iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

iUUCD ID

IUUC-Ocu-074029

Ensembl Protein ID

ENSOCUP00000005877.3

UniProt Accession

G1SRQ8; G1SRQ8_RABIT

Genbank Protein ID

ENSOCUP00000005877

Protein Name

Uncharacterized protein

Genbank Nucleotide ID

AAGW02026698

Gene Name

OPTN

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSOCUG00000006794.3	ENSOCUT00000006796.3	ENSOCUP00000005877.3

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
UBD/Alpha-Helix/UBAN	1.80e-24	85.5	359	415

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

UBD/Alpha-Helix/UBAN

   S: 1    keelletvevLkqQveiYkeDFqaERadRErlneekeeLqeqveklqkqvsklndsl 57
           +ee+let+ vL++Q+e+Y++DF+aERa+RE+++eeke+L+ q++ l+k++++++d++
   Q: 359  QEEDLETMAVLRAQMEVYCSDFHAERAAREKIHEEKEQLALQLAILLKENNAFEDGG 415
           79****************************************************986 PP

Organism

Oryctolagus cuniculus

Protein Sequence
(Fasta)

MKELLTENHQ LKEAMKLNNQ AMKGRFEELS AWSEKQKEER QFFELQSKES KERIMALSHE 60
NKKLKEELGK LKGELEKSFE RPTGHCRFPK WEAEQEMDQL KTQVARLQAD MRGIVSGLQL 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

GTGGTATGTA TAAAATAATT TTCAGAATAT GCAATAACAT ACCAAGATGT CTTCATCTTT 60
TTAGTGTGCA TTGAAAGTGC AATACTGAAG GCTTAATATC TGATGGCACC TTTGTTGAAT 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0175--Coiled coil
KW-0181--Complete proteome
KW-1185--Reference proteome

Interpro

IPR032419--CC2-LZ_dom
IPR021063--NEMO_N
IPR032939--Optineurin
IPR034735--ZF_CCHC_NOA

PROSITE

PS51801--ZF_CCHC_NOA

Pfam

PF16516--CC2-LZ
PF11577--NEMO

Gene Ontology

GO:0031410--C:cytoplasmic vesicle
GO:0005829--C:cytosol
GO:0048471--C:perinuclear region of cytoplasm
GO:0005802--C:trans-Golgi network
GO:0050829--P:defense response to Gram-negative bacterium
GO:0090161--P:Golgi ribbon formation
GO:0043001--P:Golgi to plasma membrane protein transport
GO:0016236--P:macroautophagy
GO:0043124--P:negative regulation of I-kappaB kinase/NF-kappaB signaling
GO:0001920--P:negative regulation of receptor recycling
GO:0061734--P:parkin-mediated stimulation of mitophagy in response to mitochondrial depolarization
GO:1904417--P:positive regulation of xenophagy
GO:0000042--P:protein targeting to Golgi

