iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

UUCD2 ID

IUUC-Oga-088241

UUCD1 version

Ensembl Protein ID

UniProt Accession

Genbank Protein ID

Protein Name

Uncharacterized protein

Genbank Nucleotide ID

AAQR03025173

Gene Name

NEDD4

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSOGAG00000013838.2	ENSOGAT00000013848.2	ENSOGAP00000012400.2

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 activity/HECT	4.90e-117	391.1	981	1288

Active Site

Position(s)	Description	Evidence
1258	Glycyl thioester intermediate	{ECO:0000256\|PROSITE-ProRule:PRU00104}

Domain Profile

E3 activity/HECT

   S: 28   flallskelqnpdlglflysen..dketlqpnpdsglknpehlklFeflGrllgkalqdgrlldlplsksfyklllgkklsledlee 112
           +l+  + e+ np+ g+f++     d++tlq+np+sgl+n++hl++F+f+Gr+ g+a+++g+lld ++ ++fyk++l+k+++l+d+e+
   Q: 981  WLNVFLIEVNNPKEGAFKCGCLyrDNYTLQINPNSGLCNEDHLSYFKFIGRVAGMAVYHGKLLDGFFIRPFYKMMLHKPITLHDMES 1067
           78888899*********8876556*************************************************************** PP
   S: 113  vdpelykslkeikenaesdieelgldltfsvseeilgetkeeeLkpgGenipVtneNkeeYvklvveyrlkegikeqveafreGfne 199
           vd+e+y+sl +i+en   d +e  ldl+f ++ee++g+t+++eLk+gG++i Vtn+Nk+eY+ lv+++r+ ++i++q++af+eGf e
   Q: 1068 VDSEYYNSLRWILEN---DPTE--LDLRFVIDEELFGQTHQHELKTGGSEIVVTNKNKKEYIYLVIQWRFVNRIQKQMAAFKEGFFE 1149
           *************99...6666..79************************************************************* PP
   S: 200  viplellslFteeelellicGeeeidvedlkketkykggytedspaiqwFwevleefsseerkafLqFvTgssrlPlgGfaelk... 283
           +ip++l+++F+e+elell+cG  ++dv+d++++tkyk+gy+ ++++iqwFw+++ +++se+r ++LqFvTg+sr+P++Gfael    
   Q: 1150 LIPQDLIKIFDENELELLMCGLGDVDVNDWREHTKYKNGYSVNHQVIQWFWKAVLMMDSEKRIRLLQFVTGTSRVPMNGFAELYgsn 1236
           *************************************************************************************** PP
   S: 284  .prlfvirkdasddrlPssnTCfnyLkLPeYsskeilkekLlyAieetkgFe 334
            p++f++++++s+++lP+++TCfn+L+LP+Y+s e+l +kL++Aie+t+gF+
   Q: 1237 gPQSFTVEQWGSPEKLPRAHTCFNRLDLPPYESFEELWDKLQMAIENTQGFD 1288
           ***************************************************8 PP

Organism

Otolemur garnettii

Protein Sequence
(Fasta)

MAQSLRLHFA ARRSNTYPLS ETSGDDLDSH VHMCFKRPTR ISTSNVVQMK LTPRQTTPAP 60
LIKENVKPQE RSSVVSSDNV NKKSSCLQIS LQPTRYGGCL QSSNVLADGD DASFTCVLKD 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

ATGGCACAAA GCTTACGATT GCACTTTGCA GCCAGAAGAA GCAATACTTA CCCTTTGTCA 60
GAAACCTCCG GAGATGATTT GGATAGCCAT GTTCACATGT GCTTCAAAAG ACCAACACGG 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-1185--Reference proteome
KW-0808--Transferase
KW-0833--Ubl conjugation pathway

Interpro

IPR000008--C2_dom
IPR000569--HECT_dom
IPR001202--WW_dom

PROSITE

PS50237--HECT
PS01159--WW_DOMAIN_1
PS50020--WW_DOMAIN_2

Pfam

PF00632--HECT
PF00397--WW

SMART

SM00119--HECTc
SM00456--WW

Gene Ontology

GO:0005938--C:cell cortex
GO:0000785--C:chromatin
GO:0005829--C:cytosol
GO:0043197--C:dendritic spine
GO:0070062--C:extracellular exosome
GO:0005794--C:Golgi apparatus
GO:0048471--C:perinuclear region of cytoplasm
GO:0005886--C:plasma membrane
GO:0000151--C:ubiquitin ligase complex
GO:0019871--F:sodium channel inhibitor activity
GO:0061630--F:ubiquitin protein ligase activity
GO:0002250--P:adaptive immune response
GO:0048514--P:blood vessel morphogenesis
GO:0044111--P:development involved in symbiotic interaction
GO:0003197--P:endocardial cushion development
GO:0042921--P:glucocorticoid receptor signaling pathway
GO:2000650--P:negative regulation of sodium ion transmembrane transporter activity
GO:0010768--P:negative regulation of transcription from RNA polymerase II promoter in response to UV-induced DNA damage
GO:0030948--P:negative regulation of vascular endothelial growth factor receptor signaling pathway
GO:0007528--P:neuromuscular junction development
GO:0031175--P:neuron projection development
GO:0003151--P:outflow tract morphogenesis
GO:0046824--P:positive regulation of nucleocytoplasmic transport
GO:0014068--P:positive regulation of phosphatidylinositol 3-kinase signaling
GO:0045732--P:positive regulation of protein catabolic process
GO:0050847--P:progesterone receptor signaling pathway
GO:0006513--P:protein monoubiquitination
GO:0006622--P:protein targeting to lysosome
GO:0042787--P:protein ubiquitination involved in ubiquitin-dependent protein catabolic process
GO:0032801--P:receptor catabolic process
GO:0031623--P:receptor internalization
GO:0048814--P:regulation of dendrite morphogenesis
GO:0042391--P:regulation of membrane potential
GO:1901016--P:regulation of potassium ion transmembrane transporter activity
GO:0050807--P:regulation of synapse organization
GO:0042110--P:T cell activation
GO:0019089--P:transmission of virus
GO:0043162--P:ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001201	Ailuropoda melanoleuca	86.35	0.00e+00	2202.00
IUUC-Apl-003886	Anas platyrhynchos	69.55	0.00e+00	1134.00
IUUC-Bta-012453	Bos taurus	85.05	0.00e+00	2120.00
IUUC-Cja-019034	Callithrix jacchus	84.86	0.00e+00	1255.00
IUUC-Cfa-020258	Canis familiaris	86.43	0.00e+00	2126.00
IUUC-Cpo-021648	Cavia porcellus	81.89	0.00e+00	1304.00
IUUC-Csa-023334	Chlorocebus sabaeus	87.47	0.00e+00	1338.00
IUUC-Cho-024672	Choloepus hoffmanni	82.75	0.00e+00	697.00
IUUC-Dno-029159	Dasypus novemcinctus	84.35	0.00e+00	1193.00
IUUC-Ete-032409	Echinops telfairi	78.64	0.00e+00	1042.00
IUUC-Eca-033441	Equus caballus	88.71	0.00e+00	1324.00
IUUC-Eeu-034546	Erinaceus europaeus	70.38	0.00e+00	1045.00
IUUC-Fca-036384	Felis catus	86.30	0.00e+00	2171.00
IUUC-Fal-037547	Ficedula albicollis	74.13	0.00e+00	1174.00
IUUC-Gmo-039679	Gadus morhua	60.61	0.00e+00	940.00
IUUC-Gga-040524	Gallus gallus	75.50	0.00e+00	1184.00
IUUC-Hsa-046479	Homo sapiens	88.20	0.00e+00	2215.00
IUUC-Itr-048383	Ictidomys tridecemlineatus	74.74	0.00e+00	1056.00
IUUC-Lch-050445	Latimeria chalumnae	56.36	0.00e+00	1334.00
IUUC-Loc-052645	Lepisosteus oculatus	66.59	0.00e+00	1051.00
IUUC-Laf-053638	Loxodonta africana	78.33	0.00e+00	1201.00
IUUC-Mcc-055585	Macaca mulatta	87.22	0.00e+00	2175.00
IUUC-Meu-056897	Macropus eugenii	95.12	3.00e-171	595.00
IUUC-Mga-059362	Meleagris gallopavo	69.51	0.00e+00	1149.00
IUUC-Mmr-061061	Microcebus murinus	89.26	0.00e+00	2253.00
IUUC-Mdo-062178	Monodelphis domestica	59.17	0.00e+00	1534.00
IUUC-Mmu-063318	Mus musculus	72.95	0.00e+00	1132.00
IUUC-Mpu-066567	Mustela putorius furo	87.64	0.00e+00	1400.00
IUUC-Mlu-068148	Myotis lucifugus	84.77	0.00e+00	2115.00
IUUC-Nle-069225	Nomascus leucogenys	87.59	0.00e+00	2199.00
IUUC-Oan-073019	Ornithorhynchus anatinus	79.18	0.00e+00	1246.00
IUUC-Ocu-074409	Oryctolagus cuniculus	83.82	0.00e+00	2070.00
IUUC-Oar-089797	Ovis aries	87.84	0.00e+00	1367.00
IUUC-Ptr-091629	Pan troglodytes	85.26	0.00e+00	1223.00
IUUC-Psi-093618	Pelodiscus sinensis	64.24	0.00e+00	1496.00
IUUC-Pfo-097145	Poecilia formosa	61.39	0.00e+00	930.00
IUUC-Pab-098394	Pongo abelii	87.10	0.00e+00	1349.00
IUUC-Pca-100568	Procavia capensis	71.16	0.00e+00	1016.00
IUUC-Rno-106095	Rattus norvegicus	72.70	0.00e+00	1131.00
IUUC-Sha-107370	Sarcophilus harrisii	62.85	0.00e+00	1600.00
IUUC-Tgu-117474	Taeniopygia guttata	75.12	0.00e+00	1180.00
IUUC-Tru-117675	Takifugu rubripes	59.62	0.00e+00	934.00
IUUC-Tbe-127408	Tupaia belangeri	78.66	0.00e+00	1013.00
IUUC-Ttr-128437	Tursiops truncatus	77.46	0.00e+00	1056.00
IUUC-Vpa-130503	Vicugna pacos	81.87	0.00e+00	1143.00
IUUC-Xtr-132431	Xenopus tropicalis	64.91	0.00e+00	1062.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence