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Basic Information Integrated Annotations
Tag Content
UUCD2 ID IUUC-Hsa-045757
UUCD1 version UUC-HoS-01055
Ensembl Protein ID ENSP00000379739.3
UniProt Accession Q9Y573; A2A6V4; D3DQ11; Q8N5C3; IPP_HUMAN
Genbank Protein ID AAD39007.1; BAG51233.1; CAM12886.1; CAM12886.1; CAM12886.1; CAM12889.1; CAM12889.1; CAM12889.1; EAX06950.1; EAX06951.1; AAH32544.1
Protein Name Actin-binding protein IPP; Intracisternal A particle-promoted polypeptide; Kelch-like protein 27
Genbank Nucleotide ID AF156857; AK023880; AL604028; BX664740; CR589949; BX664740; AL604028; CR589949; CH471059; CH471059; BC032544
Gene Name IPP; KLHL27
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
ENSG00000197429.10 ENST00000359942.8 ENSP00000353024.4
ENSG00000197429.10 ENST00000396478.3 ENSP00000379739.3
Annotation
Cancer Mutation
TCGAICGCCOSMICCGAP
IntOGen
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEOArrayExpressTCGAICGC
COSMICHPM
DNA & RNA Element
UTRdbAREsitecircBasecircRNADb
CircNetmiRTarBasemicroRNATRANSFAC
TargetScanRepTarSomamiRmiRcode
RAID2
Protein-protein Interaction
Mentha
Disease-associated Variation
OMIM
Post-translational Modifications (PTMs)
CPLMdbPAFPhosphositePlusdbPTM
BioGRIDmUbiSiDa
DNA Methylation
TCGAICGCCOSMIC
Protein Expression/Proteomics
THPAGPMDB
Status Unreviewed
Classification
Family E-Value Score Start End
E3 adaptor/Cullin RING/BCR/BTB_3-box: BTB 3.40e-20 73.8 37 100
E3 adaptor/Cullin RING/BCR/BTB_3-box: 3-box 1.10e-08 34.2 136 166
Active Site
Position(s) Description Evidence
N/A N/A N/A
Domain Profile

   E3 adaptor/Cullin RING/BCR/BTB_3-box: BTB
   S: 1    aDvilvvggeeffahkivLaasSsvFyalflmeleesksklmveikdvqpevfrallkFlYtgkl 65
           +Dv+l+vg+e f+ah++vLaasS++F alf+++++es  k+ v i +++++ f+ ll+F+Ytg +
   Q: 37   CDVQLQVGQESFKAHRLVLAASSPYFAALFTGGMKESS-KDVVPILGIEAGIFQILLDFIYTGIV 100
           8************************************7.***********************966 PP
   

   E3 adaptor/Cullin RING/BCR/BTB_3-box: 3-box
   S: 1    leNclgilrfAdlydcpdLkdaaldfilkhF 31
           + Nc+gi++f+++  c+dL ++ +++i+ hF
   Q: 136  PLNCIGIFQFSEQIACHDLLEFSENYIHVHF 166
           57****************************9 PP
   
Organism Homo sapiens
Protein Sequence
(Fasta)
MANEDCPKAA DSPFSSDKHA QLILAQINKM RNGQHFCDVQ LQVGQESFKA HRLVLAASSP 60
YFAALFTGGM KESSKDVVPI LGIEAGIFQI LLDFIYTGIV NIGVNNVQEL IIAADMLQLT 120
It may take some time, please wait.

Protein Fasta Sequence


>IUUC-Hsa-045757|E3,BTB_3-box|Homo sapiens
Please wait for a moment...
Nucleotide Sequence
(Fasta)
CGCGACTGCG CGCGCAGGGC CTGAGCGGGC GCCGGAGGGA AGGGGAAGCG GCGGGTAAGG 60
AGGGCCTGCG TTCGGGCGCG TCTGTGACGG GGTTGGGAAC TTCCTCTTCT ACTCCCTCCG 120
It may take some time, please wait.

Nucleotide Fasta Sequence


>IUUC-Hsa-045757|E3,BTB_3-box|Homo sapiens
Please wait for a moment...
Sequence Source Ensembl
Keyword

KW-0009--Actin-binding
KW-0025--Alternative splicing
KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0206--Cytoskeleton
KW-0880--Kelch repeat
KW-0621--Polymorphism
KW-1185--Reference proteome
KW-0677--Repeat
Interpro

IPR011705--BACK
IPR017096--BTB-kelch_protein
IPR000210--BTB/POZ_dom
IPR011043--Gal_Oxase/kelch_b-propeller
IPR030104--IPP
IPR015915--Kelch-typ_b-propeller
IPR006652--Kelch_1
IPR011333--SKP1/BTB/POZ
PROSITE

PS50097--BTB
Pfam

PF07707--BACK
PF00651--BTB
PF01344--Kelch_1
SMART

SM00875--BACK
SM00225--BTB
SM00612--Kelch
Gene Ontology

GO:0015629--C:actin cytoskeleton
GO:0031463--C:Cul3-RING ubiquitin ligase complex
GO:0005737--C:cytoplasm
GO:0003779--F:actin binding
GO:0016567--P:protein ubiquitination
KEGG hsa:3652
Orthology
iUUCD ID Species Identity E-value Score
IUUC-Aml-001672 Ailuropoda melanoleuca 97.60 0.00e+00 1190.00
IUUC-Apl-003849 Anas platyrhynchos 83.56 0.00e+00 1031.00
IUUC-Aca-004563 Anolis carolinensis 79.55 0.00e+00 921.00
IUUC-Bta-013512 Bos taurus 95.89 0.00e+00 1173.00
IUUC-Cja-018771 Callithrix jacchus 97.77 0.00e+00 1189.00
IUUC-Cfa-020097 Canis familiaris 95.87 0.00e+00 1118.00
IUUC-Cpo-022161 Cavia porcellus 95.38 0.00e+00 1175.00
IUUC-Csa-024249 Chlorocebus sabaeus 99.14 0.00e+00 1209.00
IUUC-Dno-029046 Dasypus novemcinctus 96.92 0.00e+00 1182.00
IUUC-Dor-030510 Dipodomys ordii 93.42 0.00e+00 771.00
IUUC-Dme-031884 Drosophila melanogaster 37.50 1.00e-110 394.00
IUUC-Ete-032968 Echinops telfairi 86.64 0.00e+00 1043.00
IUUC-Eca-033203 Equus caballus 90.09 0.00e+00 1086.00
IUUC-Fca-036451 Felis catus 97.26 0.00e+00 1187.00
IUUC-Fal-036931 Ficedula albicollis 82.75 0.00e+00 1003.00
IUUC-Gmo-039098 Gadus morhua 67.25 0.00e+00 818.00
IUUC-Gga-040552 Gallus gallus 84.53 0.00e+00 1028.00
IUUC-Gac-041995 Gasterosteus aculeatus 71.26 0.00e+00 870.00
IUUC-Ggo-045305 Gorilla gorilla 92.41 0.00e+00 982.00
IUUC-Itr-048686 Ictidomys tridecemlineatus 96.06 0.00e+00 1176.00
IUUC-Lch-049691 Latimeria chalumnae 65.73 4.00e-166 577.00
IUUC-Loc-052552 Lepisosteus oculatus 73.34 0.00e+00 893.00
IUUC-Laf-053779 Loxodonta africana 91.64 0.00e+00 1118.00
IUUC-Mcc-054862 Macaca mulatta 98.92 0.00e+00 1147.00
IUUC-Mga-060083 Meleagris gallopavo 85.24 0.00e+00 1038.00
IUUC-Mmr-061303 Microcebus murinus 90.04 0.00e+00 1013.00
IUUC-Mdo-062064 Monodelphis domestica 88.53 0.00e+00 1084.00
IUUC-Mmu-063410 Mus musculus 93.49 0.00e+00 1159.00
IUUC-Mpu-066841 Mustela putorius furo 97.27 0.00e+00 1119.00
IUUC-Mlu-067053 Myotis lucifugus 87.96 0.00e+00 1027.00
IUUC-Nle-070066 Nomascus leucogenys 98.25 0.00e+00 1056.00
IUUC-Ont-072640 Oreochromis niloticus 72.68 0.00e+00 882.00
IUUC-Oan-073110 Ornithorhynchus anatinus 90.66 0.00e+00 1112.00
IUUC-Ocu-073916 Oryctolagus cuniculus 87.18 0.00e+00 1050.00
IUUC-Ola-086579 Oryzias latipes 64.11 0.00e+00 782.00
IUUC-Oga-088373 Otolemur garnettii 95.03 0.00e+00 1159.00
IUUC-Oar-089314 Ovis aries 95.72 0.00e+00 1174.00
IUUC-Ptr-090515 Pan troglodytes 99.82 0.00e+00 1145.00
IUUC-Pan-092367 Papio anubis 99.14 0.00e+00 1209.00
IUUC-Psi-093109 Pelodiscus sinensis 87.33 0.00e+00 1083.00
IUUC-Pma-094467 Petromyzon marinus 45.98 9.00e-130 457.00
IUUC-Pfo-096194 Poecilia formosa 73.03 0.00e+00 867.00
IUUC-Pab-098529 Pongo abelii 90.04 0.00e+00 999.00
IUUC-Pca-100654 Procavia capensis 95.36 2.00e-112 400.00
IUUC-Pva-102519 Pteropus vampyrus 89.26 0.00e+00 757.00
IUUC-Pte-104164 Pyrenophora teres 31.67 1.00e-05 43.50
IUUC-Rno-105294 Rattus norvegicus 94.50 0.00e+00 1128.00
IUUC-Sha-106587 Sarcophilus harrisii 86.86 0.00e+00 1068.00
IUUC-Sar-113688 Sorex araneus 96.40 0.00e+00 1175.00
IUUC-Tgu-117449 Taeniopygia guttata 83.33 0.00e+00 1011.00
IUUC-Tru-118138 Takifugu rubripes 72.66 0.00e+00 880.00
IUUC-Tsy-118868 Tarsius syrichta 82.28 0.00e+00 662.00
IUUC-Tni-120684 Tetraodon nigroviridis 72.26 0.00e+00 905.00
IUUC-Ttr-128460 Tursiops truncatus 97.95 0.00e+00 711.00
IUUC-Vpa-130752 Vicugna pacos 96.23 0.00e+00 1163.00
IUUC-Xtr-131890 Xenopus tropicalis 70.77 0.00e+00 875.00
IUUC-Xma-133979 Xiphophorus maculatus 73.71 0.00e+00 844.00
Created Date 25-Jun-2017

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