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-002037	Ailuropoda melanoleuca	72.73	2.00e-180	625.00
IUUC-Apl-003812	Anas platyrhynchos	51.58	3.00e-113	402.00
IUUC-Aca-004625	Anolis carolinensis	52.95	1.00e-123	436.00
IUUC-Aly-005781	Arabidopsis lyrata	55.00	2.20e-02	33.50
IUUC-Ame-011116	Astyanax mexicanus	44.24	2.00e-52	199.00
IUUC-Bta-013240	Bos taurus	72.61	0.00e+00	683.00
IUUC-Cja-019911	Callithrix jacchus	74.77	0.00e+00	651.00
IUUC-Cfa-020330	Canis familiaris	75.42	0.00e+00	644.00
IUUC-Cpo-021753	Cavia porcellus	71.72	0.00e+00	658.00
IUUC-Csa-023662	Chlorocebus sabaeus	76.81	0.00e+00	659.00
IUUC-Cho-024574	Choloepus hoffmanni	57.04	3.00e-96	345.00
IUUC-Cme-027299	Cyanidioschyzon merolae	36.99	3.00e-03	36.60
IUUC-Dre-027720	Danio rerio	37.43	8.00e-71	261.00
IUUC-Dno-029079	Dasypus novemcinctus	70.73	7.00e-171	593.00
IUUC-Dor-030890	Dipodomys ordii	72.30	0.00e+00	647.00
IUUC-Dme-032072	Drosophila melanogaster	27.91	2.00e-04	40.40
IUUC-Ete-032568	Echinops telfairi	68.75	1.00e-169	589.00
IUUC-Eca-033528	Equus caballus	75.37	0.00e+00	674.00
IUUC-Eeu-035219	Erinaceus europaeus	62.13	8.00e-165	573.00
IUUC-Fca-035852	Felis catus	74.13	0.00e+00	635.00
IUUC-Fal-036862	Ficedula albicollis	52.36	2.00e-115	409.00
IUUC-Gmo-038735	Gadus morhua	37.52	8.00e-62	231.00
IUUC-Gga-040939	Gallus gallus	51.80	3.00e-117	415.00
IUUC-Gac-041580	Gasterosteus aculeatus	38.91	6.00e-70	258.00
IUUC-Ggo-045034	Gorilla gorilla	69.79	0.00e+00	638.00
IUUC-Hsa-046624	Homo sapiens	75.51	0.00e+00	681.00
IUUC-Itr-048288	Ictidomys tridecemlineatus	66.91	3.00e-173	601.00
IUUC-Lch-049720	Latimeria chalumnae	39.11	2.00e-51	196.00
IUUC-Loc-052185	Lepisosteus oculatus	40.75	1.00e-77	284.00
IUUC-Laf-054079	Loxodonta africana	74.41	0.00e+00	633.00
IUUC-Mcc-055674	Macaca mulatta	77.67	0.00e+00	655.00
IUUC-Meu-056769	Macropus eugenii	84.62	2.00e-70	260.00
IUUC-Mga-060203	Meleagris gallopavo	51.60	3.00e-115	408.00
IUUC-Mmr-061492	Microcebus murinus	75.80	0.00e+00	636.00
IUUC-Mdo-063051	Monodelphis domestica	66.91	1.00e-176	612.00
IUUC-Mmu-063409	Mus musculus	69.12	0.00e+00	673.00
IUUC-Mpu-065907	Mustela putorius furo	68.37	1.00e-177	616.00
IUUC-Mlu-066957	Myotis lucifugus	75.61	0.00e+00	637.00
IUUC-Nle-069973	Nomascus leucogenys	75.70	0.00e+00	684.00
IUUC-Opr-071049	Ochotona princeps	81.58	0.00e+00	674.00
IUUC-Ont-071915	Oreochromis niloticus	38.90	1.00e-72	266.00
IUUC-Oan-072965	Ornithorhynchus anatinus	65.10	7.00e-174	603.00
IUUC-Ola-087019	Oryzias latipes	38.56	5.00e-70	258.00
IUUC-Oga-088613	Otolemur garnettii	76.30	0.00e+00	669.00
IUUC-Oar-090386	Ovis aries	71.86	0.00e+00	676.00
IUUC-Ptr-091619	Pan troglodytes	75.14	0.00e+00	677.00
IUUC-Pan-092178	Papio anubis	88.44	1.00e-130	459.00
IUUC-Psi-093214	Pelodiscus sinensis	56.93	6.00e-128	451.00
IUUC-Pfo-096901	Poecilia formosa	38.02	7.00e-64	238.00
IUUC-Pab-097560	Pongo abelii	74.59	1.00e-170	592.00
IUUC-Pca-100853	Procavia capensis	88.55	1.00e-63	237.00
IUUC-Pva-102255	Pteropus vampyrus	73.08	8.00e-166	577.00
IUUC-Rno-105812	Rattus norvegicus	71.74	0.00e+00	676.00
IUUC-Sha-107225	Sarcophilus harrisii	80.25	8.00e-137	479.00
IUUC-Sar-113736	Sorex araneus	74.38	7.00e-110	390.00
IUUC-Ssc-115422	Sus scrofa	74.67	0.00e+00	672.00
IUUC-Tgu-116924	Taeniopygia guttata	67.02	6.00e-92	331.00
IUUC-Tru-117695	Takifugu rubripes	38.36	1.00e-71	263.00
IUUC-Tsy-119090	Tarsius syrichta	66.85	2.00e-113	402.00
IUUC-Tni-120645	Tetraodon nigroviridis	36.55	1.00e-70	260.00
IUUC-Tbe-127970	Tupaia belangeri	85.31	3.00e-122	432.00
IUUC-Ttr-129244	Tursiops truncatus	73.08	0.00e+00	633.00
IUUC-Vpa-130313	Vicugna pacos	70.54	1.00e-166	579.00
IUUC-Xtr-132115	Xenopus tropicalis	41.37	1.00e-77	283.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence