iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Basic Information

Integrated Annotations

Tag

Content

UUCD2 ID

IUUC-Mmu-063350

UUCD1 version

UUC-MuM-00721

Ensembl Protein ID

ENSMUSP00000118729.1

UniProt Accession

Q8CBH7; B9EIG0; MARHB_MOUSE

Genbank Protein ID

BAC29270.1; AAI39423.1; AAI39424.1

Protein Name

E3 ubiquitin-protein ligase MARCH11; Membrane-associated RING finger protein 11; Membrane-associated RING-CH protein XI; RING-type E3 ubiquitin transferase MARCH11

Genbank Nucleotide ID

AK035990; AC102845; BC139423

Gene Name

March11

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSMUSG00000022269.13	ENSMUST00000140840.7	ENSMUSP00000118729.1
ENSMUSG00000022269.13	ENSMUST00000152841.1	ENSMUSP00000120622.1

Annotation

Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEO	ArrayExpress	GXD
DNA & RNA Element
AREsite	microRNA	TRANSFAC	RepTar
RAID2
Post-translational Modifications (PTMs)
dbPAF	PhosphositePlus
Protein Expression/Proteomics
GPMDB

Status

Unreviewed

Classification

Family	Identity	E-Value	Score	Source Orthology
E3 activity/RING/RING	84.30	2.00e-153	539.00	IUUC-Hsa-047015

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Organism

Mus musculus

Functional Description
(View)

E3 ubiquitin-protein ligase that mediates polyubiquitination of CD4. E3 ubiquitin ligases accept ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfer the ubiquitin to targeted substrates. May play a role in ubuquitin-dependent protein sorting in developmenting spermatids.

Protein Sequence
(Fasta)

MSDEGKKRSS RADSLEAEPP LPPPPPPPPP GESVLVPTSP RYRPPLPAPL ERIVGSGEPP 60
VELAPRRKGA GEPLPPLPPS LLPGDQEVTA AGDSCEGPRR LPEVKLPEAA TGKGSPGEPE 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

AGAGCCGAGC CGGCGGCTCC GCTGAACAGC CGCCTCTGCG GCCGCCGCGC CGGTCCTCCG 60
CGTCCTCTCC TGGTCCCGCC TTCCTAGTCC CTTCGCCCCG GTTCCCCTTC CCACCCTCTT 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0025--Alternative splicing
KW-0181--Complete proteome
KW-0968--Cytoplasmic vesicle
KW-0472--Membrane
KW-0479--Metal-binding
KW-1185--Reference proteome
KW-0808--Transferase
KW-0812--Transmembrane
KW-1133--Transmembrane helix
KW-0833--Ubl conjugation pathway
KW-0862--Zinc
KW-0863--Zinc-finger

Interpro

IPR033275--MARCH-like
IPR011016--Znf_RING-CH
IPR013083--Znf_RING/FYVE/PHD

PROSITE

PS51292--ZF_RING_CH

Pfam

PF12906--RINGv

SMART

SM00744--RINGv

Gene Ontology

GO:0030659--C:cytoplasmic vesicle membrane
GO:0016021--C:integral component of membrane
GO:0016740--F:transferase activity
GO:0008270--F:zinc ion binding
GO:0016567--P:protein ubiquitination

KEGG

mmu:211147

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001530	Ailuropoda melanoleuca	93.45	6.00e-134	469.00
IUUC-Apl-003523	Anas platyrhynchos	93.62	6.00e-134	469.00
IUUC-Aca-004368	Anolis carolinensis	89.38	1.00e-122	432.00
IUUC-Acl-008264	Aspergillus clavatus	30.69	3.00e-08	52.80
IUUC-Ang-009870	Aspergillus niger	27.55	3.00e-07	49.30
IUUC-Bta-013095	Bos taurus	84.55	2.00e-135	475.00
IUUC-Bdi-014187	Brachypodium distachyon	34.00	5.00e-09	54.70
IUUC-Bol-015388	Brassica oleracea	38.60	2.00e-08	52.40
IUUC-Cja-019775	Callithrix jacchus	87.10	1.00e-151	529.00
IUUC-Cfa-020770	Canis familiaris	96.46	1.00e-122	431.00
IUUC-Cpo-021621	Cavia porcellus	96.88	2.00e-122	431.00
IUUC-Csa-023832	Chlorocebus sabaeus	83.97	5.00e-138	483.00
IUUC-Dno-028992	Dasypus novemcinctus	97.18	2.00e-93	334.00
IUUC-Dor-030131	Dipodomys ordii	96.41	3.00e-121	427.00
IUUC-Ete-032224	Echinops telfairi	93.53	2.00e-84	304.00
IUUC-Eca-034327	Equus caballus	97.74	1.00e-93	335.00
IUUC-Fca-036285	Felis catus	97.18	2.00e-93	334.00
IUUC-Fal-037405	Ficedula albicollis	92.77	5.00e-132	464.00
IUUC-Gga-040712	Gallus gallus	93.62	6.00e-134	470.00
IUUC-Ggo-044816	Gorilla gorilla	97.11	2.00e-133	468.00
IUUC-Hsa-047015	Homo sapiens	84.00	1.00e-142	499.00
IUUC-Hvu-047417	Hordeum vulgare	38.00	1.00e-09	56.60
IUUC-Itr-049040	Ictidomys tridecemlineatus	97.11	9.00e-134	469.00
IUUC-Lch-049580	Latimeria chalumnae	80.44	3.00e-103	367.00
IUUC-Loc-052242	Lepisosteus oculatus	77.12	2.00e-105	375.00
IUUC-Laf-054493	Loxodonta africana	97.06	1.00e-87	315.00
IUUC-Mcc-054837	Macaca mulatta	97.49	9.00e-132	463.00
IUUC-Mga-059607	Meleagris gallopavo	91.07	9.00e-123	432.00
IUUC-Mdo-062949	Monodelphis domestica	82.28	7.00e-131	460.00
IUUC-Mpu-066267	Mustela putorius furo	90.28	2.00e-132	464.00
IUUC-Mlu-067169	Myotis lucifugus	97.86	3.00e-129	454.00
IUUC-Nle-070005	Nomascus leucogenys	84.84	2.00e-141	495.00
IUUC-Opr-070775	Ochotona princeps	95.91	2.00e-88	317.00
IUUC-Oan-073458	Ornithorhynchus anatinus	84.58	1.00e-97	348.00
IUUC-Ocu-074189	Oryctolagus cuniculus	86.50	4.00e-142	497.00
IUUC-Ola-086995	Oryzias latipes	68.44	3.00e-88	317.00
IUUC-Oga-088747	Otolemur garnettii	95.45	2.00e-140	491.00
IUUC-Oar-090370	Ovis aries	98.31	1.00e-94	338.00
IUUC-Ptr-091675	Pan troglodytes	85.43	2.00e-137	481.00
IUUC-Pan-092898	Papio anubis	80.55	1.00e-138	486.00
IUUC-Psi-093400	Pelodiscus sinensis	93.27	3.00e-126	443.00
IUUC-Pma-094557	Petromyzon marinus	53.10	2.00e-66	245.00
IUUC-Pfo-097096	Poecilia formosa	70.46	2.00e-85	308.00
IUUC-Pab-098715	Pongo abelii	82.20	2.00e-133	468.00
IUUC-Rno-105703	Rattus norvegicus	96.00	3.00e-174	604.00
IUUC-Sha-107351	Sarcophilus harrisii	97.66	1.00e-89	321.00
IUUC-Ssl-108455	Sclerotinia sclerotiorum	29.55	7.00e-07	48.10
IUUC-Sar-113347	Sorex araneus	96.08	3.00e-77	280.00
IUUC-Tgu-116459	Taeniopygia guttata	91.06	1.00e-130	458.00
IUUC-Tru-118083	Takifugu rubripes	67.80	2.00e-83	301.00
IUUC-Tsy-119273	Tarsius syrichta	96.28	3.00e-130	457.00
IUUC-Tae-123878	Triticum aestivum	36.00	3.00e-09	55.80
IUUC-Tbe-127966	Tupaia belangeri	97.65	1.00e-88	318.00
IUUC-Ttr-128836	Tursiops truncatus	97.45	6.00e-130	456.00
IUUC-Vpa-130196	Vicugna pacos	97.87	2.00e-130	457.00
IUUC-Xtr-132468	Xenopus tropicalis	84.44	1.00e-109	389.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence