iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

UUCD2 ID

IUUC-Bta-013183

UUCD1 version

UUC-BoT-00998

Ensembl Protein ID

ENSBTAP00000015929.2

UniProt Accession

Q861R0; Q1RMX0; SOCS2_BOVIN

Genbank Protein ID

AAO45009.1; AAO45010.1; AAI14663.1

Protein Name

Suppressor of cytokine signaling 2

Genbank Nucleotide ID

AY183451; AY183452; BC114662

Gene Name

SOCS2

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSBTAG00000012007.2	ENSBTAT00000015929.2	ENSBTAP00000015929.2

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 adaptor/Cullin RING/ECS/SOCS_VHL_BC-box	9.70e-15	54.3	153	197

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

E3 adaptor/Cullin RING/ECS/SOCS_VHL_BC-box

   S: 4    lwllrseprSLqhLCRlaIrrclgsqrlkaidkLPLPksLkdYLlyedyq 53
           +++l ++ ++LqhLCRl+I++c+ +     +++LPLP +LkdYL+++++q
   Q: 153  TKPLYTSAPPLQHLCRLTINKCTST-----VWGLPLPTRLKDYLEEYKFQ 197
           678999*******************.....8***************9886 PP

Organism

Bos taurus

Functional Description
(View)

SOCS family proteins form part of a classical negative feedback system that regulates cytokine signal transduction. SOCS2 appears to be a negative regulator in the growth hormone/IGF1 signaling pathway. Probable substrate recognition component of a SCF-like ECS (Elongin BC-CUL2/5-SOCS-box protein) E3 ubiquitin ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins (By similarity).

Protein Sequence
(Fasta)

MTLRCLESSG NGAEGAQSQW GTAGSAEEPS PEAARLAKAL RELSHTGWYW GSMTVNEAKE 60
KLKEAPEGTF LIRDSSHSDY LLTISVKTSA GPTNLRIEYQ DGKFRLDSII CVKSKLKQFD 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

TGGGGCGCCA AAGGAGCTCG GGCCGGCGGC AGGTATCAGA CCCGGGAGCC CGAAGGCTCC 60
GCCCCCACGA GGGCTGGGGA GGGCACTGGG GCGCGGCCGC CAGCGCCAGG CAGCCTGGGC 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-0341--Growth regulation
KW-0597--Phosphoprotein
KW-1185--Reference proteome
KW-0727--SH2 domain
KW-0734--Signal transduction inhibitor
KW-0833--Ubl conjugation pathway

Interpro

IPR000980--SH2
IPR028410--SOCS2
IPR001496--SOCS_box

PROSITE

PS50001--SH2
PS50225--SOCS

Pfam

PF00017--SH2
PF07525--SOCS_box

PRINTS

PR00401--SH2DOMAIN

SMART

SM00252--SH2
SM00253--SOCS
SM00969--SOCS_box

Gene Ontology

GO:0005737--C:cytoplasm
GO:0004860--F:protein kinase inhibitor activity
GO:0019221--P:cytokine-mediated signaling pathway
GO:0060396--P:growth hormone receptor signaling pathway
GO:0035556--P:intracellular signal transduction
GO:0046627--P:negative regulation of insulin receptor signaling pathway
GO:0046426--P:negative regulation of JAK-STAT cascade
GO:0006469--P:negative regulation of protein kinase activity
GO:0016567--P:protein ubiquitination
GO:0001558--P:regulation of cell growth
GO:0032355--P:response to estradiol

KEGG

bta:338437

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-002075	Ailuropoda melanoleuca	96.46	1.00e-105	375.00
IUUC-Apl-003484	Anas platyrhynchos	79.08	3.00e-72	263.00
IUUC-Aca-004253	Anolis carolinensis	70.73	4.00e-71	260.00
IUUC-Ath-007106	Arabidopsis thaliana	35.59	2.10e-02	33.50
IUUC-Ame-011267	Astyanax mexicanus	62.87	3.00e-59	221.00
IUUC-Bra-017915	Brassica rapa	33.90	3.90e-02	32.30
IUUC-Cja-018862	Callithrix jacchus	94.44	1.00e-98	352.00
IUUC-Cfa-020226	Canis familiaris	95.43	1.00e-97	348.00
IUUC-Cpo-022414	Cavia porcellus	94.44	2.00e-103	367.00
IUUC-Csa-023758	Chlorocebus sabaeus	93.94	9.00e-103	365.00
IUUC-Cho-024471	Choloepus hoffmanni	86.84	2.00e-72	264.00
IUUC-Dre-028288	Danio rerio	56.99	1.00e-63	235.00
IUUC-Dno-029036	Dasypus novemcinctus	94.95	2.00e-104	371.00
IUUC-Dor-030447	Dipodomys ordii	97.35	1.00e-86	311.00
IUUC-Ete-033023	Echinops telfairi	91.41	1.00e-107	381.00
IUUC-Fca-036469	Felis catus	97.47	5.00e-102	363.00
IUUC-Fal-036642	Ficedula albicollis	72.84	4.00e-70	256.00
IUUC-Gmo-039331	Gadus morhua	61.54	2.00e-35	140.00
IUUC-Gga-040809	Gallus gallus	76.10	2.00e-72	264.00
IUUC-Gac-041398	Gasterosteus aculeatus	55.72	2.00e-60	224.00
IUUC-Ggo-045341	Gorilla gorilla	94.95	6.00e-99	352.00
IUUC-Hsa-046557	Homo sapiens	94.44	3.00e-111	393.00
IUUC-Itr-049013	Ictidomys tridecemlineatus	81.73	2.00e-91	328.00
IUUC-Lch-050160	Latimeria chalumnae	61.07	8.00e-50	189.00
IUUC-Loc-051825	Lepisosteus oculatus	55.73	6.00e-61	226.00
IUUC-Laf-053560	Loxodonta africana	93.43	3.00e-96	343.00
IUUC-Mcc-055890	Macaca mulatta	93.94	9.00e-98	348.00
IUUC-Meu-056218	Macropus eugenii	79.80	4.00e-96	343.00
IUUC-Mga-059755	Meleagris gallopavo	68.85	5.00e-71	259.00
IUUC-Mmr-061387	Microcebus murinus	96.46	3.00e-105	374.00
IUUC-Mdo-062383	Monodelphis domestica	81.31	6.00e-96	342.00
IUUC-Mmu-063443	Mus musculus	92.42	9.00e-100	355.00
IUUC-Mpu-066459	Mustela putorius furo	95.96	6.00e-100	356.00
IUUC-Mlu-068040	Myotis lucifugus	95.45	2.00e-105	374.00
IUUC-Nle-069016	Nomascus leucogenys	90.40	1.00e-96	345.00
IUUC-Opr-071087	Ochotona princeps	88.38	2.00e-103	367.00
IUUC-Ont-072340	Oreochromis niloticus	55.12	1.00e-59	222.00
IUUC-Oan-073443	Ornithorhynchus anatinus	78.79	8.00e-91	325.00
IUUC-Ocu-074539	Oryctolagus cuniculus	94.42	1.00e-98	352.00
IUUC-Ola-087004	Oryzias latipes	59.49	8.00e-55	205.00
IUUC-Oga-088438	Otolemur garnettii	94.95	6.00e-104	369.00
IUUC-Oar-089932	Ovis aries	98.99	5.00e-104	369.00
IUUC-Ptr-091037	Pan troglodytes	94.95	6.00e-99	352.00
IUUC-Pan-092767	Papio anubis	94.95	6.00e-99	352.00
IUUC-Psi-093099	Pelodiscus sinensis	76.73	8.00e-74	268.00
IUUC-Pma-094671	Petromyzon marinus	46.11	3.00e-36	145.00
IUUC-Pfo-097073	Poecilia formosa	50.52	2.00e-55	208.00
IUUC-Pab-098319	Pongo abelii	94.44	5.00e-104	369.00
IUUC-Pca-101117	Procavia capensis	92.93	1.00e-99	354.00
IUUC-Pva-102117	Pteropus vampyrus	94.95	2.00e-97	347.00
IUUC-Rno-105913	Rattus norvegicus	91.92	2.00e-99	354.00
IUUC-Sha-106500	Sarcophilus harrisii	81.22	2.00e-94	338.00
IUUC-Ssc-115252	Sus scrofa	97.47	5.00e-107	379.00
IUUC-Tgu-117524	Taeniopygia guttata	74.84	1.00e-69	254.00
IUUC-Tsy-119335	Tarsius syrichta	94.70	1.00e-84	305.00
IUUC-Tni-120263	Tetraodon nigroviridis	53.72	2.00e-56	211.00
IUUC-Tbe-127915	Tupaia belangeri	95.45	6.00e-98	349.00
IUUC-Ttr-128372	Tursiops truncatus	96.97	2.00e-106	377.00
IUUC-Vpa-130422	Vicugna pacos	98.68	5.00e-88	315.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence