iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSLACG00000010863.2	ENSLACT00000026050.1	ENSLACP00000023176.1
ENSLACG00000010863.2	ENSLACT00000012429.1	ENSLACP00000012336.1

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
DUB/USP	1.00e-110	370.3	152	680

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

DUB/USP

   S: 1    tGlkNlgNtCYmNSvLQcLsnipelrelllekkkeklneenpkepkgellkslqklfeelw.kskkkavsprellkalkkeaeefsgye 88
           tGlkN+gNtCYmNS+LQ+Lsn+p+lr+++ + ++  +    ++++  +l+k++qkl+  +w k++ ++v p++l++ +k+++++f+gy+
   Q: 152  TGLKNIGNTCYMNSALQALSNCPPLRQFFID-YEGLV----RTDKRYSLSKTYQKLLLDIWhKKRPGYVVPTSLFQGIKTVNPMFRGYS 235
           7******************************.44444....46789***************99999*********************** PP
   S: 89   qqDaqEflaflldqleeelkk...........eknkpkeeeeeedkselsde..................................... 129
           qqDaqEfl++l+dql+eelk+                +ee +ee++s+++ +                                     
   Q: 236  QQDAQEFLRCLMDQLHEELKEvvveiedpvsiI----VEENMEEENSQSDTDfqscescsncdkadietafkpfpegqtetsmlireke 320
           *******************99999888754432....333333333333333667799999**************************** PP
   S: 130  ......................................................................................... 129
                                                                                                    
   Q: 321  svhlsfkdrqkeknvinkhhrarsmenlekvidaaaaeansqgsikveipnklsdcstevpmnnlsrphvpipaegmsfkmsssppksa 409
           ***************************************************************************************** PP
   S: 130  ..................aeekkkkknkslisdlFqgqlksqikclecdnvssreepfldlslpvpgkeetkke............... 185
                              ++kk+k ++s+isd+F+g++ s+++cl+cd vs++ e+f+d+slp+pgke+ +k+               
   Q: 410  pvwsglssthkkgapfcpPKRKKQKTYRSVISDIFDGTIISSVQCLTCDCVSQTLETFQDISLPIPGKEDLAKLhssshqtslvkagsc 498
           *****************999999**********************************************99888*************** PP
   S: 186  ...................................slqdcLesftkeeelegenkyycekckkkqeaekklklkklPevLilhLkRfsf 239
                                              +lqdcL++f++++el+g+n+y+cekckk+++ +k +k++klPevL++hLkRf  
   Q: 499  geayapqgwiayimeyiksfmisildppwfwgpvvTLQDCLAAFFARDELKGDNMYSCEKCKKLRNGVKFCKVQKLPEVLCIHLKRF-- 585
           ***************************************************************************************.. PP
   S: 240  seeqksrekinkkvefple.LdlspfctspeekqkekkkYeLiavvvHsGslssGHYvayvknekgk.WllfdDskVtevkeeevleet 326
           ++e + ++ki+++v+fple Ldl+pf+++++ +q   ++Y+L++v++H+Gs+ sGHY+ay++n  ++ W+++dD++V+ev+e++v++  
   Q: 586  RHELMYSSKISTHVSFPLEgLDLQPFLAKDSPSQ--ITNYDLLSVICHHGSAASGHYIAYCRNYMNNlWYQYDDHTVSEVPESTVQN-- 670
           9999*************************88887..9**************************87778*******************.. PP
   S: 327  gstaYvlfYkr 337
            ++aYvlfY  
   Q: 671  -AEAYVLFYST 680
           .********75 PP

Organism

Latimeria chalumnae

Protein Sequence
(Fasta)

VNKMSCLSSD CPHLEFVGEI TKEELIEKSH GACQDCKVKG PNLWACLENG CSYVGCGESH 60
RDHSTLHSQD TRHSLTVNLT TLRVWCYICG KEVFLDRKLG PCSSVEEARP QEQHAQDLKV 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

AGGTAGCTTT AAATCAAGTT CTACGAATAA GAAACTAGGA AAGTGCTTAT TTAAAATAAT 60
TCTGAAGGTC AAACCTGTAA ACTGTTCTTA AAGAGAAAAC TACATTACTT GGATTATAAC 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-0378--Hydrolase
KW-0479--Metal-binding
KW-0645--Protease
KW-1185--Reference proteome
KW-0788--Thiol protease
KW-0833--Ubl conjugation pathway
KW-0862--Zinc
KW-0863--Zinc-finger

Interpro

IPR006615--Pept_C19_DUSP
IPR001394--Peptidase_C19_UCH
IPR018200--USP_CS
IPR028889--USP_dom
IPR013083--Znf_RING/FYVE/PHD
IPR001607--Znf_UBP

PROSITE

PS51283--DUSP
PS00972--USP_1
PS00973--USP_2
PS50235--USP_3
PS50271--ZF_UBP

Pfam

PF06337--DUSP
PF00443--UCH
PF02148--zf-UBP

SMART

SM00695--DUSP
SM00290--ZnF_UBP

Gene Ontology

GO:0004843--F:thiol-dependent ubiquitin-specific protease activity
GO:0008270--F:zinc ion binding
GO:0016579--P:protein deubiquitination
GO:0006511--P:ubiquitin-dependent protein catabolic process

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001742	Ailuropoda melanoleuca	70.17	0.00e+00	1309.00
IUUC-Apl-003987	Anas platyrhynchos	70.41	0.00e+00	1268.00
IUUC-Aca-004713	Anolis carolinensis	68.71	0.00e+00	1234.00
IUUC-Bta-013132	Bos taurus	70.81	0.00e+00	1311.00
IUUC-Cja-018811	Callithrix jacchus	70.43	0.00e+00	1311.00
IUUC-Cfa-021158	Canis familiaris	70.21	0.00e+00	1310.00
IUUC-Cpo-021910	Cavia porcellus	64.56	0.00e+00	1141.00
IUUC-Csa-023130	Chlorocebus sabaeus	70.34	0.00e+00	1305.00
IUUC-Cho-024383	Choloepus hoffmanni	50.11	1.00e-113	404.00
IUUC-Dre-028639	Danio rerio	68.52	0.00e+00	1224.00
IUUC-Dno-029416	Dasypus novemcinctus	68.95	0.00e+00	1251.00
IUUC-Dme-031837	Drosophila melanogaster	45.36	2.00e-123	436.00
IUUC-Ete-032994	Echinops telfairi	64.19	2.00e-127	449.00
IUUC-Eca-034248	Equus caballus	70.11	0.00e+00	1305.00
IUUC-Eeu-035357	Erinaceus europaeus	55.54	0.00e+00	919.00
IUUC-Fca-036013	Felis catus	68.84	0.00e+00	1269.00
IUUC-Fal-037509	Ficedula albicollis	70.52	0.00e+00	1293.00
IUUC-Gmo-038944	Gadus morhua	66.16	0.00e+00	1181.00
IUUC-Gga-040647	Gallus gallus	69.74	0.00e+00	1265.00
IUUC-Gac-041752	Gasterosteus aculeatus	68.04	0.00e+00	1228.00
IUUC-Hsa-045694	Homo sapiens	69.97	0.00e+00	1299.00
IUUC-Itr-049041	Ictidomys tridecemlineatus	69.93	0.00e+00	1277.00
IUUC-Kpa-049198	Komagataella pastoris	32.93	1.00e-28	121.00
IUUC-Loc-052616	Lepisosteus oculatus	72.66	0.00e+00	1338.00
IUUC-Laf-053493	Loxodonta africana	69.93	0.00e+00	1296.00
IUUC-Mcc-055542	Macaca mulatta	70.51	0.00e+00	1310.00
IUUC-Meu-056645	Macropus eugenii	60.11	0.00e+00	1049.00
IUUC-Mga-060019	Meleagris gallopavo	70.64	0.00e+00	1088.00
IUUC-Mmr-061241	Microcebus murinus	67.79	0.00e+00	1250.00
IUUC-Mmu-063786	Mus musculus	70.12	0.00e+00	1267.00
IUUC-Mpu-065772	Mustela putorius furo	71.49	0.00e+00	1093.00
IUUC-Mlu-067732	Myotis lucifugus	69.70	0.00e+00	1292.00
IUUC-Nle-069528	Nomascus leucogenys	69.21	0.00e+00	1302.00
IUUC-Opr-070606	Ochotona princeps	66.49	0.00e+00	1150.00
IUUC-Ont-071495	Oreochromis niloticus	68.64	0.00e+00	1239.00
IUUC-Oan-073259	Ornithorhynchus anatinus	54.97	0.00e+00	911.00
IUUC-Ocu-074457	Oryctolagus cuniculus	69.66	0.00e+00	1276.00
IUUC-Ola-086739	Oryzias latipes	67.78	0.00e+00	1262.00
IUUC-Oga-088720	Otolemur garnettii	69.67	0.00e+00	1316.00
IUUC-Oar-089921	Ovis aries	70.87	0.00e+00	1319.00
IUUC-Ptr-090526	Pan troglodytes	70.18	0.00e+00	1302.00
IUUC-Pan-092396	Papio anubis	70.82	0.00e+00	1303.00
IUUC-Psi-092971	Pelodiscus sinensis	71.58	0.00e+00	1328.00
IUUC-Pfo-097415	Poecilia formosa	68.20	0.00e+00	1247.00
IUUC-Pab-098740	Pongo abelii	70.31	0.00e+00	1325.00
IUUC-Pca-100614	Procavia capensis	54.15	0.00e+00	816.00
IUUC-Pva-102820	Pteropus vampyrus	67.62	0.00e+00	1105.00
IUUC-Rno-104894	Rattus norvegicus	69.17	0.00e+00	1273.00
IUUC-Sha-107244	Sarcophilus harrisii	65.34	0.00e+00	1159.00
IUUC-Sar-113665	Sorex araneus	68.77	0.00e+00	1281.00
IUUC-Ssc-115793	Sus scrofa	69.06	0.00e+00	1261.00
IUUC-Tgu-117487	Taeniopygia guttata	71.36	0.00e+00	1265.00
IUUC-Tru-117694	Takifugu rubripes	66.52	0.00e+00	1256.00
IUUC-Tsy-119598	Tarsius syrichta	62.00	0.00e+00	1046.00
IUUC-Tni-120189	Tetraodon nigroviridis	64.34	0.00e+00	1179.00
IUUC-Tbe-128125	Tupaia belangeri	73.56	5.00e-76	279.00
IUUC-Ttr-128269	Tursiops truncatus	69.00	0.00e+00	1238.00
IUUC-Vpa-130598	Vicugna pacos	68.95	0.00e+00	1268.00
IUUC-Xtr-132044	Xenopus tropicalis	70.16	0.00e+00	1241.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence