iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

UUCD2 ID

IUUC-Ola-087237

UUCD1 version

Ensembl Protein ID

UniProt Accession

Genbank Protein ID

Protein Name

E3 ubiquitin-protein ligase

Genbank Nucleotide ID

BAAF04008539

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSORLG00000015128.1	ENSORLT00000018959.1	ENSORLP00000018958.1

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 activity/HECT	4.10e-132	440.9	595	927

Active Site

Position(s)	Description	Evidence
896	Glycyl thioester intermediate	{ECO:0000256\|PIRSR:PIRSR001569-1, ECO:0000256\|PROSITE-ProRule:PRU00104}

Domain Profile

E3 activity/HECT

   S: 2    ksdlkkrlevefvgEegldlgGvtreflallskelqnpdlglflysendketlqpnpdsglknpehlklFeflGrllgkalqdgrlldl 90
           ++dl++rl++ ++gEegld+gG++re+++lls+e+ np+++lf+y  +++++lq+np+s + np+hl +F+f+Gr++++al++g+++d+
   Q: 595  PYDLRRRLYIIMRGEEGLDYGGIAREWFFLLSHEVLNPMYCLFEYAGKNNYCLQINPASSI-NPDHLTYFRFIGRFIAMALYHGKFIDT 682
           6799********************************************************9.89************************* PP
   S: 91   plsksfyklllgkklsledleevdpelykslkeikenaesdieelgldltfsvseeilgetkeeeLkpgGenipVtneNkeeYvklvve 179
            ++ +fyk++l+kk +l+dle++dpe+y+s++++ken   ++ e+g++l f ++ eilg++++++Lk +Gen+ Vt+eNkeeY++l+++
   Q: 683  GFTLPFYKRMLDKKPTLKDLESIDPEFYNSIMWVKEN---NLAECGVELYFAQDMEILGKVSTHQLKDDGENELVTEENKEEYISLLTD 768
           ***********************************99...9************************************************ PP
   S: 180  yrlkegikeqveafreGfneviplellslFteeelellicGeeeidvedlkketkykggytedspaiqwFwevleefsseerkafLqFv 268
           +r+++g++eq++af +Gfnev+ple+l++F+e+elel++cG++eid+ d++k+t y++ yt++s++i+wFw+v++e+++e+r ++LqFv
   Q: 769  WRFTRGVEEQTKAFLDGFNEVVPLEWLRYFDEKELELMLCGMQEIDLADWQKNTIYRH-YTKNSKQIHWFWQVVKEMDNEKRIRLLQFV 856
           ********************************************************99.****************************** PP
   S: 269  TgssrlPlgGfaelk....prlfvirkdasddrlPssnTCfnyLkLPeYsskeilkekLlyAieetkgFel 335
           Tg++rlP+gGf+el     p++f+i k +++++lP+s+TCfn+L+LP+Y+s e+l+ekLl+Aieet+gF++
   Q: 857  TGTCRLPVGGFQELIgsngPQKFCIDKVGKETWLPRSHTCFNRLDLPPYKSLEQLREKLLFAIEETEGFGQ 927
           *********************************************************************96 PP

Organism

Oryzias latipes

Protein Sequence
(Fasta)

MAAASVTRPG SAQSTEKSQL ILKVVSAKPQ SPKLPNRQSR LSSFVEVTAD GLTSETKKTG 60
KRSGNLELQW NEDLTLNVTP QSRLDLKLWS CHTLRKELLG SATIDLLETL RTHDGKMENV 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

TGGGATGTCA TGGCAGCTGC CAGCGTGACC AGACCTGGCA GTGCTCAGAG TACAGAAAAG 60
TCTCAGTTGA TCCTGAAAGG TCAGTCTTTT TTATTTTTGA TCACCTCTTC ATAGACTTTG 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-1185--Reference proteome
KW-0808--Transferase
KW-0833--Ubl conjugation pathway

Interpro

IPR000008--C2_dom
IPR024928--E3_ub_ligase_SMURF1
IPR000569--HECT_dom
IPR001202--WW_dom

PROSITE

PS50237--HECT
PS01159--WW_DOMAIN_1
PS50020--WW_DOMAIN_2

Pfam

PF00168--C2
PF00632--HECT
PF00397--WW

SMART

SM00239--C2
SM00119--HECTc
SM00456--WW

Gene Ontology

GO:0004842--F:ubiquitin-protein transferase activity
GO:0060021--P:palate development

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001575	Ailuropoda melanoleuca	85.81	0.00e+00	1077.00
IUUC-Aca-004291	Anolis carolinensis	85.12	0.00e+00	1094.00
IUUC-Bta-013231	Bos taurus	88.20	0.00e+00	1072.00
IUUC-Cja-019455	Callithrix jacchus	88.03	0.00e+00	1068.00
IUUC-Cfa-021017	Canis familiaris	88.73	0.00e+00	1078.00
IUUC-Cpo-021988	Cavia porcellus	86.27	0.00e+00	1088.00
IUUC-Csa-023549	Chlorocebus sabaeus	88.03	0.00e+00	1073.00
IUUC-Dre-028513	Danio rerio	93.36	0.00e+00	1144.00
IUUC-Dno-028976	Dasypus novemcinctus	88.56	0.00e+00	1078.00
IUUC-Dor-030176	Dipodomys ordii	83.66	0.00e+00	1066.00
IUUC-Eca-033949	Equus caballus	88.20	0.00e+00	1075.00
IUUC-Eeu-034529	Erinaceus europaeus	85.23	0.00e+00	907.00
IUUC-Fca-036236	Felis catus	85.81	0.00e+00	1090.00
IUUC-Fal-036948	Ficedula albicollis	89.18	0.00e+00	1085.00
IUUC-Gmo-038842	Gadus morhua	91.73	0.00e+00	1071.00
IUUC-Gga-040617	Gallus gallus	72.11	0.00e+00	1273.00
IUUC-Gac-041338	Gasterosteus aculeatus	91.78	0.00e+00	1113.00
IUUC-Ggo-045278	Gorilla gorilla	88.56	0.00e+00	1077.00
IUUC-Hsa-046148	Homo sapiens	88.56	0.00e+00	1078.00
IUUC-Itr-047945	Ictidomys tridecemlineatus	88.08	0.00e+00	1000.00
IUUC-Lch-050663	Latimeria chalumnae	87.67	0.00e+00	1103.00
IUUC-Loc-052604	Lepisosteus oculatus	88.62	0.00e+00	1101.00
IUUC-Laf-053944	Loxodonta africana	88.13	0.00e+00	1084.00
IUUC-Mcc-055655	Macaca mulatta	88.03	0.00e+00	1074.00
IUUC-Meu-055953	Macropus eugenii	74.38	0.00e+00	920.00
IUUC-Mga-060190	Meleagris gallopavo	71.89	0.00e+00	1278.00
IUUC-Mmr-060896	Microcebus murinus	88.38	0.00e+00	1078.00
IUUC-Mdo-062536	Monodelphis domestica	69.60	0.00e+00	1263.00
IUUC-Mmu-064017	Mus musculus	84.08	0.00e+00	1078.00
IUUC-Mpu-066608	Mustela putorius furo	81.89	0.00e+00	1033.00
IUUC-Mlu-067623	Myotis lucifugus	85.41	0.00e+00	1026.00
IUUC-Nle-069496	Nomascus leucogenys	64.48	0.00e+00	1137.00
IUUC-Opr-071054	Ochotona princeps	88.03	0.00e+00	1063.00
IUUC-Ont-071279	Oreochromis niloticus	79.74	0.00e+00	1388.00
IUUC-Oan-073512	Ornithorhynchus anatinus	84.17	0.00e+00	1044.00
IUUC-Ocu-074271	Oryctolagus cuniculus	80.88	0.00e+00	1071.00
IUUC-Oga-088164	Otolemur garnettii	81.10	0.00e+00	1075.00
IUUC-Oar-089698	Ovis aries	88.20	0.00e+00	1071.00
IUUC-Ptr-091306	Pan troglodytes	86.97	0.00e+00	1052.00
IUUC-Pan-092814	Papio anubis	86.62	0.00e+00	1050.00
IUUC-Pfo-096709	Poecilia formosa	82.25	0.00e+00	1407.00
IUUC-Pab-098494	Pongo abelii	88.36	0.00e+00	1073.00
IUUC-Pca-100596	Procavia capensis	77.29	0.00e+00	941.00
IUUC-Pva-103154	Pteropus vampyrus	85.44	0.00e+00	1030.00
IUUC-Rno-104954	Rattus norvegicus	83.75	0.00e+00	1066.00
IUUC-Sha-106781	Sarcophilus harrisii	69.64	0.00e+00	1274.00
IUUC-Ssc-116307	Sus scrofa	81.86	0.00e+00	1009.00
IUUC-Tgu-116530	Taeniopygia guttata	83.45	0.00e+00	984.00
IUUC-Tru-118287	Takifugu rubripes	93.86	0.00e+00	1092.00
IUUC-Tni-120801	Tetraodon nigroviridis	92.24	0.00e+00	1115.00
IUUC-Tbe-127793	Tupaia belangeri	75.92	0.00e+00	918.00
IUUC-Ttr-128275	Tursiops truncatus	88.20	0.00e+00	1074.00
IUUC-Xtr-132866	Xenopus tropicalis	84.01	0.00e+00	1057.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence