iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

iUUCD ID

IUUC-Ptr-090505

Ensembl Protein ID

ENSPTRP00000022925.4

UniProt Accession

H2QK59; H2QK59_PANTR

Genbank Protein ID

ENSPTRP00000022925

Protein Name

Tyrosine-protein kinase

Genbank Nucleotide ID

AACZ03124151

Gene Name

HCK

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSPTRG00000013371.5	ENSPTRT00000024836.4	ENSPTRP00000022925.4

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
UBD/SH3	3.70e-16	58.8	82	137

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

UBD/SH3

   S: 5    kvqvlydyeaqnddeLtlkkGdvvlviekeeqdegWlkgvkelegkrGlfPenFvekle 63
            v +lydyea + ++L+++kGd++ v+   e++++W+k+ + ++ k+G +P+n+v++++
   Q: 82   IVVALYDYEAIHHEDLSFQKGDQMVVL---EESGEWWKARSLATRKEGYIPSNYVARVD 137
           689************************...99*************************97 PP

Organism

Pan troglodytes

Protein Sequence
(Fasta)

LGGRSSCEDP GCPRDEERAP RMGCMKSKFL QVGGNTFSKT ETSASPHCPV YVPDPTSTIK 60
PGPNSNNSNT PGIREAGSED IIVVALYDYE AIHHEDLSFQ KGDQMVVLEE SGEWWKARSL 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

GCGAGTGGGA AGGGACTCAG ACAGTGCAGG ACGAGAAACG CCCGCGGCAC CAAAGCCCGT 60
CGGAGCGTCG CCCCCGCCTC TAGTTCTAGA AAGTCAGTTT CCCGGCACTG GCACCCCGGA 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0067--ATP-binding
KW-0181--Complete proteome
KW-0418--Kinase
KW-0547--Nucleotide-binding
KW-1185--Reference proteome
KW-0728--SH3 domain
KW-0808--Transferase
KW-0829--Tyrosine-protein kinase

Interpro

IPR011009--Kinase-like_dom
IPR000719--Prot_kinase_dom
IPR017441--Protein_kinase_ATP_BS
IPR001245--Ser-Thr/Tyr_kinase_cat_dom
IPR000980--SH2
IPR001452--SH3_domain
IPR008266--Tyr_kinase_AS
IPR020635--Tyr_kinase_cat_dom

PROSITE

PS00107--PROTEIN_KINASE_ATP
PS50011--PROTEIN_KINASE_DOM
PS00109--PROTEIN_KINASE_TYR
PS50001--SH2
PS50002--SH3

Pfam

PF07714--Pkinase_Tyr
PF00017--SH2
PF00018--SH3_1

PRINTS

PR00401--SH2DOMAIN
PR00452--SH3DOMAIN
PR00109--TYRKINASE

SMART

SM00252--SH2
SM00326--SH3
SM00219--TyrKc

Gene Ontology

GO:0031234--C:extrinsic component of cytoplasmic side of plasma membrane
GO:0005654--C:nucleoplasm
GO:0005524--F:ATP binding
GO:0004715--F:non-membrane spanning protein tyrosine kinase activity
GO:0005102--F:receptor binding
GO:0030154--P:cell differentiation
GO:0016477--P:cell migration
GO:0045087--P:innate immune response
GO:0038083--P:peptidyl-tyrosine autophosphorylation
GO:0042127--P:regulation of cell proliferation
GO:0007169--P:transmembrane receptor protein tyrosine kinase signaling pathway

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001284	Ailuropoda melanoleuca	86.91	0.00e+00	934.00
IUUC-Apl-003285	Anas platyrhynchos	74.51	0.00e+00	764.00
IUUC-Aca-004724	Anolis carolinensis	74.51	0.00e+00	746.00
IUUC-Ath-007698	Arabidopsis thaliana	26.95	6.00e-18	86.30
IUUC-Ame-011954	Astyanax mexicanus	71.99	0.00e+00	721.00
IUUC-Bta-013060	Bos taurus	87.45	0.00e+00	947.00
IUUC-Bra-017195	Brassica rapa	31.51	4.00e-17	83.20
IUUC-Cja-019817	Callithrix jacchus	91.50	0.00e+00	932.00
IUUC-Cfa-020511	Canis familiaris	87.64	0.00e+00	946.00
IUUC-Cpo-022538	Cavia porcellus	86.39	0.00e+00	895.00
IUUC-Csa-024143	Chlorocebus sabaeus	94.27	0.00e+00	980.00
IUUC-Dre-028157	Danio rerio	71.99	0.00e+00	744.00
IUUC-Dno-029761	Dasypus novemcinctus	85.35	0.00e+00	887.00
IUUC-Eca-034090	Equus caballus	84.60	0.00e+00	906.00
IUUC-Fca-035937	Felis catus	85.14	0.00e+00	889.00
IUUC-Fal-036624	Ficedula albicollis	74.51	0.00e+00	753.00
IUUC-Gmo-039009	Gadus morhua	69.11	0.00e+00	710.00
IUUC-Gga-040296	Gallus gallus	74.68	0.00e+00	731.00
IUUC-Gac-042362	Gasterosteus aculeatus	70.39	0.00e+00	734.00
IUUC-Ggo-044570	Gorilla gorilla	96.01	0.00e+00	1033.00
IUUC-Hsa-046378	Homo sapiens	96.01	0.00e+00	1046.00
IUUC-Itr-048695	Ictidomys tridecemlineatus	83.84	0.00e+00	896.00
IUUC-Loc-052904	Lepisosteus oculatus	74.56	0.00e+00	773.00
IUUC-Laf-053654	Loxodonta africana	85.77	0.00e+00	884.00
IUUC-Mcc-055317	Macaca mulatta	94.26	0.00e+00	982.00
IUUC-Mga-060194	Meleagris gallopavo	76.67	0.00e+00	717.00
IUUC-Mmr-061510	Microcebus murinus	85.74	0.00e+00	892.00
IUUC-Mdo-062035	Monodelphis domestica	79.57	0.00e+00	825.00
IUUC-Mmu-064037	Mus musculus	85.93	0.00e+00	932.00
IUUC-Mpu-066874	Mustela putorius furo	86.73	0.00e+00	901.00
IUUC-Mlu-068202	Myotis lucifugus	83.20	0.00e+00	845.00
IUUC-Nle-069222	Nomascus leucogenys	94.26	0.00e+00	969.00
IUUC-Opr-070705	Ochotona princeps	83.84	0.00e+00	917.00
IUUC-Ont-072347	Oreochromis niloticus	78.48	0.00e+00	719.00
IUUC-Ocu-074490	Oryctolagus cuniculus	85.15	0.00e+00	875.00
IUUC-Ola-086521	Oryzias latipes	77.35	0.00e+00	729.00
IUUC-Oga-088153	Otolemur garnettii	88.14	0.00e+00	916.00
IUUC-Oar-090184	Ovis aries	86.18	0.00e+00	912.00
IUUC-Pan-092260	Papio anubis	94.46	0.00e+00	984.00
IUUC-Pma-094311	Petromyzon marinus	71.59	0.00e+00	684.00
IUUC-Pab-097908	Pongo abelii	84.25	0.00e+00	857.00
IUUC-Pva-103021	Pteropus vampyrus	86.53	0.00e+00	897.00
IUUC-Rno-105309	Rattus norvegicus	85.74	0.00e+00	888.00
IUUC-Sha-107099	Sarcophilus harrisii	78.98	0.00e+00	823.00
IUUC-Tgu-116912	Taeniopygia guttata	74.46	0.00e+00	745.00
IUUC-Tru-118449	Takifugu rubripes	77.08	0.00e+00	712.00
IUUC-Tbe-128144	Tupaia belangeri	73.76	0.00e+00	770.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence