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Basic Information Integrated Annotations
Tag Content
iUUCD ID IUUC-Hsa-046323
Ensembl Protein ID ENSP00000261749.6
UniProt Accession Q6FIF0; D3DW92; D3DW94; O95792; Q9BQF7; Q9GZY3; ZFAN6_HUMAN
Genbank Protein ID CAC14876.1; AAD17528.1; AAG44674.1; CAB66533.1; CAG38507.1; EAW99122.1; EAW99123.1; EAW99124.1; EAW99125.1; EAW99127.1; AAH05283.1
Protein Name AN1-type zinc finger protein 6; Associated with PRK1 protein; Zinc finger A20 domain-containing protein 3
Genbank Nucleotide ID AJ251095; AF061739; AF261138; AL136598; CR533476; CH471136; CH471136; CH471136; CH471136; CH471136; BC005283
Gene Name ZFAND6; AWP1; ZA20D3; HT032
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
ENSG00000086666.18 ENST00000261749.10 ENSP00000261749.6
ENSG00000086666.18 ENST00000559157.5 ENSP00000454152.1
ENSG00000086666.18 ENST00000561012.5 ENSP00000453590.1
ENSG00000086666.18 ENST00000564367.5 ENSP00000454273.1
ENSG00000086666.18 ENST00000558688.5 ENSP00000452664.1
ENSG00000086666.18 ENST00000558390.5 ENSP00000453308.1
ENSG00000086666.18 ENST00000558724.1 ENSP00000452625.1
Annotation
Cancer Mutation
TCGAICGCCOSMICCGAP
IntOGen
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEOArrayExpressTCGAICGC
COSMICTHPAHPM
DNA & RNA Element
UTRdbAREsitecircBasecircRNADb
CircNetmiRTarBasemicroRNATRANSFAC
TargetScanRepTarmiRNAMapSomamiR
miRcodeRAID2
Protein-protein Interaction
IIDiRefIndexPINAHINT
MenthaInWeb_IM
Disease-associated Variation
GWASdbOMIM
Post-translational Modifications (PTMs)
CPLMdbPAFPhosphositePlusdbPTM
HPRDPhospho.ELMUniProtBioGRID
mUbiSiDa
DNA Methylation
TCGAICGCCOSMIC
Protein Expression/Proteomics
THPAHPMGPMDB
Status Unreviewed
Classification
Family E-Value Score Start End
UBD/ZnF/ZnF_A20 1.20e-19 71.6 9 42
Active Site
Position(s) Description Evidence
N/A N/A N/A
Domain Profile

   UBD/ZnF/ZnF_A20
   S: 2    pskllCkkgCgfYGnpetngyCSkCyreelrrrr 35
           ++++lC++gCgfYGnp+tng+CS+Cy+e+l+r++
   Q: 9    QVPMLCSTGCGFYGNPRTNGMCSVCYKEHLQRQN 42
           89******************************95 PP
   
Organism Homo sapiens
Functional Description
(View)

Functional Description


     Involved in regulation of TNF-alpha induced NF-kappa-B activation and apoptosis. Involved in modulation of 'Lys-48'-linked polyubiquitination status of TRAF2 and decreases association of TRAF2 with RIPK1. Required for PTS1 target sequence-dependent protein import into peroxisomes and PEX5 stability; may cooperate with PEX6. In vitro involved in PEX5 export from the cytosol to peroxisomes (By similarity).
 Involved in regulation of TNF-alpha induced NF-kappa-B activation and apoptosis. Involved in modulation of 'Lys-48'-linked polyubiquitination status of TRAF2 and decreases association of TRAF2 with RIPK1. Required for PTS1 target sequence-dependent protein import into peroxisomes and PEX5 stability; may cooperate with PEX6. In vitro involved in PEX5 export from the cytosol to peroxisomes (By similarity).
Protein Sequence
(Fasta)
MAQETNHSQV PMLCSTGCGF YGNPRTNGMC SVCYKEHLQR QNSSNGRISP PATSVSSLSE 60
SLPVQCTDGS VPEAQSALDS TSSSMQPSPV SNQSLLSESV ASSQLDSTSV DKAVPETEDV 120
It may take some time, please wait.

Protein Fasta Sequence


>IUUC-Hsa-046323|UBD,ZnF_A20|Homo sapiens
Please wait for a moment...
Nucleotide Sequence
(Fasta)
AATAATTAGC GGGCGGGCGG GGCCCGCGCG TCAGCCGCGG GAGCCGGCCA ATCCAGTGGC 60
TCTCCTCCGC GGTCGCGTCA TAGGCCGAAC AACCAAACAG AAAAGTTTAA TAAACAGCGG 120
It may take some time, please wait.

Nucleotide Fasta Sequence


>IUUC-Hsa-046323|UBD,ZnF_A20|Homo sapiens
Please wait for a moment...
Sequence Source Ensembl
Keyword

KW-0007--Acetylation
KW-0025--Alternative splicing
KW-0053--Apoptosis
KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0479--Metal-binding
KW-0597--Phosphoprotein
KW-0653--Protein transport
KW-1185--Reference proteome
KW-0813--Transport
KW-0862--Zinc
KW-0863--Zinc-finger
Interpro

IPR002653--Znf_A20
IPR000058--Znf_AN1
PROSITE

PS51036--ZF_A20
PS51039--ZF_AN1
Pfam

PF01754--zf-A20
PF01428--zf-AN1
SMART

SM00259--ZnF_A20
SM00154--ZnF_AN1
Gene Ontology

GO:0005737--C:cytoplasm
GO:0003677--F:DNA binding
GO:0031593--F:polyubiquitin binding
GO:0008270--F:zinc ion binding
GO:0006915--P:apoptotic process
GO:0071356--P:cellular response to tumor necrosis factor
GO:0043066--P:negative regulation of apoptotic process
GO:0006625--P:protein targeting to peroxisome
GO:0043122--P:regulation of I-kappaB kinase/NF-kappaB signaling
KEGG hsa:54469
Orthology
iUUCD ID Species Identity E-value Score
IUUC-Aml-001996 Ailuropoda melanoleuca 67.38 1.00e-82 299.00
IUUC-Apl-003230 Anas platyrhynchos 76.00 5.00e-91 327.00
IUUC-Aca-004458 Anolis carolinensis 80.57 5.00e-95 340.00
IUUC-Aly-005845 Arabidopsis lyrata 31.58 2.00e-23 101.00
IUUC-Ath-007039 Arabidopsis thaliana 31.63 6.00e-22 96.70
IUUC-Bol-015417 Brassica oleracea 34.67 8.00e-26 109.00
IUUC-Bra-017534 Brassica rapa 35.86 3.00e-25 107.00
IUUC-Cja-019854 Callithrix jacchus 98.08 6.00e-107 379.00
IUUC-Cfa-020592 Canis familiaris 95.19 4.00e-116 409.00
IUUC-Cpo-022191 Cavia porcellus 88.94 1.00e-92 332.00
IUUC-Cre-022706 Chlamydomonas reinhardtii 31.40 2.00e-23 101.00
IUUC-Csa-023200 Chlorocebus sabaeus 98.56 3.00e-104 370.00
IUUC-Cho-025055 Choloepus hoffmanni 86.16 9.00e-69 252.00
IUUC-Cme-027230 Cyanidioschyzon merolae 60.71 8.00e-07 47.00
IUUC-Dno-029778 Dasypus novemcinctus 97.60 6.00e-109 386.00
IUUC-Dor-030783 Dipodomys ordii 78.85 2.00e-74 271.00
IUUC-Dme-032180 Drosophila melanogaster 40.87 8.00e-36 143.00
IUUC-Ete-033057 Echinops telfairi 92.82 2.00e-104 371.00
IUUC-Eca-033680 Equus caballus 95.67 5.00e-109 386.00
IUUC-Fca-036284 Felis catus 93.24 4.00e-114 403.00
IUUC-Fal-036744 Ficedula albicollis 80.86 5.00e-93 333.00
IUUC-Gga-041083 Gallus gallus 81.34 1.00e-91 328.00
IUUC-Gma-043379 Glycine max 32.69 8.00e-23 99.40
IUUC-Ggo-045187 Gorilla gorilla 99.52 2.00e-108 384.00
IUUC-Itr-048209 Ictidomys tridecemlineatus 91.93 4.00e-107 380.00
IUUC-Lch-049537 Latimeria chalumnae 71.23 3.00e-78 284.00
IUUC-Lpe-050729 Leersia perrieri 56.45 3.00e-20 92.80
IUUC-Loc-051871 Lepisosteus oculatus 66.82 2.00e-74 271.00
IUUC-Laf-053415 Loxodonta africana 89.24 2.00e-113 401.00
IUUC-Mcc-055523 Macaca mulatta 98.56 3.00e-104 370.00
IUUC-Meu-056041 Macropus eugenii 78.95 2.00e-88 318.00
IUUC-Mga-059999 Meleagris gallopavo 74.89 3.00e-88 317.00
IUUC-Mmr-061275 Microcebus murinus 88.94 2.00e-105 374.00
IUUC-Mdo-062315 Monodelphis domestica 94.26 8.00e-115 405.00
IUUC-Mmu-063968 Mus musculus 88.34 6.00e-112 396.00
IUUC-Mac-065404 Musa acuminata 34.85 5.00e-26 110.00
IUUC-Mpu-066705 Mustela putorius furo 92.31 5.00e-112 396.00
IUUC-Mlu-067748 Myotis lucifugus 86.16 2.00e-96 345.00
IUUC-Nle-069143 Nomascus leucogenys 98.08 7.00e-106 376.00
IUUC-Opr-070483 Ochotona princeps 89.42 2.00e-95 341.00
IUUC-Oan-073186 Ornithorhynchus anatinus 84.21 2.00e-99 354.00
IUUC-Ocu-073771 Oryctolagus cuniculus 91.83 2.00e-91 328.00
IUUC-Oga-088957 Otolemur garnettii 95.67 4.00e-108 383.00
IUUC-Oar-089228 Ovis aries 95.19 2.00e-116 410.00
IUUC-Ptr-090990 Pan troglodytes 99.52 2.00e-108 384.00
IUUC-Pan-092389 Papio anubis 98.08 3.00e-104 370.00
IUUC-Psi-093513 Pelodiscus sinensis 84.69 7.00e-93 332.00
IUUC-Ppa-095693 Physcomitrella patens 33.84 9.00e-26 109.00
IUUC-Pab-098666 Pongo abelii 99.04 4.00e-108 383.00
IUUC-Pca-100099 Procavia capensis 84.13 5.00e-96 343.00
IUUC-Pva-102935 Pteropus vampyrus 94.31 2.00e-104 371.00
IUUC-Rno-104975 Rattus norvegicus 88.34 6.00e-112 396.00
IUUC-Sha-106855 Sarcophilus harrisii 87.56 9.00e-112 395.00
IUUC-Sly-111918 Solanum lycopersicum 38.57 5.00e-27 114.00
IUUC-Ssc-116012 Sus scrofa 86.70 1.00e-106 378.00
IUUC-Tgu-116855 Taeniopygia guttata 81.34 4.00e-94 337.00
IUUC-Tsy-119175 Tarsius syrichta 90.91 2.00e-107 381.00
IUUC-Tae-125099 Triticum aestivum 32.83 7.00e-25 106.00
IUUC-Tbe-127440 Tupaia belangeri 56.96 2.00e-42 164.00
IUUC-Ttr-128188 Tursiops truncatus 96.15 2.00e-87 314.00
IUUC-Vpa-130770 Vicugna pacos 96.63 9.00e-99 352.00
Created Date 25-Jun-2017

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