iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

iUUCD ID

IUUC-Mlu-066957

Ensembl Protein ID

ENSMLUP00000005105.2

UniProt Accession

G1P540; G1P540_MYOLU

Genbank Protein ID

ENSMLUP00000005105

Protein Name

Uncharacterized protein

Genbank Nucleotide ID

AAPE02011028

Gene Name

OPTN

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSMLUG00000005582.2	ENSMLUT00000005589.2	ENSMLUP00000005105.2

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
UBD/Alpha-Helix/UBAN	2.60e-24	85.0	448	504

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

UBD/Alpha-Helix/UBAN

   S: 1    keelletvevLkqQveiYkeDFqaERadRErlneekeeLqeqveklqkqvsklndsl 57
           +ee+let++vL++Q+e+Y++DF+aERa+RE+++eeke+L+ q++ l+k+++ ++d++
   Q: 448  QEEDLETMTVLRAQMEVYCSDFHAERAAREKIHEEKEQLALQLAILLKDNNVFEDGG 504
           79****************************************************986 PP

Organism

Myotis lucifugus

Protein Sequence
(Fasta)

MSYQPLNCLT EKGDSPNEAT GNGPPNLPHP NLNMFTPEEL LQQMKELLTE NHQLKEAMKL 60
NNQAMKGRFQ ELSAWTEKQK EERHFFEIQS KEAKERLMAV SHENEKLKEE LGKLKGKTER 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

ATGTCCTACC AACCACTTAA CTGCCTGACT GAAAAGGGGG ACAGCCCCAA TGAAGCCACA 60
GGGAATGGAC CCCCCAATCT GCCTCACCCA AACCTGAACA TGTTTACTCC AGAGGAGCTG 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0175--Coiled coil
KW-0181--Complete proteome
KW-1185--Reference proteome

Interpro

IPR032419--CC2-LZ_dom
IPR021063--NEMO_N
IPR032939--Optineurin
IPR034735--ZF_CCHC_NOA

PROSITE

PS51801--ZF_CCHC_NOA

Pfam

PF16516--CC2-LZ
PF11577--NEMO

Gene Ontology

GO:0031410--C:cytoplasmic vesicle
GO:0005829--C:cytosol
GO:0048471--C:perinuclear region of cytoplasm
GO:0005802--C:trans-Golgi network
GO:0050829--P:defense response to Gram-negative bacterium
GO:0090161--P:Golgi ribbon formation
GO:0043001--P:Golgi to plasma membrane protein transport
GO:0016236--P:macroautophagy
GO:0043124--P:negative regulation of I-kappaB kinase/NF-kappaB signaling
GO:0001920--P:negative regulation of receptor recycling
GO:0061734--P:parkin-mediated stimulation of mitophagy in response to mitochondrial depolarization
GO:1904417--P:positive regulation of xenophagy
GO:0000042--P:protein targeting to Golgi

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-002037	Ailuropoda melanoleuca	80.74	0.00e+00	793.00
IUUC-Apl-003812	Anas platyrhynchos	56.47	3.00e-148	518.00
IUUC-Aca-004625	Anolis carolinensis	55.11	5.00e-140	491.00
IUUC-Aly-005781	Arabidopsis lyrata	47.62	2.80e-02	33.10
IUUC-Ame-011116	Astyanax mexicanus	47.06	9.00e-49	187.00
IUUC-Bta-013240	Bos taurus	82.40	0.00e+00	879.00
IUUC-Cel-018324	Caenorhabditis elegans	45.83	1.70e+00	27.30
IUUC-Cja-019911	Callithrix jacchus	82.93	0.00e+00	827.00
IUUC-Cfa-020330	Canis familiaris	84.15	0.00e+00	840.00
IUUC-Cpo-021753	Cavia porcellus	78.99	0.00e+00	794.00
IUUC-Csa-023662	Chlorocebus sabaeus	83.62	0.00e+00	833.00
IUUC-Cho-024574	Choloepus hoffmanni	66.92	2.00e-118	419.00
IUUC-Dre-027720	Danio rerio	41.74	5.00e-91	328.00
IUUC-Dno-029079	Dasypus novemcinctus	79.79	0.00e+00	761.00
IUUC-Dor-030890	Dipodomys ordii	78.41	0.00e+00	795.00
IUUC-Ete-032568	Echinops telfairi	76.62	0.00e+00	657.00
IUUC-Eca-033528	Equus caballus	84.27	0.00e+00	848.00
IUUC-Eeu-035219	Erinaceus europaeus	73.83	0.00e+00	771.00
IUUC-Fca-035852	Felis catus	84.30	0.00e+00	846.00
IUUC-Fal-036862	Ficedula albicollis	58.56	2.00e-142	499.00
IUUC-Gmo-038735	Gadus morhua	38.49	3.00e-68	252.00
IUUC-Gga-040939	Gallus gallus	55.83	4.00e-142	498.00
IUUC-Gac-041580	Gasterosteus aculeatus	42.44	2.00e-88	319.00
IUUC-Ggo-045034	Gorilla gorilla	74.39	0.00e+00	744.00
IUUC-Hsa-046624	Homo sapiens	82.07	0.00e+00	825.00
IUUC-Itr-048288	Ictidomys tridecemlineatus	74.74	0.00e+00	766.00
IUUC-Lch-049720	Latimeria chalumnae	49.11	5.00e-81	294.00
IUUC-Loc-052185	Lepisosteus oculatus	45.11	6.00e-98	351.00
IUUC-Laf-054079	Loxodonta africana	81.29	0.00e+00	800.00
IUUC-Mcc-055674	Macaca mulatta	84.49	0.00e+00	828.00
IUUC-Meu-056769	Macropus eugenii	82.25	4.00e-68	252.00
IUUC-Mga-060203	Meleagris gallopavo	56.50	3.00e-133	468.00
IUUC-Mmr-061492	Microcebus murinus	83.10	0.00e+00	823.00
IUUC-Mdo-063051	Monodelphis domestica	72.82	0.00e+00	753.00
IUUC-Mmu-063409	Mus musculus	75.56	0.00e+00	817.00
IUUC-Mpu-065907	Mustela putorius furo	77.21	0.00e+00	812.00
IUUC-Nle-069973	Nomascus leucogenys	82.76	0.00e+00	833.00
IUUC-Opr-071049	Ochotona princeps	77.03	0.00e+00	710.00
IUUC-Ont-071915	Oreochromis niloticus	43.41	3.00e-89	322.00
IUUC-Oan-072965	Ornithorhynchus anatinus	71.40	0.00e+00	731.00
IUUC-Ocu-074029	Oryctolagus cuniculus	75.61	0.00e+00	655.00
IUUC-Ola-087019	Oryzias latipes	42.24	7.00e-85	307.00
IUUC-Oga-088613	Otolemur garnettii	83.30	0.00e+00	828.00
IUUC-Oar-090386	Ovis aries	82.06	0.00e+00	875.00
IUUC-Ptr-091619	Pan troglodytes	82.24	0.00e+00	826.00
IUUC-Pan-092178	Papio anubis	82.50	0.00e+00	812.00
IUUC-Psi-093214	Pelodiscus sinensis	62.85	3.00e-160	558.00
IUUC-Pfo-096901	Poecilia formosa	41.39	3.00e-83	302.00
IUUC-Pab-097560	Pongo abelii	75.17	0.00e+00	702.00
IUUC-Pca-100853	Procavia capensis	70.78	7.00e-113	400.00
IUUC-Pva-102255	Pteropus vampyrus	84.90	0.00e+00	782.00
IUUC-Rno-105812	Rattus norvegicus	77.13	0.00e+00	803.00
IUUC-Sha-107225	Sarcophilus harrisii	78.82	2.00e-150	525.00
IUUC-Sar-113736	Sorex araneus	69.21	1.00e-122	433.00
IUUC-Ssc-115422	Sus scrofa	84.32	0.00e+00	870.00
IUUC-Tgu-116924	Taeniopygia guttata	58.62	3.00e-145	508.00
IUUC-Tru-117695	Takifugu rubripes	38.20	1.00e-80	293.00
IUUC-Tsy-119090	Tarsius syrichta	78.43	6.00e-144	503.00
IUUC-Tni-120645	Tetraodon nigroviridis	41.53	1.00e-84	307.00
IUUC-Tbe-127970	Tupaia belangeri	66.49	5.00e-179	620.00
IUUC-Ttr-129244	Tursiops truncatus	82.99	0.00e+00	810.00
IUUC-Vpa-130313	Vicugna pacos	82.64	0.00e+00	780.00
IUUC-Xtr-132115	Xenopus tropicalis	43.50	7.00e-96	344.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence