iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

iUUCD ID

IUUC-Tru-118559

Ensembl Protein ID

ENSTRUP00000011084.1

UniProt Accession

H2SFA3; H2SFA3_TAKRU

Protein Name

Tyrosine-protein kinase

Gene Name

lck

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSTRUG00000004669.1	ENSTRUT00000011144.1	ENSTRUP00000011084.1
ENSTRUG00000004669.1	ENSTRUT00000011145.1	ENSTRUP00000011085.1

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
UBD/SH3	3.70e-14	53.6	67	122

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

UBD/SH3

   S: 3    kekvqvlydyeaqnddeLtlkkGdvvlviekeeqdegWlkgvkelegkrGlfPenFve 60
           +++v ++y+ye+++d++L ++kGd++++i   ++d +W  +++ ++g+rG +P nFv+
   Q: 67   DNLVVAIYSYEPKHDGDLGFEKGDKLKII--SKEDPEWYLAESLTTGQRGYVPYNFVA 122
           5789*************************..889**********************96 PP

Organism

Takifugu rubripes

Protein Sequence
(Fasta)

MGCNCSSDYS DGEWIENLDE MCEHCNCPIA PQSCNPNSSS MFSPQYTDQL IPIHSPQLSP 60
PSSPLPDNLV VAIYSYEPKH DGDLGFEKGD KLKIISKEDP EWYLAESLTT GQRGYVPYNF 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

AGATGCAGAC ATTTCGTTAA GACAGACAGG CAGACAATGA CCTGCTGGCG CGTTGGTCGA 60
AAACCTACAA ACCTGTGAAA GAAACCTTTA TAAACCAGTA ATTACATGGC AGCGTGCAGA 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0067--ATP-binding
KW-0181--Complete proteome
KW-0418--Kinase
KW-0547--Nucleotide-binding
KW-1185--Reference proteome
KW-0728--SH3 domain
KW-0808--Transferase
KW-0829--Tyrosine-protein kinase

Interpro

IPR011009--Kinase-like_dom
IPR000719--Prot_kinase_dom
IPR017441--Protein_kinase_ATP_BS
IPR001245--Ser-Thr/Tyr_kinase_cat_dom
IPR000980--SH2
IPR001452--SH3_domain
IPR008266--Tyr_kinase_AS
IPR020635--Tyr_kinase_cat_dom

PROSITE

PS00107--PROTEIN_KINASE_ATP
PS50011--PROTEIN_KINASE_DOM
PS00109--PROTEIN_KINASE_TYR
PS50001--SH2
PS50002--SH3

Pfam

PF07714--Pkinase_Tyr
PF00017--SH2
PF00018--SH3_1

PRINTS

PR00401--SH2DOMAIN
PR00452--SH3DOMAIN
PR00109--TYRKINASE

SMART

SM00252--SH2
SM00326--SH3
SM00219--TyrKc

Gene Ontology

GO:0031234--C:extrinsic component of cytoplasmic side of plasma membrane
GO:0005524--F:ATP binding
GO:0004715--F:non-membrane spanning protein tyrosine kinase activity
GO:0005102--F:receptor binding
GO:0050853--P:B cell receptor signaling pathway
GO:0016477--P:cell migration
GO:0045087--P:innate immune response
GO:0038083--P:peptidyl-tyrosine autophosphorylation
GO:0042127--P:regulation of cell proliferation
GO:0030217--P:T cell differentiation
GO:0007169--P:transmembrane receptor protein tyrosine kinase signaling pathway

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001315	Ailuropoda melanoleuca	63.59	0.00e+00	712.00
IUUC-Apl-004134	Anas platyrhynchos	68.12	5.00e-179	620.00
IUUC-Ame-010831	Astyanax mexicanus	75.06	0.00e+00	689.00
IUUC-Bta-013264	Bos taurus	66.73	0.00e+00	727.00
IUUC-Cfa-021161	Canis familiaris	63.40	0.00e+00	711.00
IUUC-Cpo-022492	Cavia porcellus	68.10	0.00e+00	727.00
IUUC-Dre-028005	Danio rerio	74.66	0.00e+00	771.00
IUUC-Dno-029365	Dasypus novemcinctus	65.38	0.00e+00	686.00
IUUC-Dor-030892	Dipodomys ordii	67.86	0.00e+00	689.00
IUUC-Eca-033325	Equus caballus	65.62	0.00e+00	698.00
IUUC-Eeu-035004	Erinaceus europaeus	58.52	1.00e-153	536.00
IUUC-Fca-035908	Felis catus	67.12	0.00e+00	726.00
IUUC-Gmo-038984	Gadus morhua	75.10	0.00e+00	794.00
IUUC-Gga-040997	Gallus gallus	68.55	0.00e+00	734.00
IUUC-Gac-041854	Gasterosteus aculeatus	84.15	0.00e+00	883.00
IUUC-Ggo-045238	Gorilla gorilla	63.77	0.00e+00	712.00
IUUC-Hsa-047039	Homo sapiens	67.51	0.00e+00	728.00
IUUC-Itr-048479	Ictidomys tridecemlineatus	67.51	0.00e+00	730.00
IUUC-Lch-049568	Latimeria chalumnae	69.56	0.00e+00	753.00
IUUC-Loc-052222	Lepisosteus oculatus	69.75	0.00e+00	693.00
IUUC-Laf-054499	Loxodonta africana	64.17	0.00e+00	711.00
IUUC-Meu-056879	Macropus eugenii	67.56	0.00e+00	716.00
IUUC-Mga-059971	Meleagris gallopavo	67.83	0.00e+00	719.00
IUUC-Mmr-060740	Microcebus murinus	67.12	0.00e+00	728.00
IUUC-Mdo-062192	Monodelphis domestica	67.91	0.00e+00	733.00
IUUC-Mmu-064241	Mus musculus	66.93	0.00e+00	725.00
IUUC-Mpu-066595	Mustela putorius furo	67.12	0.00e+00	726.00
IUUC-Mlu-067069	Myotis lucifugus	66.60	0.00e+00	727.00
IUUC-Opr-070472	Ochotona princeps	64.39	0.00e+00	706.00
IUUC-Ont-071711	Oreochromis niloticus	83.17	0.00e+00	850.00
IUUC-Ocu-074221	Oryctolagus cuniculus	66.80	0.00e+00	717.00
IUUC-Ola-087000	Oryzias latipes	79.61	0.00e+00	839.00
IUUC-Oga-088225	Otolemur garnettii	66.54	0.00e+00	720.00
IUUC-Oar-090244	Ovis aries	58.82	0.00e+00	674.00
IUUC-Pan-091804	Papio anubis	67.91	0.00e+00	732.00
IUUC-Psi-093252	Pelodiscus sinensis	60.42	4.00e-180	624.00
IUUC-Pfo-096542	Poecilia formosa	80.97	0.00e+00	865.00
IUUC-Pab-098168	Pongo abelii	73.48	0.00e+00	706.00
IUUC-Rno-105542	Rattus norvegicus	66.93	0.00e+00	727.00
IUUC-Sha-107524	Sarcophilus harrisii	68.67	0.00e+00	731.00
IUUC-Sar-113235	Sorex araneus	61.97	6.00e-173	600.00
IUUC-Ssc-115624	Sus scrofa	66.73	0.00e+00	723.00
IUUC-Tni-119928	Tetraodon nigroviridis	79.38	0.00e+00	830.00
IUUC-Tca-121341	Theobroma cacao	36.27	2.00e-21	97.80
IUUC-Ttr-129002	Tursiops truncatus	61.37	0.00e+00	672.00
IUUC-Xtr-132224	Xenopus tropicalis	68.10	0.00e+00	706.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence