00	1696.00
IUUC-Mpu-065825	Mustela putorius furo	82.31	0.00e+00	920.00
IUUC-Mlu-068176	Myotis lucifugus	71.97	0.00e+00	2406.00
IUUC-Nle-069178	Nomascus leucogenys	74.15	0.00e+00	2551.00
IUUC-Opr-070574	Ochotona princeps	58.47	0.00e+00	1874.00
IUUC-Ont-072380	Oreochromis niloticus	49.05	2.00e-59	224.00
IUUC-Oan-073243	Ornithorhynchus anatinus	76.19	6.00e-35	139.00
IUUC-Ocu-074424	Oryctolagus cuniculus	67.25	0.00e+00	2294.00
IUUC-Ola-086863	Oryzias latipes	48.15	1.00e-56	215.00
IUUC-Oar-089938	Ovis aries	72.07	0.00e+00	2558.00
IUUC-Ptr-090960	Pan troglodytes	74.47	0.00e+00	2538.00
IUUC-Pan-092609	Papio anubis	72.14	0.00e+00	2232.00
IUUC-Psi-093889	Pelodiscus sinensis	29.63	3.00e-43	170.00
IUUC-Pfo-096328	Poecilia formosa	50.94	1.00e-60	228.00
IUUC-Pab-097982	Pongo abelii	74.09	0.00e+00	2550.00
IUUC-Pca-100698	Procavia capensis	66.18	0.00e+00	688.00
IUUC-Pva-102631	Pteropus vampyrus	78.36	0.00e+00	1195.00
IUUC-Rno-105879	Rattus norvegicus	53.58	0.00e+00	1666.00
IUUC-Sha-106701	Sarcophilus harrisii	38.88	0.00e+00	689.00
IUUC-Spo-108335	Schizosaccharomyces pombe	33.71	1.00e-09	57.80
IUUC-Sar-113047	Sorex araneus	62.61	0.00e+00	1484.00
IUUC-Ssc-115846	Sus scrofa	74.30	0.00e+00	2672.00
IUUC-Tgu-116785	Taeniopygia guttata	30.59	4.00e-92	333.00
IUUC-Tru-117895	Takifugu rubripes	39.45	5.00e-53	203.00
IUUC-Tsy-118885	Tarsius syrichta	56.32	0.00e+00	678.00
IUUC-Tni-119654	Tetraodon nigroviridis	44.29	8.00e-50	192.00
IUUC-Tre-121992	Trichoderma reesei	41.30	6.00e-07	48.90
IUUC-Tbe-127421	Tupaia belangeri	57.26	4.00e-142	499.00
IUUC-Ttr-128685	Tursiops truncatus	75.91	0.00e+00	2546.00
IUUC-Vda-129783	Verticillium dahliae	35.29	1.00e-08	54.70
IUUC-Vpa-130216	Vicugna pacos	69.11	0.00e+00	831.00
IUUC-Xtr-132398	Xenopus tropicalis	39.34	6.00e-65	243.00
IUUC-Xma-133651	Xiphophorus maculatus	50.89	7.00e-46	179.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence