iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

UUCD2 ID

IUUC-Cfa-020248

UUCD1 version

UUC-CaF-00424

Ensembl Protein ID

ENSCAFP00000014945.2

UniProt Accession

E2RKN7; F1Q0D5; FXL15_CANLF

Protein Name

F-box/LRR-repeat protein 15

Gene Name

FBXL15

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSCAFG00000010176.3	ENSCAFT00000016159.2	ENSCAFP00000014945.2
ENSCAFG00000010176.3	ENSCAFT00000044702.1	ENSCAFP00000042809.1

Status

Unreviewed

Classification

Family	Identity	E-Value	Score	Source Orthology
E3 adaptor/Cullin RING/SCF/F-box	96.67	5.00e-151	531.00	IUUC-Hsa-046910

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Organism

Canis familiaris

Functional Description
(View)

Substrate recognition component of a SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of SMURF1, thereby acting as a positive regulator of the BMP signaling pathway. Required for dorsal/ventral pattern formation and bone mass maintenance. Also mediates ubiquitination of SMURF2 and WWP2 (By similarity).

Protein Sequence
(Fasta)

MEPPMEPSGG EQEPGAVRLL DLPWEDVLLP HILSRVPLRQ LLRLQRVSRA FRALVQLHLA 60
GLRRFDAAQV GPQIPRAALA WLLRDAEGLQ ELALAPCHEW LSDEDLVPVL TRNPQLRSVA 120

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Nucleotide Sequence
(Fasta)

ATGGAGCCAC CGATGGAGCC GTCCGGAGGG GAGCAAGAGC CGGGAGCCGT CAGGTACCGA 60
GCACCGGAGG GGCCGAGAAA GGGAAGAAGG ACCTAGGGGA GGGGAGCTGA ATTGGGCCGT 120

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Sequence Source

Ensembl

Keyword

KW-0007--Acetylation
KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0433--Leucine-rich repeat
KW-1185--Reference proteome
KW-0677--Repeat
KW-0833--Ubl conjugation pathway

Interpro

IPR001810--F-box_dom
IPR032675--L_dom-like
IPR001611--Leu-rich_rpt
IPR006553--Leu-rich_rpt_Cys-con_subtyp

Pfam

PF00646--F-box
PF13516--LRR_6

SMART

SM00367--LRR_CC

Gene Ontology

GO:0005737--C:cytoplasm
GO:0019005--C:SCF ubiquitin ligase complex
GO:0030282--P:bone mineralization
GO:0009953--P:dorsal/ventral pattern formation
GO:0000086--P:G2/M transition of mitotic cell cycle
GO:0030513--P:positive regulation of BMP signaling pathway
GO:0016567--P:protein ubiquitination
GO:0031146--P:SCF-dependent proteasomal ubiquitin-dependent protein catabolic process

KEGG

cfa:100855612

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-002259	Ailuropoda melanoleuca	96.00	4.00e-149	520.00
IUUC-Apl-003471	Anas platyrhynchos	66.21	2.00e-80	291.00
IUUC-Aca-005211	Anolis carolinensis	63.42	2.00e-101	362.00
IUUC-Ame-011477	Astyanax mexicanus	56.57	5.00e-95	340.00
IUUC-Bta-013461	Bos taurus	96.67	2.00e-163	567.00
IUUC-Cja-019278	Callithrix jacchus	97.66	4.00e-148	517.00
IUUC-Cpo-021313	Cavia porcellus	92.98	2.00e-131	461.00
IUUC-Csa-023633	Chlorocebus sabaeus	97.00	7.00e-163	565.00
IUUC-Cin-025760	Ciona intestinalis	30.86	2.00e-36	145.00
IUUC-Csv-025866	Ciona savignyi	31.90	6.00e-40	157.00
IUUC-Dre-027366	Danio rerio	58.09	1.00e-99	356.00
IUUC-Dno-029700	Dasypus novemcinctus	97.00	8.00e-152	529.00
IUUC-Dor-031069	Dipodomys ordii	93.29	4.00e-154	537.00
IUUC-Dme-031701	Drosophila melanogaster	31.52	2.00e-26	112.00
IUUC-Ete-032998	Echinops telfairi	87.29	2.00e-132	465.00
IUUC-Eca-034140	Equus caballus	98.33	3.00e-150	523.00
IUUC-Fca-035431	Felis catus	99.33	2.00e-156	544.00
IUUC-Fal-036960	Ficedula albicollis	65.60	2.00e-101	362.00
IUUC-Gmo-039411	Gadus morhua	57.80	1.00e-95	342.00
IUUC-Gga-040351	Gallus gallus	65.96	3.00e-101	361.00
IUUC-Gac-041972	Gasterosteus aculeatus	57.80	3.00e-87	314.00
IUUC-Ggo-044538	Gorilla gorilla	96.33	3.00e-147	513.00
IUUC-Hsa-046910	Homo sapiens	96.67	2.00e-147	514.00
IUUC-Itr-048011	Ictidomys tridecemlineatus	96.99	6.00e-152	529.00
IUUC-Lch-049710	Latimeria chalumnae	55.63	5.00e-99	353.00
IUUC-Loc-052288	Lepisosteus oculatus	59.73	2.00e-98	352.00
IUUC-Laf-053590	Loxodonta africana	88.10	3.00e-133	467.00
IUUC-Meu-056548	Macropus eugenii	80.22	2.00e-122	431.00
IUUC-Mga-059794	Meleagris gallopavo	65.25	2.00e-99	355.00
IUUC-Mmr-060829	Microcebus murinus	96.33	2.00e-151	528.00
IUUC-Mdo-062207	Monodelphis domestica	82.09	3.00e-134	471.00
IUUC-Mmu-063353	Mus musculus	97.00	4.00e-152	530.00
IUUC-Mpu-065841	Mustela putorius furo	99.67	1.00e-156	545.00
IUUC-Mlu-068035	Myotis lucifugus	93.77	2.00e-142	498.00
IUUC-Nle-069269	Nomascus leucogenys	97.67	7.00e-149	519.00
IUUC-Opr-070289	Ochotona princeps	90.25	2.00e-110	392.00
IUUC-Ont-072581	Oreochromis niloticus	56.21	3.00e-94	337.00
IUUC-Oan-073529	Ornithorhynchus anatinus	68.75	3.00e-79	287.00
IUUC-Ocu-074827	Oryctolagus cuniculus	96.00	2.00e-155	541.00
IUUC-Ola-087306	Oryzias latipes	56.04	1.00e-96	345.00
IUUC-Oga-088596	Otolemur garnettii	95.56	1.00e-137	481.00
IUUC-Oar-089473	Ovis aries	75.59	1.00e-83	302.00
IUUC-Ptr-091197	Pan troglodytes	96.67	9.00e-148	515.00
IUUC-Pan-092908	Papio anubis	97.00	2.00e-157	548.00
IUUC-Psi-093318	Pelodiscus sinensis	60.28	2.00e-68	251.00
IUUC-Pfo-097479	Poecilia formosa	57.43	2.00e-96	345.00
IUUC-Pab-097744	Pongo abelii	96.67	2.00e-147	515.00
IUUC-Pca-100930	Procavia capensis	92.33	1.00e-140	492.00
IUUC-Pva-102763	Pteropus vampyrus	90.71	1.00e-60	226.00
IUUC-Rno-105651	Rattus norvegicus	96.00	3.00e-155	540.00
IUUC-Tgu-117097	Taeniopygia guttata	66.31	2.00e-103	369.00
IUUC-Tru-118057	Takifugu rubripes	57.24	6.00e-95	340.00
IUUC-Tni-120693	Tetraodon nigroviridis	56.55	2.00e-93	335.00
IUUC-Tbe-127992	Tupaia belangeri	97.91	3.00e-104	372.00
IUUC-Xtr-132283	Xenopus tropicalis	56.85	1.00e-99	356.00
IUUC-Xma-134238	Xiphophorus maculatus	57.89	1.00e-95	342.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence