iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

iUUCD ID

IUUC-Sha-107247

Ensembl Protein ID

ENSSHAP00000021710.1

UniProt Accession

G3X205; G3X205_SARHA

Genbank Protein ID

ENSSHAP00000021710

Protein Name

Uncharacterized protein

Genbank Nucleotide ID

AEFK01163400

Gene Name

GRB2

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSSHAG00000018383.1	ENSSHAT00000021884.1	ENSSHAP00000021710.1

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
UBD/SH3	4.50e-25	87.5	131	188

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

UBD/SH3

   S: 2    skekvqvlydyeaqnddeLtlkkGdvvlviekeeqdegWlkgvkelegkrGlfPenFvekle 63
           +  +vq+l+d+++q+d+eL +++Gd+++v+  ++ d +W+kg    +g+ G+fP n+v+ ++
   Q: 131  QPTYVQALFDFDPQEDGELGFRRGDFIQVL--DNSDPNWWKG--ACHGQTGMFPRNYVTPVN 188
           5689**************************..9*********..8**************997 PP

Organism

Sarcophilus harrisii

Protein Sequence
(Fasta)

VLNEECDQNW YKAELNGKDG FIPKNYIEMK PHPWFFGKIP RAKAEEMLGK QRHDGAFLIR 60
ESESAPGDFS LSVKFGNDVQ HFKVLRDGAG KYFLWVVKFN SLNELVDYHR STSVSRNQQI 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

GTATTGAATG AAGAATGTGA TCAAAATTGG TATAAAGCAG AACTTAATGG AAAAGATGGC 60
TTCATTCCCA AAAACTACAT AGAAATGAAA CCACATCCGT AAGTTAAATT CCACTAATTT 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-1185--Reference proteome
KW-0728--SH3 domain

Interpro

IPR000980--SH2
IPR001452--SH3_domain

PROSITE

PS50001--SH2
PS50002--SH3

Pfam

PF00017--SH2
PF00018--SH3_1

PRINTS

PR00401--SH2DOMAIN
PR00452--SH3DOMAIN

SMART

SM00252--SH2
SM00326--SH3

Gene Ontology

GO:0005911--C:cell-cell junction
GO:0008180--C:COP9 signalosome
GO:0005768--C:endosome
GO:0070062--C:extracellular exosome
GO:0070436--C:Grb2-EGFR complex
GO:0005730--C:nucleolus
GO:0005654--C:nucleoplasm
GO:0012506--C:vesicle membrane
GO:0003723--F:RNA binding
GO:0048646--P:anatomical structure formation involved in morphogenesis
GO:0060670--P:branching involved in labyrinthine layer morphogenesis
GO:0030154--P:cell differentiation
GO:0071479--P:cellular response to ionizing radiation
GO:0008286--P:insulin receptor signaling pathway
GO:0030838--P:positive regulation of actin filament polymerization
GO:2000379--P:positive regulation of reactive oxygen species metabolic process
GO:0009967--P:positive regulation of signal transduction
GO:0031623--P:receptor internalization
GO:0043408--P:regulation of MAPK cascade
GO:0042770--P:signal transduction in response to DNA damage

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001345	Ailuropoda melanoleuca	97.91	1.00e-111	395.00
IUUC-Apl-003322	Anas platyrhynchos	99.48	1.00e-112	398.00
IUUC-Aca-005193	Anolis carolinensis	99.48	3.00e-113	400.00
IUUC-Ago-007965	Ashbya gossypii	50.00	5.00e-13	67.80
IUUC-Ame-010929	Astyanax mexicanus	93.72	9.00e-108	382.00
IUUC-Bta-012932	Bos taurus	97.91	2.00e-112	397.00
IUUC-Cel-018665	Caenorhabditis elegans	57.07	6.00e-61	226.00
IUUC-Cja-019225	Callithrix jacchus	97.91	2.00e-112	397.00
IUUC-Cfa-020887	Canis familiaris	97.91	2.00e-112	397.00
IUUC-Cpo-022488	Cavia porcellus	97.91	2.00e-112	397.00
IUUC-Csa-023326	Chlorocebus sabaeus	97.91	2.00e-112	397.00
IUUC-Cho-024953	Choloepus hoffmanni	97.33	8.00e-86	309.00
IUUC-Dre-028403	Danio rerio	95.81	3.00e-110	390.00
IUUC-Dno-029120	Dasypus novemcinctus	97.38	2.00e-111	394.00
IUUC-Dor-030763	Dipodomys ordii	97.91	2.00e-112	397.00
IUUC-Dme-031741	Drosophila melanogaster	63.44	4.00e-66	243.00
IUUC-Ete-032354	Echinops telfairi	64.74	8.00e-66	242.00
IUUC-Eca-033222	Equus caballus	97.91	2.00e-112	397.00
IUUC-Eeu-034513	Erinaceus europaeus	68.06	4.00e-71	260.00
IUUC-Fca-036294	Felis catus	97.91	2.00e-112	397.00
IUUC-Fal-037130	Ficedula albicollis	98.43	9.00e-112	395.00
IUUC-Gmo-039546	Gadus morhua	94.76	1.00e-108	385.00
IUUC-Gga-041139	Gallus gallus	99.48	2.00e-113	400.00
IUUC-Gac-041968	Gasterosteus aculeatus	96.86	1.00e-110	392.00
IUUC-Ggo-044562	Gorilla gorilla	97.91	2.00e-112	397.00
IUUC-Hsa-046730	Homo sapiens	97.91	2.00e-112	397.00
IUUC-Itr-049025	Ictidomys tridecemlineatus	97.91	2.00e-112	397.00
IUUC-Lch-050230	Latimeria chalumnae	96.95	1.00e-72	265.00
IUUC-Loc-052723	Lepisosteus oculatus	97.38	4.00e-111	393.00
IUUC-Laf-053774	Loxodonta africana	96.34	4.00e-111	393.00
IUUC-Mcc-054603	Macaca mulatta	97.91	2.00e-112	397.00
IUUC-Meu-056173	Macropus eugenii	96.84	3.00e-90	323.00
IUUC-Mga-059950	Meleagris gallopavo	99.48	2.00e-113	400.00
IUUC-Mmr-060878	Microcebus murinus	97.91	2.00e-112	397.00
IUUC-Mdo-062454	Monodelphis domestica	99.48	2.00e-113	400.00
IUUC-Mmu-063913	Mus musculus	97.38	6.00e-112	395.00
IUUC-Mpu-066125	Mustela putorius furo	97.91	2.00e-112	397.00
IUUC-Mlu-068007	Myotis lucifugus	97.91	2.00e-112	397.00
IUUC-Nle-069101	Nomascus leucogenys	97.91	2.00e-112	397.00
IUUC-Opr-071075	Ochotona princeps	97.91	2.00e-112	397.00
IUUC-Ont-072253	Oreochromis niloticus	91.62	2.00e-105	374.00
IUUC-Ocu-074583	Oryctolagus cuniculus	97.91	2.00e-112	397.00
IUUC-Ola-086586	Oryzias latipes	96.92	2.00e-71	262.00
IUUC-Oga-089047	Otolemur garnettii	97.91	2.00e-112	397.00
IUUC-Oar-089904	Ovis aries	89.58	5.00e-101	359.00
IUUC-Ptr-090678	Pan troglodytes	97.91	2.00e-112	397.00
IUUC-Pan-092090	Papio anubis	97.91	2.00e-112	397.00
IUUC-Psi-093765	Pelodiscus sinensis	98.95	9.00e-113	398.00
IUUC-Pma-094650	Petromyzon marinus	85.34	1.00e-97	348.00
IUUC-Pfo-096131	Poecilia formosa	95.29	2.00e-109	387.00
IUUC-Pab-098709	Pongo abelii	97.91	2.00e-112	397.00
IUUC-Pca-100581	Procavia capensis	96.86	8.00e-111	392.00
IUUC-Pva-103066	Pteropus vampyrus	97.91	2.00e-112	397.00
IUUC-Rno-105224	Rattus norvegicus	97.91	2.00e-112	397.00
IUUC-Sce-106302	Saccharomyces cerevisiae	55.56	3.00e-16	78.20
IUUC-Sar-113277	Sorex araneus	96.84	1.00e-90	325.00
IUUC-Ssc-115478	Sus scrofa	97.91	2.00e-112	397.00
IUUC-Tgu-117479	Taeniopygia guttata	98.43	1.00e-111	395.00
IUUC-Tru-118451	Takifugu rubripes	84.24	2.00e-92	331.00
IUUC-Tsy-119029	Tarsius syrichta	91.79	1.00e-67	248.00
IUUC-Tbe-128097	Tupaia belangeri	97.38	2.00e-111	394.00
IUUC-Ttr-128871	Tursiops truncatus	99.23	2.00e-74	271.00
IUUC-Vpa-130754	Vicugna pacos	97.91	2.00e-112	397.00
IUUC-Xtr-132275	Xenopus tropicalis	92.12	4.00e-109	386.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence