iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSG00000015153.14	ENST00000327791.8	ENSP00000328004.5
ENSG00000015153.14	ENST00000534854.6	ENSP00000439256.2
ENSG00000015153.14	ENST00000380790.4	ENSP00000370167.4
ENSG00000015153.14	ENST00000552109.5	ENSP00000448533.1
ENSG00000015153.14	ENST00000547351.5	ENSP00000450394.1
ENSG00000015153.14	ENST00000551268.5	ENSP00000448291.1
ENSG00000015153.14	ENST00000548661.5	ENSP00000447217.1
ENSG00000015153.14	ENST00000546726.5	ENSP00000447863.1
ENSG00000015153.14	ENST00000552928.5	ENSP00000450097.1
ENSG00000015153.14	ENST00000555248.2	ENSP00000451626.2

Annotation

Cancer Mutation
TCGA	ICGC	COSMIC	CGAP
IntOGen
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEO	ArrayExpress	TCGA	ICGC
COSMIC	THPA	HPM
DNA & RNA Element
UTRdb	AREsite	circBase	CircNet
miRTarBase	microRNA	TRANSFAC	TargetScan
RepTar	SomamiR	miRcode	RAID2
Protein-protein Interaction
IID	PINA	HINT	Mentha
InWeb_IM
Protein 3D Structure
PDB	MMDB
Disease-associated Variation
GWASdb	OMIM
Post-translational Modifications (PTMs)
CPLM	dbPAF	PhosphositePlus	dbPTM
HPRD	Phospho.ELM	UniProt	PHOSIDA
BioGRID	mUbiSiDa
DNA Methylation
TCGA	ICGC
Protein Expression/Proteomics
THPA	HPM	GPMDB

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
UBD/ZnF/NZF	1.10e-12	48.8	20	48

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

UBD/ZnF/NZF

   S: 2    eaqWaCsaCTflNePeavkCemCsrpRgc 30
           e+ W+Cs+CTf+N++ea+kC mC+ ++g+
   Q: 20   EGYWDCSVCTFRNSAEAFKCMMCDVRKGT 48
           677************************95 PP

Organism

Homo sapiens

Functional Description
(View)

Binds to MYC and inhibits MYC-mediated transactivation. Also binds to MYCN and enhances MYCN-dependent transcriptional activation. Increases calpain 2-mediated proteolysis of YY1 in vitro. Component of the E2F6.com-1 complex, a repressive complex that methylates 'Lys-9' of histone H3, suggesting that it is involved in chromatin-remodeling.

Protein Sequence
(Fasta)

MGDKKSPTRP KRQPKPSSDE GYWDCSVCTF RNSAEAFKCM MCDVRKGTST RSTLFEVIVS 60
ASRTKEPLKF PISGRKPRPV SQLVAQQVTQ QFVPPTQSKK EKKDKVEKEK SEKETTSKKN 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

AGCTGGAGGC TGCGTGGGAT CCGGCGGCGG CTCCCGAGCG CGGCGGTGCG GCCTTCCCCG 60
CCCCCTCCCT CCCTCCTCCC CCGCCCGCTT CCGCCCGGCT TATTATCCTC CTTATTGACA 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0002--3D-structure
KW-0025--Alternative splicing
KW-0181--Complete proteome
KW-0479--Metal-binding
KW-0539--Nucleus
KW-0597--Phosphoprotein
KW-1185--Reference proteome
KW-0804--Transcription
KW-0805--Transcription regulation
KW-0862--Zinc
KW-0863--Zinc-finger

Interpro

IPR033774--YAF2_RYBP
IPR001876--Znf_RanBP2

PROSITE

PS01358--ZF_RANBP2_1
PS50199--ZF_RANBP2_2

Pfam

PF17219--YAF2_RYBP
PF00641--zf-RanBP

SMART

SM00547--ZnF_RBZ

Gene Ontology

GO:0005829--C:cytosol
GO:0005654--C:nucleoplasm
GO:0005634--C:nucleus
GO:0003713--F:transcription coactivator activity
GO:0003714--F:transcription corepressor activity
GO:0008270--F:zinc ion binding
GO:0045892--P:negative regulation of transcription, DNA-templated
GO:0045893--P:positive regulation of transcription, DNA-templated
GO:0006351--P:transcription, DNA-templated

KEGG

hsa:10138

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001905	Ailuropoda melanoleuca	87.23	3.00e-40	157.00
IUUC-Aca-004478	Anolis carolinensis	86.76	4.00e-54	203.00
IUUC-Ame-011908	Astyanax mexicanus	75.73	3.00e-62	231.00
IUUC-Bta-012681	Bos taurus	84.31	3.00e-40	157.00
IUUC-Cja-018878	Callithrix jacchus	100.00	8.00e-68	249.00
IUUC-Cfa-020696	Canis familiaris	98.98	5.00e-62	230.00
IUUC-Cpo-022486	Cavia porcellus	86.73	2.00e-44	171.00
IUUC-Cho-024392	Choloepus hoffmanni	87.03	1.00e-38	152.00
IUUC-Dre-028175	Danio rerio	71.50	8.00e-44	169.00
IUUC-Dno-030093	Dasypus novemcinctus	100.00	5.00e-21	93.20
IUUC-Dme-031799	Drosophila melanogaster	42.04	1.00e-23	102.00
IUUC-Eeu-034971	Erinaceus europaeus	86.89	2.00e-37	147.00
IUUC-Fca-036586	Felis catus	100.00	5.00e-21	92.80
IUUC-Gmo-038950	Gadus morhua	66.67	1.00e-47	182.00
IUUC-Gga-040428	Gallus gallus	87.75	7.00e-45	173.00
IUUC-Gac-042503	Gasterosteus aculeatus	67.55	6.00e-47	180.00
IUUC-Ggo-044644	Gorilla gorilla	87.76	5.00e-45	173.00
IUUC-Itr-048494	Ictidomys tridecemlineatus	100.00	1.00e-27	114.00
IUUC-Lch-050130	Latimeria chalumnae	80.39	9.00e-59	219.00
IUUC-Loc-052825	Lepisosteus oculatus	69.17	1.00e-49	189.00
IUUC-Laf-054318	Loxodonta africana	87.25	4.00e-47	180.00
IUUC-Mcc-054885	Macaca mulatta	66.98	6.00e-34	135.00
IUUC-Meu-056465	Macropus eugenii	68.66	1.00e-48	185.00
IUUC-Mga-059338	Meleagris gallopavo	100.00	5.00e-19	86.30
IUUC-Mmr-060766	Microcebus murinus	96.23	5.00e-28	116.00
IUUC-Mdo-062390	Monodelphis domestica	86.76	3.00e-48	184.00
IUUC-Mmu-063437	Mus musculus	78.43	7.00e-53	199.00
IUUC-Nle-070014	Nomascus leucogenys	100.00	8.00e-68	249.00
IUUC-Ont-071471	Oreochromis niloticus	71.36	5.00e-59	220.00
IUUC-Ocu-073946	Oryctolagus cuniculus	82.56	5.00e-58	216.00
IUUC-Ola-086923	Oryzias latipes	72.20	3.00e-59	221.00
IUUC-Oga-089162	Otolemur garnettii	82.08	5.00e-31	127.00
IUUC-Oar-090289	Ovis aries	95.56	3.00e-23	99.80
IUUC-Ptr-091285	Pan troglodytes	100.00	8.00e-68	249.00
IUUC-Pma-094646	Petromyzon marinus	56.88	5.00e-39	153.00
IUUC-Pfo-097428	Poecilia formosa	60.00	2.00e-42	164.00
IUUC-Pva-102993	Pteropus vampyrus	88.24	1.00e-49	189.00
IUUC-Rno-105835	Rattus norvegicus	80.39	8.00e-49	186.00
IUUC-Sha-107285	Sarcophilus harrisii	86.27	2.00e-48	185.00
IUUC-Tgu-116993	Taeniopygia guttata	87.25	2.00e-44	171.00
IUUC-Tru-118599	Takifugu rubripes	64.74	2.00e-45	174.00
IUUC-Tsy-119409	Tarsius syrichta	100.00	2.00e-20	91.30
IUUC-Tni-120574	Tetraodon nigroviridis	67.96	2.00e-55	208.00
IUUC-Ttr-128187	Tursiops truncatus	86.08	5.00e-41	160.00
IUUC-Vpa-130247	Vicugna pacos	86.67	4.00e-43	167.00
IUUC-Xtr-132148	Xenopus tropicalis	81.37	5.00e-67	246.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence